| 1. |
- Haller, Kristian, et al.
(författare)
-
Method for Dynamic Automated Laser Measurement applied on Lightweight Test Panels
- 1999
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- This thesis describes an automated approach to modal testing utilizing a robot control to position a laser vibrometer beam. The method developed reduces the time-consuming data acquisition considerable. A double curved aluminium panel was chosen as test specimen. The selected specimen is suitable because it is hard to measure the dynamic properties of these kind of lightweight structures with accelerometers. Results from the experimental modal analysis were compared to the results given from the FEM calculations. An excellent agreement between the two models was found.
|
|
| 2. |
- Haller, Kristian, et al.
(författare)
-
Method for Dynamic Automated Laser Measurement Applied on Lightweight Test Panels
- 1999
-
Konferensbidrag (refereegranskat)abstract
- This paper describes an automated approach to modal testing utilizing a robot control to position a Laser Doppler Vibrometer (LVD) [1]. A programmed robotic system was used for the laser positioning. This kept the measurement set correctly identified with respect to the specimen geometry. The communication between the measurement program and the robot, the identification of the candidate robot system, and the mechanical design of the robot-vibrometer interface is described. For verification a sample measurement was performed and results are briefly presented.
|
|
| 3. |
- Hassan, M, et al.
(författare)
-
A mechanism-based pharmacokinetic-enzyme model for cyclophosphamide autoinduction in breast cancer patients
- 1999
-
Ingår i: British Journal of Clinical Pharmacology. - 0306-5251 .- 1365-2125. ; 48:5, s. 669-677
-
Tidskriftsartikel (refereegranskat)abstract
- Aims This study investigated the pharmacokinetics of cyclophosphamide (CP) and its main metabolite 4-hydroxycyclophosphamide (4-OH-CP) in patients with breast cancer undergoing high dose chemotherapy prior to autologous stem cell transplantation. An enzyme turn-over model was also developed to study the time course of cyclophosphamide induction. Methods Fourteen patients received a combination of CP (6 g m(-2)), thiotepum (500 mg m(-2)) and carboplatin (800 mg m(-2)) as a 96 h infusion. Plasma concentrations of CP and 4-OH-CP were determined with h.p.l.c. and a pharmacokinetic and enzyme turn-over model applied to data using NONMEM. Results CP plasma concentrations were described by a two-compartment model with a noninducible and an inducible pathway, the latter forming 4-OH-CP. In the final enzyme model, CP affects the amount of enzymes by increasing the enzyme production rate. CP concentrations decreased during the infusion with no subsequent change in 4-OH-CP concentrations. CP inducible and noninducible clearance were estimated to 1.76 1 h(-1) (90% C.I. 0.92-2.58) and 1.14 1 h(-1) (0.31-1.85), respectively. The induction resulted in an approximately doubled CP clearance through the inducible pathway at the end of treatment. The model predicted the enzyme turn-over half-life to be 24 h. Conclusions The presented mechanism-based enzyme induction model where the pharmacokinetics of the inducer and the enzyme pool counterbalance each other successfully described CP autoinduction. It is reasonable to believe that CP affects its own elimination by increasing the enzyme production rate and thereby increasing the amount of enzyme by which CP is eliminated.
|
|
| 4. |
- Olsson, Ulrika, et al.
(författare)
-
Dynamic Automated Measurement on Light Weight Test Panels
- 1999
-
Konferensbidrag (refereegranskat)abstract
- This paper describes an automated approach to modal testing utilizing a robot control to position a Laser Doppler Vibrometer (LDV) beam. The LDV measures the velocity response of test panels to a broad band force excitation. The implementation of the laser beam approach involves moving the beam once for each member of the velocity-force set. It is critical that the beam is positioned precisely, and the measurement set is correctly correlated to the specimen geometry. A programmed robotic system was used for the laser positioning and for keeping the measurement set correctly identified with respect to the specimen geometry. The result clearly shows the possibility to automate time consuming modal measurement of lightweight structures by utilizing a robot to control a LDV.
|
|
