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Sökning: WFRF:(PROCTOR S) > (2010-2014)

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  • Franke, Andre, et al. (författare)
  • Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
  • 2010
  • Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:12, s. 1118-1125
  • Tidskriftsartikel (refereegranskat)abstract
    • We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the top association signals in 15,694 cases, 14,026 controls and 414 parent-offspring trios. We identified 30 new susceptibility loci meeting genome-wide significance (P < 5 × 10⁻⁸). A series of in silico analyses highlighted particular genes within these loci and, together with manual curation, implicated functionally interesting candidate genes including SMAD3, ERAP2, IL10, IL2RA, TYK2, FUT2, DNMT3A, DENND1B, BACH2 and TAGAP. Combined with previously confirmed loci, these results identify 71 distinct loci with genome-wide significant evidence for association with Crohn's disease.
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  • Michaloski, John, et al. (författare)
  • Push–Button Discrete Event Simulation for Analysis of Factory Floor Operations
  • 2010
  • Ingår i: ASME 2010 International Mechanical Engineering Congress and Exposition, IMECE 2010; Vancouver, BC; Canada; 12 November 2010 through 18 November 2010. - 9780791844274 ; 3:PARTS A AND B, s. 313-319
  • Konferensbidrag (refereegranskat)abstract
    • In manufacturing, Discrete Event Simulation (DES) can beeffectively used to model production and provide sustainability analysis of equipment and system operation by measuring throughput, capacity, and bottlenecks. DES allows analysis under different scenarios and conditions that can then be used to forecast more optimal system performance. For discrete parts production, DES is rarely used because of the difficulty in attaining timely and accurate statistical modeling of the equipment and process operation. In this paper we look at the use of the plant floor interoperability standard, MTConnect, as a means to improve the access to machine tool data. Given data access, we develop a Finite State Model in order to streamline Machine Tool and DES integration. A case study of a prototype Capacity Planning system using DES as a modeling back–end will be described to help in understanding resource allocation of shop floor machines to a batch of aerospace parts. Direct machine tool statistical parameterization into a Web–based DES leads to “Push–button” automated simulations.
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