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- Ek, Anna, et al.
(författare)
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Physical Activity and Mobile Phone Apps in the Preschool Age: Perceptions of Teachers and Parents
- 2019
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Ingår i: JMIR mhealth and uhealth. - : JMIR Publications. - 2291-5222. ; 7:4
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND:Physical activity (PA) is already beneficial at the preschool age. In many countries, young children spend most of their days in the preschool setting, making it a common arena for PA interventions. Mobile health tools are becoming increasingly popular to promote PA in different populations; however, little is known about the interest for and how the preschool setting could incorporate such a tool.OBJECTIVE:This study aimed to examine how teachers and parents perceive PA in preschool-aged children in general and their perceptions of how a mobile phone app could be used to promote PA in the preschool setting.METHODS:Semistructured interviews were conducted with 15 teachers (93%, [14/15] women, mean age 43.5 years, 47%, [7/15] with a university degree and 10 parents [91%, 9/10] women, mean age 38.9 years, all with a university degree) recruited from 2 urban preschools in central Sweden. The interviews were recorded, fully transcribed, coded, and analyzed using thematic analysis by means of an inductive approach.RESULTS:The analysis revealed 4 themes: (1) children are physically active by nature, (2) the environment as a facilitator or a barrier, (3) prerequisites of the adult world, and (4) an app in the preschool setting-challenges and possibilities. Parents and teachers perceived preschoolers as being spontaneously physically active; however, high-intensity PA was perceived as low. The PA was specifically performed during the day in the preschool. Identified facilitators of PA were access to safe and engaging outdoor environments such as forests, spacious indoor areas, and adult involvement. Adult involvement was considered especially important for children preferring sedentary activities. Identified barriers for PA were restricted indoor and outdoor space, rules for indoor activities, and lack of adult involvement because of time constraints. The teachers perceived that they had limited skills and experiences using apps in general, although they also acknowledged the increasing role of technological tools in the curriculum. Thus, the teachers expressed an interest for an app designed as a support tool for them, especially for situations when PA was limited because of perceived barriers. They suggested the app to include accessible information regarding the health benefits of PA in children linked to a library of activities for different settings and seasons. Parents suggested interactive app features including problem-solving tasks and music and dance, but not video clips as they made children passive.CONCLUSIONS:Vigorous PA was perceived as low in preschool-aged children. Future tailoring of interventions in the preschool setting should work around barriers and support facilitators to PA, especially PA of high intensity. In such work, an app could serve as a source of inspiration for PA in different ages, settings, and seasons and thus reduce environmental and structural inequalities in the preschool setting.
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- Michno, Wojciech, 1992, et al.
(författare)
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Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1–40 deposition underlies plaque polymorphism in progressing Alzheimer's disease pathology
- 2019
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Ingår i: Journal of Biological Chemistry. - : AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC. - 0021-9258 .- 1083-351X. ; 294:17, s. 6719-6732
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Tidskriftsartikel (refereegranskat)abstract
- Amyloid- (A) pathology in Alzheimer's disease (AD) is characterized by the formation of polymorphic deposits comprising diffuse and cored plaques. Because diffuse plaques are predominantly observed in cognitively unaffected, amyloid-positive (CU-AP) individuals, pathogenic conversion into cored plaques appears to be critical to AD pathogenesis. Herein, we identified the distinct A species associated with amyloid polymorphism in brain tissue from individuals with sporadic AD (s-AD) and CU-AP. To this end, we interrogated A polymorphism with amyloid conformation-sensitive dyes and a novel in situ MS paradigm for chemical characterization of hyperspectrally delineated plaque morphotypes. We found that maturation of diffuse into cored plaques correlated with increased A1-40 deposition. Using spatial in situ delineation with imaging MS (IMS), we show that A1-40 aggregates at the core structure of mature plaques, whereas A1-42 localizes to diffuse amyloid aggregates. Moreover, we observed that diffuse plaques have increased pyroglutamated Ax-42 levels in s-AD but not CU-AP, suggesting an AD pathology-related, hydrophobic functionalization of diffuse plaques facilitating A1-40 deposition. Experiments in tgAPP(Swe) mice verified that, similar to what has been observed in human brain pathology, diffuse deposits display higher levels of A1-42 and that A plaque maturation over time is associated with increases in A1-40. Finally, we found that A1-40 deposition is characteristic for cerebral amyloid angiopathy deposition and maturation in both humans and mice. These results indicate that N-terminal Ax-42 pyroglutamation and A1-40 deposition are critical events in priming and maturation of pathogenic A from diffuse into cored plaques, underlying neurotoxic plaque development in AD.
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- Nyström, Fredrika, et al.
(författare)
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Hur får jag dem att prata? : En klassrumsstudie i spanska
- 2019
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Rapport (populärvet., debatt m.m.)abstract
- I föreliggande artikel beskrivs en klassrumsstudie i spanska. Studien genomfördes huvudsakligen läsåret 2015-2016 och handlade om hur elevernas muntliga interaktion påmålspråket kan främjas genom uppgifters utformning. Studien bestod av fyra cykler vilkagenomfördes i språkgrupper i åk 9 samt kurs 2 och 3 på gymnasiet. Den gemensammautgångspunkten var svårigheten att få elever på lägre nivåer att tala målspråket i klassrummet. Inledningsvis låg fokus på elevernas användning av språkliga strategier i tal, men efterhand övergick vi till att analysera i vilken utsträckning själva aktivitetens eller uppgiftensutformning kunde främja muntlig interaktion. Studien genomfördes i fyra olika språkgrupper och som teoretiskt ramverk användes slutligen TBLT, Task Based Language Teaching.Inom TBLT, som på svenska heter uppgiftsbaserad språkundervisning, betonas själva uppgiftensom ska lösas och användningen av målspråket blir ett av verktygen som används. I artikelnbeskrivs hur en sådan uppgift utformades i en svensk skolkontext. Resultaten visade på enökad muntlig interaktion genom användningen av en uppgiftsbaserad aktivitet. Resultatenvisade också vikten av att medvetandegöra ett antal konjunktioner, pronomen och andrabindeord som eleverna har i sitt passiva ordförråd, vilka namnges som utvecklare. Artikelnbeskriver de reflektioner och antaganden som gjorts under arbetets gång, samt formulerarnya frågor kring undervisningens utformning och uppgifters konstruktion för att få eleverna att tala mer på målspråket under lektionerna i moderna språk.
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- Reitsma, Lizette, et al.
(författare)
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Spilltime : Designing for the relationship between QS, CO2e and climate goals
- 2019
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Ingår i: The Design Journal. - : Taylor and Francis Ltd.. - 1460-6925 .- 1756-3062. ; 22:sup1, s. 1087-1100
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Tidskriftsartikel (refereegranskat)abstract
- In order to deal with major climate challenges, different climate goals havebeen set. These goals are on an abstract, political level, making them difficult tounderstand for citizens. This is a problem, since in order to reach a sustainablesociety, all layers in society should be involved. We present a design process, in whichwe made invisible carbon emission goals tangible so that citizens can relate to them.By extracting different modes of carbon footprint feedback and translating those intoa network of objects, we have provided an alternative viewpoint on how to involvepeople into understanding complex data. By giving different modes of feedback,people can find different ways to relate to the data. This way, the designer providesthe tools, but people can use it to shape their own understanding. We consider thisapproach relevant in empowering citizens to voice their concerns in the climatedebate.
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| 6. |
- Svensson, Lennart, et al.
(författare)
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ProViz : a tool for explorative 3-D visualization and template matching in electron tomograms
- 2017
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Ingår i: Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization. - : Taylor & Francis. - 2168-1163 .- 2168-1171. ; 5:6, s. 446-454
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Tidskriftsartikel (refereegranskat)abstract
- Visual understanding is a key aspect when studying electron tomography data-sets, aside quantitative assessments such as registration of high-resolution structures. We here present the free software tool ProViz (Protein Visualization) for visualisation and template matching in electron tomograms of biological samples. The ProViz software contains methods and tools which we have developed, adapted and computationally optimised for easy and intuitive visualisation and analysis of electron tomograms with low signal-to-noise ratio. ProViz complements existing software in the application field and serves as an easy and convenient tool for a first assessment and screening of the tomograms. It provides enhancements in three areas: (1) improved visualisation that makes connections as well as intensity differences between and within objects or structures easier to see and interpret, (2) interactive transfer function editing with direct visual result feedback using both piecewise linear functions and Gaussian function elements, (3) computationally optimised template matching and tools to visually assess and interactively explore the correlation results. The visualisation capabilities and features of ProViz are demonstrated on various biological volume data-sets: bacterial filament structures in vitro, a desmosome and the transmembrane cadherin connections therein in situ, and liposomes filled with doxorubicin in solution. The explorative template matching is demonstrated on a synthetic IgG data-set.
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