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1.
  • Habs, D., et al. (författare)
  • The REX-ISOLDE project
  • 2000
  • Ingår i: Hyperfine Interactions. - 0304-3843 .- 1572-9540. ; 129:1-4, s. 43-66
  • Tidskriftsartikel (refereegranskat)abstract
    • The Radioactive Beam Experiment REX-ISOLDE [1-3] is a pilot experiment at ISOLDE (CERN) testing the new concept of post acceleration of radioactive ion beams by using charge breeding of the ions in a high charge state ion source and the efficient acceleration of the highly charged ions in a short LINAC using modern ion accelerator structures. In order to prepare the ions for the experiments singly charged radioactive ions from the on-line mass separator ISOLDE will be cooled and bunched in a Penning trap, charge bred in an electron beam ion source (EBIS) and finally accelerated in the LINAC. The LINAC consists of a radiofrequency quadrupole (RFQ) accelerator, which accelerates the ions up to 0.3 MeV/u, an interdigital H-type (IH) structure with a final energy between 1.1 and 1.2 MeV/u and three seven gap resonators, which allow the variation of the final energy. With an energy of the radioactive beams between 0.8 MeV/u and 2.2 MeV/u a wide range of experiments in the field of nuclear spectroscopy, astrophysics and solid state physics will be addressed by REX-ISOLDE.
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2.
  • Jeppesen, H., et al. (författare)
  • News on beta delayed particle emission from 14Be
  • 2002
  • Ingår i: Progress of Theoretical Physics. - 0033-068X. ; :146 SUPPL., s. 520-524
  • Tidskriftsartikel (refereegranskat)abstract
    • Beta delayed charged particles from 14Be have been measured and give an upper limit on beta delayed alpha particles of B(βα)<6.7×10-5 and a tentative branching ratio on beta delayed tritons of 7.5×10-5
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  • Highlights from the first year of Odin observations
  • 2003
  • Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 402, s. L39-L46
  • Tidskriftsartikel (refereegranskat)abstract
    • Key Odin operational and instrumental features and highlights from our sub-millimetre and millimetre wave observations of H2O, H218O, NH3, 15NH3 and O2 are presented, with some insights into accompanying Odin Letters in this A&A issue. We focus on new results where Odin's high angular resolution, high frequency resolution, large spectrometer bandwidths, high sensitivity or/and frequency tuning capability are crucial: H2O mapping of the Orion KL, W3, DR21, S140 regions, and four comets; H2O observations of Galactic Centre sources, of shock enhanced H2O towards the SNR IC443, and of the candidate infall source IRAS 16293-2422; H218O detections in Orion KL and in comet Ikeya-Zhang; sub-mm detections of NH3 in Orion KL (outflow, ambient cloud and bar) and ρ Oph, and very recently, of 15NH3 in~Orion KL. Simultaneous sensitive searches for the 119 GHz line of O2 have resulted in very low abundance limits, which are difficult to accomodate in chemical models. We also demonstrate, by means of a quantitative comparison of Orion KL H2O results, that the Odin and SWAS observational data sets are very consistently calibrated. Odin is a Swedish-led satellite project funded jointly by the Swedish National Space Board (SNSB), the Canadian Space Agency (CSA), the National Technology Agency of Finland (Tekes), and the Centre National d'études Spatiales (CNES, France). The Swedish Space Corporation (SSC) has been the prime industrial contractor, and is also responsible for the satellite operation from its Odin Mission Control Centre at SSC in Solna and its Odin Control Centre at ESRANGE near Kiruna in northern Sweden. See also the SNSB Odin web page: http://www.snsb.se/eng_odin_intro.shtml
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8.
  • Kester, O., et al. (författare)
  • Accelerated radioactive beams from REX-ISOLDE
  • 2003
  • Ingår i: Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms. - 0168-583X. ; 204, s. 20-20
  • Konferensbidrag (refereegranskat)abstract
    • In 2001 the linear accelerator of the Radioactive beam EXperiment (REX-ISOLDE) delivered for the first time accelerated radioactive ion beams, at a beam energy of 2 MeV/u. REX-ISOLDE uses the method of charge-state breeding, in order to enhance the charge state of the ions before injection into the LINAC. Radioactive singly-charged ions from the on-line mass separator ISOLDE are first accumulated in a Penning trap, then charge bred to an A/q
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9.
  • Markenroth, Karin, 1973, et al. (författare)
  • Crossing the dripline to N-11 using elastic resonance scattering
  • 2000
  • Ingår i: Physical Review C - Nuclear Physics. - 2469-9985 .- 2469-9993. ; 6203:3
  • Tidskriftsartikel (refereegranskat)abstract
    • The level structure of the unbound nucleus N-11 has been studied by C-10+p elastic resonance scattering in inverse geometry with the LISE3 spectrometer at GANIL, using a C-10 beam with an energy of 9.0 MeV/ nucleon. An additional measurement was done at the A1200 spectrometer at MSU. The excitation function above the C-10+p threshold has been determined up to 5 MeV. A potential-model analysis revealed three resonance states at energies 1.27(-0.05)(+0.18) MeV (Gamma = 1.44 +/- 0.2 MeV), 2.01(-0.05)(+0.15) MeV (Gamma = 0.84 +/- 0.2 MeV), and 3.75 +/- 0.05 MeV (Gamma = 0.60 +/- 0.05 MeV) with the spin-parity assignments I-pi=1/2+,1/2,-,5/2+, respectively. Hence, N-11 is shown to have a ground state parity inversion completely analogous to its mirror partner Be-11. A narrow resonance in the excitation function at 4.33 +/- 0.05 MeV was also observed and assigned spin parity 3/2-.
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14.
  • Aleksandrov, D., et al. (författare)
  • Halo excitations in fragmentation of He-6 at 240 MeV/u on carbon and lead targets
  • 2000
  • Ingår i: Nuclear Physics A. - 0375-9474. ; 669:1-2, s. 51-64
  • Tidskriftsartikel (refereegranskat)abstract
    • Dissociation of a 240 MeV/u beam of He-6, incident on carbon and lead targets, has been studied in kinematically complete experiments to investigate low-lying excitation modes in the halo nucleus He-6. It is shown that alignment effects characterize the inelastic scattering and allow an unambiguous assignment of the spin of a narrow resonance observed in the excitation energy spectrum. The differential cross sections for the He-6 inelastic scattering on carbon and lead targets were deduced from the measured moments of the two neutrons and the a-particle. An analysis of these distributions shows that quadrupole and, possibly, monopole excitations characterize the hadronic interaction, while the dipole mode is dominating in Coulomb dissociation. Neither theoretically predicted new resonance states in He-6 nor nuclear excitation of a dipole mode were found. Direct evidence has been obtained for strong suppression of Coulornb post-acceleration in direct Coulomb breakup in a lead target.
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15.
  • Axelsson, L., et al. (författare)
  • Deriving the angular variation of p(parallel to)-distributions for halo neutrons with robust statistics
  • 2001
  • Ingår i: Nuclear Physics A. - 0375-9474. ; 679:3-4, s. 215-230
  • Tidskriftsartikel (refereegranskat)abstract
    • The longitudinal neutron momentum distribution from core breakup of Li-11 and Be-11 have been measured at 29.9 MeV/u and 38.5 MeV/u, respectively. Separate measurements on Li-9 and Be-10 allowed extraction of the halo neutron distribution. The shapes of the distributions are analyzed using robust and descriptive statistics, For both isotopes the shape is changing with angle. (C) 2001 Elsevier Science B.V. All rights reserved.
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16.
  • Bergmann, U. C., et al. (författare)
  • Analysis of decay data from neutron-rich nuclei
  • 2001
  • Ingår i: European Physical Journal A. - 1434-601X .- 1434-6001. ; 11:3, s. 279-284
  • Tidskriftsartikel (refereegranskat)abstract
    • The beta -decays of the neutron-rich nuclei Be-12 and Ne-29 have been studied. The statistical correlations between the almost identical half-lives of Be-12 and its daughter B-12 are analysed for a large sample of Be-12 decay data. Stringent mutual bounds are obtained on the parameter set, leading to a precise determination of the Be-12 half-life of 21.50 +/- 0.04 ms. From a simultaneous detection of beta -particles and neutrons from the decay of Ne-29 the neutron emission probability, P-n, is determined to 17 +/- 5%. No indication of two-neutron emission is seen from this nucleus. An upper limit of 2.2% (90% confidence level) is established for P-2n.
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17.
  • Bergmann, U. C., et al. (författare)
  • On the beta-decay of C-9
  • 2001
  • Ingår i: Nuclear Physics A. - 0375-9474. ; 692:3-4, s. 427-450
  • Tidskriftsartikel (refereegranskat)abstract
    • In beta -decay experiments on C-9 at CERN/ISOLDE the beta -strength was determined to the ground state, the 12.2 MeV excited state and the Isobaric Analog State (IAS) at 14.655 MeV in B-9. A large beta -strength asymmetry is deduced for the mirror transitions of C-9 and Li-9 to states around 12 MeV excitation energy. A satisfactory description of the three-body decay from a narrow energy region around the 12.2 MeV resonance is obtained within a sequential model involving the ground and first-excited states of Li-5 and Be-8. From the study of angular correlations the spin of the 12.2 MeV state is determined as 5/2(-). For the first time the population of the IAS is observed in beta -decay and new information on the decay of this state is obtained. The advantages of a closely packed. highly segmented detector setup are demonstrated. (C) 2001 Elsevier Science B.V. All rights reserved.
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18.
  • Borge, M. J. G., et al. (författare)
  • Asymmetry in the super-allowed beta-transitions of the A=9 isobars
  • 2004
  • Ingår i: Nuclear Physics A. - : Elsevier BV. - 0375-9474. ; 738:1-4 SUPPL., s. 206-210
  • Tidskriftsartikel (refereegranskat)abstract
    • We report here on the recent beta-decay studies of the A = 9 isobar made at ISOLDE/CERN. Mirror beta transitions in the A=9 chain are compared and a large asymmetry factor is deduced for the transitions to high excitation energy in Be-9 (11.8 MeV) and B-9 (12.2 MeV) fed in the beta-decay of Li-9 and C-9 respectively. It is shown that the asymmetry is not due to experimental problems or differences in the mechanisms of breakup or in the spin of the states. Only differences in the partial decay branches of the breakup channels have been found. As no asymmetry is found in the gs to gs transition it must be due to the particular structure of these excited states.
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19.
  • Borge, M. J. G., et al. (författare)
  • Beta-delayed multiparticle emission studies at ISOL-type facilities
  • 2004
  • Ingår i: Nuclear Physics A. - : Elsevier BV. - 0375-9474. ; 746, s. 243-243
  • Konferensbidrag (refereegranskat)abstract
    • We report here on the recent beta-decay studies made at ISOL-type Facilities to determine the multiparticle breakup mechanism of excited states in light nuclei by studying them in full kinematics. In particular the results obtained for the A = 9 isobars and the breakup of the 12.7 MeV state in C-12 of unnatural parity are discussed. The breakup of the latter has been debated since more than a decade. Mirror beta transitions in the A = 9 chain are compared and a large asymmetry factor is deduced for the transitions to high excitation energy in Be-9 (11.8 MeV) and B-9 (12.2 MeV) fed in the beta-decay of Li-9 and C-9 respectively. It is shown that the asymmetry is not due to experimental problems or differences in the mechanisms of breakup or in the spin of the states. As no asymmetry is found in the gs to gs transition it must be due to the particular structure of these excited states. The controversy on the breakup mechanism of the 12.7 MeV state is resolved.
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20.
  • Borge, M. J. G., et al. (författare)
  • Proton dripline studies at ISOLDE: Ar-31 and C-9
  • 2002
  • Ingår i: Nuclear Physics A. - 0375-9474. ; 701, s. 373C-377C
  • Konferensbidrag (refereegranskat)abstract
    • In this contribution examples of the application of new technologies to disentangle the mechanism of beta-delayed multiparticle emission are given. In particular the mechanism of beta-delayed two-proton emission from Ar-31 has been resolved and proved to be sequential, a preview of C-9-decay data is discussed. (C) 2002 Elsevier Science B.V. All rights reserved.
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21.
  • Broliden, K, et al. (författare)
  • [Parvovirus B19 infection--an incidious chameleon]
  • 2000
  • Ingår i: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke. - 0029-2001. ; 120:4, s. 455-8
  • Tidskriftsartikel (refereegranskat)
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22.
  • Cederkäll, Joakim, et al. (författare)
  • REX-ISOLDE - experiences from the first year of operation
  • 2004
  • Ingår i: Nuclear Physics A. - : Elsevier BV. - 0375-9474. ; 746, s. 17-17
  • Konferensbidrag (refereegranskat)abstract
    • The Radioactive beam EXperiment (REX) at CERN-ISOLDE has been commissioned and the first experiments successfully completed during 2002 and 2003. The concept used for post-acceleration has proven to be flexible and the experimental program has therefore been extended during the past year. This paper relays some experiences drawn from using the machine in the current program and also conveys some plans for the future.
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23.
  • Ekvall, Jimmy, et al. (författare)
  • Bioactive carbohydrates in vegetables and fruits.
  • 2003
  • Ingår i: Health promoting compounds in vegetables and fruit. Proceedings of workshop. (DIAS report, Plant Production ; 29). - 1397-9884. ; :29
  • Konferensbidrag (refereegranskat)
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  • Fynbo, H. O. U., et al. (författare)
  • New information on the beta-decay of Li-11 from Doppler broadened gamma lines
  • 2004
  • Ingår i: Nuclear Physics A. - : Elsevier BV. - 0375-9474. ; 736:1-2, s. 39-54
  • Tidskriftsartikel (refereegranskat)abstract
    • The gamma-ray spectrum following beta-decay of Li-11 has been remeasured at the ISOLDE facility at CERN. Two new transitions were observed through the use of large Ge-detectors. Most gamma-decays will follow beta-delayed neutron emission. Information on the energy of the neutron is derived from analysis of the gamma line-shape and used to construct a partial decay scheme for Li-11. Lifetime values for the 1(-) and 2(-) levels in Be-10 are also derived. A new partial decay scheme is presented. (C) 2004 Elsevier B.V. All rights reserved.
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26.
  • Fynbo, H. O. U., et al. (författare)
  • News on C-12 from beta-decay studies
  • 2004
  • Ingår i: Nuclear Physics A. - : Elsevier BV. - 0375-9474. ; 738, s. 59-65
  • Konferensbidrag (refereegranskat)abstract
    • We discuss the importance of the spectroscopic properties of the resonances of C-12 just above the 3alpha-threshold, and review the existing experimental information of this region with emphasis on 0(+) and 2(+) states. A new experimental approach for studying the beta-decays of B-12 and N-12 is presented based on techniques developed in the context of Radioactive beam (rare isotope) physics. Finally preliminary results from an ongoing analysis of two recent experiments are given.
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27.
  • Fynbo, H. O. U., et al. (författare)
  • The beta 2p decay mechanism of Ar-31
  • 2000
  • Ingår i: Nuclear Physics A. - 0375-9474. ; 677, s. 38-60
  • Tidskriftsartikel (refereegranskat)abstract
    • We have measured the beta-decay of Ar-31 with a high granularity setup sensitive to multiparticle decay branches. Two-proton emission is observed from the isobaric analog state in Cl-31 to the four lowest states in P-29 and furthermore from a large number of states fed in Gamow-Teller transitions. The mechanism of two-proton emission is studied via energy and angular correlations between the two protons. In all cases the mechanism is found to be sequential yielding information about states in S-30 up to 8 MeV excitation energy. Improved data on the beta-delayed one-proton branches together with the two-proton data provide precise information about the beta-strength distribution up to 15 MeV excitation energy.
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28.
  • Greenberg, R, et al. (författare)
  • Endovascular repair of descending thoracic aortic aneurysms: an early experience with intermediate-term follow-up
  • 2000
  • Ingår i: Journal of Vascular Surgery. - 1097-6809. ; 31:1 Pt 1, s. 147-156
  • Tidskriftsartikel (refereegranskat)abstract
    • PURPOSE: The purpose of this study was to report an initial experience with the endovascular repair of descending thoracic aortic aneurysm. Complications and intermediate-term morphologic changes were identified with the intent of altering patient selection and device design. METHODS: Endografts were placed into 25 patients at high-risk for conventional surgical repair over a 3(1/2)-year period. Devices were customized on the basis of preoperative imaging information. Follow-up computed tomography scans were obtained at 1, 3, 6, and 12 months and yearly thereafter. Additional interventions occurred in the setting of endoleaks, migration, and aneurysm growth. RESULTS: The overall 30-day mortality rate was 20% (12.5% for elective cases; 33% for emergent cases). There were 3 conversions to open repair. Neurologic deficits developed in 3 patients; 1 insult resulted in permanent paraplegia. Neurologic deficits were associated with longer endografts (P =.019). Three endoleaks required treatment, and 1 fatal rupture of the thoracic aneurysm treated occurred 6 months after the initial repair. Migrations were detected in 4 patients. The maximal aneurysm size decreased yearly by 9.15% (P =.01) or by 13.5% (P =.0005) if patients with endoleaks (n = 3 patients) were excluded. Both the proximal and distal neck dilated slightly over the course of follow-up (P =.019 and P =.001, respectively). The length of the proximal neck was a significant predictor of the risk for endoleakage (P =.02). CONCLUSION: The treatment of descending thoracic aortic aneurysms with an endovascular approach is feasible and may, in some patients, offer the best means of therapy. Early complications were primarily related to device design and patient selection. All aneurysms without endoleaks decreased in size after treatment. Late complications were associated with changing aneurysm morphologic features and device migration. The morphologic changes remain somewhat unpredictable; however, alterations in device design may result in improved fixation and more durable aneurysm exclusion.
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29.
  • Hall, MA, et al. (författare)
  • Basalioma after amiodarone therapy-not only in Britain
  • 2004
  • Ingår i: The British journal of dermatology. - : Oxford University Press (OUP). - 0007-0963 .- 1365-2133. ; 151:4, s. 932-933
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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30.
  • Jeppesen, H. B., et al. (författare)
  • News on beta delayed particle emission from Be-14
  • 2002
  • Ingår i: Progress of Theoretical Physics Supplement. - 0375-9687. ; :146, s. 520-524
  • Konferensbidrag (refereegranskat)abstract
    • Beta delayed charged particles from Be-14 have been measured and give an upper limit on beta delayed alpha particles of B(betaalpha)
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  • Markenroth, Karin, 1973, et al. (författare)
  • He-8-He-6: a comparative study of nuclear fragmentation reactions
  • 2001
  • Ingår i: Nuclear Physics A. - 0375-9474. ; 679:3-4, s. 462-480
  • Tidskriftsartikel (refereegranskat)abstract
    • Dissociation of 227 MeV/u He-8 in a carbon target has been studied in kinematically complete experiments. The data include the relative energy spectrum, angular distributions in the neutron knock-out channel (He-6 + n) as well as diffractive dissociation and inelastic scattering into the (He-6 + 2n) channel. The data are compared with corresponding results from the well-known halo nucleus He-6. In both cases it is found that neutron knock-out is the: dominating reaction channel. The relative energy spectrum (He-6 + n) shows a structure, which is interpreted as being due to the I-pi = 3/2(-) resonance in the He-7 ground state with about equal contribution from its I-pi = 1/2(-) spin-orbit partner. The He-7 resonance shows a spin alignment similar to that observed in He-5, but with a smaller anisotropy indicating that the structure of the He-8 ground state is more complicated than that of He-6. The data in the (He-6 + 2n) channel were used to identify resonances in the excitation energy spectrum of He-8. If the spectrum is interpreted as two overlapping resonances, the spin-parity assignment for these is found to be 2(+) and 1(-), respectively.
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34.
  • Nilsson, Thomas, 1965, et al. (författare)
  • Halo-nuclei at ISOLDE
  • 2000
  • Ingår i: Hyperfine Interactions. - 0304-3843 .- 1572-9540. ; 129:1-4, s. 67-81
  • Tidskriftsartikel (refereegranskat)abstract
    • Nuclear halo states are studied experimentally with a wide range of techniques. We review the results coming from ISOLDE, emphasizing the beta -decay experiments. Some general comments on the role of beta -decays for halo research are given. We outline the possibilities for low-energy reaction experiments arising from REX-ISOLDE.
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  • Nyman, Ulf, et al. (författare)
  • Commentary on the viewpoint of Spinosa et al
  • 2002
  • Ingår i: Radiology. - : Radiological Society of North America (RSNA). - 1527-1315 .- 0033-8419. ; 223:2, s. 326-327
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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38.
  • Olsson, M E, et al. (författare)
  • Antioxidants, low molecular weight carbohydrates, and total antioxidant capacity in strawberries (Fragaria x ananassa): Effects of cultivar, ripening, and storage
  • 2004
  • Ingår i: Journal of Agricultural and Food Chemistry. - : American Chemical Society (ACS). - 0021-8561 .- 1520-5118. ; 52:9, s. 2490-2498
  • Tidskriftsartikel (refereegranskat)abstract
    • Four cultivars of strawberries (Senga Sengana, BFr77111, Elsanta, and Honeoye) were studied for their content of antioxidants, total antioxidant capacity, and low molecular weight carbohydrates in relation to harvest year, ripening stage, and cold storage. For ascorbic acid, chlorogenic acid, ellagic acid, and total antioxidative capacity, measured in both water-soluble and water-insoluble extracts, there was a 2-5-fold variation among cultivars. Unripe berries contained lower concentrations of chlorogenic acid and p-coumaric acid and also quercetin and kaempferol compared with riper berries. During cold storage for up to 3 days, relatively few changes in the concentration of the different antioxidants occurred. The concentrations of several investigated parameters were interrelated, for example, for ascorbic acid and water-soluble antioxidant capacity and for ellagic acid and water-insoluble antioxidant capacity. The dominating sugars in strawberries were fructose and glucose, but considerable amounts of sucrose were also present, and their contents varied among cultivars, giving a predicted glycemic index of similar to81. Verbascose, raffinose, and stachyose were found in only minor amounts. The study shows that the concentration of a number of bioactive compounds in strawberries varied according to cultivar, ripening stage, and storage. This information should make it possible to select strawberries with an optimal content of bioactive compounds.
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39.
  • Prezado, Y., et al. (författare)
  • Large asymmetry in the strongest beta-transition for A=9
  • 2003
  • Ingår i: Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 576:1-2, s. 55-61
  • Tidskriftsartikel (refereegranskat)abstract
    • A new measurement of the beta-decay of Li-9 has clarified the feeding to the highest accessible states in Be-9. It is found that the P-decay mainly populates the 11.8 MeV state, whose spin is determined as 5/2(-). The extracted B-GT value of 5.3(0.9) is a factor 4.4(1.0) larger than that of the mirror transition from C-9. A theoretical explanation of such a pronounced beta-decay asymmetry is presently lacking. (C) 2003 Elsevier B.V. All rights reserved.
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  • Sutinen, J, et al. (författare)
  • Effects of rosiglitazone on gene expression in subcutaneous adipose tissue in highly active antiretroviral therapy-associated lipodystrophy
  • 2004
  • Ingår i: American journal of physiology. Endocrinology and metabolism. - : American Physiological Society. - 0193-1849 .- 1522-1555. ; 286:6, s. E941-E949
  • Tidskriftsartikel (refereegranskat)abstract
    • Highly active antiretroviral therapy (HAART) has improved the prognosis of human immunodeficiency virus (HIV)-infected patients but is associated with severe adverse events, such as lipodystrophy and insulin resistance. Rosiglitazone did not increase subcutaneous fat in patients with HAART-associated lipodystrophy (HAL) in a randomized, double-blind, placebo-controlled trial, although it attenuated insulin resistance and decreased liver fat content. The aim of this study was to examine effects of rosiglitazone on gene expression in subcutaneous adipose tissue in 30 patients with HAL. The mRNA concentrations in subcutaneous adipose tissue were measured using real-time PCR. Twenty-four-week treatment with rosiglitazone (8 mg/day) compared with placebo significantly increased the expression of adiponectin, peroxisome proliferator-activated receptor-γ (PPARγ), and PPARγ coactivator 1 and decreased IL-6 expression. Expression of other genes involved in lipogenesis, fatty acid metabolism, or glucose transport, such as acyl-CoA synthase, adipocyte lipid-binding protein, CD45, fatty acid transport protein-1 and -4, GLUT1, GLUT4, keratinocyte lipid-binding protein, lipoprotein lipase, PPARδ, and sterol regulatory element-binding protein-1c, remained unchanged. Rosiglitazone also significantly increased serum adiponectin concentration. The change in serum adiponectin concentration was inversely correlated with the change in fasting serum insulin concentration and liver fat content. In conclusion, rosiglitazone induced significant changes in gene expression in subcutaneous adipose tissue and ameliorated insulin resistance in patients with HAL. Increased expression of adiponectin might have mediated most of the favorable insulin-sensitizing effects of rosiglitazone in these patients.
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