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| 2. |
- Mårild, Karl, 1982, et al.
(författare)
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Histologic activity in inflammatory bowel disease and risk of serious infections : A nationwide study
- 2024
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Ingår i: Clinical Gastroenterology and Hepatology. - : Elsevier. - 1542-3565 .- 1542-7714. ; 22:4, s. 831-846
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND AND AIMS: Individuals with inflammatory bowel disease (IBD) are at increased risk of serious infections, but whether this risk varies by histological disease activity is unclear.METHODS: A national population-based study of 55,626 individuals diagnosed with IBD in 1990-2016 with longitudinal data on ileo-colorectal biopsies followed through 2016. Serious infections were defined as having an inpatient infectious disease diagnosis in the Swedish National Patient Register. We used Cox regression to estimate hazard ratios (HRs) for serious infections in the 12 months following documentation of histologic inflammation (vs. histological remission), adjusting for social and demographic factors, chronic comorbidities, prior IBD-related surgery and hospitalization. We also adjusted for IBD-related medications in sensitivity analyses.RESULTS: With histological inflammation vs. remission, there was 4.62 (95%CI=4.46-4.78) and 2.53 (95%CI=2.36-2.70) serious infections per 100 person-years of follow-up, respectively (adjusted [a]HR=1.59; 95%CI=1.48-1.72). Histological inflammation (vs. remission) were associated with an increased risk of serious infections in ulcerative colitis (UC, aHR=1.68; 95%CI=1.51-1.87) and Crohn's disease (CD, aHR=1.59; 95%CI=1.40-1.80). The aHRs of sepsis and opportunistic infections were 1.66 (95%CI=1.28-2.15) and 1.71 (95%CI=1.22-2.41), respectively. Overall, results were consistent across age groups, sex and education level and remained largely unchanged after adjustment for IBD-related medications (aHR=1.47; 95%CI=1.34-1.61).CONCLUSION: Histological inflammation of IBD was an independent risk factor of serious infections, including sepsis, suggesting that achieving histological remission may reduce infections in IBD.
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| 3. |
- Brandt, P. H., et al.
(författare)
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"Profitability is sustainability:" framing of forest management practices by the Swedish forest industry
- 2023
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Ingår i: Scandinavian Journal of Forest Research. - : Taylor & Francis. - 0282-7581 .- 1651-1891. ; 38:7/8, s. 429-441
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Tidskriftsartikel (refereegranskat)abstract
- This article investigates how the Swedish forest industry, as represented by the three largest Swedish private forest companies (Svenska Cellulosa AB, Stora Enso, and Holmen), through their main public relations (PR) channels frame the current dominant Swedish forestry model and alternative models that are promoted by the European Union (EU). The content analysis of the three companies' trade magazines published between 2019 and 2022 explores the patterns in the PR framing of the forest management models with respect to economic, environmental, and social aspects. The time interval is centered by the July 2021 announcement of the EU's new Forest Strategy for 2030. The magazines' target audience is private forest owners, from whom Svenska Cellulosa AB, Stora Enso, and Holmen buy 40-50% of the timber used in production. The main finding of the study is that these corporations did not present alternative methods as viable options to replace the Swedish forestry model. The magazines, with some individual variations, respond to the alternative methods promoted by the EU and environmental associations by an increased emphasis on the benefits, mainly environmental, of the Swedish forestry model - framing the model as not only the most profitable but also the most ecologically sustainable.
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| 4. |
- Olsson, Daniel, 1973, et al.
(författare)
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Feedback Control in Swedish Multi-Family Buildings for Lower Energy Demand and Assured Indoor Temperature—Measurements and Interviews
- 2023
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Ingår i: Energies. - 1996-1073 .- 1996-1073. ; 16:18
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Tidskriftsartikel (refereegranskat)abstract
- Europe needs to save energy, and lowered indoor temperature is frequently promoted as part of the solution. To facilitate this, heating control systems with feedback from indoor temperature sensors are often required to avoid thermal discomfort and achieve long-term temperature reductions. This article describes a measurement- and interview-based study on feedback control where 107 Swedish multifamily buildings were analysed. The obtained results show that buildings with lowered indoor temperatures had reduced annual heating demand by 4 kWh/m2 and a reduced indoor temperature of 0.4 °C. There were, however, significant individual differences and even buildings with increased indoor temperatures, which harmed the energy savings. Temperature fluctuation was most often significantly reduced, but the impact on heating power demand during cold weather was, on average, only 2%. An interview with different actors indicated higher energy savings, possibly due to their stock’s original room temperature levels. Several interviewees also mentioned other advantages of temperature mapping. Most of the results obtained in this study were in line with several previous investigations. The study’s novelty lies in the large number of investigated buildings with mature commercial heat control technology, including PI-control for adjusting supply temperature, indoor temperature sensors in almost every apartment and a parallel analysis of additional affected parameters.
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| 5. |
- Olsson, Daniel, et al.
(författare)
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Weather Forecast Control for Heating of Multi-Family Buildings in Comparison with Feedback and Feedforward Control
- 2024
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Ingår i: Energies. - 1996-1073 .- 1996-1073. ; 17:1
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Tidskriftsartikel (refereegranskat)abstract
- Our joint environmental and energy commitments mean we must reduce the building’s energy use. Improved central heating control can play a role in how this is accomplished. There are three common control strategies: feedforward (traditional), feedback, and model predictive control (MPC). The latter two often work in parallel, where feedback uses indoor temperature sensors to adjust the supply water temperature. In contrast, the supply temperature setpoint is continuously calculated in MPC, fed with weather forecasts. The weather forecasts are often highlighted as essential ingredients in MPC, but at the same time, it is emphasized that temperature sensors are used to ensure a pleasant indoor temperature. To an outside observer, it is difficult to determine what is what in such combined control arrangements. Is energy saved because of the room sensors or because of the model? And what role do the weather forecasts play? This study quantifies the impact of the control strategy on energy use and indoor temperature. It concludes that PI-based feedback heating control saves approximately as much energy as MPC, and weather forecasts do not save significantly more energy than real-time weather data but are easier to obtain. The overall results for both control strategies align with the lower end of the result ranges of previous studies. The novelty is that the impact of weather forecasts has been studied separately and that different control strategies are compared against each other based on a model of a typical Swedish multi-family building.
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| 6. |
- Rodríguez-Varela, Ricardo, et al.
(författare)
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The genetic history of Scandinavia from the Roman Iron Age to the present
- 2023
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Ingår i: Cell. - : Elsevier. - 0092-8674 .- 1097-4172. ; 186:1, s. 32-46
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Tidskriftsartikel (refereegranskat)abstract
- We investigate a 2,000-year genetic transect through Scandinavia spanning the Iron Age to the present, based on 48 new and 249 published ancient genomes and genotypes from 16,638 modern individuals. We find regional variation in the timing and magnitude of gene flow from three sources: the eastern Baltic, the British-Irish Isles, and southern Europe. British-Irish ancestry was widespread in Scandinavia from the Viking period, whereas eastern Baltic ancestry is more localized to Gotland and central Sweden. In some regions, a drop in current levels of external ancestry suggests that ancient immigrants contributed proportionately less to the modern Scandinavian gene pool than indicated by the ancestry of genomes from the Viking and Medieval periods. Finally, we show that a north-south genetic cline that characterizes modern Scandinavians is mainly due to the differential levels of Uralic ancestry and that this cline existed in the Viking Age and possibly earlier.
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