| 1. |
- Boutachkov, P., et al.
(författare)
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High-spin isomers in 96Ag : excitations across the Z=38 and Z=50, N=50 closed shells
- 2011
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 84:4
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Tidskriftsartikel (refereegranskat)abstract
- Excited states in (96)Ag were populated in fragmentation of an 850-MeV/u (124)Xe beam on a 4-g/cm(2) Be target. Three new high-spin isomers were identified and the structure of the populated states was investigated. The level scheme of (96)Ag was established, and a spin parity of (13(-)), (15(+)), and (19(+)) was assigned to the new isomeric states. Shell-model calculations were performed in various model spaces, including pi nu(p(1/2), g(9/2), f(5/2), p(3/2)) and the large-scale shell-model space pi nu(gds), to account for the observed parity changing M2 and E3 transitions from the (13(-)) isomer and the E2 and E4 transitions from the (19(+)) core-excited isomer, respectively. The calculated level schemes and reduced transition strengths are found to be in very good agreement with the experiment.
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| 2. |
- Andersson, Anders, et al.
(författare)
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Vehicle Powertrain Test Bench Co-Simulation with a Moving Base Simulator Using a Pedal Robot
- 2013
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Ingår i: SAE International Journal of Passenger Cars - Electronic and Electrical Systems. - : SAE International. - 1946-4614 .- 1946-4622. ; 6:1, s. 169-179
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Tidskriftsartikel (refereegranskat)abstract
- To evaluate driver perception of a vehicle powertrain a moving base simulator is a well-established technique. We are connecting the moving base simulator Sim III, at the Swedish National Road and Transport Research Institute with a newly built chassis dynamometer at Vehicular Systems, Linköping University.The purpose of the effort is to enhance fidelity of moving base simulators by letting drivers experience an actual powertrain. At the same time technicians are given a new tool for evaluating powertrain solutions in a controlled environment.As a first step the vehicle model from the chassis dynamometer system has been implemented in Sim III. Interfacing software was developed and an optical fiber covering the physical distance of 500 m between the facilities is used to connect the systems. Further, a pedal robot has been developed that uses two linear actuators pressing the accelerator and brake pedals. The pedal robot uses feedback loops on accelerator position or brake cylinder pressure and is controlled via an UDP interface.Results from running the complete setup showed expected functionality and we are successful in performing a driving mission based on real road topography data. Vehicle acceleration and general driving feel was perceived as realistic by the test subjects while braking still needs improvements. The pedal robot construction enables use of a large set of cars available on the market and except for mounting the brake pressure sensor the time to switch vehicle is approximately 30 minutes.
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| 3. |
- Apelqvist, Jan, et al.
(författare)
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Factors related to outcome of neuroischemic/ischemic foot ulcer in diabetic patients.
- 2011
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Ingår i: Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter. - : Elsevier BV. - 1097-6809. ; 53, s. 1582-1588
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: Peripheral vascular disease (PVD) is an important limiting factor for healing in neuroischemic or ischemic diabetic foot ulcer. The purpose of this study was to identify factors related to healing in patients with diabetes with foot ulcers and severe PVD. METHODS: Patients with diabetes with a foot ulcer, consecutively presenting at a multidisciplinary foot center with a systolic toe pressure <45 mm Hg or an ankle pressure <80 mm Hg were prospectively included, followed according to a preset program, and with the exception of specified exclusions, subjected to angiography offered vascular intervention when applicable. All patients had continuous follow-up until healing or death irrespective of the type of vascular intervention. RESULTS: One thousand one hundred fifty-one patients were included. Eighty-two percent had a toe pressure <45 mm Hg and 49% had an ankle pressure <80 mm Hg. Eight hundred one patients (70%) underwent an angiography. Out of these, 63% had vascular intervention, either percutaneous transluminal angioplasty (PTA; 39%) or reconstructive surgery (24%). Nine percent of the patients had one or more complications after angiography. PTA was multisegmental in 46% and to the crural arteries in 46%. Reconstructive surgery was distal in 51%. Age (P < .001), renal function impairment (P = .005), congestive heart failure (P = .01), number and type of ulcer (P < .001), and severity of PVD (P = .003) affected the outcome of ulcers. PTA and reconstructive vascular surgery increased the probability of healing without amputation (odds ratio [OR], 1.77 and 2.05, respectively). CONCLUSION: Probability of ulcer healing is strongly related to comorbidity, extent of tissue involvement, and severity of PVD in patients with diabetes with severe PVD.
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| 4. |
- Bäckman, Lars, et al.
(författare)
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Dopamine D(1) receptors and age differences in brain activation during working memory
- 2011
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Ingår i: Neurobiology of Aging. - Fayetteville, N.Y : Elsevier. - 0197-4580 .- 1558-1497. ; 32:10, s. 1849-1856
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Tidskriftsartikel (refereegranskat)abstract
- In an fMRI study, 20 younger and 20 healthy older adults were scanned while performing a spatial working-memory task under two levels of load. On a separate occasion, the same subjects underwent PET measurements using the radioligand [(11)C] SCH23390 to determine dopamine D(1) receptor binding potential (BP) in caudate nucleus and dorsolateral prefrontal cortex (DLPFC). The fMRI study revealed a significant load modulation of brain activity (higher load>lower load) in frontal and parietal regions for younger, but not older, adults. The PET measurements showed marked age-related reductions of D(1) BP in caudate and DLPFC. Statistical control of caudate and DLPFC D(1) binding eliminated the age-related reduction in load-dependent BOLD signal in left frontal cortex, and attenuated greatly the reduction in right frontal and left parietal cortex. These findings suggest that age-related alterations in dopaminergic neurotransmission may contribute to underrecruitment of task-relevant brain regions during working-memory performance in old age.
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| 5. |
- Drevenhorn, Eva, et al.
(författare)
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Consultation training of nurses for cardiovascular prevention - A randomized study of 2 years duration
- 2012
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Ingår i: Blood Pressure. - : Informa Healthcare. - 0803-7051 .- 1651-1999. ; 21:5, s. 293-299
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to increase patients adherence to the treatment of hypertension through the consultation training of nurses. Thirty-three nurses were included in the study. In the intervention group (IG), 19 nurses took part in a 3-day residential training course on the Stages of Change model, Motivational Interviewing and guidelines for cardiovascular prevention, and recruited 153 patients. Sixteen nurses in the control group (CG) recruited 59 patients. A decrease in systolic and diastolic blood pressure and total cholesterol was noticed in both groups over the 2 years. Heart rate (p = 0.027), body mass index (p = 0.019), weight (p = 0.0001), waist (p = 0.041), low-density lipoprotein-cholesterol (p = 0.0001), the waist-hip ratio (p = 0.024), and perceived stress (p = 0.001) decreased to any great extent only in the IG. After 2 years, 52.6% of the patients in the IG (p = 0.13) reached the target of andlt;= 140/90 mmHg in blood pressure compared with 39.2% in the CG. For self-reported physical activity, there was a significant (p = 0.021) difference between the groups. The beneficial effects of the consultation training on patients weight parameters, physical activity, perceived stress and the proportion of patients who achieved blood pressure control emphasize consultation training and the use of behavioural models in motivating patients to adhere to treatment.
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| 6. |
- Drevenhorn, Eva, et al.
(författare)
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Effects on hypertensive patients' satisfaction with information about their medication after nurses' consultation training
- 2014
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Ingår i: Pragmatic and Observational Research. - : Dove Press. - 1179-7266. ; 5, s. 35-41
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Tidskriftsartikel (refereegranskat)abstract
- Background: There is a well-known problem in hypertension care with patients' adherence to treatment. Patients who score high in answering the instrument Satisfaction with Information about Medicine Scale are reported to have greater adherence to their medication.Aim: To explore how hypertensive patients' satisfaction with information about their medicines was affected by nurses' education in Motivational Interviewing.Material and methods: The Stages of Change model and Motivational Interviewing was the theoretical base for consultation training for nurses. Nineteen nurses attended 3 days of video-recorded consultation training with simulated patients. They were updated in hypertensive medication and were trained in motivating patients to improve their self-management as well as adherence to lifestyle changes and medication. The satisfaction with information instrument identifies patients' satisfaction with information about the action and usage of medication as well as potential problems with it. The instrument was used to assess how well the needs of individual patients for medicine information were met at baseline and 2 years after the training. The 19 trained nurses in the intervention group worked with 137 patients, and a control group of 16 nurses, who gave normal care, worked with 51 patients.Results: There was a difference between the intervention and control group in total score (P=0.028) 2 years after the intervention. Patients in the intervention group perceived higher satisfaction with the action and usage of their medication (P=0.001) and a lower degree of potential problems with their medication (P=0.001). Patients in the control group also perceived a lower degree of potential problems with their medication (P=0.028).Conclusion: We suggest that consultation training for nurses with the aim of motivating patients to be more self-directed in their self-care improves satisfaction with information about medication.
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| 7. |
- Edlund, Karolina, et al.
(författare)
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CD99 is a novel prognostic stromal marker in non-small cell lung cancer
- 2012
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 131:10, s. 2264-2273
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Tidskriftsartikel (refereegranskat)abstract
- The complex interaction between cancer cells and the microenvironment plays an essential role in all stages of tumourigenesis. Despite the significance of this interplay, alterations in protein composition underlying tumourstroma interactions are largely unknown. The aim of this study was to identify stromal proteins with clinical relevance in non-small cell lung cancer (NSCLC). A list encompassing 203 stromal candidate genes was compiled based on gene expression array data and available literature. The protein expression of these genes in human NSCLC was screened using the Human Protein Atlas. Twelve proteins were selected that showed a differential stromal staining pattern (BGN, CD99, DCN, EMILIN1, FBN1, PDGFRB, PDLIM5, POSTN, SPARC, TAGLN, TNC and VCAN). The corresponding antibodies were applied on tissue microarrays, including 190 NSCLC samples, and stromal staining was correlated with clinical parameters. Higher stromal expression of CD99 was associated with better prognosis in the univariate (p = 0.037) and multivariate (p = 0.039) analysis. The association was independent from the proportion of tumour stroma, the fraction of inflammatory cells and clinical and pathological parameters like stage, performance status and tumour histology. The prognostic impact of stromal CD99 protein expression was confirmed in an independent cohort of 240 NSCLC patients (p = 0.008). Furthermore, double-staining confocal fluorescence microscopy showed that CD99 was expressed in stromal lymphocytes as well as in cancer-associated fibroblasts. Based on a comprehensive screening strategy the membrane protein CD99 was identified as a novel stromal factor with clinical relevance. The results support the concept that stromal properties have an important impact on tumour progression.
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| 8. |
- Elgzyri, Targ, et al.
(författare)
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Early Revascularization after Admittance to a Diabetic Foot Center Affects the Healing Probability of Ischemic Foot Ulcer in Patients with Diabetes.
- 2014
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Ingår i: European Journal of Vascular and Endovascular Surgery. - : Elsevier BV. - 1532-2165 .- 1078-5884. ; 48:4, s. 440-446
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Tidskriftsartikel (refereegranskat)abstract
- There is limited information about whether time from recognition of decreased perfusion to revascularization affects the probability of healing in a patient with a diabetic foot ulcer. The aim of the present study was to examine whether time to revascularization after referral to a multidisciplinary foot center was related to the outcome of foot ulcers in patients with diabetes and severe peripheral arterial disease (PAD).
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| 9. |
- Forward, Sonja, et al.
(författare)
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Effekten av de nya reglerna för AM-behörighet (moped klass I) : en för- och efterstudie
- 2012
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Den 1 oktober 2009 infördes AM-behörigheten för att få köra moped klass I och samtidigt infördes krav på att föraren måste genomgå en praktisk och teoretisk utbildning hos behörig utbildare. Syftet med denna studie var att med hjälp av en för- och en efterstudie undersöka effekten av den nya utbildningen. Enkäten baserades på två olika teorier; theory of planned behaviour och prototype willingness model. Ett ytterligare syfte var att beskriva hur ungdomar ser på risker och vilka faktorer som påverkar dem att agera på ett eller annat sätt. I studien deltog personer i åldern 15–-24 år; 901 personer i förstudien och 946 personer i efterstudien. Resultaten visade på relativt små skillnader mellan för- och efterstudien. Inställningen till att köra i 65 km/tim i tätort visade att mopedisterna i efterstudien inte ansåg att beteendet var lika vanligt bland kamrater och de hade en mindre tro på sin egen förmåga att köra fort. Med avseende på deras inställning till att dricka två starköl och sedan köra hem noterades också några signifikanta skillnader. Mopedisterna i efterstudien var i mindre grad bekymrade över att bli stoppade av polisen eller att råka ut för en trafikolycka. Rent allmänt fick den nya utbildningen ett gott betyg eftersom ungdomarna tyckte att den var bra och att man hade lärt sig mycket. Det man främst hade lärt sig handlade om regler och bestämmelser i trafiken. Resultaten från teorin prototype willingness model visade att de som själva ville köra för fort eller med alkohol i kroppen ansåg i högre grad än de andra att en sådan person var tuff, säker och klok. En modell testades utifrån de två olika teorierna. Resultaten visade att modellen förklarade 52 procent av deras vilja att köra för fort och 19 procent av deras vilja att köra hem efter festen.
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| 10. |
- Forward, Sonja, et al.
(författare)
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Utvärdering av en ny obligatorisk riskutbildning för motorcyklister
- 2011
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Från den 1 november 2009 infördes en obligatorisk riskutbildning för behörighet A och A1 (tung respektive lätt motorcykel). Utbildningen är både teoretisk och praktisk och specifikt riktad till motorcyklister. Syftet med föreliggande studie är att undersöka om det skett någon förändring i synen på risktagning efter införandet av den nya riskutbildningen. Undersökningen genomfördes i form av en webbenkätstudie och två olika grupper jämfördes: de somavslutade mc-utbildningen före riskutbildningens införande den 1 november 2009 och de som avslutadeutbildningen efter detta datum. I studien deltog 1 472 personer (förstudie=541; efterstudie=931).Medelåldern var 30 år och andelen kvinnor 20 procent. Resultaten visar att det skett relativt småförändringar i attityder, normer och intentioner i jämförelsen mellan för- och efterstudie. De skillnadersom konstaterades gick oftast i ”rätt” riktning, det vill säga en ökad förståelse för olika risker. De negativa förändringar som kan ses finns främst inom den yngsta gruppen (16-–20 år) avseende hastighet, alkohol, trötthet och synen på den egna förmågan i jämförelse med andra motorcyklister. Sammanfattningsvis visar studien att det dels finns behov av ytterligare studier av utbildningens effekter, dels utbildningens form och upplägg avseende till exempel pedagogik riktat till specifika målgrupper. Hur de aktuella resultaten kan hjälpa till att utveckla den obligatoriska riskutbildningen för behörighet A och A1 diskuteras.
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| 11. |
- Fransson, Rebecca, 1980-, et al.
(författare)
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Constrained H-Phe-Phe-NH2 Analogues With High Affinity to the Substance P 1-7 Binding Site and With Improved Metabolic Stability and Cell Permeability
- 2013
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Ingår i: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 56:12, s. 4953-4965
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Tidskriftsartikel (refereegranskat)abstract
- We recently reported the discovery of H-Phe-Phe-NH2 as a small and high affinity ligand for the substance P 1-7 (SP1-7, H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-OH) specific binding site and its intriguing ability to reduce neuropathic pain. With the overall aim to develop stable and orally bioavailable SP1-7 mimetics, the dipeptide was chosen as a lead compound. Herein the structure-activity relationship (SAR) of a set of modified H-Phe-Phe-NH2 analogues is presented together with their potential active uptake by PEPT1 transporter, intestinal permeability, and metabolic stability. Local constraints via peptide backbone methylation or preparation of cyclized analogues based on pyrrolidine were evaluated and were shown to significantly improve the in vitro pharmacokinetic properties. The SAR was rationalized by deriving a plausible binding pose for the high affinity ligands. Rigidification using a 3-phenylpyrrolidine moiety in the C-terminal of H-Phe-Phe-NH2 resulted in high affinity and improved intrinsic clearance and intestinal epithelial permeability.
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| 12. |
- Garmy, Pernilla, et al.
(författare)
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Development and Psychometric Evaluation of a New Instrument for Measuring Sleep Length and Television and Computer Habits of Swedish School-Age Children.
- 2012
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Ingår i: Journal of School Nursing. - : SAGE Publications. - 1546-8364 .- 1059-8405. ; 28, s. 138-143
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Tidskriftsartikel (refereegranskat)abstract
- The aim was to develop a new instrument for measuring length of sleep as well as television and computer habits in school-age children. A questionnaire was constructed for use when children visit the school health care unit. Three aspects of the validity of the questionnaire were examined: its face validity, content validity, and construct validity. Test-retest reliability was assessed by giving the questionnaire twice, 2 weeks apart, to the respondents. The questionnaire was assessed as being reasonably valid, the test-retest results (n = 138) showing 90.4% of the estimates regarding bedtime on weeknights on the two survey occasions to lie within ± 30 min of each other, the test-retest agreement also being rather close (κ > .600) regarding both sleep and media habits. The instrument can be a valuable tool in a clinical setting, both for measuring sleep habits in a class and for discussing sleep with individual school children and their families.
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| 13. |
- Garmy, Pernilla, 1973-, et al.
(författare)
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Overweight and television and computer habits in Swedish school-age children and adolescents : a cross-sectional study
- 2014
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Ingår i: Nursing and Health Sciences. - : Wiley-Blackwell. - 1441-0745 .- 1442-2018. ; 16:2, s. 143-148
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this cross-sectional study was to investigate the prevalence of overweight and obesity in children and adolescents (6-16 years), and relationships between being overweight and sleep, experiencing of fatigue, enjoyment of school, and time spent in watching television and in sitting at the computer. Trained school nurses measured the weight and height of 2891 children aged 6, 7, 10, 14, and 16, and distributed a questionnaire to them regarding television and computer habits, sleep, and enjoyment of school. Overweight, obesity included, was present in 16.1% of the study population. Relationships between lifestyle factors and overweight were studied using multivariate logistic regression analysis. Having a bedroom television and spending more than 2 h a day watching television were found to be associated with overweight (OR 1.26 and 1.55 respectively). No association was found between overweight and time spent at the computer, short sleep duration, enjoyment of school, tiredness at school, or difficulties in sleeping and waking up. It is recommended that the school health service discuss with pupils their media habits so as to promote their maintaining a healthy lifestyle.
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| 14. |
- Garmy, Pernilla, et al.
(författare)
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Overweight and television and computer habits in Swedish school-age children and adolescents : a cross-sectional study
- 2014
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Ingår i: Nursing and Health Sciences. - : Wiley-Blackwell Publishing Ltd. - 1441-0745 .- 1442-2018. ; 16:2, s. 143-148
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this cross-sectional study was to investigate the prevalence of overweight and obesity in children and adolescents (6-16 years), and relationships between being overweight and sleep, experiencing of fatigue, enjoyment of school, and time spent in watching television and in sitting at the computer. Trained school nurses measured the weight and height of 2891 children aged 6, 7, 10, 14, and 16, and distributed a questionnaire to them regarding television and computer habits, sleep, and enjoyment of school. Overweight, obesity included, was present in 16.1% of the study population. Relationships between lifestyle factors and overweight were studied using multivariate logistic regression analysis. Having a bedroom television and spending more than 2 h a day watching television were found to be associated with overweight (OR 1.26 and 1.55 respectively). No association was found between overweight and time spent at the computer, short sleep duration, enjoyment of school, tiredness at school, or difficulties in sleeping and waking up. It is recommended that the school health service discuss with pupils their media habits so as to promote their maintaining a healthy lifestyle.
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| 15. |
- Garmy, Pernilla, 1973-, et al.
(författare)
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Sleep and television and computer habits of Swedish school-age children
- 2012
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Ingår i: Journal of School Nursing. - : SAGE Publications. - 1059-8405 .- 1546-8364. ; 28:6, s. 469-476
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to investigate sleep, television and computer habits and enjoyment and feelings of tiredness in school of school-age children and adolescents in Sweden. An instrument found to be valid and reliable here was distributed to 3,011 children aged 6, 7, 10, 14, and 16 years. Those sleeping less than the median length of time reported a significantly lower degree of enjoyment of school. Short sleep was found to be associated with having a bedroom TV, spending more than 2 hr a day at the TV or the computer, being tired in school, and having difficulties both in waking up and in sleeping. Discussing sleep and media habits with schoolchildren and their parents regarding matters of optimal sleep and of how media habits affect sleep and learning is seen to be an important task of the school health service.
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| 16. |
- Garmy, Pernilla, et al.
(författare)
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Sleep and Television and Computer Habits of Swedish School-Age Children
- 2012
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Ingår i: Journal of School Nursing. - : SAGE Publications. - 1546-8364 .- 1059-8405. ; 28:6, s. 469-476
-
Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to investigate sleep, television and computer habits and enjoyment and feelings of tiredness in school of school-age children and adolescents in Sweden. An instrument found to be valid and reliable here was distributed to 3,011 children aged 6, 7, 10, 14, and 16 years. Those sleeping less than the median length of time reported a significantly lower degree of enjoyment of school. Short sleep was found to be associated with having a bedroom TV, spending more than 2 hr a day at the TV or the computer, being tired in school, and having difficulties both in waking up and in sleeping. Discussing sleep and media habits with schoolchildren and their parents regarding matters of optimal sleep and of how media habits affect sleep and learning is seen to be an important task of the school health service.
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| 17. |
- Hagell, Peter, et al.
(författare)
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Effects of method of translation of patient-reported health outcome questionnaires : a randomized study of the translation of the Rheumatoid Arthritis Quality of Life (RAQoL) Instrument for Sweden
- 2010
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Ingår i: Value in Health. - : Wiley-Blackwell. - 1098-3015 .- 1524-4733. ; 13:4, s. 424-430
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Tidskriftsartikel (refereegranskat)abstract
- AIMS: To compare two versions of a questionnaire translated using forward-backward (FB) translation and dual-panel (DP) methodologies regarding preference of wording and psychometric properties.METHODS: The Rheumatoid Arthritis Quality of Life instrument was adapted into Swedish by two independent groups using FB and DP methodologies, respectively. Seven out of thirty resulting items were identical. Nonidentical items were evaluated regarding preference of wording by 23 bilingual Swedes, 50 people with rheumatoid arthritis (RA), and 2 lay panels (n = 11). Psychometric performance was assessed from a postal survey of 200 people with RA randomly assigned to complete one version first and the other 2 weeks later.RESULTS: Preference did not differ among the 23 bilinguals (P = 0.196), whereas patients and lay people preferred DP over FB item versions (P < 0.0001). Postal survey response rates were 74% (FB) and 75% (DP). There were more missing item responses in the FB than the DP version (6.9% vs. 5.6%; P < 0.0001). Floor/ceiling effects were small (FB, 6.1/0%; DP, 4.4/0.7%) and reliability was 0.92 for both versions. Construct validity was similar for both versions. Differential item functioning by version was detected for five items but cancelled out and did not affect estimated person measures.CONCLUSIONS: The DP approach showed advantages over FB translation in terms of preference by the target population and by lay people, whereas there were no obvious psychometric differences. This suggests advantages of DP over FB translation from the patients' perspective, and does not support the commonly held view that FB translation is the "gold standard."
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| 18. |
- Hagell, Peter, et al.
(författare)
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Effects of Method of Translation of Patient-Reported Health Outcome Questionnaires: A Randomized Study of the Translation of the Rheumatoid Arthritis Quality of Life (RAQoL) Instrument for Sweden.
- 2010
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Ingår i: Value in Health. - : Elsevier BV. - 1098-3015. ; 13, s. 424-430
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Tidskriftsartikel (refereegranskat)abstract
- ABSTRACT Aims: To compare two versions of a questionnaire translated using forward-backward (FB) translation and dual-panel (DP) methodologies regarding preference of wording and psychometric properties. Methods: The Rheumatoid Arthritis Quality of Life instrument was adapted into Swedish by two independent groups using FB and DP methodologies, respectively. Seven out of thirty resulting items were identical. Nonidentical items were evaluated regarding preference of wording by 23 bilingual Swedes, 50 people with rheumatoid arthritis (RA), and 2 lay panels (n = 11). Psychometric performance was assessed from a postal survey of 200 people with RA randomly assigned to complete one version first and the other 2 weeks later. Results: Preference did not differ among the 23 bilinguals (P = 0.196), whereas patients and lay people preferred DP over FB item versions (P < 0.0001). Postal survey response rates were 74% (FB) and 75% (DP). There were more missing item responses in the FB than the DP version (6.9% vs. 5.6%; P < 0.0001). Floor/ceiling effects were small (FB, 6.1/0%; DP, 4.4/0.7%) and reliability was 0.92 for both versions. Construct validity was similar for both versions. Differential item functioning by version was detected for five items but cancelled out and did not affect estimated person measures. Conclusions: The DP approach showed advantages over FB translation in terms of preference by the target population and by lay people, whereas there were no obvious psychometric differences. This suggests advantages of DP over FB translation from the patients' perspective, and does not support the commonly held view that FB translation is the "gold standard."
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| 19. |
- Hjaltadottir, Ingibjörg, et al.
(författare)
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Health status and functional profile at admission of nursing home residents in Iceland over 11-year period.
- 2011
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Ingår i: International journal of older people nursing. - : Wiley. - 1748-3743 .- 1748-3735.
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Tidskriftsartikel (refereegranskat)abstract
- Health status and functional profile at admission of nursing home residents in Iceland over 11-year period. International Journal of Older People Nursing doi: 10.1111/j.1748-3743.2011.00287.x Background. The knowledge over time of the health status and changes in care needs of newly admitted nursing home residents is limited. Objectives. To investigate trends in residents' health status and functional profile at admission to nursing homes and compare rural and capital areas in Iceland over an 11-year period. Design. Retrospective analysis of nursing home data over 11 years (1996-2006). Participants. Residents, who had been assessed with the Minimum Data Set assessment within 90 days from admittance (n = 2206). Method. Non-parametric tests for descriptive statistics and linear regressions were used to analyse time trends. Results. The mean age ranged from 80.1 to 82.8, and women accounted for 52.7% to 67.1%. The level of independency indicated intact cognitive performance in 28.6-61.4% and in 42.5-68% in activities of daily living performance. A weak, but significant, linear trend was seen in residents' health becoming less stable, their cognitive performance improving, more pain being reported and greater participation in social activities over the 11 years. Conclusion. Some residents might have stayed at home longer had they been given appropriate home care and the opportunity of rehabilitation. Pain management and social activities are areas where more staff knowledge seems to be needed. Implications for practice. Resources to enable old people to remain at home need to be explored before their entry into nursing homes. Whereas providing services at the appropriate level is important for society as well as older people.
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| 20. |
- Hjaltadottir, Ingibjörg, et al.
(författare)
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Predicting mortality of residents at admission to nursing home: A longitudinal cohort study
- 2011
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Ingår i: BMC Health Services Research. - : Springer Science and Business Media LLC. - 1472-6963. ; 11
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Tidskriftsartikel (refereegranskat)abstract
- Background: An increasing numbers of deaths occur in nursing homes. Knowledge of the course of development over the years in death rates and predictors of mortality is important for officials responsible for organizing care to be able to ensure that staff is knowledgeable in the areas of care needed. The aim of this study was to investigate the time from residents' admission to Icelandic nursing homes to death and the predictive power of demographic variables, health status (health stability, pain, depression and cognitive performance) and functional profile (ADL and social engagement) for 3-year mortality in yearly cohorts from 1996-2006. Methods: The samples consisted of residents (N=2206) admitted to nursing homes in Iceland in 1996-2006, who were assessed once at baseline with a Minimum Data Set (MDS) within 90 days of their admittance to the nursing home. The follow-up time for survival of each cohort was 36 months from admission. Based on Kaplan-Meier analysis (log rank test) and non-parametric correlation analyses (Spearman's rho), variables associated with survival time with a p-value < 0.05 were entered into a multivariate Cox regression model. Results: The median survival time was 31 months, and no significant difference was detected in the mortality rate between cohorts. Age, gender (HR 1.52), place admitted from (HR 1.27), ADL functioning (HR 1.33-1.80), health stability (HR 1.61-16.12) and ability to engage in social activities (HR 1.51-1.65) were significant predictors of mortality. A total of 28.8% of residents died within a year, 43.4% within two years and 53.1% of the residents died within 3 years. Conclusion: It is noteworthy that despite financial constraints, the mortality rate did not change over the study period. Health stability was a strong predictor of mortality, in addition to ADL performance. Considering these variables is thus valuable when deciding on the type of service an elderly person needs. The mortality rate showed that more than 50% died within 3 years, and almost a third of the residents may have needed palliative care within a year of admission. Considering the short survival time from admission, it seems relevant that staff is trained in providing palliative care as much as restorative care.
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| 21. |
- Hjaltadottir, Ingibjörg, et al.
(författare)
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Quality of care in Icelandic nursing homes measured with Minimum Data Set quality indicators: Retrospective analysis of nursing home data over 7 years.
- 2012
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Ingår i: International Journal of Nursing Studies. - : Elsevier BV. - 1873-491X .- 0020-7489.
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The increasing need for long-term care as well as diminished financial resources may compromise the quality of care of older people. Thus the need for clinically based quality of care monitoring to guide development of long-term services has been pointed out. OBJECTIVES: The aim of this study was to investigate trends in quality of care during 2003-2009 as reflected in the Minimum Data Set quality indicator outcome in Icelandic nursing homes and to investigate the association of Minimum Data Set quality indicators with residents' health status (health stability, pain, depression and cognitive performance) and functional profile (activities of daily living and social engagement). DESIGN: Retrospective analysis of nursing home data over 7 years. METHODS: The sample used for analysis was 11,034 Minimum Data Set assessments of 3694 residents living in Icelandic nursing homes in 2003-2009. Minimum Data Set quality indicators were used to measure quality of care. The chi-square test for trend and multivariate logistic regression were used to analyse the data. RESULTS: The mean age of residents during the period of the study ranged from 82.3 (SD 9.1) to 85.1 (SD 8.3) and women accounted for from 65.2% to 67.8%. Findings for 16 out of 20 quality indicators indicated a decline in quality of care (p<0.05), although in 12 out of 20 indicators the prevalence was lower than 25%. One quality indicator showed improvement, i.e. for "Bladder and bowel incontinence without a toileting plan" from 17.4% in 2003 decreasing to 11.5% in 2009 (p<0.001). Residents' health and functional status partially explain the increased prevalence of the quality indicators over time. CONCLUSION: Further developments in quality of care in Icelandic nursing homes need to be monitored as well as the association between residents' health and functional status and the Minimum Data Set quality indicator outcome. The areas of care where the Minimum Data Set quality indicators showed need for improvement included treatment of depression, number of medications, resident activity level and behavioural symptoms.
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| 22. |
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| 23. |
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| 24. |
- Karlsson, Sari, et al.
(författare)
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Relationship of dopamine D1 receptor binding in striatal and extrastriatal regions to cognitive functioning in healthy humans
- 2011
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Ingår i: NeuroImage. - : Elsevier. - 1053-8119 .- 1095-9572. ; 57:2, s. 346-351
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Tidskriftsartikel (refereegranskat)abstract
- Dopamine (DA) availability in both striatal and extrastriatal brain regions has been implicated in cognitive performance. Given that different brain regions are neuroanatomically and functionally different, DA receptor binding in different brain regions may be selectively important to specific cognitive functions. Using PET and the radioligand SCH23390, we measured D1 receptor binding potential (BP(ND)) in dorsolateral prefrontal cortex (DLPFC), hippocampus (HC), as well as in sensorimotor (SMST), associative (AST), and limbic (LST) striatum in 20 healthy younger persons. Subjects completed tasks assessing executive functioning, episodic memory, speed, and general knowledge. Unlike previous reports, we found no linear or curvilinear relationships between D1 receptor binding in DLPFC and performance in any cognitive task. However, BP(ND) in HC was positively linked to executive performance as well as to speed and knowledge. With regard to the striatal subregions, D1 BP(ND) in SMST was more strongly related to speed compared to the other striatal subregions, whereas D1 BP(ND) in AST was more strongly linked to general knowledge. These findings provide support for the notion that D1 receptors in separate brain regions are differentially related to performance in tasks tapping various cognitive domains.
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| 25. |
- Knutsson, Ida, et al.
(författare)
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Interpretation of response categories in patient-reported rating scales: a controlled study among people with Parkinson's disease
- 2010
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Ingår i: Health and Quality of Life Outcomes. - : Springer Science and Business Media LLC. - 1477-7525. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- Background: Unambiguous interpretation of ordered rating scale response categories requires distinct meanings of category labels. Also, summation of item responses into total scores assumes equal intervals between categories. While studies have identified problems with rating scale response category functioning there is a paucity of empirical studies regarding how respondents interpret response categories. We investigated the interpretation of commonly used rating scale response categories and attempted to identify distinct and roughly equally spaced response categories for patient-reported rating scales in Parkinson's disease (PD) and age-matched control subjects. Methods: Twenty-one rating scale response categories representing frequency, intensity and level of agreement were presented in random order to 51 people with PD (36 men; mean age, 66 years) and 36 age-matched controls (14 men; mean age, 66). Respondents indicated their interpretation of each category on 100-mm visual analog scales (VAS) anchored by Never - Always, Not at all - Extremely, and Totally disagree - Completely agree. VAS values were compared between groups, and response categories with mean values and non-overlapping 95% CIs corresponding to equally spaced locations on the VAS line were sought to identify the best options for three-, four-, five-, and six-category scales. Results: VAS values did not differ between the PD and control samples (P = 0.286) or according to educational level (P = 0.220), age (P = 0.220), self-reported physical functioning (P = 0.501) and mental health (P = 0.238), or (for the PD sample) PD duration (P = 0.213) or presence of dyskinesias (P = 0.212). Attempts to identify roughly equally spaced response categories for three-, four-, five-, and six-category scales were unsuccessful, as the 95% CIs of one or several of the identified response categories failed to include the criterion values for equal distances. Conclusions: This study offers an evidence base for selecting more interpretable patient-reported rating scale response categories. However, problems associated with raw rating scale data, primarily related to their ordinal structure also became apparent. This argues for the application of methodologies such as Rasch measurement. Rating scale response categories need to be treated with rigour in the construction and analysis of rating scales.
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| 26. |
- Kågedal, Matts, et al.
(författare)
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A positron emission tomography study in healthy volunteers to estimate mGluR5 receptor occupancy of AZD2066-Estimating occupancy in the absence of a reference region
- 2013
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Ingår i: NeuroImage. - : Elsevier BV. - 1053-8119 .- 1095-9572. ; 82, s. 160-169
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Tidskriftsartikel (refereegranskat)abstract
- AZD2066 is a new chemical entity pharmacologically characterized as a selective, negative allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5). Antagonism of mGluR5 has been implicated in relation to various diseases such as anxiety, depression, and pain disorders. To support translation from preclinical results and previous experiences with this target in man, a positron emission tomography study was performed to estimate the relationship between AZD2066 plasma concentrations and receptor occupancy in the human brain, using the mGluR5 radioligand [C-11]-ABP688. The study involved PET scans on 4 occasions in 6 healthy volunteers. The radioligand was given as a tracer dose alone and following oral treatment with different doses of AZD2066. The analysis was based on the total volume of distribution derived fro m each PET-assessment. A non-linear mixed effects model was developed where ten delineated brain regions of interest from all PET scans were included in one simultaneous fit. For comparison the analysis was also performed according to a method described previously by Lassen et al. (1995). The results of the analysis showed that the total volume of distribution decreased with increasing drug concentrations in all regions with an estimated Kipl of 1170 nM. Variability between individuals and occasions in non-displaceable volume of distribution could explain most of the variability in the total volume of distribution. The Lassen approach provided a similar estimate for Kipl, but the variability was exaggerated and difficult to interpret.
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| 27. |
- Kågedal, Matts, et al.
(författare)
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Non-linear mixed effects modelling of positron emission tomography data for simultaneous estimation of radioligand kinetics and occupancy in healthy volunteers
- 2012
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Ingår i: NeuroImage. - : Elsevier BV. - 1053-8119 .- 1095-9572. ; 61:4, s. 849-856
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this work was to develop a model simultaneously estimating (11)C-AZD9272 radioligand kinetics and the relationship between plasma concentration of AZD9272 and receptor occupancy in the human brain.AZD9272 is a new chemical entity pharmacologically characterised as a noncompetitive antagonist at the metabotropic glutamate receptor subtype 5 (mGluR5). Positron emission tomography (PET) was used to measure the time course of ((11)C-AZD9272) in the brain. The study included PET measurements in six healthy volunteers where the radioligand was given as a tracer dose alone as well as post oral treatment with different doses of unlabelled AZD9272. Estimation of radioligand kinetics, including saturation of receptor binding was performed by use of non-linear mixed effects modelling. Data from the regions with the highest (ventral striatum) and lowest (cerebellum) radioligand concentrations were included in the analysis. It was assumed that the extent of non-displaceable brain uptake was the same in both regions while the rate of CNS uptake and the receptor density differed.The results of the analysis showed that AZD9272 binding at the receptor is saturable with an estimated plasma concentration corresponding to 50% occupancy of approximately 200nM. The density of the receptor binding sites was estimated to 800nM and 200nM in ventral striatum and cerebellum respectively. By simultaneously analysing data from several PET measurements and different brain regions in a non-linear mixed effects framework it was possible to estimate parameters of interest that would otherwise be difficult to quantify.
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| 28. |
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| 29. |
- Narayanan, Prakash, et al.
(författare)
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A Comparative Analysis of WHR System in HD Engines Using Conventional Diesel Combustion and Partially-Premixed Combustion
- 2012
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Ingår i: SAE Technical Paper Series. - 400 Commonwealth Drive, Warrendale, PA, United States : SAE International. - 0148-7191.
-
Konferensbidrag (refereegranskat)abstract
- In the truck industry there is a continuous demand to increase the efficiency and to decrease the emissions. To acknowledge both these issues a waste heat recovery system (WHR) is combined with a partially premixed combustion (PPC) engine to deliver an efficient engine system. Over the past decades numerous attempts to increase the thermal efficiency of the diesel engine has been made. One such attempt is the PPC concept that has demonstrated potential for substantially increased thermal efficiency combined with much reduced emission levels. So far most work on increasing engine efficiency has been focused on improving the thermal efficiency of the engine while WHR, which has an excellent potential for another 1-5 % fuel consumption reduction, has not been researched that much yet. In this paper a WHR system using a Rankine cycle has been developed in a modeling environment using IPSEpro. A comparative investigation of the WHR potential between the existing conventional diesel combustion and the novel PPC combustion is done. Even though the PPC is a low temperature combustion concept (LTC), implying that the exhaust temperatures are lower than for the traditional diesel combustion, the EGR quantity is higher which in total still offers improved WHR potential as that of conventional combustion. The EGR cooler offers higher quality heat when compared to exhaust gas and CAC, hence the WHR potential using only the EGR system is considered in this paper.
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| 30. |
- Nilsson, Lisbeth, et al.
(författare)
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Driving to Learn in a powered wheelchair: Inter-rater reliability of a tool for assessment of joystick-use.
- 2011
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Ingår i: Australian Occupational Therapy Journal. - : Wiley. - 1440-1630 .- 0045-0766. ; 58:6, s. 447-454
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Tidskriftsartikel (refereegranskat)abstract
- Background/aim: People with profound cognitive disabilities are not expected to learn powered mobility use. The Driving to Learn project focussed on what this population could achieve from practising in a joystick-operated powered wheelchair. By means of using grounded theory methodology an eight-phase process 'growing consciousness of joystick-use' was identified. In addition, a tool for assessment of actual phase of joystick-use and facilitating strategies for each phase emerged. The aim of the present study was to evaluate inter-rater reliability of the assessment tool. Methods: The first author (LN) selected 24 video-sequences within the video data collected in the project. Each of the eight phases in the identified process were represented by three video-clips. The video-clips ranged in length between two to five minutes. LN's ratings served as criterion rating against which three independent raters' judgements were compared. The three raters were all occupational therapists, and two were experienced with the Driving to Learn™ method, powered wheelchair provision and the target population; and one was inexperienced. Results: When comparing the three raters' assessments with that of LN (N = 72), the calculation gave a weighted kappa value of 0.85. All raters judged the tool as having a high degree of usability for assessing phases of joystick-use. Minimal differences were found between the experienced and inexperienced raters. Conclusion and significance of the study: The inter-rater reliability of the assessment tool was very good. The findings indicate that the tool is reliable and has clinical usability in occupational therapy practice.
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| 31. |
- Nilsson, Lisbeth, et al.
(författare)
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Driving to Learn in a Powered Wheelchair: The Process of Learning Joystick Use in People With Profound Cognitive Disabilities
- 2011
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Ingår i: American Journal of Occupational Therapy. - : AOTA Press. - 0272-9490 .- 1943-7676. ; 65:6, s. 652-660
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Tidskriftsartikel (refereegranskat)abstract
- The Driving to Learn project explored ways to help people with profound cognitive disabilities practice operating a joystick-operated powered wheelchair. The project used a grounded theory approach with constant comparative analysis and was carried out over 12 yr. The participants were 45 children and adults with profound cognitive disabilities. Reference groups included 17 typically developing infants and 64 participants with lesser degrees of cognitive disability. The data sources included video recordings, field notes, open interviews, and a rich mixture of literature. The findings that emerged yielded strategies for facilitating achievements, an 8-phase learning process, an assessment tool, and a grounded theory of deplateauing explaining the properties necessary for participants to exceed expected limitations and plateaus. Eight participants with profound cognitive disabilities reached goal-directed driving or higher. Participants were empowered by attaining increased control over tool use, improving their autonomy and quality of life.
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| 32. |
- Nilsson, Lisbeth, et al.
(författare)
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Training characteristics important for growing consciousness of joystick-use in people with profound cognitive disabilities
- 2010
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Ingår i: International Journal of Therapy and Rehabilitation. - : Mark Allen Group. - 1759-779X .- 1741-1645. ; 17:11, s. 588-595
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Tidskriftsartikel (refereegranskat)abstract
- Aim: The Driving to Learn project focused on people with profound cognitive disabilities and their possible achievements from practicing joystick-use in a powered wheelchair. The aim of this study within the project was to statistically analyse the participants' outcomes, and to explore factors, in terms of participant and training characteristics, associated with a favourable outcome of training joystick-use. Methods: In this study, previously collected and analysed data and findings from 45 participants (aged 12 months to 52 years) were used to extract participant and training characteristics. Associations between participant and training characteristics and the participant's outcome of joystick-use were calculated. Results: The results showed that training characteristics were decisive for reaching steering control, whereas participant characteristics were not. Factors significantly associated with participant's reaching 'control of steering' were: taking part in more than 30 training sessions (p=0.004), training at two or more training venues (p=0.007), undergoing a training period longer than two years (p=0.016), and a high degree of training with professional trainers (p=0.045). Conclusions: Appropriate training characteristics assisted growing consciousness of joystick-use in people with profound cognitive disabilities. Findings from the project also include the identification of an eight-phase process of growing consciousness of joystick-use and the development of a tool for assessment of phases, which were used to measure the participants outcome.
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| 33. |
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| 34. |
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| 35. |
- Nyberg, Andre, et al.
(författare)
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Limited scientific evidence supports the use of conservative treatment interventions for pain and function in patients with subacromial impingement syndrome : randomized control trials
- 2010
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Ingår i: Physical Therapy Reviews. - 1083-3196 .- 1743-288X. ; 15:6, s. 436-452
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Tidskriftsartikel (refereegranskat)abstract
- Background: Different conservative treatment interventions are often used to decrease pain and improve function in patients with subacromial impingement syndrome (SAIS). However, the current evidence to support the use of these interventions has not been established. Objectives: To determine the evidence for conservative treatment interventions regarding pain and function compared to any intervention for SAIS patients. Methods: A systematic review of randomized controlled trials, published in English between 1 January 1999 and 31 May 2010, was performed using PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Cochrane Library and manual searching. The methodological quality (PEDro scale) and evidence grade (SBU) were rated. Eight studies were of high quality, four were medium quality, and eight were low quality. Various conservative treatment interventions were evaluated: acupuncture, electrotherapy modalities, exercises, mixed modalities, changing posture, and use of a functional brace. Results: Limited scientific evidence (LSE) indicates positive effects of exercise and mixed modalities regarding pain and function and high-intensity laser therapy (HILT) regarding pain in SAIS patients. LSE also indicate no effect of electrotherapy modalities, apart from HILT, as treatment for SAIS. Conclusions: The lack of high quality interventions limits the ability to draw conclusions regarding efficacy from several of the included studies. However, exercise may be as efficient as surgery, manual therapy in combination with exercise seems to be more effective than exercise alone and high-dose exercises seem to be more effective than low-dose exercises. Furthermore, there is contradictory evidence to support the use of acupuncture.
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| 36. |
- Nyberg, Daniel, 1980, et al.
(författare)
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Effects of intrinsic radiation Q on mismatch factor of three types of small antennas: single-resonance, gradual-transition and cascaded-resonance types
- 2010
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Ingår i: IET Microwaves, Antennas and Propagation. - : Institution of Engineering and Technology (IET). - 1751-8725 .- 1751-8733. ; 4:1, s. 83-90
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Tidskriftsartikel (refereegranskat)abstract
- Resonators are traditionally characterised by their quality factor Q, which is inversely proportional to the relative bandwidth. Small antennas are often resonant, so they can be characterised by a Q, except for the fact that the correct quality measure of an antenna is the inverse Q, that is the relative bandwidth, rather than Q. Still, it has become common to study fundamental size limitations of small antennas in terms of a so-called radiation Q (or antenna Q). This study explains how this intrinsic radiation Q relates to: (i) the bandwidth-efficiency product of small single-resonance-type antennas, (ii) the gradual cut-off of spherical waves for wideband gradual-transition-type small antennas and (iii) the number of resonances needed to cover a certain frequency band for wideband cascaded-resonance-type small antennas. The study also introduces one intrinsic radiation Q for basic single TE and TM spherical mode sources, and another for combined TE and TM sources.
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| 37. |
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| 38. |
- Nyberg, Martin, et al.
(författare)
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PCA3 as a diagnostic marker for prostate cancer: A validation study on a Swedish patient population.
- 2010
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Ingår i: Scandinavian Journal of Urology and Nephrology. - : Informa UK Limited. - 1651-2065 .- 0036-5599. ; 44, s. 378-383
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Tidskriftsartikel (refereegranskat)abstract
- Abstract Objective. Prostate cancer antigen 3 in urine (uPCA3) has been shown to perform better than total prostate-specific antigen in serum (tPSA) to predict prostate cancer (PCa) detection. The aim of this study was to validate the diagnostic precision of uPCA3 in a mixed set of patients with no previous history of PCa, including patients with previous negative biopsies. Material and methods. The study included 62 men scheduled for prostate biopsy at Skåne University Hospital Malmö, Sweden. Urine samples were obtained according to the Progensa™ uPCA3 assay. Logistic regression and receiver operating characteristic curves were used to test associations between levels of biomarkers and prostate cancer. Results. According to pathological examination of core needle biopsies, PCa was found in 18 out of 62 patients. A one-step increase in uPCA3 was associated with an increase in the odds of cancer of 1.026 (p = 0.005). Differences in the odds ratio between uPCA3 and tPSA were not statistically significant. A model using both markers did not increase prediction of event. Areas under the curve for uPCA3, tPSA and a model combining uPCA3 and tPSA did not differ significantly. No significant correlation was found between uPCA3 and tPSA or prostate volume. Conclusion. In this small set of mixed patients uPCA3 alone and tPSA performed equally well as diagnostic markers for PCa. A combination of the two markers did not improve the diagnostic performance. This study does not support a role for the uPCA3 urine test to replace or be added to tPSA in PCa detection.
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| 39. |
- Nyberg, Per, et al.
(författare)
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Predation av fisk och signalkräfta på rödingrom - resultat från en fältstudie i Vättern
- 2012
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Vätterns unika bestånd av storröding har minskat kraftigt de senaste decennierna och orsakerna till minskningen diskuteras livligt. Bland föreslagna orsaker nämns exvis konkurrens från inplanterad lax, överexploatering och klimatförändringar. Därutöver befaras även signalkräftan, via predation på rödingrom kunna ha en negativ inverkan på rödingens reproduktion. För att undersöka predationen på rödingrom från såväl fisk som signalkräfta utfördes 2009 ett fältförsök vid en känd lekplats i norra Vättern. I de använda försöksburarna var den uppskattade mortaliteten av ägg till följd av kräftpredation 5 gånger högre än den till följd av fiskpredation. Resultaten indikerar därmed att predationen på rödingrom från signalkräfta kan vara kraftigt underskattad och att den kan ha påverkat rödingbeståndets återhämtning i Vättern negativt.
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| 40. |
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| 41. |
- Plaven-Sigray, Pontus, et al.
(författare)
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Dopamine D1 receptor availability is related to social behavior : A positron emission tomography study
- 2014
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Ingår i: NeuroImage. - : Elsevier BV. - 1053-8119 .- 1095-9572. ; 102, s. 590-595
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Tidskriftsartikel (refereegranskat)abstract
- Dysfunctional interpersonal behavior is thought to underlie a wide spectrum of psychiatric disorders; however, the neurobiological underpinnings of these behavioral disturbances are poorly understood. Previous molecular imaging studies have shown associations between striatal dopamine (DA) D2-receptor binding and interpersonal traits, such as social conformity. The objective of this study was to explore, for the first time, the role of DA D1-receptors (D1-Rs) in human interpersonal behavior. Twenty-three healthy subjects were examined using positron emission tomography and the radioligand [C-11] SCH23390, yielding D1-R binding potential values. Striatal D1-R binding was related to personality scales selected to specifically assess one dimension of interpersonal behavior, namely a combination of affiliation and dominance (i.e., the Social Desirability, Verbal Trait Aggression and Physical Trait Aggression scales from Swedish Universities Scales of Personality). An exploratory analysis was also performed for extrastriatal brain regions. D1-R binding potential values in the limbic striatum(r= .52; p= .015), associative striatum(r= .55; p= .009), and sensorimotor striatum(r= .67; p= .001) were positively related to Social Desirability scores. D1-R binding potential in the limbic striatum (r= -.51; p = .019) was negatively associated with Physical Trait Aggression scores. For extrastriatal regions, Social Desirability scores showed positive correlations in the amygdala (r = .60; p = .006) and medial frontal cortex (r= .60; p = .004). This study provides further support for the role of DA function in the expression of disaffiliative and dominant traits. Specifically, D1-R availability may serve as a marker for interpersonal behavior in humans. Associations were demonstrated for the same dimension of interpersonal behavior as for D2-R, but in the opposite direction, suggesting that the two receptor subtypes are involved in the same behavioral processes, but with different functional roles.
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| 42. |
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| 43. |
- Rieckmann, Anna, et al.
(författare)
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Dopamine D1 Receptor Associations within and between Dopaminergic Pathways in Younger and Elderly Adults : Links to Cognitive Performance
- 2011
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Ingår i: Cerebral Cortex. - Oxford : Oxford University Press. - 1047-3211 .- 1460-2199. ; 21:9, s. 2023-2032
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Tidskriftsartikel (refereegranskat)abstract
- Age-related dopamine (DA) losses have been extensively demonstrated for the D2 receptor subtype. Comparatively little is known about adult age changes regarding D1 receptors. In this study, we demonstrate marked age-related D1 receptor losses in striatal, limbic, and cortical areas using positron emission tomography and the radioligand [11C]SCH23390 in humans. Interregional correlations of binding potential (BP) values were high for areas within DA pathways in younger and elderly adults alike. Furthermore, interregional correlations in D1 BP between DA pathways were uniformly high in younger adults, indicating that D1 receptor densities in striatal, limbic, and cortical areas are not regulated independently, despite dopaminergic innervation from different midbrain areas. For elderly adults, between-pathway correlations of D1 receptor densities were preserved only between mesolimbic and mesocortical areas, whereas striatal BPs were weakly related to those in limbic and neocortical regions. Importantly, weak between-pathway correlations in elderly adults were found only for the slower half of the sample when BP was estimated during a cognitive interference task. These results suggest that D1 receptor densities in different pathways are not regulated independently in younger adults, but segregate in older age, and that this segregation of D1 receptor systems may be related to age-related cognitive slowing.
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| 44. |
- Sandgren, Anna, 1970-, et al.
(författare)
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Symptoms, care needs and diagnosis in palliative cancer patients in acute care hospitals: A 5-year follow-up survey
- 2010
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Ingår i: Acta Oncologica. - : Informa Healthcare. - 0284-186X .- 1651-226X. ; 49:4, s. 460-466(7)
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Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION: Palliative cancer care in acute hospitals is scarcely studied. We therefore described and compared symptoms, care needs and types of cancer sites in 2002 compared to 2007 and analysed the relationships between these factors. METHODS: The study was population-based with a cross-sectional design and was carried out in medical, surgical and oncology wards in two acute care hospitals with no advanced palliative home care service. In 2002, 82 one-day-inventories were done (1 352 patients) compared to 142 one-day-inventories in 2007 (2 972 patients). Symptoms, care needs and cancer site were registered according to a questionnaire. Multiple logistic regression models were used to analyse associations between symptoms, care needs and cancer site. RESULTS: The proportion of palliative cancer patients had decreased during a five year period (14% vs. 11%, p<0.01). The patients were older in 2007 (74 vs. 70 years, p<0.001) and had more symptoms and care needs per patient (2.6 vs. 1.6, p<0.001). The most common symptoms were pain and deterioration and the most common cancer sites were prostate and colorectal cancer in both samples. Associations between symptoms, care needs and cancer site were mostly weak. Deterioration was associated with colorectal cancer, whereas pain was not associated with any specific cancer site. In haematological malignancies there was a high occurrence of infections and a high need of blood transfusions and infusions. Stomach/oesophagus cancers were significantly associated with nausea, nutritional problems and need of infusions while unknown primary malignancies were associated with abdominal surgery and infusions. DISCUSSION: Although we do not know all the causes for hospitalization, this study indicates that more focus should be on the symptoms instead of the specific cancer diagnosis. The findings also indicate that many palliative cancer patients' problems would be suitable for advanced palliative home care instead of acute hospital care.
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| 45. |
- Singh, B. S. Nara, et al.
(författare)
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16(+) Spin-Gap Isomer in (96)Cd
- 2011
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 107:17, s. 172502-
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Tidskriftsartikel (refereegranskat)abstract
- A beta-decaying high-spin isomer in (96)Cd, with a half-life T(1/2) = 0.29(-0.10)(+0.11) s, has been established in a stopped beam rare isotope spectroscopic investigations at GSI (RISING) experiment. The nuclei were produced using the fragmentation of a primary beam of (124)Xe on a (9)Be target. From the half-life and the observed gamma decays in the daughter nucleus, (96)Ag, we conclude that the beta-decaying state is the long predicted 16(+) "spin-gap'' isomer. Shell-model calculations, using the Gross-Frenkel interaction and the pi nu(p(1/2,)g(9/2)) model space, show that the isoscalar component of the neutron-proton interaction is essential to explain the origin of the isomer. Core excitations across the N = Z = 50 gaps and the Gamow-Teller strength, Bd(GT) distributions have been studied via large-scale shell-model calculations using the pi nu(g, d, s) model space to compare with the experimental B(GT) value obtained from the half-life of the isomer.
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| 46. |
- Öberg, Per, et al.
(författare)
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A New Chassis Dynamometer Laboratory for Vehicle Research
- 2013
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Ingår i: SAE International Journal of Passenger Cars - Electronic and Electrical Systems. - : SAE International. - 1946-4614 .- 1946-4622. ; 6:1, s. 152-161
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Tidskriftsartikel (refereegranskat)abstract
- In recent years the need for testing, calibration and certification of automotive components and powertrains have increased, partly due to the development of new hybrid concepts. At the same time, the development within electrical drives enables more versatile chassis dynamometer setups with better accuracy at a reduced cost. We are developing a new chassis dynamometer laboratory for vehicle research, aiming at extending a recently commercially available dynamometer, building a new laboratory around it, and applying the resulting facility to some new challenging vehicle research problems. The projects are enabled on one hand by collaboration with the dynamometer manufacturer, and on the other hand on collaboration with automotive industry allowing access to relevant internal information and equipment. The test modes of the chassis dynamometer are under development in a joint collaboration with the manufacturer. The laboratory has been operational since September 2011 and has already been used for NVH-analysis for a tire pressure indication application, chassis dynamometer road force co-simulation with a moving base simulator, co-surge modeling and control for a 6-cylinder bi-turbo engine, and traditional engine mapping. We are also looking at projects with focus on look-ahead control, as well as clutch and transmission modeling and control, and driving cycle related research.
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