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| 7. |
- Evangelista, C, et al.
(författare)
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Measurement of the (p)over-barp->KsKs reaction for 0.6 to 1.9 GeV/c
- 1997
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Ingår i: PHYSICAL REVIEW D. - : AMER INST PHYSICS. - 0556-2821. ; 56:7, s. 3803-3810
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Tidskriftsartikel (refereegranskat)abstract
- The <(p)over bar p> --> KSKS --> 4 pi(+/-) cross section was measured at incident antiproton momenta between 0.6 and 1.9 GeV/c using the CERN Low Energy Antiproton Ring. This investigation was part of a systematic study of in-flight antiproton-proton anni
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| 8. |
- Evangelista, C, et al.
(författare)
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Study of the reaction (p)over-bar-p ->phi phi from 1.1 to 2.0 GeV/c
- 1998
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Ingår i: PHYSICAL REVIEW D. - : AMERICAN PHYSICAL SOC. - 0556-2821. ; 57:9, s. 5370-5381
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Tidskriftsartikel (refereegranskat)abstract
- A study has been performed of the reaction <(p)over bar p>-->4K(+/-) using in-flight antiprotons from 1.1 to 2.0 GeV/c incident momentum interacting with a hydrogen jet target. The reaction is dominated by the production of a pair of phi mesons. The <(p)o
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| 11. |
- Löfdahl, Claes-Göran, et al.
(författare)
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The European Respiratory Society study on chronic obstructive pulmonary disease (EUROSCOP): recruitment methods and strategies
- 1998
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Ingår i: Respiratory Medicine. - 1532-3064. ; 92:3, s. 467-472
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Tidskriftsartikel (refereegranskat)abstract
- The European Respiratory Society's study on chronic obstructive pulmonary disease (EUROSCOP) is a multicentre study performed initially in 12 countries to assess the effect of 3 years' treatment with inhaled corticosteroids on lung function decline in smokers with chronic obstructive pulmonary disease (COPD). It aimed at recruiting 50 subjects in 50 European centres. This study discusses the most successful, countrywise, recruitment strategies, an important issue since many multicentre European studies may follow in the future. The total number of recruited subjects was 2147 in 39 participating centres. In total, at least 25,000 screening spirometries were performed, and about 80,000 hospital records were checked. The most effective way of recruiting subjects was to screen subjects by spirometry after mass media campaigns (eight out of nine countries). Others used workplace screenings and different types of population survey, and only a few centres successfully recruited participants by hospital records. Inclusion criteria were slightly changed upon low initial accrual rate. Initial surveys in one country, where 2405 subjects were screened by spirometry, gave an important indication for the change of the inclusion criteria. Extension of the upper age limit from 60 to 65 yr considerably improved recruitment, as did a change of the upper limit of FEV1 from below 80% predicted normal to below 100% predicted normal, while maintaining the FEV1/VC ratio below 70%. A tremendous effort is needed to recruit individuals with preclinical COPD, but this is certainly feasible with adequate strategies adjusted to each country.
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| 12. |
- Pauwels, R A, et al.
(författare)
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Long-term treatment with inhaled budesonide in persons with mild chronic obstructive pulmonary disease who continue smoking. European Respiratory Society Study on Chronic Obstructive Pulmonary Disease
- 1999
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Ingår i: New England Journal of Medicine. - 0028-4793. ; 340:25, s. 1948-1953
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Although patients with chronic obstructive pulmonary disease (COPD) should stop smoking, some do not. In a double-blind, placebo-controlled study, we evaluated the effect of the inhaled glucocorticoid budesonide in patients with mild COPD who continued smoking. After a six-month run-in period, we randomly assigned 1277 subjects (mean age, 52 years; mean forced expiratory volume in one second [FEV1], 77 percent of the predicted value; 73 percent men) to twice-daily treatment with 400 microg of budesonide or placebo, inhaled from a dry-powder inhaler, for three years. RESULTS: Of the 1277 subjects, 912 (71 percent) completed the study. Among these subjects, the median decline in the FEV1 after the use of a bronchodilator over the three-year period was 140 ml in the budesonide group and 180 ml in the placebo group (P=0.05), or 4.3 percent and 5.3 percent of the predicted value, respectively. During the first six months of the study, the FEV1 improved at the rate of 17 ml per year in the budesonide group, as compared with a decline of 81 ml per year in the placebo group (P<0.001). From nine months to the end of treatment, the FEV1 declined at similar rates in the two groups (P=0.39). Ten percent of the subjects in the budesonide group and 4 percent of those in the placebo group had skin bruising (P<0.001). Newly diagnosed hypertension, bone fractures, postcapsular cataracts, myopathy, and diabetes occurred in less than 5 percent of the subjects, and the diagnoses were equally distributed between the groups. CONCLUSIONS: In patients with mild COPD who continue smoking, the use of inhaled budesonide is associated with a small one-time improvement in lung function but does not appreciably affect the long-term progressive decline.
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- Alfredsson, G, et al.
(författare)
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Stability of sulphonamide drugs in meat during storage
- 1998
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Ingår i: FOOD ADDITIVES AND CONTAMINANTS. - : TAYLOR & FRANCIS LTD. ; 15:3
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Incurred samples from a pig treated with sulphamethazine and spiked samples of the same concentration were compared during frozen storage. The contents of sulphamethazine in the different types of samples decreased similarly to about 50% after 15 months.
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- Bertilsson, G, et al.
(författare)
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Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction
- 1998
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Ingår i: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. - : Proceedings of the National Academy of Sciences. - 0027-8424. ; 95:21, s. 12208-12213
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Nuclear receptors regulate metabolic pathways in response to changes in the environment by appropriate alterations in gene expression of key metabolic enzymes, Here, a computational search approach based on iteratively built hidden Markov models of nuclea
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- Cui, H, et al.
(författare)
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Inactivation of H19, an imprinted and putative tumor repressor gene, is a preneoplastic event during Wilms' tumorigenesis
- 1997
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Ingår i: Cancer Research. ; 57:20, s. 4469-4473
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Tidskriftsartikel (refereegranskat)abstract
- Genetic evidence shows that the parent of origin-dependent expression patterns of the Igf2 and H19 genes is coordinated in mouse, such that H19 controls the activity of Igf2 in cis. Equally compelling evidence for a similar situation in humans is absent, although the frequently observed activation of the maternal IGF2 allele (ie., loss of imprinting) in Wilms' tumors has been attributed to the silencing of the maternal H19 locus. We show here that loss of H19 activity is generally a preneoplastic event, which may be linked with an overgrowth lesion that has been proposed to be permissive for tumor formation. Although our results document one instance in which a postneoplastic loss of H19 activity correlates with loss of IGF2 imprinting at the cellular level, it appears that inactivation of H19 is more generally independent of loss of imprinting of IGF2, at least in our specimens. Our results imply that inactivation of H19 correlates with blastema overgrowth and can be independent of a regulatory role with respect to IGF2 imprinting status in cis.
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- Elneihoum, A. M., et al.
(författare)
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Leukocyte activation detected by increased plasma levels of inflammatory mediators in patients with ischemic cerebrovascular diseases
- 1996
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Ingår i: Stroke: a journal of cerebral circulation. - 0039-2499. ; 27:10, s. 1734-1738
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Tidskriftsartikel (refereegranskat)abstract
- Background and Purpose: Leukocytes have been implicated in the development of ischemia atherosclerotic vascular disease. In a prospective study we investigated whether the plasma concentration of inflammatory mediator, ie, proteases and cytokine, as markers for systemic leukocyte activation, are increased in patient with acute ischemic cerebrovascular diseases. Methods: Using enzyme-linked immunosorbent assays, we measured the plasma level of neutrophil gelatinase-associated lipocalin (NGAL), neutrophil proteinase 4 (NP4), tumor necrosis factor-α (TNF)m and soluble TNF receptor protein-1 p55 (sTNFR-1) in 120 patients with acute ischemic cerebrovascular insult (72 with and 48 stroke and 48 with transient ischemic attack (TIAl) and in 35 age-and sex-matched healthy subject. Results: Compared with the control group, plasma NGAL levels were higher in the stroke group (P<.0001) and the TIA group (P<.01); plasma NP4 levels were higher in the stroke group (P<.0001) and the TIA group (P<.01); and plasma sTNFR-1 levels wee higher in the stroke group (P<.04). There was significant correlation between the plasma levels of fibrinogen and those of both sTNFR-1 (r=.32; P=32; P=.005) and NGAL 9r=.40; P=.0001) and between the erythrocyte sedimentation rate and the plasma levels of both sTNFR-1 (r=.35; P=.001) and NGAL (r=.34;P=.002). Conclusions: Our study demonstrated that marker for systemic leukocyte activation, ie, plasma levels of cytokine and protease, were higher in patients with acute ischemic cerebrovascular disease than in healthy control subject. Activated leukocytes and leukocytic mediator may have an important role in acute cerebrovascular ischemia and it consequences.
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| 23. |
- Göthe, Sten, et al.
(författare)
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Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation.
- 1999
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Ingår i: Genes & development. - : Cold Spring Harbor Laboratory. - 0890-9369. ; 13:10, s. 1329-41
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Tidskriftsartikel (refereegranskat)abstract
- Thyroid hormone (T3) has widespread functions in development and homeostasis, although the receptor pathways by which this diversity arises are unclear. Deletion of the T3 receptors TRalpha1 or TRbeta individually reveals only a small proportion of the phenotypes that arise in hypothyroidism, implying that additional pathways must exist. Here, we demonstrate that mice lacking both TRalpha1 and TRbeta (TRalpha1(-/-)beta-/-) display a novel array of phenotypes not found in single receptor-deficient mice, including an extremely hyperactive pituitary-thyroid axis, poor female fertility and retarded growth and bone maturation. These results establish that major T3 actions are mediated by common pathways in which TRalpha1 and TRbeta cooperate with or substitute for each other. Thus, varying the balance of use of TRalpha1 and TRbeta individually or in combination facilitates control of an extended spectrum of T3 actions. There was no evidence for any previously unidentified T3 receptors in TRalpha1(-/-)beta-/- mouse tissues. Compared to the debilitating symptoms of severe hypothyroidism, the milder overall phenotype of TRalpha1(-/-)beta-/- mice, lacking all known T3 receptors, indicates divergent consequences for hormone versus receptor deficiency. These distinctions suggest that T3-independent actions of T3 receptors, demonstrated previously in vitro, may be a significant function in vivo.
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| 25. |
- Ivarson, A., et al.
(författare)
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Reflection phenomena in Co2 laser cutting
- 1997
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Ingår i: Proceedings of the 6th Nordic Laser Material Processing Conference, Luleå, Sweden, August 27-29, 1997. - Luleå : Luleå tekniska universitet. ; , s. 16-24
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Konferensbidrag (refereegranskat)
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| 30. |
- Nilsson, L O, et al.
(författare)
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Demonstration of estrogen receptor-beta immunoreactivity in human growth plate cartilage.
- 1999
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Ingår i: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 0021-972X. ; 84:1, s. 370-3
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Tidskriftsartikel (refereegranskat)abstract
- Estrogens affect longitudinal bone growth through their action on endochondral bone formation. Two estrogen receptors are known, the classical estrogen receptor-alpha (ER alpha), newly demonstrated in human growth plate cartilage, and a recently cloned estrogen receptor-beta (ER beta). The present study aimed to localize a possible expression of ER beta protein in human growth plates. Tissue samples were obtained from tibial and femoral growth plates in four female pubertal patients undergoing epiphyseal surgery. Immunohistochemistry, using two different ER beta-specific antibodies, demonstrated positive staining for ER beta in hypertrophic epiphyseal chondrocytes from all patients. No staining was noted in resting or proliferative chondrocytes. These data suggest that in addition to ER alpha, human epiphyseal chondrocytes also express ER beta. The physiological role of ER beta in the regulation of longitudinal bone growth in humans remains to be elucidated.
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| 35. |
- Ohlsson, H, et al.
(författare)
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Political cycles and cyclical policies
- 1996
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Ingår i: SCANDINAVIAN JOURNAL OF ECONOMICS. - : BLACKWELL PUBL LTD. ; 98:2
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- We test how government revenue and expenditure depend on ideology, elections and economic activity. We show how fiscal forecasts can be used to identify the determinants of government revenue and expenditure. The approach is illustrated using a unique, u
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| 43. |
- Piamonte, D. Paul T., et al.
(författare)
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Testing videophone graphical symbols in Southeast Asia
- 1999
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Ingår i: Human-computer interaction. - : IEEE Communications Society. ; , s. 793-797
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Konferensbidrag (refereegranskat)abstract
- This paper aimed to study how symbols designed and tested in Europe fared among subjects from different countries in Southeast Asia. It was part of an international study on graphic symbols involving countries from Southeast Asia. Specifically, videotelephone symbols designed and tested by the European Telecommunication Standards Institute (ETSI) were evaluated using subjects from five Southeast Asian countries.
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| 44. |
- Piamonte, D. Paul T., et al.
(författare)
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Understanding small graphical symbols : a cross-cultural study
- 1999
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Ingår i: Proceedings of the 10th year anniversary of M. Sc. ergonomics. - Luleå : Luleå University of Technology. Department of Human Work Sciences. Division of Industrial Ergonomics. ; , s. 274-280
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Konferensbidrag (refereegranskat)
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| 47. |
- Vidal, Olle, et al.
(författare)
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Disproportional body growth in female estrogen receptor-alpha-inactivated mice.
- 1999
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Ingår i: Biochemical and biophysical research communications. - : Elsevier BV. - 0006-291X. ; 265:2, s. 569-71
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Tidskriftsartikel (refereegranskat)abstract
- Estrogens play an important role in the regulation of longitudinal bone growth in man, as demonstrated by recent descriptions of individuals with estrogen insensitivity or aromatase deficiency. Two estrogen receptors, ERalpha and ERbeta, have been cloned. The aim of the present study was to investigate the function of ERalpha in the regulation of body growth and skeletal growth. Adult female mice with inactivated ERalpha (ERalpha-/-) demonstrated an increased body weight compared with wild-type mice (114% of control). However, the length of the appendicular skeleton was decreased in adult ERalpha-/- mice (femur 93% of control). In contrast, the axial skeleton was normal (crown-rump length 98% of control). The decreased growth of the appendicular skeleton was associated with decreased serum levels of IGF-I (77% of control), indicating that the GH/IGF-I axis may be involved in the decreased longitudinal bone growth seen in female ERalpha-/- mice.
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| 48. |
- Windahl, Sara H, 1971, et al.
(författare)
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Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ERbeta(-/-) mice.
- 1999
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Ingår i: The Journal of clinical investigation. - 0021-9738. ; 104:7, s. 895-901
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Tidskriftsartikel (refereegranskat)abstract
- Ovariectomy in young, growing rodents results in decreased trabecular bone mineral density (BMD) and increased radial growth of the cortical bone. Both of these effects are reversed by treatment with estrogen. The aim of the present study was to determine the physiological role of estrogen receptor-beta (ERbeta) on bone structure and bone mineral content (BMC). The BMC was increased in adult (11 weeks old), but not prepubertal (4 weeks old), female ERbeta(-/-) mice compared with wild-type (WT) mice. This increase in BMC in females was not due to increased trabecular BMD, but to an increased cross-sectional cortical bone area associated with a radial bone growth. Male ERbeta(-/-) mice displayed no bone abnormalities compared with WT mice. Ovariectomy decreased the trabecular BMD to the same extent in adult female ERbeta(-/-) mice as in WT mice. The expression levels of osteoblast-associated genes - alpha1(I) collagen, alkaline phosphatase, and osteocalcin mRNAs - were elevated in bone from adult ERbeta(-/-) females compared with WT mice. These observations provide a possible explanation for the increased radial bone growth seen in female mutants, suggesting a repressive function for ERbeta in the regulation of bone growth during female adolescence. In summary, ERbeta is essential for the pubertal feminization of the cortical bone in female mice but is not required for the protective effect of estrogens on trabecular BMD.
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