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Contribution of ant...
Contribution of antibody-based protein profiling to the human chromosome-centric proteome project (C-HPP)
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- Fagerberg, Linn (author)
- KTH,Science for Life Laboratory, SciLifeLab
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- Oksvold, Per (author)
- KTH,Science for Life Laboratory, SciLifeLab
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- Skogs, Marie (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab
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Älgenäs, C. (author)
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- Lundberg, Emma (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab
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- Pontén, Fredrik (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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- Sivertsson, Åsa (author)
- KTH,Science for Life Laboratory, SciLifeLab
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- Odeberg, Jacob (author)
- KTH,Science for Life Laboratory, SciLifeLab
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- Klevebring, Daniel (author)
- Karolinska Institutet,KTH,Science for Life Laboratory, SciLifeLab
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- Kampf, Caroline (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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- Asplund, Anna (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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- Sjöstedt, Evelina (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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Al-Khalili Szigyarto, Cristina (author)
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- Edqvist, Per-Henrik (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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- Olsson, IngMarie (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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- Rydberg, U. (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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Hudson, P. (author)
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Ottosson Takanen, J. (author)
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Berling, H. (author)
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- Björling, Lisa (author)
- KTH,Science for Life Laboratory, SciLifeLab
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- Tegel, Hanna (author)
- KTH,Proteomik och nanobioteknologi
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Rockberg, J. (author)
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- Nilsson, Peter (author)
- KTH,Science for Life Laboratory, SciLifeLab
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Navani, S. (author)
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- Jirström, Karin (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Schwenk, Jochen M. (author)
- Karolinska Institutet,KTH,Science for Life Laboratory, SciLifeLab
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- Schwenk, Jochen M. (author)
- KTH,Science for Life Laboratory, SciLifeLab
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- Zwahlen, Martin (author)
- KTH,Science for Life Laboratory, SciLifeLab
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- Hober, Sophia (author)
- KTH,Science for Life Laboratory, SciLifeLab
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- Forsberg, Mattias (author)
- KTH,Science for Life Laboratory, SciLifeLab
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- Von Feilitzen, Kalle (author)
- KTH,Science for Life Laboratory, SciLifeLab
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- Uhlén, Mathias (author)
- KTH,Proteomik och nanobioteknologi,Science for Life Laboratory, SciLifeLab
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(creator_code:org_t)
- 2012-12-31
- 2013
- English.
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In: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 12:6, s. 2439-2448
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Subject headings
Close
- A gene-centric Human Proteome Project has been proposed to characterize the human protein-coding genes in a chromosome-centered manner to understand human biology and disease. Here, we report on the protein evidence for all genes predicted from the genome sequence based on manual annotation from literature (UniProt), antibody-based profiling in cells, tissues and organs and analysis of the transcript profiles using next generation sequencing in human cell lines of different origins. We estimate that there is good evidence for protein existence for 69% (n = 13985) of the human protein-coding genes, while 23% have only evidence on the RNA level and 7% still lack experimental evidence. Analysis of the expression patterns shows few tissue-specific proteins and approximately half of the genes expressed in all the analyzed cells. The status for each gene with regards to protein evidence is visualized in a chromosome-centric manner as part of a new version of the Human Protein Atlas (www.proteinatlas.org).
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
Keyword
- Antibody-based protein profiling
- C-HPP
- Antibody-based protein profiling
- C-HPP
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Fagerberg, Linn
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Oksvold, Per
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Skogs, Marie
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Älgenäs, C.
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Lundberg, Emma
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Pontén, Fredrik
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show more...
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Sivertsson, Åsa
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Odeberg, Jacob
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Klevebring, Dani ...
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Kampf, Caroline
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Asplund, Anna
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Sjöstedt, Evelin ...
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Al-Khalili Szigy ...
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Edqvist, Per-Hen ...
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Olsson, IngMarie
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Rydberg, U.
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Hudson, P.
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Ottosson Takanen ...
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Berling, H.
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Björling, Lisa
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Tegel, Hanna
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Rockberg, J.
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Nilsson, Peter
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Navani, S.
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Jirström, Karin
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Schwenk, Jochen ...
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Zwahlen, Martin
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Hober, Sophia
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Forsberg, Mattia ...
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Von Feilitzen, K ...
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Uhlén, Mathias
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Bioinformatics a ...
- Articles in the publication
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Journal of Prote ...
- By the university
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Royal Institute of Technology
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Lund University
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Uppsala University
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Karolinska Institutet