| 1. |
- Dunham, I, et al.
(författare)
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The DNA sequence of human chromosome 22
- 1999
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 402:6761, s. 489-495
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Edelson, R. A., et al.
(författare)
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Multiwavelength observations of short-timescale variability in NGC 4151. IV. Analysis of multiwavelength continuum variability
- 1996
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 470:1, s. 364-377377
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Tidskriftsartikel (refereegranskat)abstract
- For pt.III see ibid., vol.470, no.1, p.349-63 (1996). Combines data from the three preceding papers in order to analyze the multi wave-band variability and spectral energy distribution of the Seyfert 1 galaxy NGC 4151 during the 1993 December monitoring campaign. The source, which was near its peak historical brightness, showed strong, correlated variability at X-ray, ultraviolet, and optical wavelengths. The strongest variations were seen in medium-energy (~1.5 keV) X-rays, with a normalized variability amplitude (NVA) of 24%. Weaker (NVA=6%) variations (uncorrelated with those at lower energies) were seen at soft gamma-ray energies of ~100 keV. No significant variability was seen in softer (0.1-1 keV) X-ray bands. In the ultraviolet/optical regime, the NVA decreased from 9% to 1% as the wavelength increased from 1275 to 6900 Aring. These data do not probe extreme ultraviolet (1200 Aring to 0.1 keV) or hard X-ray (250 keV) variability. The phase differences between variations in different bands were consistent with zero lag, with upper limits of lsim0.15 day between 1275 Aring and the other ultraviolet bands, lsim0.3 day between 1275 Aring and 1.5 keV, and lsim1 day between 1275 and 5125 Aring. These tight limits represent more than an order of magnitude improvement over those determined in previous multi-wave-band AGN monitoring campaigns. The ultraviolet fluctuation power spectra showed no evidence for periodicity, but were instead well fitted with a very steep, red power law (ales-2.5)
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| 3. |
- Crenshaw, D. M., et al.
(författare)
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Multiwavelength observations of short-timescale variability in NGC 4151. I. Ultraviolet observations
- 1996
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 470:1, s. 322-335335
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Tidskriftsartikel (refereegranskat)abstract
- Presents the results of an intensive ultraviolet monitoring campaign on the Seyfert 1 galaxy NGC 4151, as part of an effort to study its short-timescale variability over a broad range in wavelength. The nucleus of NGC 4151 was observed continuously with the International Ultraviolet Explorer for 9.3 days, yielding a pair of LWP and SWP spectra every ~70 minutes, and during 4 hr periods for 4 days prior to and 5 days after the continuous-monitoring period. The sampling frequency of the observations is an order of magnitude higher than that of any previous UV monitoring campaign on a Seyfert galaxy. The continuum fluxes in bands from 1275 to 2688 Aring went through four significant and well-defined ldquoeventsrdquo of duration 2-3 days during the continuous-monitoring period. The authors find that the amplitudes of the continuum variations decrease with increasing wavelength, which extends a general trend for this and other Seyfert galaxies to smaller timescales (i.e., a few days). The continuum variations in all the UV bands are simultaneous to within an accuracy of ~0.15 days, providing a strict constraint on continuum models. The emission-line light curves show only one major event during the continuous monitoring (a slow rise followed by a shallow dip) and do not correlate well with continuum light curves over the short duration of the campaign, because the timescale for continuum variations is apparently smaller than the response times of the emission lines
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| 4. |
- Lane, G. J., et al.
(författare)
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Identification of excited states in doubly odd [Formula Presented]Sb : Smooth band termination
- 1997
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Ingår i: Physical Review C - Nuclear Physics. - 0556-2813. ; 55:5, s. 2127-2131
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Tidskriftsartikel (refereegranskat)abstract
- Excited states in [Formula Presented]Sb have been identified for the first time in a series of [Formula Presented]-spectroscopy experiments using both thin and backed targets, including neutron-fold and recoil-mass measurements to provide unambiguous channel identification. The three decoupled intruder bands observed in [Formula Presented]Sb are based upon configurations involving 2p-2h excitations across the [Formula Presented] shell gap and show the features of smooth band termination. The yrast intruder band, which has been connected to the low-spin levels, is tentatively identified up to its predicted termination at [Formula Presented]. Excellent agreement with configuration-dependent cranked Nilsson-Strutinsky calculations is obtained for the high-spin states near termination.
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| 5. |
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| 6. |
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| 7. |
- ERKENS, U, et al.
(författare)
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MONITORING OF ACTIVE GALACTIC NUCLEI .6. THE QUASAR MKN-876
- 1995
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Ingår i: ASTRONOMY AND ASTROPHYSICS. - : SPRINGER VERLAG. - 0004-6361. ; 296:1, s. 90-98
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- We present the results of a 6 month monitoring campaign of Mkn 876, a low luminosity quasar with M(abs) approximate to -24. High resolution spectroscopy and direct imaging in the Johnson filters B, V, R, I was carried out in the first half of 1990. Line a
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| 8. |
- Erkens, U., et al.
(författare)
-
Monitoring of active galactic nuclei. VI. The quasar Mrk 876
- 1995
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Ingår i: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 296:1, s. 90-9898
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Tidskriftsartikel (refereegranskat)abstract
- For pt. V see ibid., vol. 285, no. 3, p. 857-67 (1994). We present the results of a 6 month monitoring campaign of Mrk 876, a low luminosity quasar with M absap-24. High resolution spectroscopy and direct imaging in the Johnson filters B, V, R, I was carried out in the first half of 1990. Line and continuum light curves are presented. Mrk 876 showed a decrease of 17% in the continuum over the whole observing period whereas the line flux of Hbeta and Halpha stayed constant. This implies, that the radius of the broad line region is larger than 6 light months. Coadded spectra of Hbeta and Halpha are presented which confirm an extreme asymmetry of the line profiles to the red. With respect to much earlier spectra the line profiles changed considerably
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| 9. |
- Gizon, J., et al.
(författare)
-
Terminating bands in the doubly odd nucleus [Formula Presented]
- 1999
-
Ingår i: Physical Review C - Nuclear Physics. - 0556-2813. ; 59:2, s. 570-574
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Tidskriftsartikel (refereegranskat)abstract
- High spin states have been populated in [Formula Presented] using the reaction [Formula Presented] at 130 MeV. The γ rays have been detected with the EUROGAM2 array. The level structure of [Formula Presented] has been investigated. Several bands have been identified and established over a wide range of spin. They are interpreted using the Nilsson-Strutinsky cranking formalism and explained in terms of band terminations. Their configurations are built from the valence particles and valence holes relative to a [Formula Presented] core: [Formula Presented] protons (and [Formula Presented] proton holes) and [Formula Presented] and [Formula Presented] neutrons. After [Formula Presented] is the second heavy nucleus and the first odd-odd nucleus in which configurations in the valence space are followed from low spin up to their termination.
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| 10. |
- Koratkar, A, et al.
(författare)
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The disappearing broad absorption lines and variable emission lines in NGC 3516
- 1996
-
Ingår i: ASTROPHYSICAL JOURNAL. - : UNIV CHICAGO PRESS. - 0004-637X. ; 470:1, s. 378-393
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The Seyfert 1 galaxy NGC 3516 was monitored during 1993 February 16-May 13 by IUE every 4 days for the first month, and then every 2 days for 2 months giving a total of 40 observations. This paper gives the initial results from this campaign, (1) The broa
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| 11. |
- Simon, M P, et al.
(författare)
-
Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma.
- 1997
-
Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 15:1, s. 95-8
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Tidskriftsartikel (refereegranskat)abstract
- Dermatofibrosarcoma protuberans (DP), an infiltrative skin tumour of intermediate malignancy, presents specific features such as reciprocal translocations t(17;22)(q22;q13) and supernumerary ring chromosomes derived from the t(17;22). In this report, the breakpoints from translocations and rings in DP and its juvenile form, giant cell fibroblastoma (GCF), were characterised on the genomic and RNA level. These rearrangements fuse the platelet-derived growth factor B-chain (PDGFB, c-sis proto-oncogene) and the collagen type I alpha 1 (COL1A1) genes. PDGFB has transforming activity and is a potent mitogen for a number of cell types, but its role in oncogenic processes is not fully understood. COL1A1 is a major constituent of the connective tissue matrix. Neither PDGFB nor COL1A1 have so far been implicated in any tumour translocations. These gene fusions delete exon 1 of PDGFB, and release this growth factor from its normal regulation.
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| 12. |
- Clark, R M, et al.
(författare)
-
Relative deformations of superdeformed bands in Ce-131,Ce-132
- 1996
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 76:19, s. 3510-3513
-
Tidskriftsartikel (refereegranskat)abstract
- The quadrupole moments Q(0) of five superdeformed bands in Ce-131,Ce-132 have been established using the Doppler-shift attenuation method; for the first time, we can compare relative deformations of yrast and excited bands in different nuclei to an accuracy of similar or equal to(5-7)%. Four of the five bands have very similar deformations, while the excited band in Ce-131 has a somewhat larger quadrupole moment. Important new information is presented on the shape-driving force of the vi(13/2) orbital, the stability of the second minimum with respect to particle excitations, the relative deformations of identical bands, the nature of the sidefeeding, and the time scale of the decay process.
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| 13. |
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| 14. |
- Gisselsson, D, et al.
(författare)
-
A case of dermatofibrosarcoma protuberans with a ring chromosome 5 and a rearranged chromosome 22 containing amplified COL1A1 and PDGFB sequences
- 1998
-
Ingår i: Cancer Letters. - 0304-3835 .- 1872-7980. ; 133:2, s. 34-129
-
Tidskriftsartikel (refereegranskat)abstract
- Dermatofibrosarcoma protuberans (DFSP) is a cutaneous tumour of borderline malignancy, the cytogenetic features of which include the translocation t(17;22)(q22;q13) or, more commonly, supernumerary ring chromosomes containing material from 17q22 and 22q13. These rearrangements result in the COL1A1/PDGFB fusion gene. Here, we describe a case of DFSP displaying a ring chromosome 5 together with a large marker chromosome composed of chromosome 22 alphoid DNA, material from distal 12q and amplified COL1A1 and PDGFB sequences. This is the first case of DFSP with multiple copies of COL1A1 and PDGFB not confined to ring chromosomes, showing that DFSP is similar to other borderline malignant mesenchymal tumours, where rings and giant markers are alternative vehicles for amplified material.
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| 15. |
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| 16. |
- Joss, D T, et al.
(författare)
-
Lifetime measurements of a triaxial band in Ce-133
- 1998
-
Ingår i: Acta Physica Hungarica A. - 1219-7580 .- 1588-2675. ; 7:1, s. 111-112
-
Tidskriftsartikel (refereegranskat)abstract
- The Doppler shift attenuation method has been used to determine the transition quadrupole moment of a triaxial band belonging to the gamma-soft nucleus, Ce-133. Doppler broadened lineshape (DBLS) analysis has revealed the magnitude of the Q(t) value to be similar to 2.4 eb. This contribution provides new information of (i) the transition quadrupole moment of this band (ii) the lifetimes of in-band and sidefeeding transitions and (iii) the relative deformations of coexisting nuclear shapes.
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| 17. |
- Joss, D T, et al.
(författare)
-
Lifetime measurements of a triaxial band in Ce-133
- 1998
-
Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 58:6, s. 3219-3222
-
Tidskriftsartikel (refereegranskat)abstract
- Lifetimes of states within a triaxial band belonging to;the gamma-soft nucleus Ce-133 have been determined through a Doppler-broadened line shape analysis. A value, Q(t)approximate to 2.2 eb, has been found for the transition quadrupole moment which is considerably smaller than that of superdeformed structures (Q(t)approximate to 7.4 e b) in this mass region. The results are discussed in terms of deformation self-consistent calculations based on the total Routhian surface formalism. [S0556-2813(98)01912-8].
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| 18. |
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| 19. |
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| 20. |
- Ma, Zhi, et al.
(författare)
-
Quantitative immunohistochemical analysis of islet amyloid polypeptide (IAPP) in normal, impaired glucose tolerant, and diabetic cats
- 1998
-
Ingår i: Amyloid. - : Informa UK Limited. - 1350-6129 .- 1744-2818. ; 5:4, s. 255-261
-
Tidskriftsartikel (refereegranskat)abstract
- Islet amyloid polypeptide (IAPP, “amylin”) has been proposed as having important roles in the pathogenesis of type 2 diabetes mellitus via its biological activity and by forming islet amyloid. The domestic cat develops a type of diabetes that closely resembles type 2 diabetes in humans, including the frequent formation of islet amyloid deposits in the impaired glucose tolerant (IGT) and diabetic state. With the aid of computerized image analysis and immuno-histochemistry, we examined the IAPP and insulin content inpancreatic islets of normal, IGT and diabetic cats. IAPP immunoreactivity in beta cells from IGT cats was significantly stronger (p < 0.01) as compared with cells from normal cats, while the insulin labelling strength was unchanged. Overtly diabetic cats were usually almost devoid of beta cells. As in humans, cellular IAPP but not IAPP in islet amyloid deposits was labelled by the newly developed monoclonal antibody to IAPP 4A5, thus providing further evidence that IAPP is modified by a yet unknown mechanism during the amyloidogenic process. The study provides evidence that an increased beta cell storage of IAPP independent of insulin may be an important factor in the early phase of the development of islet amyloid in this form of diabetes.
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| 21. |
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