| 1. |
- Thorleifsson, Gudmar, et al.
(author)
-
Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma
- 2010
-
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:10, s. 906-909
-
Journal article (peer-reviewed)abstract
- We conducted a genome-wide association study for primary open-angle glaucoma (POAG) in 1,263 affected individuals (cases) and 34,877 controls from Iceland. We identified a common sequence variant at 7q31 (rs4236601[ A], odds ratio (OR) = 1.36, P = 5.0 x 10(-10)). We then replicated the association in sample sets of 2,175 POAG cases and 2,064 controls from Sweden, the UK and Australia (combined OR = 1.18, P = 0.0015) and in 299 POAG cases and 580 unaffected controls from Hong Kong and Shantou, China (combined OR = 5.42, P = 0.0021). The risk variant identified here is located close to CAV1 and CAV2, both of which are expressed in the trabecular meshwork and retinal ganglion cells that are involved in the pathogenesis of POAG.
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
|
|
| 11. |
|
|
| 12. |
|
|
| 13. |
- Möller, Per, et al.
(author)
-
Data set on sedimentology, palaeoecology and chronology of Middle to Late Pleistocene deposits on the Taimyr Peninsula, Arctic Russia
- 2019
-
In: Data in Brief. - : Elsevier. - 2352-3409. ; 25, s. 1-35
-
Journal article (peer-reviewed)abstract
- This Data in Brief paper contains data (including images) from Quaternary sedimentary successions investigated along the Bol'shaya Balakhnya River and the Luktakh-Upper Taimyra-Logata river system on southern Taimyr Peninsula, NW Siberia (Russia). Marine foraminifera and mollusc fauna composition, extracted from sediment samples, is presented. The chronology (time of deposition) of the sediment successions is reconstructed from three dating methods; (i) radiocarbon dating of organic detritus (from lacustrine/fluvial sediment) and molluscs (marine sediment) as finite ages (usually <42 000 years) or as non-finite ages (>42 000-48 000 years) on samples/sediments beyond the radiocarbon dating limit; (ii) Electron Spin Resonance (ESR) dating on marine molluscs (up to ages >400 000 years); (iii) Optically Stimulated Luminescence (OSL) dating, usually effective up to 100-150 0000 years. Terrestrial Cosmogenic Nuclide (TCN) exposure dating has been applied to boulders resting on top of moraine ridges (Ice Marginal Zones). See (Moller et al., 2019) (doi.org/10.1016/j.earscirev.2019.04.004) for interpretation and discussion of all data. (c) 2019 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
|
|
| 14. |
- Möller, Per, et al.
(author)
-
Glacial history and palaeo-environmental change of southern Taimyr Peninsula, Arctic Russia, during the Middle and Late Pleistocene
- 2019
-
In: Earth-Science Reviews. - : Elsevier. - 0012-8252 .- 1872-6828. ; 196
-
Research review (peer-reviewed)abstract
- We here reconstruct a glacial and climate history of arctic NW Siberia for the last similar to 600,000 years, based on the stratigraphy and chronology of 35 studied river sections on the southern Taimyr Peninsula. From this strati graphic mosaic we have identified four glacial events, marked by tills/glaciotectonics, which are intercalated with mainly marine sediments deposited in proglacial settings during transitions from glacial conditions into subsequent interglacials/interstadials. The traces of early shelf-based Kara Sea Ice Sheet (KSIS) glaciations in marine isotope stages (MIS) 12-14 and 8 are sparsely preserved, but these ice advances are suggested to have terminated far south into the central Siberian uplands, as also was the case with the younger Taz glaciation (MIS 6). The inception phase of the latter glaciation was complex, with ice advancing into a proglacial marine basin both from the south (Putorana - Anabar uplands) and the north. The deglaciation leading into the Karginsky interglacial (MIS 5e) was marked by the development of the southerrunost ice-marginal zones (IMZs) on the Taimyr lowlands - the Urdakh and Sampesa IMZs. The most recent (late Pleistocene) glacial cycle is recorded by three successively smaller KSIS advances from the Kara Sea shelf onto Taimyr, of which only the first, during Early Zyryanka (MIS 5d), reached south of the Byrranga Mountains, with its maximum extent marked by the Jangoda - Syntabul - Severokokorsky IMZ. Retreat of the ice margin during MIS 5c-b was accompanied by deposition of glaciomarine sediment in the proglacial basin and deposition of large successions of delta sediments in the foothills of the Byrranga Motmtains, reaching a >= 100 m above present sea level. The region north of the Byrranga Mountains was subjected to two subsequent KSIS glaciations, during MIS 4 and MIS 2, while the area south of the Byrranga Mountains transitioned to a terrestrial environment from the Middle into the Lower Zyryanka, as evidenced by deposition of fluvial, aeolian and ice-complex (Yedoma) sediments.
|
|
| 15. |
|
|
| 16. |
|
|
| 17. |
|
|
| 18. |
|
|
