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| 2. |
- Pringle, K., Hearn, J., Mueller, U., Oleksy, E., Lattu, E., Chernova, J., Ferguson, H., Holter, O.G., Kolga, V., Novikova, I., Pitch, T., Ventimiglia, C., Lattu, E. and Millett, J.
(författare)
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Developing European-Wide Critical Studies on Men: A Theoretical, Political, Substantive and Practical Review
- 2001
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 3. |
- Pringle, K., J. Hearn, U. Mueller, E. Oleksy, J. Chernova, H. Ferguson, O.G. Holter, V. Kolga, I. Novikova, T. Pitch, C. Ventimiglia, E. Lattu, E. Olsvik and J. Millett
(författare)
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The European Research Network on Men in Europe: the social problem of men
- 2001
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Ingår i: Journal of European Social Policy. ; 11:2, s. 171-173
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Tidskriftsartikel (refereegranskat)
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| 4. |
- Hearn, J., Mueller, U., Oleksy, E., Pringle, K., Chernova, J., Ferguson, H., Holter, O.G., Kolga, V., Novikova, I., Pitch, T., Ventimiglia, C., Lattu, E., Tallberg, T. and Olsvik, E
(författare)
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Summary Report on Workpackage 3 on Ten National Reports on Law and Policy on Men
- 2001
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Rapport (övrigt vetenskapligt/konstnärligt)
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| 5. |
- Hearn, J., Pringle, K., Mueller, U., Oleksy, E., Lattu, E., Chernova, J., Ferguson, H., Holter, O.G., Kolga, V., Novikova, I., Pitch, T., Ventimiglia, C., Olsvik, E. and Tallberg, T
(författare)
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Critical Studies on Men in Ten European Countries (1): the state of academic research
- 2001
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Ingår i: Men and Masculinities. ; :5
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Tidskriftsartikel (refereegranskat)
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| 6. |
- Mårdh, Per-Anders, et al.
(författare)
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Facts and myths on recurrent vulvovaginal candidosis-a review on epidemiology, clinical manifestations, diagnosis, pathogenesis and therapy.
- 2002
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Ingår i: International Journal of STD and AIDS. - 0956-4624. ; 13:8, s. 522-539
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Forskningsöversikt (refereegranskat)abstract
- Approximately three-quarters of all women will experience an episode of vulvovaginal candidosis at least once in their life and 5-10% of them will have more than one attack. Women suffering from three to four attacks within 12 months will be diagnosed with recurrent vulvovaginal candidosis (RVVC). This review covers the large number of proposed aetiological factors for RVVC. The diagnosis of the condition made by conventional means by health providers is often false and is also often misdiagnosed by the affected woman herself. The review covers various methods of diagnosing RVVC and the current knowledge on potential pathogenetic mechanisms proposed for genital candida infections. Treatment of RVVC, including local and systemic antimicrobial therapy and behaviour modification to decrease the risk of recurrences, are discussed. Recent knowledge on drug resistance in candida is also included.
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| 7. |
- Novikov, Lev N, et al.
(författare)
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Exogenous brain-derived neurotrophic factor regulates the synaptic composition of axonally lesioned and normal adult rat motoneurons
- 2000
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Ingår i: Neuroscience. - : Elsevier. - 0306-4522 .- 1873-7544. ; 100:1, s. 171-181
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Tidskriftsartikel (refereegranskat)abstract
- Brain-derived neurotrophic factor has previously been shown to promote survival and axonal regeneration in injured spinal motoneurons and, also, to modulate synaptic transmission and regulate the density of synaptic innervation in a variety of neurons. The present light and electron microscopic study demonstrates synaptotrophic effects of exogenously applied brain-derived neurotrophic factor on the synaptic composition of both normal and axonally lesioned adult rat spinal motoneurons. After L5-L6 ventral root avulsion, a massive loss of all types of boutons occurred on the somata of the lesioned motoneurons which persisted for at least 12 weeks postoperatively. We found that (i) intrathecal infusion of brain-derived neurotrophic factor during the first postoperative week did not prevent the synaptic detachment and activation of glial cells; (ii) prolonged treatment for four weeks restored synaptic covering and significantly reduced microglial reaction; (iii) the synaptotrophic effect remained significant for at least eight weeks after cessation of the treatment; (iv) brain-derived neurotrophic factor mainly supported F-type boutons with presumably inhibitory function, while it had little effect on S-type boutons associated with excitatory action; and (v) in normal unlesioned motoneurons, four weeks of treatment with brain-derived neurotrophic factor induced sprouting of F-type boutons, a loss of S-type boutons and motoneuron atrophy. The present data show that exogenous neurotrophins not only help to restore synaptic circuitry in axonally injured motoneurons, but also strongly influence the synaptic composition in normal motoneurons.
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| 8. |
- Novikova, Liudmila N, et al.
(författare)
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BDNF abolishes the survival effect of NT-3 in axotomized Clarke neurons of adult rats
- 2000
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Ingår i: Journal of Comparative Neurology. - : Wiley-Liss, Inc.. - 0021-9967 .- 1096-9861. ; 428:4, s. 671-680
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Tidskriftsartikel (refereegranskat)abstract
- Neurotrophin-3 (NT-3) and brain-derived neurotrophic factor (BDNF) have previously been shown to support survival and axonal regeneration in various types of neurons. Also, synergistic neuroprotective effects of these neurotrophins have been reported in descending rubrospinal neurons after cervical spinal cord injury (Novikova et al., [2000] Eur. J. Neurosci. 12:776-780). The present study investigates the effects of intrathecally delivered NT-3 and BDNF on the survival and atrophy of ascending spinocerebellar neurons of Clarke nucleus (CN) after cervical spinal cord injury in adult rats. At 8 weeks after cervical spinal cord hemisection, 40% of the axotomized CN neurons had been lost, and the remaining cells exhibited marked atrophy. Microglial activity was significantly increased in CN of the operated side. Intrathecal infusion of NT-3 for 8 weeks postoperatively resulted in 91% cell survival and a reduction in cell atrophy, but did not reduce microglial activity. In spite of the fact that the CN neurons expressed both TrkC and TrkB receptors, only NT-3 had a neuroprotective effect, whereas BDNF was ineffective. Furthermore, when a combination of BDNF and NT-3 was administered, the neuroprotective effect of NT-3 was lost. The present results indicate a therapeutic potential for NT-3 in the treatment of spinal cord injury, but also demonstrate that in certain neuronal populations the neuroprotection obtained by a combination of neurotrophic factors may be less than that of a single neurotrophin.
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| 9. |
- Novikova, Liudmila N, et al.
(författare)
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Survival effects of BDNF and NT-3 on axotomized rubrospinal neurons depend on the temporal pattern of neurotrophin administration
- 2000
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Ingår i: European Journal of Neuroscience. - : Wiley-Blackwell. - 0953-816X .- 1460-9568. ; 12:2, s. 776-780
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Tidskriftsartikel (refereegranskat)abstract
- This study shows that both BDNF and NT-3 can prevent cell death in axotomized adult rat rubrospinal neurons (RSNs), but that the efficacy of neuroprotection depends on the temporal pattern of treatment. At 8 weeks after cervical spinal cord injury, 51% of the RSNs had died. Subarachnoidal BDNF infusion into the cisterna magna for 4 weeks resulted in neuronal hypertrophy and 71% survival. Continuous infusion for 8 weeks into the lumbar subarachnoidal space with either BDNF or NT-3 gave similar survival rates, while a combination of BDNF and NT-3 resulted in 96% survival, although the cells were atrophic. When administration of either BDNF or NT-3 was delayed and performed during postoperative weeks 5-8, the number of surviving neurons was increased compared to early treatment. Delayed treatment with a combination of BDNF and NT-3 resulted in complete survival and a reduction in neuronal atrophy. A decreased expression of TrkB receptors and microtubule-associated protein-2 in the RSNs after axotomy was counteracted by BDNF and NT-3. Microglial activity remained increased even when complete cell survival was achieved. Thus, the combination of neurotrophins as well as the temporal pattern of treatment need to be adequately defined to optimize survival of injured spinal tract neurons.
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