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| 13. |
- Aaron, F. D., et al.
(författare)
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Combined inclusive diffractive cross sections measured with forward proton spectrometers in deep inelastic ep scattering at HERA
- 2012
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 72:10
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Tidskriftsartikel (refereegranskat)abstract
- A combination of the inclusive diffractive cross section measurements made by the H1 and ZEUS Collaborations at HERA is presented. The analysis uses samples of diffractive deep inelastic ep scattering data at a centre-of-mass energy root s = 318 GeV where leading protons are detected by dedicated spectrometers. Correlations of systematic uncertainties are taken into account, resulting in an improved precision of the cross section measurement which reaches 6 % for the most precise points. The combined data cover the range 2.5 < Q(2) < 200 GeV2 in photon virtuality, 0.00035 < x(P) < 0.09 in proton fractional momentum loss, 0.09 < vertical bar t vertical bar < 0.55 GeV2 in squared four-momentum transfer at the proton vertex and 0.0018 < beta < 0.816 in beta = x/x(P), where x is the Bjorken scaling variable.
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| 14. |
- Aaron, F. D., et al.
(författare)
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Combined measurement and QCD analysis of the inclusive e(+/-)p scattering cross sections at HERA
- 2010
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Ingår i: Journal of High Energy Physics. - 1029-8479. ; :1
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Tidskriftsartikel (refereegranskat)abstract
- A combination is presented of the inclusive deep inelastic cross sections measured by the H1 and ZEUS Collaborations in neutral and charged current unpolarised e(+/-)p scattering at HERA during the period 1994-2000. The data span six orders of magnitude in negative four-momentum-transfer squared, Q(2), and in Bjorken x. The combination method used takes the correlations of systematic uncertainties into account, resulting in an improved accuracy. The combined data are the sole input in a NLO QCD analysis which determines a new set of parton distributions, HERAPDF1.0, with small experimental uncertainties. This set includes an estimate of the model and parametrisation uncertainties of the fit result.
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| 15. |
- Aaron, F. D., et al.
(författare)
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Events with an isolated lepton and missing transverse momentum and measurement of W production at HERA
- 2010
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Ingår i: Journal of High Energy Physics. - 1029-8479. ; 2010:3, s. 1-19
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Tidskriftsartikel (refereegranskat)abstract
- A search for events containing an isolated electron or muon and missing trans verse momentum produced in e(+/-)p collisions is performed with the H1 and ZEUS detectors at HERA. The data were taken in the period 1994-2007 and correspond to an integrated luminosity of 0.98 fb(-1). The observed event yields are in good overall agreement with the Standard Model prediction, which is dominated by single W production. In the e(+)p data, at large hadronic transverse momentum P-T(X) > 25GeV, a total of 23 events are observed compared to a prediction of 14.0 +/- 1.9. The total single W boson production cross section is measured as 1.06 +/- 0.16 (stat.) +/- 0.07 (sys.) pb, in agreement with an Standard Model (SM) expectation of 1.26 +/- 0.19 pb.
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| 16. |
- Abramowicz, H., et al.
(författare)
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Combination and QCD analysis of charm production cross section measurements in deep-inelastic ep scattering at HERA
- 2013
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 73:2
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Tidskriftsartikel (refereegranskat)abstract
- Measurements of open charm production cross sections in deep-inelastic ep scattering at HERA from the H1 and ZEUS Collaborations are combined. Reduced cross sections sigma(c (c) over bar)(red) for charm production are obtained in the kinematic range of photon virtuality 2.5 <= Q(2) <= 2000 GeV2 and Bjorken scaling variable 3 . 10(-5) <= x <= 5 . 10(-2). The combination method accounts for the correlations of the systematic uncertainties among the different data sets. The combined charm data together with the combined inclusive deep-inelastic scattering cross sections from HERA are used as input for a detailed NLO QCD analysis to study the influence of different heavy flavour schemes on the parton distribution functions. The optimal values of the charm mass as a parameter in these different schemes are obtained. The implications on the NLO predictions for W-+/- and Z production cross sections at the LHC are investigated. Using the fixed flavour number scheme, the running mass of the charm quark is determined.
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| 17. |
- Jiang, X., et al.
(författare)
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Shared heritability and functional enrichment across six solid cancers
- 2019
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r(g) = 0.57, p = 4.6 x 10(-8)), breast and ovarian cancer (r(g) = 0.24, p = 7 x 10(-5)), breast and lung cancer (r(g) = 0.18, p = 1.5 x 10(-6)) and breast and colorectal cancer (r(g) = 0.15, p = 1.1 x 10(-4)). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.
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| 20. |
- Pulit, S. L., et al.
(författare)
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Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes
- 2018
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Ingår i: Neurology-Genetics. - : Ovid Technologies (Wolters Kluwer Health). - 2376-7839. ; 4:6
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Tidskriftsartikel (refereegranskat)abstract
- Objective We sought to assess whether genetic risk factors for atrial fibrillation (AF) can explain cardioembolic stroke risk. We evaluated genetic correlations between a previous genetic study of AF and AF in the presence of cardioembolic stroke using genome-wide genotypes from the Stroke Genetics Network (N = 3,190 AF cases, 3,000 cardioembolic stroke cases, and 28,026 referents). We tested whether a previously validated AF polygenic risk score (PRS) associated with cardioembolic and other stroke subtypes after accounting for AF clinical risk factors. We observed a strong correlation between previously reported genetic risk for AF, AF in the presence of stroke, and cardioembolic stroke (Pearson r = 0.77 and 0.76, respectively, across SNPs with p < 4.4 x 10(-4) in the previous AF meta-analysis). An AF PRS, adjusted for clinical AF risk factors, was associated with cardioembolic stroke (odds ratio [OR] per SD = 1.40, p = 1.45 x 10(-48)), explaining similar to 20% of the heritable component of cardioembolic stroke risk. The AF PRS was also associated with stroke of undetermined cause (OR per SD = 1.07,p = 0.004), but no other primary stroke subtypes (all p > 0.1). Genetic risk of AF is associated with cardioembolic stroke, independent of clinical risk factors. Studies are warranted to determine whether AF genetic risk can serve as a biomarker for strokes caused by AF.
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| 21. |
- Aaron, F. D., et al.
(författare)
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Search for first generation leptoquarks in ep collisions at HERA
- 2011
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 704:5, s. 388-396
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Tidskriftsartikel (refereegranskat)abstract
- A search for first generation scalar and vector leptoquarks produced in ep collisions is performed by the H1 experiment at HERA. The full H1 data sample is used in the analysis, corresponding to an integrated luminosity of 446 pb(-1). No evidence for the production of leptoquarks is observed in final states with a large transverse momentum electron or with large missing transverse momentum, and constraints on leptoquark models are derived. For leptoquark couplings of electromagnetic strength lambda = 0.3, first generation leptoquarks with masses up to 800 GeV are excluded at 95% confidence level. (C) 2011 Elsevier B.V. All rights reserved.
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| 22. |
- Klionsky, Daniel J., et al.
(författare)
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Guidelines for the use and interpretation of assays for monitoring autophagy
- 2012
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Ingår i: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
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Forskningsöversikt (refereegranskat)abstract
- In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
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| 23. |
- Beral, V., et al.
(författare)
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Ovarian cancer and smoking: individual participant meta-analysis including 28 114 women with ovarian cancer from 51 epidemiological studies
- 2012
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Ingår i: The Lancet Oncology. - 1474-5488. ; 13:9, s. 946-956
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Tidskriftsartikel (refereegranskat)abstract
- Background Smoking has been linked to mucinous ovarian cancer, but its effects on other ovarian cancer subtypes and on overall ovarian cancer risk are unclear, and the findings from most studies with relevant data are unpublished. To assess these associations, we review the published and unpublished evidence. Methods Eligible epidemiological studies were identified by electronic searches, review articles, and discussions with colleagues. Individual participant data for 28 114 women with and 94 942 without ovarian cancer from 51 epidemiological studies were analysed centrally, yielding adjusted relative risks (RRs) of ovarian cancer in smokers compared with never smokers. Findings After exclusion of studies with hospital controls, in which smoking could have affected recruitment, overall ovarian cancer incidence was only slightly increased in current smokers compared with women who had never smoked (RR 1.06, 95% CI 1.01-1.11, p=0.01). Of 17 641 epithelial cancers with specified histology, 2314 (13%) were mucinous, 2360 (13%) endometrioid, 969 (5%) clear-cell, and 9086 (52%) serous. Smoking-related risks varied substantially across these subtypes (p(heterogeneity)<0.0001). For mucinous cancers, incidence was increased in current versus never smokers (1.79, 95% CI 1.60-2.00, p<0.0001), but the increase was mainly in borderline malignant rather than in fully malignant tumours (2.25, 95% CI 1.91-2.65 vs 1.49, 1.28-1.73; p(heterogeneity)=0.01; almost half the mucinous tumours were only borderline malignant). Both endometrioid (0.81, 95% CI 0.72-0.92, p=0.001) and clear-cell ovarian cancer risks (0.80, 95% CI 0.65-0.97, p=0.03) were reduced in current smokers, and there was no significant association for serous ovarian cancers (0.99, 95% CI 0.93-1.06, p=0.8). These associations did not vary significantly by 13 sociodemographic and personal characteristics of women including their body-mass index, parity, and use of alcohol, oral contraceptives, and menopausal hormone therapy. Interpretation The excess of mucinous ovarian cancers in smokers, which is mainly of tumours of borderline malignancy, is roughly counterbalanced by the deficit of endometrioid and clear-cell ovarian cancers. The substantial variation in smoking-related risks by tumour subtype is important for understanding ovarian carcinogenesis.
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| 24. |
- Beral, V., et al.
(författare)
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Ovarian Cancer and Body Size : Individual Participant Meta-Analysis Including 25,157 Women with Ovarian Cancer from 47 Epidemiological Studies
- 2012
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Ingår i: PLoS Medicine. - : PUBLIC LIBRARY SCIENCE. - 1549-1277 .- 1549-1676. ; 9:4
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Tidskriftsartikel (refereegranskat)abstract
- Background: Only about half the studies that have collected information on the relevance of women's height and body mass index to their risk of developing ovarian cancer have published their results, and findings are inconsistent. Here, we bring together the worldwide evidence, published and unpublished, and describe these relationships. Methods and Findings: Individual data on 25,157 women with ovarian cancer and 81,311 women without ovarian cancer from 47 epidemiological studies were collected, checked, and analysed centrally. Adjusted relative risks of ovarian cancer were calculated, by height and by body mass index. Ovarian cancer risk increased significantly with height and with body mass index, except in studies using hospital controls. For other study designs, the relative risk of ovarian cancer per 5 cm increase in height was 1.07 (95% confidence interval [CI], 1.05-1.09; p<0.001); this relationship did not vary significantly by women's age, year of birth, education, age at menarche, parity, menopausal status, smoking, alcohol consumption, having had a hysterectomy, having first degree relatives with ovarian or breast cancer, use of oral contraceptives, or use of menopausal hormone therapy. For body mass index, there was significant heterogeneity (p<0.001) in the findings between ever-users and never-users of menopausal hormone therapy, but not by the 11 other factors listed above. The relative risk for ovarian cancer per 5 kg/m(2) increase in body mass index was 1.10 (95% CI, 1.07-1.13; p<0.001) in never-users and 0.95 (95% CI, 0.92-0.99; p = 0.02) in ever-users of hormone therapy. Conclusions: Ovarian cancer is associated with height and, among never-users of hormone therapy, with body mass index. In high-income countries, both height and body mass index have been increasing in birth cohorts now developing the disease. If all other relevant factors had remained constant, then these increases in height and weight would be associated with a 3% increase in ovarian cancer incidence per decade.
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| 25. |
- Aaron, F. D., et al.
(författare)
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Diffractive electroproduction of rho and phi mesons at HERA
- 2010
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Ingår i: Journal of High Energy Physics. - 1029-8479. ; 2010:5, s. 1-111
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Tidskriftsartikel (refereegranskat)abstract
- Diffractive electroproduction of rho and phi mesons is measured at HERA with the H1 detector in the elastic and proton dissociative channels. The data correspond to an integrated luminosity of 51 pb(-1). About 10500 rho and 2000 phi events are analysed in the kinematic range of squared photon virtuality 2.5 <= Q(2) <= 60 GeV2, photon-proton centre of mass energy 35 <= W <= 180 GeV and squared four-momentum transfer to the proton vertical bar t vertical bar <= 3 GeV2. The total, longitudinal and transverse cross sections are measured as a function of Q(2), W and vertical bar t vertical bar. The measurements show a transition to a dominantly "hard" behaviour, typical of high gluon densities and small q (q) over bar dipoles, for Q(2) larger than 10 to 20 GeV2. They support flavour independence of the diffractive exchange, expressed in terms of the scaling variable (Q(2) + M-V(2))/4, and proton vertex factorisation. The spin density matrix elements are measured as a function of kinematic variables. The ratio of the longitudinal to transverse cross sections, the ratio of the helicity amplitudes and their relative phases are extracted. Several of these measurements have not been performed before and bring new information on the dynamics of diffraction in a QCD framework. The measurements are discussed in the context of models using generalised parton distributions or universal dipole cross sections.
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| 26. |
- Aaron, F. D., et al.
(författare)
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Jet production in ep collisions at high Q(2) and determination of alpha(s)
- 2010
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 65:3-4, s. 363-383
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Tidskriftsartikel (refereegranskat)abstract
- The production of jets is studied in deep-inelastic e(+/-) p scattering at large negative four momentum transfer squared 150 < Q(2) < 15000 GeV2 using HERA data taken in 1999-2007, corresponding to an integrated luminosity of 395 pb(-1). Inclusive jet, 2-jet and 3-jet cross sections, normalised to the neutral current deep-inelastic scattering cross sections, are measured as functions of Q(2), jet transverse momentum and proton momentum fraction. The measurements are well described by perturbative QCD calculations at next-to-leading order corrected for hadronisation effects. The strong coupling as determined from these measurements
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| 27. |
- Aaron, F. D., et al.
(författare)
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Measurement of the charm and beauty structure functions using the H1 vertex detector at HERA
- 2010
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 65:1-2, s. 89-109
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Tidskriftsartikel (refereegranskat)abstract
- Inclusive charm and beauty cross sections are measured in e (-) p and e (+) p neutral current collisions at HERA in the kinematic region of photon virtuality 5a parts per thousand currency signQ (2)a parts per thousand currency sign2000 GeV2 and Bjorken scaling variable 0.0002a parts per thousand currency signxa parts per thousand currency sign0.05. The data were collected with the H1 detector in the years 2006 and 2007 corresponding to an integrated luminosity of 189 pb(-1). The numbers of charm and beauty events are determined using variables reconstructed by the H1 vertex detector including the impact parameter of tracks to the primary vertex and the position of the secondary vertex. The measurements are combined with previous data and compared to QCD predictions.
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| 28. |
- Aaron, F. D., et al.
(författare)
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Prompt photons in photoproduction at HERA
- 2010
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 66:1-2, s. 17-33
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Tidskriftsartikel (refereegranskat)abstract
- The production of prompt photons is measured in the photoproduction regime of electron-proton scattering at HERA. The analysis is based on a data sample corresponding to a total integrated luminosity of 340 pb(-1) collected by the H1 experiment. Cross sections are measured for photons with transverse momentum and pseudorapidity in the range 6< E-T(gamma) < 15 GeV and -1.0< eta(gamma) < 2.4, respectively. Cross sections for events with an additional jet are measured as a function of the transverse energy and pseudorapidity of the jet, and as a function of the fractional momenta x(gamma) and x(p) carried by the partons entering the hard scattering process. The correlation between the photon and the jet is also studied. The results are compared with QCD predictions based on the collinear and on the k(T) factorization approaches.
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| 29. |
- Aaron, F. D., et al.
(författare)
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Search for lepton flavour violation at HERA
- 2011
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 701:1, s. 20-30
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Tidskriftsartikel (refereegranskat)abstract
- A search for second and third generation scalar and vector leptoquarks produced in ep collisions via the lepton flavour violating processes ep -> mu X and ep -> tau X is performed by the H1 experiment at HERA. The full data sample taken at a centre-of-mass energy root s = 319 GeV is used for the analysis, corresponding to an integrated luminosity of 245 pb(-1) of e(+)p and 166 pb(-1) of e(-)p collision data. No evidence for the production of such leptoquarks is observed in the H1 data. Leptoquarks produced in e(+/-)p collisions with a coupling strength of lambda = 0.3 and decaying with the same coupling strength to a muon-quark pair or a tau-quark pair are excluded at 95% confidence level up to leptoquark masses of 712 GeV and 479 GeV, respectively. (C) 2011 Elsevier B.V. All rights reserved.
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| 30. |
- Marini, S., et al.
(författare)
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Association of Apolipoprotein E With Intracerebral Hemorrhage Risk by Race/Ethnicity A Meta-analysis
- 2019
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Ingår i: Jama Neurology. - : American Medical Association (AMA). - 2168-6149 .- 2168-6157. ; 76:4, s. 480-491
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Tidskriftsartikel (refereegranskat)abstract
- IMPORTANCE Genetic studies of intracerebral hemorrhage (ICH) have focused mainly on white participants, but genetic risk may vary or could be concealed by differing nongenetic coexposures in nonwhite populations. Transethnic analysis of risk may clarify the role of genetics in ICH risk across populations. OBJECTIVE To evaluate associations between established differences in ICH risk by race/ethnicity and the variability in the risks of apolipoprotein E (APOE) epsilon 4 alleles, the most potent genetic risk factor for ICH. DESIGN, SETTING, AND PARTICIPANTS This case-control study of primary ICH meta-analyzed the association of APOE allele status on ICH risk, applying a 2-stage clustering approach based on race/ethnicity and stratified by a contributing study. A propensity score analysis was used to model the association of APOE with the burden of hypertension across race/ethnic groups. Primary ICH cases and controls were collected from 3 hospital- and population-based studies in the United States and 8 in European sites in the International Stroke Genetic Consortium. Participants were enrolled from January 1, 1999, to December 31, 2017. Participants with secondary causes of ICH were excluded from enrollment. Controls were regionally matched within each participating study. MAIN OUTCOMES AND MEASURES Clinical variables were systematically obtained from structured interviews within each site. APOE genotype was centrally determined for all studies. RESULTS In total, 13 124 participants (7153 [54.5%] male with a median [interquartile range] age of 66 [56-76] years) were included. In white participants, APOE epsilon 2 (odds ratio [OR], 1.49; 95% CI, 1.24-1.80; P < .001) and APOE epsilon 4 (OR, 1.51; 95% CI, 1.23-1.85; P < .001) were associated with lobar ICH risk; however, within self-identified Hispanic and black participants, no associations were found. After propensity score matching for hypertension burden, APOE epsilon 4 was associated with lobar ICH risk among Hispanic (OR, 1.14; 95% CI, 1.03-1.28; P = .01) but not in black (OR, 1.02; 95% CI, 0.98-1.07; P = .25) participants. APOE epsilon 2 and epsilon 4 did not show an association with nonlobar ICH risk in any race/ethnicity. CONCLUSIONS AND RELEVANCE APOE epsilon 4 and epsilon 2 alleles appear to affect lobar ICH risk variably by race/ethnicity, associations that are confirmed in white individuals but can be shown in Hispanic individuals only when the excess burden of hypertension is propensity score-matched; further studies are needed to explore the interactions between APOE alleles and environmental exposures that vary by race/ethnicity in representative populations at risk for ICH.
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| 31. |
- Aaron, F. D., et al.
(författare)
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Diffractive dijet photoproduction in ep collisions at HERA
- 2010
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 70:1-2, s. 15-37
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Tidskriftsartikel (refereegranskat)abstract
- Measurements are presented of single and double-differential dijet cross sections in diffractive photoproduction based on a data sample with an integrated luminosity of 47 pb(-1). The events are of the type ep -> eXY, where the hadronic system X contains at least two jets and is separated by a large rapidity gap from the system Y, which consists of a leading proton or low-mass proton excitation. The dijet cross sections are compared with QCD calculations at next-to-leading order and with a Monte Carlo model based on leading order matrix elements with parton showers. The measured cross sections are smaller than those obtained from the next-to-leading order calculations by a factor of about 0.6. This suppression factor has no significant dependence on the fraction x (gamma) of the photon four-momentum entering the hard subprocess. Ratios of the diffractive to the inclusive dijet cross sections are measured for the first time and are compared with Monte Carlo models.
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| 32. |
- Aaron, F. D., et al.
(författare)
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Jet production in ep collisions at low Q(2) and determination of alpha(s)
- 2010
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 67:1-2, s. 1-24
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Tidskriftsartikel (refereegranskat)abstract
- The production of jets is studied in deep-inelastic e(+) p scattering at low negative four momentum transfer squared 5 < Q(2) < 100 GeV2 and at inelasticity 0.2 < y < 0.7 using data recorded by the H1 detector at HERA in the years 1999 and 2000, corresponding to an integrated luminosity of 43.5 pb(-1). Inclusive jet, 2-jet and 3-jet cross sections as well as the ratio of 3-jet to 2-jet cross sections are measured as a function of Q(2) and jet transverse momentum. The 2-jet cross section is also measured as a function of the proton momentum fraction xi. The measurements are well described by perturbative quantum chromodynamics at next-to-leading order corrected for hadronisation effects and are subsequently used to extract the strong coupling as.
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| 33. |
- Aaron, F. D., et al.
(författare)
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Measurement of the D*(+/-) meson production cross section and F-2(c(c)over-bar) at high Q(2) in ep scattering at HERA
- 2010
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 686:2-3, s. 91-100
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Tidskriftsartikel (refereegranskat)abstract
- The inclusive production of D*(+/-)(2010) mesons in deep-inelastic e(+/-)p scattering is measured in the kinematic region of photon virtuality 100 < Q(2) < 1000 GeV2 and inelasticity 002 < y < 0 7 Single and double differential cross sections for inclusive D* meson production are measured in the visible range defined by vertical bar eta(D*)vertical bar < 1 5 and p(gamma)(D*) > 1 5 GeV The data were collected by the H1 experiment during the period from 2004 to 2007 and correspond to an integrated luminosity of 351 pb(-1) The charm contribution. F-2(c (c) over bar), to the proton structure function F-2 is determined. The measurements are compared with QCD predictions. (C) 2010 Elsevier B V All rights reserved
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| 34. |
- Figlioli, G, et al.
(författare)
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The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer
- 2019
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Ingår i: NPJ breast cancer. - : Springer Science and Business Media LLC. - 2374-4677. ; 5, s. 38-
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Tidskriftsartikel (refereegranskat)abstract
- Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a breast cancer predisposition gene, with greater effects for the ER-negative and triple-negative breast cancer (TNBC) subtypes. We tested the three recurrent protein-truncating variants FANCM:p.Arg658*, p.Gln1701*, and p.Arg1931* for association with breast cancer risk in 67,112 cases, 53,766 controls, and 26,662 carriers of pathogenic variants of BRCA1 or BRCA2. These three variants were also studied functionally by measuring survival and chromosome fragility in FANCM−/− patient-derived immortalized fibroblasts treated with diepoxybutane or olaparib. We observed that FANCM:p.Arg658* was associated with increased risk of ER-negative disease and TNBC (OR = 2.44, P = 0.034 and OR = 3.79; P = 0.009, respectively). In a country-restricted analysis, we confirmed the associations detected for FANCM:p.Arg658* and found that also FANCM:p.Arg1931* was associated with ER-negative breast cancer risk (OR = 1.96; P = 0.006). The functional results indicated that all three variants were deleterious affecting cell survival and chromosome stability with FANCM:p.Arg658* causing more severe phenotypes. In conclusion, we confirmed that the two rare FANCM deleterious variants p.Arg658* and p.Arg1931* are risk factors for ER-negative and TNBC subtypes. Overall our data suggest that the effect of truncating variants on breast cancer risk may depend on their position in the gene. Cell sensitivity to olaparib exposure, identifies a possible therapeutic option to treat FANCM-associated tumors.
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| 35. |
- Gapstur, S. M., et al.
(författare)
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Menopausal hormone use and ovarian cancer risk: individual participant meta-analysis of 52 epidemiological studies
- 2015
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Ingår i: The Lancet. - 1474-547X. ; 385:9980, s. 1835-1842
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Tidskriftsartikel (refereegranskat)abstract
- Background Half the epidemiological studies with information about menopausal hormone therapy and ovarian cancer risk remain unpublished, and some retrospective studies could have been biased by selective participation or recall. We aimed to assess with minimal bias the effects of hormone therapy on ovarian cancer risk. Methods Individual participant datasets from 52 epidemiological studies were analysed centrally. The principal analyses involved the prospective studies (with last hormone therapy use extrapolated forwards for up to 4 years). Sensitivity analyses included the retrospective studies. Adjusted Poisson regressions yielded relative risks (RRs) versus never-use. Findings During prospective follow-up, 12 110 postmenopausal women, 55% (6601) of whom had used hormone therapy, developed ovarian cancer. Among women last recorded as current users, risk was increased even with <5 years of use (RR 1.43, 95% CI 1.31-1.56; p<0.0001). Combining current-or-recent use (any duration, but stopped <5 years before diagnosis) resulted in an RR of 1.37 (95% CI 1.29-1.46; p<0.0001); this risk was similar in European and American prospective studies and for oestrogen-only and oestrogen-progestagen preparations, but differed across the four main tumour types (heterogeneity p<0.0001), being definitely increased only for the two most common types, serous (RR 1.53, 95% CI 1.40-1.66; p<0.0001) and endometrioid (1.42, 1.20-1.67; p<0.0001). Risk declined the longer ago use had ceased, although about 10 years after stopping long-duration hormone therapy use there was still an excess of serous or endometrioid tumours (RR 1.25, 95% CI 1.07-1.46, p=0.005). Interpretation The increased risk may well be largely or wholly causal; if it is, women who use hormone therapy for 5 years from around age 50 years have about one extra ovarian cancer per 1000 users and, if its prognosis is typical, about one extra ovarian cancer death per 1700 users.
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| 36. |
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| 37. |
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| 38. |
- Aaron, F. D., et al.
(författare)
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Determination of the integrated luminosity at HERA using elastic QED Compton events
- 2012
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 72:10
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Tidskriftsartikel (refereegranskat)abstract
- A measurement of the integrated luminosity at the ep collider HERA is presented, exploiting the elastic QED Compton process ep -> e gamma p. The electron and the photon are detected in the backward calorimeter of the H1 experiment. The integrated luminosity of the data recorded in 2003 to 2007 is determined with a precision of 2.3%. The measurement is found to be compatible with the corresponding result obtained using the Bethe-Heitler process.
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| 39. |
- Aaron, F. D., et al.
(författare)
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Inclusive deep inelastic scattering at high Q(2) with longitudinally polarised lepton beams at HERA
- 2012
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Ingår i: Journal of High Energy Physics. - 1029-8479. ; :9
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Tidskriftsartikel (refereegranskat)abstract
- Inclusive e(+/-)p single and double differential cross sections for neutral and charged current deep inelastic scattering processes are measured with the H1 detector at HERA. The data were taken at a centre-of-mass energy of root s = 319 GeV with a total integrated luminosity of 333.7 pb(-1) shared between two lepton beam charges and two longitudinal lepton polarisation modes. The differential cross sections are measured in the range of negative four-momentum transfer squared, Q(2), between 60 and 50 000GeV(2), and Bjorken x between 0.0008 and 0.65. The measurements are combined with earlier published unpolarised H1 data to improve statistical precision and used to determine the structure function xF(3)(gamma Z). A measurement of the neutral current parity violating structure function F-2(gamma Z) is presented for the first time. The polarisation dependence of the charged current total cross section is also measured. The new measurements are well described by a next-to-leading order QCD fit based on all published H1 inclusive cross section data which are used to extract the parton distribution functions of the proton.
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| 40. |
- Aaron, F. D., et al.
(författare)
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Inclusive measurement of diffractive deep-inelastic scattering at HERA
- 2012
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 72:7
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Tidskriftsartikel (refereegranskat)abstract
- The diffractive process ep -> eXY, where Y denotes a proton or its low mass excitation with M-Y < 1.6 GeV, is studied with the H1 experiment at HERA. The analysis is restricted to the phase space region of the photon virtuality 3 <= Q(2) <= 1600 GeV2, the square of the fourmomentum transfer at the proton vertex vertical bar t vertical bar < 1.0 GeV2 and the longitudinal momentum fraction of the incident proton carried by the colourless exchange x(P) < 0.05. Triple differential cross sections are measured as a function of x(P), Q(2) and beta = x/x(P) where x is the Bjorken scaling variable. These measurements are made after selecting diffractive events by demanding a large empty rapidity interval separating the final state hadronic systems X and Y. High statistics measurements covering the data taking periods 1999-2000 and 2004-2007 are combined with previously published results in order to provide a single set of diffractive cross sections from the H1 experiment using the large rapidity gap selection method. The combined data represent a factor between three and thirty increase in statistics with respect to the previously published results. The measurements are compared with predictions from NLO QCD calculations based on diffractive parton densities and from a dipole model. The proton vertex factorisation hypothesis is tested.
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| 41. |
- Aaron, F. D., et al.
(författare)
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Measurement of beauty photoproduction near threshold using di-electron events with the H1 detector at HERA
- 2012
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 72:10
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Tidskriftsartikel (refereegranskat)abstract
- The cross section for ep -> eb (b) over barX in photoproduction is measured with the H1 detector at the ep-collider HERA. The decay channel b (b) over bar -> eeX' is selected by identifying the semi-electronic decays of the b-quarks. The total production cross section is measured in the kinematic range given by the photon virtuality Q(2) <= 1 GeV2, the inelasticity 0.05 <= y <= 0.65 and the pseudorapidity of the b-quarks vertical bar eta(b)vertical bar, vertical bar eta((b) over bar)vertical bar <= 2. The differential production cross section is measured as a function of the average transverse momentum of the beauty quarks < P-T(b)> down to the threshold. The results are compared to next-to-leading-order QCD predictions.
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| 42. |
- Aaron, F. D., et al.
(författare)
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Measurement of charm and beauty jets in deep inelastic scattering at HERA
- 2011
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 71:1
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Tidskriftsartikel (refereegranskat)abstract
- Measurements of cross sections for events with charm and beauty jets in deep inelastic scattering at HERA are presented. Events with jets of transverse energy E-T(jet) > 6 GeV and pseudorapidity - 1.0 < eta(jet) < 1.5 in the laboratory frame are selected in the kinematic region of photon virtuality Q(2) > 6 GeV2 and inelasticity variable 0.07 < y < 0.625. Measurements are also made requiring a jet in the Breit frame with E-T(*jet) > 6 GeV. The data were collected with the H1 detector in the years 2006 and 2007 corresponding to an integrated luminosity of 189 pb(-1). The numbers of charm and beauty jets are determined using variables reconstructed using the H1 vertex detector with which the impact parameters of the tracks to the primary vertex and the position of secondary vertices are measured. The measurements are compared with QCD predictions and with previous measurements where heavy flavours are identified using muons.
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| 43. |
- Aaron, F. D., et al.
(författare)
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Measurement of D*(+/-) meson production and determination of F-2(c(c)over-bar) at low Q(2) in deep-inelastic scattering at HERA
- 2011
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 71:10
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Tidskriftsartikel (refereegranskat)abstract
- Inclusive production of D* mesons in deep-inelastic ep scattering at HERA is studied in the range 5 < Q(2) < 100 GeV2 of the photon virtuality and 0.02 < y < 0.7 of the inelasticity of the scattering process. The observed phase space for the D* meson is (pT) (D*) > 1.25 GeV and |eta( D*)| < 1.8. The data sample corresponds to an integrated luminosity of 348 pb(-1) collected with the H1 detector. Single and double differential cross sections are measured and the charm contribution F-2(c (c) over bar) to the proton structure function F-2 is determined. The results are compared to perturbative QCD predictions at next-to-leading order implementing different schemes for the charm mass treatment and with Monte Carlo models based on leading order matrix elements with parton showers.
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| 44. |
- Aaron, F. D., et al.
(författare)
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Measurement of dijet production in diffractive deep-inelastic scattering with a leading proton at HERA
- 2012
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 72:4
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Tidskriftsartikel (refereegranskat)abstract
- The cross section of diffractive deep-inelastic scattering ep -> eXp is measured, where the system X contains at least two jets and the leading final state proton is detected in the H1 Forward Proton Spectrometer. The measurement is performed for fractional proton longitudinal momentum loss x(P) < 0.1 and covers the range 0.1 < vertical bar t vertical bar < 0.7 GeV2 in squared four-momentum transfer at the proton vertex and 4 < Q(2) < 110 GeV2 in photon virtuality. The differential cross sections extrapolated to vertical bar t vertical bar < 1 GeV2 are in agreement with next-to-leading order QCD predictions based on diffractive parton distribution functions extracted from measurements of inclusive and dijet cross sections in diffractive deep-inelastic scattering. The data are also compared with leading order Monte Carlo models.
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| 45. |
- Aaron, F. D., et al.
(författare)
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Measurement of photon production in the very forward direction in deep-inelastic scattering at HERA
- 2011
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 71:10
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Tidskriftsartikel (refereegranskat)abstract
- The production of photons at very small angles with respect to the proton beam direction is studied in deep-inelastic positron-proton scattering at HERA. The data are taken with the H1 detector in the years 2006 and 2007 and correspond to an integrated luminosity of 126 pb(-1). The analysis covers the range of negative four momentum transfer squared at the positron vertex 6 < Q(2) < 100 GeV2 and inelasticity 0.05 < y < 0.6. Cross sections are measured for the most energetic photon with pseudorapidity eta > 7.9 as a function of its transverse momentum p(T)(lead) and longitudinal momentum fraction of the incoming proton x(L)(lead). In addition, the cross sections are studied as a function of the sum of the longitudinal momentum fraction x(L)(sum) L of all photons in the pseudorapidity range. > 7.9. The cross sections are normalised to the inclusive deep-inelastic scattering cross section and compared to the predictions of models of deep-inelastic scattering and models of the hadronic interactions of high energy cosmic rays.
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| 46. |
- Aaron, F. D., et al.
(författare)
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Measurement of the azimuthal correlation between the most forward jet and the scattered positron in deep-inelastic scattering at HERA
- 2012
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 72:3
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Tidskriftsartikel (refereegranskat)abstract
- Deep-inelastic positron-proton scattering events at low photon virtuality, Q(2), with a forward jet, produced at small angles with respect to the proton beam, are measured with the H1 detector at HERA. A subsample of events with an additional jet in the central region is also studied. For both samples, differential cross sections and normalised distributions are measured as a function of the azimuthal angle difference, Delta phi, between the forward jet and the scattered positron in bins of the rapidity distance, Y, between them. The data are compared to predictions of Monte Carlo generators based on different evolution approaches as well as to next-to-leading order calculations in order to test the sensitivity to QCD evolution mechanisms.
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| 47. |
- Aaron, F. D., et al.
(författare)
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Measurement of the cross section for diffractive deep-inelastic scattering with a leading proton at HERA
- 2011
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 71:3
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Tidskriftsartikel (refereegranskat)abstract
- The cross section for the diffractive deep-inelastic scattering process ep -> eXp is measured, with the leading final state proton detected in the H1 Forward Proton Spectrometer. The data sample covers the range x(P) < 0.1 in fractional proton longitudinal momentum loss, 0.1 < vertical bar t vertical bar < 0.7 GeV2 in squared four-momentum transfer at the proton vertex and 4 < Q(2) < 700 GeV2 in photon virtuality. The cross section is measured four-fold differentially in t, x(P), Q2 and beta = x/x(P), where x is the Bjorken scaling variable. The t and x(P) dependences are interpreted in terms of an effective pomeron trajectory and a sub-leading exchange. The data are compared with perturbative QCD predictions at next-to-leading order based on diffractive parton distribution functions previously extracted from complementary measurements of inclusive diffractive deep-inelastic scattering. The ratio of the diffractive to the inclusive ep cross section is studied as a function of Q(2), beta and x(P).
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| 48. |
- Aaron, F. D., et al.
(författare)
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Measurement of the diffractive longitudinal structure function F(L)(D) at HERA
- 2011
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 71:12
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Tidskriftsartikel (refereegranskat)abstract
- First measurements are presented of the diffractive cross section sigma(ep) -> eXY at centre-of-mass energies root s of 225 and 252 GeV, together with a precise new measurement at root s of 319 GeV, using data taken with the H1 detector in the years 2006 and 2007. Together with previous H1 data at root s of 301 GeV, the measurements are used to extract the diffractive longitudinal structure function F(L)(D) in the range of photon virtualities 4.0 <= Q(2) <= 44.0 GeV(2) and fractional proton longitudinal momentum loss 5 x 10(-4) <= x(P) <= 3 x 10(-3). The measured F(L)(D) is compared with leading twist predictions based on diffractive parton densities extracted in NLO QCD fits to previous measurements of diffractive Deep-Inelastic Scattering and with a model which additionally includes a higher twist contribution derived from a colour dipole approach. The ratio of the diffractive cross section induced by longitudinally polarised photons to that for transversely polarised photons is extracted and compared with the analogous quantity for inclusive Deep-Inelastic Scattering.
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| 49. |
- Aaron, F. D., et al.
(författare)
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Measurement of the inclusive e(+/-) p scattering cross section at high inelasticity y and of the structure function F-L
- 2011
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 71:3
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Tidskriftsartikel (refereegranskat)abstract
- A measurement is presented of the inclusive neutral current e(+/-) p scattering cross section using data collected by the H1 experiment at HERA during the years 2003 to 2007 with proton beam energies E-p of 920, 575, and 460 GeV. The kinematic range of the measurement covers low absolute four-momentum transfers squared, 1.5 GeV2 < Q(2) < 120 GeV2, small values of Bjorken x, 2.9 . 10(-5) < x < 0.01, and extends to high inelasticity up to y = 0.85. The structure function F-L is measured by combining the new results with previously published H1 data at E-p = 920 GeV and E-p = 820 GeV. The new measurements are used to test several phenomenological and QCD models applicable in this low Q(2) and low x kinematic domain.
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| 50. |
- Aaron, F. D., et al.
(författare)
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Search for contact interactions in e(+/-)p collisions at HERA H1 Collaboration
- 2011
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 705:1-2, s. 52-58
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Tidskriftsartikel (refereegranskat)abstract
- A search for physics beyond the Standard Model in neutral current deep inelastic scattering at high negative four-momentum transfer squared Q(2) is performed in e(+/-)p collisions at HERA. The differential cross section d sigma/dQ(2), measured using the full H1 data sample corresponding to an integrated luminosity of 446 pb(-1), is compared to the Standard Model prediction. No significant deviation is observed. Limits on various models predicting new phenomena at high Q(2) are derived. For general four-fermion eeqq contact interaction models, lower limits on the compositeness scale A are set in the range 3.6 TeV to 7.2 TeV. Leptoquarks with masses M-LQ and couplings lambda are constrained to M-LQ/lambda > 0.41-1.86 TeV and limits on squarks in R-parity violating supersymmetric models are derived. A lower limit on the gravitational scale in 4 + n dimensions of M-S > 0.9 TeV is established for low-scale quantum gravity effects in models with large extra dimensions. For the light quark radius an upper bound of R-q < 0.65 . 10(-18) m is determined. (C) 2011 Elsevier B.V. All rights reserved.
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