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- Elihn, Kristina, et al.
(författare)
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Size distributions and synthesis of nanoparticles by photolytic dissociation of ferrocene
- 2001
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Ingår i: APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING. - 0947-8396. ; 72:1, s. 29-34
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Tidskriftsartikel (refereegranskat)abstract
- Iran-containing nanoparticles were made by laser-assisted (ArF excimer laser, lambda = 193 nm) photolytic dissociation of ferrocene (Fe(C5H5)(2) or FeCp2) in argon and an oxygen/argon gas mixture. The particle-size distributions were obtained on-line by u
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- Gassler, N, et al.
(författare)
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Distinct expression of calnexin in major human salivary glands
- 2003
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Ingår i: Histology and Histopathology. - 1699-5848. ; 18:1, s. 121-127
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Tidskriftsartikel (refereegranskat)abstract
- Calnexin (Cnx) has been characterized as a membrane-bound protein that transiently interacts in a unique chaperone system with newly synthesized glycoproteins in order to allow the establishment of their proper tertiary and, in most cases, quarternary structures. The aim of the study was to identify and to locate the expression of Cnx in the three major salivary glands of humans by different methods. Strong expression of Cnx protein and mRNA were generally found in serous salivary secretory units. With regard to mucous secretory units, expression of Cnx was only detectable at a low level in mucous acinar cells of sublingual glands, but not of submandibular glands. Expression of Cnx was always preserved in the surface epithelium of intralobar and interlobular duct segments. In addition, expression of Cnx was detected in sebaceous glands of parotid tissues, with a distribution pattern resembling that seen in sebaceous glands of the normal skin. In conclusion, production of saliva is associated with the expression of Cnx. Synthesis of molecules in mucous secretory units is not necessarily associated with a strong Cnx expression, whereas synthesis in serous secretory units apparently is. The tissue-specific Cnx expression is also paralleled by the observation that the secretions produced by the major salivary glands differ in their composition and amount.
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- Gassler, N, et al.
(författare)
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Expression of osteopontin (Eta-1) in Crohn disease of the terminal ileum
- 2002
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Ingår i: Scandinavian Journal of Gastroenterology. - 1502-7708. ; 37:11, s. 1286-1295
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Tidskriftsartikel (refereegranskat)abstract
- Background: The causes of Crohn disease (CD) are still regarded as unknown, but impaired mucosal immunoregulation with activation of T-helper-1 (Th-1) cytokine responses is probably involved and may contribute to the morphological changes. We investigated a possible role of osteopontin (Opn) in the pathogenesis of CD. This glycoprotein has been suggested to be involved in the generation of Th-1-type immune responses; moreover, it carries anti-inflammatory activities. Methods: Ileal samples from CD patients-both actively inflamed and inactive areas as well as unaffected intestinal specimens from controls (normal ileum)-were investigated by Western blot analysis, immunohistochemistry and in situ hybridization. Results: In normal gut, Opn was found to be regularly expressed by plasma cells (CD 38) and a subset of lamina propria mononuclear cells (MNC) as well as by intestinal epithelial cells (IEC). In active CD, immunohistochemistry and in situ hybridization analysis revealed a loss of Opn expression by IEC adjacent to ulcerative lesions, whereas especially plasma cells (CD 38) in the vicinity of such lesions were found to express the molecule. In addition, a slight overexpression of Opn protein was found in metaplastic crypts. However, quantitative analysis of total Opn protein in the ileal mucosa of CD patients did not reveal any difference vis-A-vis control tissues. Conclusions: The constitutive expression of Opn in normal gut indicates that it is involved in intestinal immune homeostasis. Downregulation of Opn expression in IEC might favour the disintegration of the epithelial barrier. The expression of Opn in lamina propria plasma cells could contribute to disease chronification, probably by affecting cell survival.
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- Mollenhauer, Jan, et al.
(författare)
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Carcinogen inducibility in vivo and down-regulation of DMBT1 during breast carcinogenesis.
- 2004
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Ingår i: Genes, chromosomes & cancer. - : Wiley. - 1045-2257. ; 39:3, s. 185-94
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Tidskriftsartikel (refereegranskat)abstract
- Deleted in malignant brain tumors 1 (DMBT1) has been proposed as a candidate tumor suppressor for brain and epithelial cancer. Initial studies suggested loss of expression rather than mutation as the predominant mode of DMBT1 inactivation. However, in situ studies in lung cancer demonstrated highly sophisticated changes of DMBT1 expression and localization, pointing to a chronological order of events. Here we report on the investigation of DMBT1 in breast cancer in order to test whether these principles might also be attributable to other tumor types. Comprehensive mutational analyses did not uncover unambiguous inactivating DMBT1 mutations in breast cancer. Expression analyses in the human and mouse mammary glands pointed to the necessity of DMBT1 induction. While age-dependent and hormonal effects could be ruled out, 9 of 10 mice showed induction of Dmbt1 expression after administration of the carcinogen 7,12-dimethybenz(alpha)anthracene prior to the onset of tumorigenesis or other histopathological changes. DMBT1 displayed significant up-regulation in human tumor-flanking tissues compared to in normal breast tissues (P < 0.05). However, the breast tumor cells displayed a switch from lumenal secretion to secretion to the extracellular matrix and a significant down-regulation compared to that in matched normal flanking tissues (P < 0.01). We concluded that loss of expression also is the predominant mode of DMBT1 inactivation in breast cancer. The dynamic behavior of DMBT1 in lung carcinoma is fully reflected in breast cancer, which suggests that this behavior might be common to tumor types arising from monolayered epithelia.
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- Thörngren Engblom, Pia, et al.
(författare)
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Experimental search for evidence of the three-nucleon force and a new analysis method
- 2004
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Ingår i: FEW-BODY PROBLEMS IN PHYSICS. - : AIP. - 0735402531 ; , s. 65-68
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- A research program with the aim of investigating the spin dependence of the three-nucleon continuum in pd collisions at intermediate energies was carried out at IUCF using the Polarized INternal Target EXperiments (PINTEX) facility. In the elastic scattering experiment at 135 and 200 MeV proton beam energies a total of 15 independent spin observables were obtained. The breakup experiment was done with a vector and tensor polarized beam of 270 MeV and an internal polarized hydrogen gas target. We developed a novel technique for the analysis of the breakup observables, the sampling method. The new approach takes into account acceptance and non-uniformities of detection efficiencies and is suitable for any kinematically complete experiment with three particles in the final state.
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