| 1. |
- Hallert, Claes, 1945-, et al.
(författare)
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Increasing Fecal Butyrate in Ulcerative Colitis Patients by Diet : Controlled Pilot Study
- 2003
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Ingår i: Inflammatory Bowel Diseases. - : Lippincott Williams & Wilkins. - 1078-0998 .- 1536-4844. ; 9:2, s. 116-121
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Tidskriftsartikel (refereegranskat)abstract
- Topical butyrate has been shown to be effective in the treatment of ulcerative colitis (UC). Butyrate is derived from colonic fermentation of dietary fiber, and our aim was to study whether UC patients could safely increase the fecal butyrate level by dietary means. We enrolled 22 patients with quiescent UC (mean age, 44 years; 45% women; median time from last relapse, 1 year) in a controlled pilot trial lasting 3 months. The patients were instructed to add 60 g oat bran (corresponding to 20 g dietary fiber) to the daily diet, mainly as bread slices. Fecal short-chain fatty acids (SCFAs) including butyrate, disease activity, and gastrointestinal symptoms were recorded every 4 weeks. During the oat bran intervention the fecal butyrate concentration increased by 36% at 4 weeks (from 11 +/- 2 (mean +/- SEM) to 15 +/- 2 mumol/g feces) (p < 0.01). The mean butyrate concentration over the entire test period was 14 +/-1 μmol/g feces (p < 0.05). Remaining fecal SCFA levels were unchanged. No patient showed signs of colitis relapse. Unlike controls, the patients showed no increase in gastrointestinal complaints during the trial. Yet patients reporting abdominal pain and reflux complaints at entry showed significant improvement at 12 weeks that returned to baseline 3 months later. This pilot study shows that patients with quiescent UC can safely take a diet rich in oat bran specifically to increase the fecal butyrate level. This may have clinical implications and warrants studies of the long-term benefits of using oat bran in the maintenance therapy in UC.
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| 2. |
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Highlights from the first year of Odin observations
- 2003
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 402, s. L39-L46
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Tidskriftsartikel (refereegranskat)abstract
- Key Odin operational and instrumental features and highlights from our sub-millimetre and millimetre wave observations of H2O, H218O, NH3, 15NH3 and O2 are presented, with some insights into accompanying Odin Letters in this A&A issue. We focus on new results where Odin's high angular resolution, high frequency resolution, large spectrometer bandwidths, high sensitivity or/and frequency tuning capability are crucial: H2O mapping of the Orion KL, W3, DR21, S140 regions, and four comets; H2O observations of Galactic Centre sources, of shock enhanced H2O towards the SNR IC443, and of the candidate infall source IRAS 16293-2422; H218O detections in Orion KL and in comet Ikeya-Zhang; sub-mm detections of NH3 in Orion KL (outflow, ambient cloud and bar) and ρ Oph, and very recently, of 15NH3 in~Orion KL. Simultaneous sensitive searches for the 119 GHz line of O2 have resulted in very low abundance limits, which are difficult to accomodate in chemical models. We also demonstrate, by means of a quantitative comparison of Orion KL H2O results, that the Odin and SWAS observational data sets are very consistently calibrated. Odin is a Swedish-led satellite project funded jointly by the Swedish National Space Board (SNSB), the Canadian Space Agency (CSA), the National Technology Agency of Finland (Tekes), and the Centre National d'études Spatiales (CNES, France). The Swedish Space Corporation (SSC) has been the prime industrial contractor, and is also responsible for the satellite operation from its Odin Mission Control Centre at SSC in Solna and its Odin Control Centre at ESRANGE near Kiruna in northern Sweden. See also the SNSB Odin web page: http://www.snsb.se/eng_odin_intro.shtml
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| 3. |
- Kumm, Mia, 1967-, et al.
(författare)
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Försök med mobila fläktar i Masthamnstunneln, Stockholm
- 2003
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Tunnlar byggs i allt större utsträckning och trenderna går mot fler och större underjordsstationer, inte enbart för tunnelbana, utan även för pendel- och fjärrtåg. På de större resecenter som byggs koncentreras flera olika trafikslag och genomströmningen av trafikanter är stor. Ventilationen av brandgaser i händelse av en brand är av central betydelse såväl vid utrymning av trafikanter och personal som ur ett insatsperspektiv.Kunskapen gällande ventilation av brandgaser i tunnel har ökat markant det senaste decenniet. Dock finns idag en mängd tunnlar som ännu används, men är byggda efter den standard som var aktuell vid tiden för byggnationen. Tunnlarna har en lång livstid och skall kunna nyttjas kanske hundra år framåt i tiden.Syftet med detta försök är att se om de mindre fläktar, som Räddningstjänsten redan förfogar över, kan vara ett alternativ vid evakuering av brandgaser i trafiktunnlar. Målsättningen är också att peka på de begränsningar som föreligger vid användandet och föreslå en strategi för den fortsatta utvärderingen.
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| 4. |
- Nord, Johan, et al.
(författare)
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Transient kinetics of ligand binding and role of the C-terminus in the dUTPase from equine infectious anemia virus
- 2000
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Ingår i: FEBS Letters. - 1873-3468. ; 472:2-3, s. 312-316
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Tidskriftsartikel (refereegranskat)abstract
- Transient kinetics of the equine infectious anemia virus deoxyuridine 5'-triphosphate nucleotide hydrolase were characterized by monitoring the fluorescence of the protein. Rate constants for the association and dissociation of substrate and inhibitors were determined and found to be consistent with a one-step mechanism for substrate binding. A C-terminal part of the enzyme presumed to be flexible was removed by limited trypsinolysis. As a result, the activity of the dUTPase was completely quenched, but the rate constants and fluorescent signal of the truncated enzyme were affected only to a minor degree. We conclude that the flexible C-terminus is not a prerequisite for substrate binding, but indispensable for catalysis.
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