| 1. |
- Scanlan, Leona D, et al.
(författare)
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Gene transcription, metabolite and lipid profiling in eco-indicator daphnia magna indicate diverse mechanisms of toxicity by legacy and emerging flame-retardants.
- 2015
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Ingår i: Environmental Science and Technology. - : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 49:12
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Tidskriftsartikel (refereegranskat)abstract
- The use of chemical flame-retardants (FR) in consumer products has steadily increased over the last 30 years. Toxicity data exist for legacy FRs such as pentabromodiphenyl ether (pentaBDE), but less is known about effects of new formulations. To address this issue, the toxicity of seven FR chemicals and formulations was assessed on the freshwater crustacean Daphnia magna. Acute 48-h nominal LC50 values for penta- and octabromodiphenyl ether (pentaBDE, octaBDE), Firemaster 550 (FM550), Firemaster BZ-54 (BZ54), bis(2-ethylhexyl) tetrabromophthalate (BEH-TEBP), triphenyl phosphate (TPhP), and nonbrominated BEH-TEBP analog bis(2-ethylhexyl) phthalate (BEHP) ranged from 0.058 mg/L (pentaBDE) to 3.96 mg/L (octaBDE). mRNA expression, (1)H NMR-based metabolomic and lipidomic profiling at 1/10 LC50 revealed distinct patterns of molecular response for each exposure, suggesting pentaPBDE affects transcription and translation, octaBDE and BEH-TEBP affect glycosphingolipid biosynthesis and BZ54 affects Wnt and Hedgehog signal pathways as well as glycosaminoglycan degradation. Brominated components of FM550 (i.e., BZ54) were significantly higher in Daphnia after 48 h following 1/10 LC50 exposure. FM550 elicited significant mRNA changes at five concentrations across a range from 1/10(6) LC50 to 1/2 LC50. Analyses suggest FM550 impairs nutrient utilization or uptake in Daphnia.
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| 2. |
- Perez, Mauricio D., et al.
(författare)
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New Approach for Clinical Data Analysis of Microwave Sensor Based Bone Healing Monitoring System in Craniosynostosis Treated Pediatric Patients
- 2018
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Ingår i: 2018 IEEE Conference On Antenna Measurements & Applications (CAMA). - : IEEE. - 9781538657959
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Konferensbidrag (refereegranskat)abstract
- In the BDAS project one of the goals is to provide a solution to the monitoring bone healing issue complementing current techniques. Data have been collected in clinical trials from infants treated for Craniosynostosis by a craniotomy surgery. The data are collected with a biomedical sensor based in microwave technology. This sensor could be able to sense changes in the composition of the different tissues in the upper-hemisphere of the head by noticing a difference in the propagation of the microwaves, as the bone injury from the craniotomy heals over time. In this thesis, we analyse the clinical data in BDAS project incorporating new approaches with respect to previous analysis methods. These new approaches could give new insight into the proposed solution, but more analysis need to be done.
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| 3. |
- Redzwan, Syaiful, et al.
(författare)
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Initial in-vitro trial for intra-cranial pressure monitoring using subdermal proximity-coupled split-ring resonator
- 2018
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Ingår i: IMBioc 2018 - 2018 IEEE/MTT-S International Microwave Biomedical Conference. - : Institute of Electrical and Electronics Engineers (IEEE). - 9781538659182 ; , s. 73-75
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Konferensbidrag (refereegranskat)abstract
- Intra cranial pressure (ICP) monitoring is used in treating severe traumatic brain injury (TBI) patients. All current clinical available measurement methods are invasive presenting considerable social costs. This paper presents a preliminary investigation of the feasibility of ICP monitoring using an innovative microwave-based non-invasive approach. A phantom mimicking the dielectric characteristics of human tissues of the upper part of the head at low microwave frequencies is employed together to a proof-of-concept prototype based on the proposed approach consisting in a readout system and a sub-dermally implanted passive device, both based in split ring resonator techniques. This study shows the potential of our approach to detect two opposite pressure variation stages inside the skull. The employed phantom model needs to be improved to support finer variations in the pressure and better phantom parts, principally for the skull mimic and the loss tangent of all mimics.
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| 4. |
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| 5. |
- Velander, Jacob, et al.
(författare)
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A Four-Layer Phantom for Testing In-Vitro Microwave-Based Sensing Approach in Intra-Cranial Pressure Monitoring
- 2018
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Ingår i: Proceedings Of The 2018 IEEE/MTT-S International Microwave Biomedical Conference (IMBioC). - : IEEE. - 9781538659182 ; , s. 49-51
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Konferensbidrag (refereegranskat)abstract
- Multi-layer phantoms in proofs of concept, designs and validations of both microwave-based biomedical sensing and imaging system are becoming popular means to facilitate in-vitro experiments. In addition, they can contribute significantly to reduce animal use in scientific experimentation. In this paper, we design and fabricate a four-layer phantom composed of skin, skull, cerebrospinal fluid and brain mimic tissues to work between 2 and 3 GHz. In addition, the phantom incorporates a mechanism to produce pressure variation between the cerebrospinal fluid and the brain mimic tissues. This phantom is used in an in-vitro experiment to test and validate a new approach which could sense intra-cranial pressure variations through a microwave-based reflection method. The similarity of the phantom's tissues with human tissues from the viewpoint of the microwave response is analyzed in comparison with data from Italian Institute of Applied Physics in Florence. We found good agreement for the dielectric constant (Rel. Err. < 13 % for 68% of significance) in skin, cerebrospinal fluid and brain mimic tissues. For the skin, we got also good agreement for the loss tangent (Rel. Err. < 11 % for 68% of significance). The skull mimic phantom was stiff enough, but even presenting considerable errors, it was still good enough for the experiment. In addition, the capability of the phantom to operate at different pressures is discussed.
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