| 1. |
- Azevedo, Flavio, et al.
(författare)
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Social and moral psychology of COVID-19 across 69 countries
- 2023
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Ingår i: Scientific Data. - : NATURE PORTFOLIO. - 2052-4463. ; 10:1
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Tidskriftsartikel (refereegranskat)abstract
- The COVID-19 pandemic has affected all domains of human life, including the economic and social fabric of societies. One of the central strategies for managing public health throughout the pandemic has been through persuasive messaging and collective behaviour change. To help scholars better understand the social and moral psychology behind public health behaviour, we present a dataset comprising of 51,404 individuals from 69 countries. This dataset was collected for the International Collaboration on Social & Moral Psychology of COVID-19 project (ICSMP COVID-19). This social science survey invited participants around the world to complete a series of moral and psychological measures and public health attitudes about COVID-19 during an early phase of the COVID-19 pandemic (between April and June 2020). The survey included seven broad categories of questions: COVID-19 beliefs and compliance behaviours; identity and social attitudes; ideology; health and well-being; moral beliefs and motivation; personality traits; and demographic variables. We report both raw and cleaned data, along with all survey materials, data visualisations, and psychometric evaluations of key variables.
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| 2. |
- Van Bavel, Jay J., et al.
(författare)
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National identity predicts public health support during a global pandemic
- 2022
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Ingår i: Nature Communications. - : Nature Portfolio. - 2041-1723. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic. Changing collective behaviour and supporting non-pharmaceutical interventions is an important component in mitigating virus transmission during a pandemic. In a large international collaboration (Study 1, N = 49,968 across 67 countries), we investigated self-reported factors associated with public health behaviours (e.g., spatial distancing and stricter hygiene) and endorsed public policy interventions (e.g., closing bars and restaurants) during the early stage of the COVID-19 pandemic (April-May 2020). Respondents who reported identifying more strongly with their nation consistently reported greater engagement in public health behaviours and support for public health policies. Results were similar for representative and non-representative national samples. Study 2 (N = 42 countries) conceptually replicated the central finding using aggregate indices of national identity (obtained using the World Values Survey) and a measure of actual behaviour change during the pandemic (obtained from Google mobility reports). Higher levels of national identification prior to the pandemic predicted lower mobility during the early stage of the pandemic (r = -0.40). We discuss the potential implications of links between national identity, leadership, and public health for managing COVID-19 and future pandemics.
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| 3. |
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| 7. |
- Grönqvist Olsson, Catharina, et al.
(författare)
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Replikskifte om "Den mjuka staten"
- 2024
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Ingår i: Svenska Dagbladet. - 1101-2412.
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Tidskriftsartikel (populärvet., debatt m.m.)
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| 8. |
- Götberg, Matthias, et al.
(författare)
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5-Year Outcomes of PCI Guided by Measurement of Instantaneous Wave-Free Ratio Versus Fractional Flow Reserve
- 2022
-
Ingår i: Journal of the American College of Cardiology. - : Elsevier. - 0735-1097 .- 1558-3597. ; 79:10, s. 965-974
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Instantaneous wave-free ratio (iFR) is a coronary physiology index used to assess the severity of coronary artery stenosis to guide revascularization. iFR has previously demonstrated noninferior short-term outcome compared to fractional flow reserve (FFR), but data on longer-term outcome have been lacking.OBJECTIVES: The purpose of this study was to investigate the prespecified 5-year follow-up of the primary composite outcome of all-cause mortality, myocardial infarction, and unplanned revascularization of the iFR-SWEDEHEART trial comparing iFR vs FFR in patients with chronic and acute coronary syndromes.METHODS: iFR-SWEDEHEART was a multicenter, controlled, open-label, registry-based randomized clinical trial using the Swedish Coronary Angiography and Angioplasty Registry for enrollment. A total of 2,037 patients were randomized to undergo revascularization guided by iFR or FFR.RESULTS: No patients were lost to follow-up. At 5 years, the rate of the primary composite endpoint was 21.5% in the iFR group and 19.9% in the FFR group (HR: 1.09; 95% CI: 0.90-1.33). The rates of all-cause death (9.4% vs 7.9%; HR: 1.20; 95% CI: 0.89-1.62), nonfatal myocardial infarction (5.7% vs 5.8%; HR: 1.00; 95% CI: 0.70-1.44), and unplanned revascularization (11.6% vs 11.3%; HR: 1.02; 95% CI: 0.79-1.32) were also not different between the 2 groups. The outcomes were consistent across prespecified subgroups.CONCLUSIONS: In patients with chronic or acute coronary syndromes, an iFR-guided revascularization strategy was associated with no difference in the 5-year composite outcome of death, myocardial infarction, and unplanned revascularization compared with an FFR-guided revascularization strategy. (Evaluation of iFR vs FFR in Stable Angina or Acute Coronary Syndrome [iFR SWEDEHEART]; NCT02166736)
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| 9. |
- Olsson, Erik J, et al.
(författare)
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Den mjuka staten : Feminiseringen av samhället och dess konsekvenser
- 2024
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- Under de senaste femtio åren har kvinnors makt i Sverige stärkts på ett dramatiskt sätt. Från att tidigare ha varit det generellt underordnade könet har kvinnor idag rentav en ledande ställning på många centrala områden. Viktiga yrken och samhällsinstitutioner som tidigare dominerats av män domineras idag av kvinnor.I Den mjuka staten undersöker Erik J. Olsson och Catharina Grönqvist Olsson, utifrån aktuell forskning från flera vetenskapliga fält, vad denna omvälvande demografiska utveckling innebär och vad den fått för konsekvenser. De behandlar även vad som kan komma att ske om maktbalansen mellan könen fortsätter att förskjutas i den riktning den gör för närvarande.Sammantaget ger boken en unik belysning av ett nytt och angeläget men sällan diskuterat samhällsfenomen: den ökande feminiseringen av stat och samhälle. Särskild betoning ligger på skolan och andra delar av den offentliga sektorn.Författarna driver tesen att kvinnors ökade inflytande inte bara har fått odelat positiva effekter, utan även är en viktig faktor bakom att Sverige idag kan kategoriseras som en mjuk stat. Termen myntades av nationalekonomen Gunnar Myrdal för att beskriva stater som på grund av bristande lagstiftning eller regelefterlevnad lider av social oordning.
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| 10. |
- Olsson, Erik J, et al.
(författare)
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Hilpinen's Theory of Inquiry
- 2022
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Ingår i: Agency, Norms, Inquiry, and Artifacts : Essays in Honor of Risto Hilpinen - Essays in Honor of Risto Hilpinen. - Cham : Springer International Publishing. - 2542-8292 .- 0166-6991. - 9783030907495 - 9783030907518 - 9783030907488 ; 454, s. 175-191
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Bokkapitel (refereegranskat)abstract
- Risto Hilpinen’s name is associated with seminal contributions to many areas of analytic philosophy, including influential work on deontic logic and the theory of artifacts, as well as important early investigations into inductive logic and indefeasibility analyses of knowledge. A somewhat lesser known body of Hilpinen’s work concerns the theory of inquiry, whereby the central questions are how to conceptualize and understand human investigations from a general epistemological perspective. The present contribution traces the development of Hilpinen’s theory of inquiry through his main contributions to the topic in the 1980s and 1990s with special attention to how the problems in the initial formulation of the theory were eventually given more detailed and convincing solutions.
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| 11. |
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| 13. |
- Ossenkoppele, Rik, et al.
(författare)
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Accuracy of Tau Positron Emission Tomography as a Prognostic Marker in Preclinical and Prodromal Alzheimer Disease : A Head-to-Head Comparison against Amyloid Positron Emission Tomography and Magnetic Resonance Imaging
- 2021
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Ingår i: JAMA Neurology. - : American Medical Association (AMA). - 2168-6149. ; 78:8, s. 961-971
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Tidskriftsartikel (refereegranskat)abstract
- Importance: Tau positron emission tomography (PET) tracers have proven useful for the differential diagnosis of dementia, but their utility for predicting cognitive change is unclear. Objective: To examine the prognostic accuracy of baseline fluorine 18 (18F)-flortaucipir and [18F]RO948 (tau) PET in individuals across the Alzheimer disease (AD) clinical spectrum and to perform a head-to-head comparison against established magnetic resonance imaging (MRI) and amyloid PET markers. Design, Setting, and Participants: This prognostic study collected data from 8 cohorts in South Korea, Sweden, and the US from June 1, 2014, to February 28, 2021, with a mean (SD) follow-up of 1.9 (0.8) years. A total of 1431 participants were recruited from memory clinics, clinical trials, or cohort studies; 673 were cognitively unimpaired (CU group; 253 [37.6%] positive for amyloid-β [Aβ]), 443 had mild cognitive impairment (MCI group; 271 [61.2%] positive for Aβ), and 315 had a clinical diagnosis of AD dementia (315 [100%] positive for Aβ). Exposures: [18F]Flortaucipir PET in the discovery cohort (n = 1135) or [18F]RO948 PET in the replication cohort (n = 296), T1-weighted MRI (n = 1431), and amyloid PET (n = 1329) at baseline and repeated Mini-Mental State Examination (MMSE) evaluation. Main Outcomes and Measures: Baseline [18F]flortaucipir/[18F]RO948 PET retention within a temporal region of interest, MRI-based AD-signature cortical thickness, and amyloid PET Centiloids were used to predict changes in MMSE using linear mixed-effects models adjusted for age, sex, education, and cohort. Mediation/interaction analyses tested whether associations between baseline tau PET and cognitive change were mediated by baseline MRI measures and whether age, sex, and APOE genotype modified these associations. Results: Among 1431 participants, the mean (SD) age was 71.2 (8.8) years; 751 (52.5%) were male. Findings for [18F]flortaucipir PET predicted longitudinal changes in MMSE, and effect sizes were stronger than for AD-signature cortical thickness and amyloid PET across all participants (R2, 0.35 [tau PET] vs 0.24 [MRI] vs 0.17 [amyloid PET]; P <.001, bootstrapped for difference) in the Aβ-positive MCI group (R2, 0.25 [tau PET] vs 0.15 [MRI] vs 0.07 [amyloid PET]; P <.001, bootstrapped for difference) and in the Aβ-positive CU group (R2, 0.16 [tau PET] vs 0.08 [MRI] vs 0.08 [amyloid PET]; P <.001, bootstrapped for difference). These findings were replicated in the [18F]RO948 PET cohort. MRI mediated the association between [18F]flortaucipir PET and MMSE in the groups with AD dementia (33.4% [95% CI, 15.5%-60.0%] of the total effect) and Aβ-positive MCI (13.6% [95% CI, 0.0%-28.0%] of the total effect), but not the Aβ-positive CU group (3.7% [95% CI, -17.5% to 39.0%]; P =.71). Age (t = -2.28; P =.02), but not sex (t = 0.92; P =.36) or APOE genotype (t = 1.06; P =.29) modified the association between baseline [18F]flortaucipir PET and cognitive change, such that older individuals showed faster cognitive decline at similar tau PET levels. Conclusions and Relevance: The findings of this prognostic study suggest that tau PET is a promising tool for predicting cognitive change that is superior to amyloid PET and MRI and may support the prognostic process in preclinical and prodromal stages of AD.
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| 14. |
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| 15. |
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| 16. |
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| 17. |
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| 18. |
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| 19. |
- Bereketoglu, Ceyhun, et al.
(författare)
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The brominated flame retardants TBECH and DPTE alter prostate growth, histology and gene expression patterns in the mouse
- 2021
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Ingår i: Reproductive Toxicology. - : Elsevier. - 0890-6238 .- 1873-1708. ; 102, s. 43-55
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Tidskriftsartikel (refereegranskat)abstract
- The brominated flame retardants (BFRs), 1,2-dibromo-4-(1,2 dibromoethyl)cyclohexane (TBECH) and 2,3-dibromopropyl-2,4,6-tribromophenyl ether (DPTE) bind to the androgen receptor (AR). In vitro bioassays have shown that TBECH is a potent androgen agonist while DPTE is a potent AR antagonist. Both TBECH and DPTE alter gene expression associated with AR regulation. However, it remains to be determined if TBECH and DPTE can affect the prostate. For this reason, we exposed CD1 mice to a 1:1 mixture of TBECH diastereomers α and β, a 1:1 mixture of γ and δ, and to DPTE, and tested their effects on prostate growth, histology and gene expression profiles. Castrated (C) mice were used to study the androgenic effects of TBECHαβ and TBECHγδ while the antagonistic effects of DPTE were studied in non-castrated (NC) mice. We observed that testosterone and TBECHγδ increased body and prostate weights while TBECHαβ affected neither of them; and that DPTE had no effect on body weight but reduced prostate weight drastically. Histomorphometric analysis of the prostate revealed epithelial and glandular alterations in the TBECHγδ group comparable to those in testosterone group while alterations in the TBECHαβ group were less pronounced. DPTE displayed androgen antagonist activity reminiscent of castration. The transcription profile of the prostate was altered by castration and exposure to testosterone and to TBECHγδ reversed several of these changes. Testosterone and TBECHγδ also regulated the expression of several androgen responsive genes implicated in prostate growth and cancer. While DPTE resulted in a drastic reduction in prostate weight, it only affected a small number of genes. The results indicate that TBECHγδ and DPTE are of high human health concern as they may contribute to changes in prostate growth, histology and function.
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| 20. |
- Brijs, J., et al.
(författare)
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Prevalence and severity of cardiac abnormalities and arteriosclerosis in farmed rainbow trout (Oncorhynchus mykiss)
- 2020
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Ingår i: Aquaculture. - : Elsevier BV. - 0044-8486 .- 1873-5622. ; 526
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Tidskriftsartikel (refereegranskat)abstract
- Cardiovascular disease may pose a major threat to the health and welfare of farmed fish. By investigating a range of established cardiovascular disease indicators, we aimed to determine the prevalence, severity and consequences of this affliction in farmed rainbow trout (Oncorhynchus mykiss) from an open cage farm in the Baltic Sea, an open cage farm in a freshwater lake, and a land-based recirculating aquaculture system. We also aimed to identify environmental, anthropogenic and physiological factors contributing towards the development of the disease. The majority of trout possessed enlarged hearts with rounded ventricles (mean height:width ratios of 1.0–1.1 c.f. ~1.3 in wild fish) and a high degree of vessel misalignment (mean angles between the longitudinal ventricular axis and the axis of the bulbus arteriosus of 28–31 °c.f. ~23° in wild fish). The prevalence and severity of coronary arteriosclerosis was also high, as 92–100% of fish from the different aquaculture facilities exhibited coronary lesions. Mean lesion incidence and severity indices were 67–95% and 3.1–3.9, respectively, which resulted in mean coronary arterial blockages of 19–32%. To evaluate the functional significance of these findings, we modelled the effects of arterial blockages on coronary blood flow and experimentally tested the effects of coronary occlusion in a sub-sample of fish. The observed coronary blockages were estimated to reduce coronary blood flow by 34–54% while experimental coronary occlusion adversely affected the electrocardiogram of trout. Across a range of environmental (water current, predation), anthropogenic (boat traffic intensity, hatchery of origin, brand of feed pellets) and physiological factors (condition factor, haematological and plasma indices), the hatchery of origin was the main factor contributing towards the observed variation in the development of cardiovascular disease. Therefore, further research on the effects of selective breeding programs and rearing strategies on the development of cardiovascular disease is needed to improve the welfare and health of farmed fish. © 2020 The Authors
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| 21. |
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Diversity, lnclusion, Equity and the Threat to Academic Freedom
- 2022
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Samlingsverk (redaktörskap) (övrigt vetenskapligt/konstnärligt)abstract
- There can be no doubt that discrimination based on sex, race, ethnicity, religion or beliefs should not be tolerated in academia. Surprisingly, however, in recent years, policies of Diversity, Inclusion and Equity (DIE), officially introduced to counteract discrimination, have increasingly led to quite the opposite result: the exclusion of individuals who do not share a radical ‘woke’ ideology on identity politics (feminism, other gender activisms, critical race theory, etc.), and to the suppression of the academic freedom to discuss such dogmas. This subversion of academia — disguised Trojan-horse style as universal human rights advocacy — is unacceptable because academia must be politically neutral and protect freedom of speech, a cornerstone of professional scholarly activity without which universities as we know them will slowly but surely suffocate.The purpose of this book is to put together some particularly illustrative cases of such repression in a single volume, testifying to a ubiquitous trend within western culture, irreducible to a few isolated complaints. The essays contained here illustrate the abuse of power, censorship and witch-hunts at many universities and research centres in the name of DIE.
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| 22. |
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| 23. |
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| 24. |
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| 25. |
- Ekström, Axel G., et al.
(författare)
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Self-imposed Filter Bubbles : Selective Attention and Exposure in Online Search
- 2022
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Ingår i: Computers in Human Behavior Reports. - : Elsevier BV. - 2451-9588. ; 7
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Tidskriftsartikel (refereegranskat)abstract
- It is commonly assumed that algorithmic curation of search results creates filter bubbles, where users’ beliefs are continually reinforced and opposing views are suppressed. However, empirical evidence has failed to support this hypothesis. Instead, it has been suggested that filter bubbles may result from individuals engaging selectively with information in search engine results pages. However, this “self-imposed filter bubble hypothesis” has remained empirically untested. In this study, we find support for the hypothesis using eye-tracking technology and link selection data. We presented partisan participants (n = 48) with sets of simulated Google Search results, controlling for the ideological leaning of each link. Participants spent more time viewing own-side links than other links (p = .037). In our sample, participants who identified as right-wing exhibited a greater such bias than those that identified as left wing (p < .001). In addition, we found that both liberals and conservatives tended to select own-side links (p < .001). Finally, there was a significant effect of trust, such that links associated with less trusted sources were attended less and selected less often by liberals and conservatives alike (p < .001). Our study challenges the efficacy of policies that aim at combatting filter bubbles by presenting users with an ideologically diverse set of search results.
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| 26. |
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| 27. |
- Geelen, Inge G. P., et al.
(författare)
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Switching from imatinib to nilotinib plus pegylated interferon-α2b in chronic phase CML failing to achieve deep molecular response : clinical and immunological effects
- 2023
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Ingår i: Annals of Hematology. - : Springer. - 0939-5555 .- 1432-0584. ; 102:6, s. 1395-1408
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Tidskriftsartikel (refereegranskat)abstract
- In order to improve molecular response for a discontinuation attempt in chronic myeloid leukemia (CML) patients in chronic phase, who had not achieved at least a molecular response <0.01% BCR-ABL1IS (MR4.0) after at least 2 years of imatinib therapy, we prospectively evaluated whether they could attain MR4.0 after a switch to a combination of nilotinib and 9 months of pegylated interferon-α2b (PegIFN). The primary endpoint of confirmed MR4.0 at month 12 (a BCR-ABL1IS level ≤ 0.01% both at 12 and 15 months) was reached by 44% (7/16 patients, 95% confidence interval (CI): 23- 67%) of patients, with 81% (13/16 patients, 95% CI: 57-93%) of patients achieving an unconfirmed MR4.0. The scheduled combination was completed by 56% of the patients, with premature discontinuations, mainly due to mood disturbances after the introduction of PegIFN, questioning the feasibility of the combination of nilotinib and PegIFN for this patient population and treatment goal. A comprehensive clinical substudy program was implemented to characterize the impact of the treatment changes on the immunological profile.
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| 28. |
- Genot, Emmanuel, et al.
(författare)
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The Dissemination of Scientific Fake News : On the Ranking of Retracted Articles in Google
- 2021
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Ingår i: The Epistemology of Fake News. - : Oxford University PressOxford. - 9780198863977 ; , s. 228-242
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Bokkapitel (refereegranskat)abstract
- Fake news can originate from an ordinary person carelessly posting what turns out to be false information orfrom the intentional actions of fake news factory workers,but broadly speaking it can also originate from scientific fraud. In the latter case, the article can be retracted upon discovery of the fraud. A case study shows, however, that such fake sciencecan be visible in Google even after the article was retracted, in fact more visible thanthe retraction notice. We hypothesize that the reason for this lies in the popularity-based logic governing Google, in particular its foundational PageRank algorithm,in conjunction with a psychological law which we refer to as the “law of retraction”: a retraction notice is typically taken to be less interestingand therefore less popular with internet users than the original content retracted. We conduct anempiricalstudy drawing on records of articles retracted due to fraud (fabrication of data) in the Retraction Watch public database. The study tests the extent to which such retracted scientific articles are still highly ranked in Google –and more so than information about the retraction. We find, among other things, thatboth Google Search and Google Scholar more often than not rankeda link to the original article higher than a link indicating that the article has been retracted.Surprisingly, Google Scholar did not perform better in this regard than Google Search.We also foundcases in which Google didnot track the retraction of anarticle on the first result page at all.We conclude thatboth Google Search and Google Scholar runthe risk of disseminating fake science through theirranking algorithms.
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| 29. |
- Hagsund, Tora, et al.
(författare)
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β-blockers after myocardial infarction and 1-year clinical outcome - A retrospective study
- 2020
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Ingår i: BMC Cardiovascular Disorders. - : Springer Science and Business Media LLC. - 1471-2261. ; 20:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Long term β-blocker therapy after myocardial infarction (MI) reduces mortality and recurrent MI but evidence for this treatment predates contemporary acute coronary care. β-blocker treatment is a key quality of care indicator in the Swedish national quality register for acute coronary care, Riks-HIA. Between 2011 and 2015 a declining number of MI-patients discharged with a β-blocker from the coronary care unit (CCU) at Helsingborg and other hospitals was reported. This retrospective observational study aimed to investigate the causes for discharge without a β-blocker and relate it to outcome, compared to patients discharged with a β-blocker. Methods: MI-patients registered in Riks-HIA discharged without β-blocker during 2011-2015 (no-β-group) and a control group (β-group) comprised of patients discharged with β-blocker treatment between January 1 to December 31, 2013, were matched by RIKS-HIA criteria for β-blocker use. Clinical characteristics, date of death, readmission for MI, other cardiovascular events were collected from Riks-HIA and medical records. Results: The no-β-group included 141 patients, where 65.2% had a justified reason for non-β-blocker use. The β-group included 206 patients. There was no difference in cardiovascular risk factor profile. There were a trend towards a higher number of readmissions for MI in the no-β-group was (n = 8 (5.7%) vs n = 2 (1.0%), p = 0.02), but not mortality (6 (4.3%) vs 2 (1.0%), p = 0.07) and combined readmission for angina pectoris, heart failure, arrhythmias or stroke/TIA (n = 23 (16.3%) vs n = 25 (12.1%), p = 0.27). Conclusion: A majority of the patients in the no-β-group had a justified absence of a β-blocker. β-blocker treatment post-MI showed a trend towards fewer readmissions for MI. But important quality information is lacking to make a firm conclusion of the effect on outcome.
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| 30. |
- Hahn, Ulrike, et al.
(författare)
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Truth Tracking Performance of Social Networks: How Connectivity and Clustering Can Make Groups Less Competent
- 2020
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Ingår i: Synthese. - : Springer Science and Business Media LLC. - 0039-7857 .- 1573-0964. ; 197:4, s. 1511-1541
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Tidskriftsartikel (refereegranskat)abstract
- Our beliefs and opinions are shaped by others, making our social networks crucial in determining what we believe to be true. Sometimes this is for the good because our peers help us form a more accurate opinion. Sometimes it is for the worse because we are led astray. In this context, we address via agent-based computer simulations the extent to which patterns of connectivity within our social networks affect the likelihood that initially undecided agents in a network converge on a true opinion following group deliberation. The model incorporates a fine-grained and realistic representation of belief (opinion) and trust, and it allows agents to consult outside information sources. We study a wide range of network structures and provide a detailed statistical analysis concerning the exact contribution of various network metrics to collective competence. Our results highlight and explain the collective risks involved in an overly networked or partitioned society. Specifically, we find that 96% of the variation in collective competence across networks can be attributed to differences in amount of connectivity (average degree) and clustering, which are negatively correlated with collective competence. A study of bandwagon or “group think” effects indicates that both connectivity and clustering increase the probability that the network, wholly or partly, locks into a false opinion. Our work is interestingly related to Gerhard Schurz’s work on meta-induction and can be seen as broadly addressing a practical limitation of his approach.
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| 31. |
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| 32. |
- Kanne, Thomas, et al.
(författare)
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Epitaxial Pb on InAs nanowires for quantum devices
- 2021
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Ingår i: Nature Nanotechnology. - : Springer Science and Business Media LLC. - 1748-3387 .- 1748-3395. ; 16:7, s. 776-781
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Tidskriftsartikel (refereegranskat)abstract
- Semiconductor-superconductor hybrids are used for realizing complex quantum phenomena but are limited in the accessible magnetic field and temperature range. Now, hybrid devices made from InAs nanowires and epitaxially matched, single-crystal, atomically flat Pb films present superior characteristics, doubling the available parameter space. Semiconductor-superconductor hybrids are widely used to realize complex quantum phenomena, such as topological superconductivity and spins coupled to Cooper pairs. Accessing new, exotic regimes at high magnetic fields and increasing operating temperatures beyond the state-of-the-art requires new, epitaxially matched semiconductor-superconductor materials. One challenge is the generation of favourable conditions for heterostructural formation between materials with the desired properties. Here we harness an increased knowledge of metal-on-semiconductor growth to develop InAs nanowires with epitaxially matched, single-crystal, atomically flat Pb films with no axial grain boundaries. These highly ordered heterostructures have a critical temperature of 7 K and a superconducting gap of 1.25 meV, which remains hard at 8.5 T, and therefore they offer a parameter space more than twice as large as those of alternative semiconductor-superconductor hybrids. Additionally, InAs/Pb island devices exhibit magnetic field-driven transitions from a Cooper pair to single-electron charging, a prerequisite for use in topological quantum computation. Semiconductor-Pb hybrids potentially enable access to entirely new regimes for a number of different quantum systems.
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| 33. |
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| 34. |
- Morreau, Michael, et al.
(författare)
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Learning from Ranters : The Effect of Information Resistance on the Epistemic Quality of Social Network Deliberation
- 2022
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Ingår i: Social Virtue Epistemology. - New York : Routledge. - 9780367808952 - 9780367407643
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- People who spread misinformation in public debates expose others to the risk of forming false beliefs. Excluding them from participation can limit this exposure, but fact-checking takes up resources of time and money, and censorship violates social and political norms. Here, computer simulations of Bayesian learning in social networks suggest that, in some contexts anyway, the epistemic benefits of excluding sources of misinformation might be small or nonexistent, and not worth associated costs. It is shown more specifically that, under certain conditions, open-minded agents in a network can learn just as well in the presence of false ranters: information resistant agents that repeatedly broadcast falsity within the network. Relevant conditions are that the open-minded agents can keep track of their social sources and maintain appropriate levels of trust in them, and that some sufficiently reliable sources introduce truth into the network.
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| 35. |
- Morreau, Michael, et al.
(författare)
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Michael Morreau and Erik J. Olsson's Response to Commentaries
- 2022
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Ingår i: Social Virtue Epistemology. - New York : Routledge. - 9780367808952 - 9780367407643
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Bokkapitel (refereegranskat)abstract
- This chapter reports preliminary findings from a study of epistemic consequences of misinformation in social networks. It uses the methodology of computer simulation, constructing computer models of Bayesian learning in networks that include untrustworthy sources. Censorship and de-platforming take time and money, and they violate social and democratic norms of inclusiveness and free speech. Enquirers came to recognize false ranters as such, and to treat their testimony as evidence to the contrary. Gardiner in her commentary recognizes that there are “cases where assertions can be a reason to believe the opposite” but claims that these are “marginal, require significant background evidence and context, and are about limited domains of assertion”. Real-life sources of misinformation, Nguyen argues, are harder to identify than our reliably false ranters. They “provide a mixture of true claims and false claims” and “strategically clever misinformation specialists will work to ensure that their true claims are relatively easy to verify, and their false claims relatively hard to”.
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| 36. |
- Måseide, Ragnhild J., et al.
(författare)
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Haemophilia early arthropathy detection with ultrasound and haemophilia joint health score in the moderate haemophilia (MoHem) study
- 2021
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Ingår i: Haemophilia. - : Wiley. - 1351-8216 .- 1365-2516. ; 27:2
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Detection of early arthropathy is crucial for the management of haemophilia, but data on moderate haemophilia are limited. Therefore, we evaluated joint health and treatment modalities in Nordic patients with moderate haemophilia A (MHA) and B (MHB). Aim: To explore and compare the Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) and Haemophilia Joint Health Score (HJHS) to detect early arthropathy in moderate haemophilia. Methods: A cross-sectional, multicentre study covering Nordic patients with MHA and MHB. Arthropathy was evaluated by HEAD-US and HJHS 2.1. Results: We assessed 693 joints in 118 patients. HEAD-US scores (medians [interquartile ranges]) were as follows: elbows 0 points (0–0), knees 0 (0–0) and ankles 0 (0–1). Respectively, by HJHS: elbows 0 (0–1), knees 0 (0–1) and ankles 0 (0–1). Cartilage (14%) and bone (13%) were most commonly affected by HEAD-US. Frequent HJHS findings were crepitus on motion in knees (39%), and loss of flexion (23%) and extension (13%) in ankles. HEAD-US correlated strongly with HJHS (elbows r =.70, knees r =.60 and ankles r =.65), but 24% had discordant scores. Joints with HJHS zero points, 5% captured HEAD-US ≥1 point. Moreover, 26% had HJHS findings without HEAD-US pathology. Notably, 31% of knees had crepitus on motion and normal HEAD-US. Conclusion: Overall, the joints attained low scores implying good joint health. HEAD-US correlated strongly with HJHS. In 5%, HEAD-US detected subclinical pathology. Crepitus on motion was frequently reported despite normal HEAD-US, thus not necessarily reflecting arthropathy. HEAD-US therefore improves the joint assessment in moderate haemophilia.
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| 37. |
- Måseide, Ragnhild J., et al.
(författare)
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Health-related quality of life and physical activity in Nordic patients with moderate haemophilia A and B (the MoHem study)
- 2024
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Ingår i: Haemophilia. - 1351-8216. ; 30:1, s. 98-105
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: The impact of moderate haemophilia on health-related quality of life (HRQoL) and physical activity (PA) is not well known. In previous studies, persons with factor VIII/factor IX activity (FVIII/FIX:C) below 3 IU/dL were associated with a more severe bleeding phenotype than predicted. Aim: To explore HRQoL and PA in patients with moderate haemophilia A (MHA) and B (MHB). Methods: A cross-sectional, multicentre study covering patients with MHA and MHB in Sweden, Finland, and Norway. HRQoL was assessed with the EuroQoL 5-Dimensions (EQ-5D) form and PA with the International Physical Activity Questionnaire among participants aged ≥15 years. Results: We report on 104 patients aged 15–84 years from the MoHem study. Overall, EQ-5D utility was.85 (median) (Q1–Q3 0.73–1.0) with corresponding visual analogue scale (VAS) 80 (70–90), which were similar regardless of treatment modality, FVIII/FIX:C, and MHA or MHB. Pain and mobility were most frequently affected dimensions. Utility (r = -.54), VAS (r = -.42), and PA (r = -.32) correlated negatively with arthropathy (HJHS). Only patients aged 41–50 years displayed lower utility (p =.02) and VAS (p <.01) than the Norwegian population norm. Patients on prophylaxis aged 35–54 years reported higher PA than those treated on-demand (p =.01). Conclusion: Haemophilic arthropathy had negative impact on HRQoL and PA in Nordic patients with moderate haemophilia. Middle-aged patients captured lower utility and VAS than observed in the general population. Tailored prophylaxis and improved joint health may influence positively on HRQoL and PA also in moderate haemophilia.
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| 38. |
- Måseide, Ragnhild J., et al.
(författare)
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Joint health and treatment modalities in Nordic patients with moderate haemophilia A and B – The MoHem study
- 2020
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Ingår i: Haemophilia. - : Wiley. - 1351-8216 .- 1365-2516. ; 26:5, s. 891-897
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: The prevalence of arthropathy in moderate haemophilia A (MHA) and B (MHB) is not well known. Aim: We evaluated joint health in Nordic patients in relation to their treatment modality. Methods: A cross-sectional, multicentre study covering MHA and MHB in Sweden, Finland and Norway. Arthropathy was evaluated by ultrasound (HEAD-US) and Haemophilia Joint Health Score (HJHS). Results: We report on 145 patients: median age 28 years (IQR 13-52) and 61% MHA. Baseline factor VIII/factor IX activity (FVIII/FIX:C) was 2 IU/dL (median) (IQR 2-4): lower for MHB (2 IU/dL, IQR 1-2) than MHA (3 IU/dL, IQR 2-4) (P <.01). Eighty-five per cent of MHA and 73% MHB had a history of haemarthrosis (P =.07). Age at first joint bleed was lower for MHA (5 years [median], IQR 3-7) than MHB (7 years, IQR 5-12) (P =.01). Thirty-eight per cent received prophylaxis, started at median 10 years of age (IQR 4-24). Median joint bleeds and serious other bleeds during the last 12 months were both zero (IQR 0-1). Total HEAD-US captured 0/48 points (median) (IQR 0-2) and HJHS 4/120 points (IQR 1-10) with strong correlation between them (r =.72). FVIII/FIX:C ≤ 3 IU/dL was associated with higher HJHS (P =.04). Fifteen per cent had undergone orthopaedic surgery. Conclusion: The current joint health in Nordic moderate haemophilia patients was rather good, but a subgroup had severe arthropathy. FVIII/FIX:C ≤ 3 IU/dL and MHA were associated with a more severe bleeding phenotype. We suggest primary prophylaxis to all patients with FVIII/FIX:C ≤ 3 IU/dL.
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| 39. |
- Olsson, Erik, 1965, et al.
(författare)
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Development of a unified design buckling curve for fibre reinforced polymer plates subjected to in-plane uniaxial and uniform compression
- 2023
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Ingår i: Thin-Walled Structures. - : Elsevier BV. - 0263-8231. ; 183
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Tidskriftsartikel (refereegranskat)abstract
- Presented are 24 non-dimensional buckling curves to estimate the strengths of Fibre-Reinforced Polymer (FRP) square plates having four simply supported edges and subjected to in-plane uniaxial and uniform in-plane compression. The curves are constructed by the authors from a parametric numerical analysis using ABAQUS® software with changing variables for: material properties; initial geometrical imperfections; laminate lay-ups; and plate thicknesses. These strength curves express relationships for the buckling reduction factor with plate slenderness, and account for post-buckling strength. We observe that regardless of the laminate lay-up (except for purely unidirectional), the choice of FRP material and the magnitude of the initial geometrical imperfection the predicted buckling reduction factors display a meaningful correlation with plate slenderness. Presented is a proposed unified buckling design curve, defined as the lower bound to 18 of the 24 ABAQUS®-generated buckling curves. This new curve is benchmarked by the authors against experimental test results extracted from the literature and it is found that there is a reasonable agreement. The authors recommend that the proposed buckling design curve has the potential to be introduced into structural design standards as a procedure to design the buckling strengths of FRP plates.
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| 40. |
- Olsson, Erik J
(författare)
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A diachronic perspective on peer disagreement in veritistic social epistemology
- 2020
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Ingår i: Synthese. - : Springer Science and Business Media LLC. - 0039-7857 .- 1573-0964. ; 197:10, s. 4475-4493
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Tidskriftsartikel (refereegranskat)abstract
- The main issue in the epistemology of peer disagreement is whether known disagreement among those who are in symmetrical epistemic positions undermines the rationality of their maintaining their respective views. Douven and Kelp have argued convincingly that this problem is best understood as being about how to respond to peer disagreement repeatedly over time, and that this diachronic issue can be best approached through computer simulation. However, Douven and Kelp’s favored simulation framework cannot naturally handle Christensen’s famous Mental Math example. As a remedy, I introduce an alternative (Bayesian) simulation framework, Laputa, inspired by Alvin Goldman’s seminal work on veritistic social epistemology. I show that Christensen’s conciliatory response, reasonably reconstructed and supplemented, gives rise to an increase in epistemic (veritistic) value only if the peers continue to recheck their mental math; else the peers might as well be steadfast. On a meta-level, the study illustrates the power of Goldman’s approach when combined with simulation techniques for handling the computational issues involved.
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| 41. |
- Olsson, Erik J
(författare)
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Academic Freedom and the Decolonisation of Knowledge : Curriculum Transformation in South Africa from a UNESCO Perspective
- 2023
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Ingår i: Studies in Higher Education. - : Informa UK Limited. - 0307-5079 .- 1470-174X. ; 48:8, s. 1172-1182
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Tidskriftsartikel (refereegranskat)abstract
- Decolonisation aims at exposing the ills of colonialism in an attempt to undo their long-standing effects. Important criticism of curriculum decolonisation has focused on potential conflicts with academic freedom. However, this criticism has to some extent suffered from a perceived lack of agreement on the concept and status of academic freedom itself. The present study views decolonisation in South Africa from the perspective of the international standard afforded by the UNESCO recommendation concerning the status of higher-education teaching personnel (1997). It is argued that, whereas some conceptions of decolonisation are intrinsically in conflict with the recommendation, compliance depends in other cases on implementational details. Moreover, regarding several conceptions, furthering decolonisation and implementing the UNESCO recommendation go hand in hand. In a case study, the Nelson Mandela University Transformation Plan 2018–2020 is critically examined. Finally, it is suggested that there may be considerable benefits associated with using the UNESCO recommendation as a guide in and throughout curriculum transformation.
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| 42. |
- Olsson, Erik J
(författare)
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Coherentism
- 2022
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Bok (refereegranskat)abstract
- Perhaps the most fundamental question of epistemology asks on what grounds our knowledge of the world ultimately rests. The traditional Cartesian answer is that it rests on indubitable facts arrived at through rational insight or introspection. Coherentists reject this answer, claiming instead that knowledge arises from relations of coherence or mutual support: if our beliefs cohere, we can be sure that they are mostly true. The first part of this Element introduces the reader to the main ideas and problems of coherentism. The next part describes the 'probabilistic turn', leading up to recent demonstrations that coherence fails to be conducive to truth. The final part reassesses the current debate about the proper definition of coherence from the standpoint of Rudolf Carnap's methodology of explication. The upshot is a tentative and qualified defence of one of the early coherence measures.
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| 43. |
- Olsson, Erik J, et al.
(författare)
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Commentaries from Erik J. Olsson
- 2022
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Ingår i: Social Virtue Epistemology. - New York : Routledge. - 9780367808952 - 9780367407643
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- In this chapter, the author argues that there are cases in which a nonexpert’s autonomously-formed belief is based on evidence that would otherwise be sufficient for justification, but where this belief is rendered unjustified by (potential) evidence which the nonexpert fails to take into account. He gives various examples in support of his claim. One involves Roger, a food scientist for a large food corporation, who is also an enthusiastic cook. The rules of thumb he has derived from his cooking experience are very reliable, but not as reliable as the scientific method he masters. The author reports that he has argued, in earlier work, that the source of the “ought” is in the normative expectations others are entitled to have based on a person’s participation in various social practices. He thinks that his account underpins a kind of “social-epistemic bootstrapping”, which he thinks is “happy”.
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| 44. |
- Olsson, Erik J, et al.
(författare)
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Commentary from Erik J. Olsson
- 2022
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Ingår i: Social Virtue Epistemology. - New York : Routledge. - 9780367808952 - 9780367407643
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- The term hypothesis denotes something like a policy proposal rather than a factual claim. An organisational tool stands a greater chance of success if it is easy and fun to work with. Better Beliefs represents the current credibility status of hypotheses using the amusing analogy with a horse race, each horse representing a hypothesis. The colour of a horse depends on the votes and evidence provided for or against the hypothesis that it represents. A general prohibition against asserting falsehood or harmful propositions would have a chilling effect on free speech in violation of, for example, article 10 of the European convention of human rights. Only in particular cases, which in the legal frameworks of modern liberal democracies described in sufficiently precise terms, is false or harmful speech prohibited, for example in the interest of protecting a citizen’s reputation, in which case a precise law to this effect needs to be in place.
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| 45. |
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| 46. |
- Olsson, Erik J
(författare)
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Explicationist Epistemology and the Explanatory Role of Knowledge
- 2022
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Ingår i: Journal for General Philosophy of Science. - : Springer Science and Business Media LLC. - 1572-8587 .- 0925-4560. ; 53:1, s. 41-60
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Tidskriftsartikel (refereegranskat)abstract
- It has been argued that much of contemporary epistemology can be unified under Carnap’s methodology of explication, which originated in the neighboring field of philosophy of science. However, it is unclear to what extent epistemological theories that emphasize the explanatory role of knowledge fit into this picture, Kornblith’s natural kind epistemology and Williamson’s knowledge first approach being cases in point. In this connection, I raise three questions. Can we harvest the insights of these approaches without loss in the more standard and less idiosyncratic explicationist framework? Can we do so without falling prey to prominent criticism raised against those approaches? Finally, do the approaches come out as coherent under an explicationist rendering? I argue that in Kornblith’s case the answer to all three questions is essentially in the affirmative. Much of the knowledge first approach is also translatable into explicationism. However, from that perspective, Williamson’s central argument for treating knowledge as undefinable, referring to persistent yet unsuccessful attempts to solve the Gettier problem, amounts to an overreaction to that problem. Leaving explicationism aside, I ask, in the penultimate section, what Williamson’s own philosophical method really amounts to.
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| 47. |
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| 48. |
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| 49. |
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| 50. |
- Olsson, Erik J, et al.
(författare)
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Konvergenstanken i Hans Larssons filosofi
- 2024
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Ingår i: Humanisten Hans Larsson : Filosofiska och litterära praktiker för vår tid - Filosofiska och litterära praktiker för vår tid. - 0436-8096. - 9789198520736 - 9789198520729 ; 27, s. 11-42
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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