| 1. |
- Berg, LM, et al.
(författare)
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Fitness and sexual response to population density in Daphnia pulex
- 2001
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Ingår i: FRESHWATER BIOLOGY. - 0046-5070. ; 46:5, s. 667-677
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Tidskriftsartikel (refereegranskat)abstract
- 1. The switch between asexual and sexual reproduction is an important fitness component in cyclically parthenogenetic populations as it is the key to persistence in unstable habitats and because it influences population genetic characteristics such as lin
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| 2. |
- Masquelier, M, et al.
(författare)
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Low density lipoprotein as a carrier of cytostatics in cancer chemotherapy : Study of stability of drug-carrier complexes in blood
- 2000
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Ingår i: Journal of drug targeting (Print). - 1061-186X .- 1029-2330. ; 8:3, s. 155-164
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Tidskriftsartikel (refereegranskat)abstract
- Several solid tumour and leukemia cell types have a higher low density lipoprotein (LDL) uptake than the corresponding normal cells. We are investigating the possibilities to use LDL as a drug carrier to increase the selectivity of antineoplastic drugs in cancer chemotherapy. We have developed a method to incorporate lipophilic cytotoxic agents without interfering with the in vitro and in vivo properties of LDL, In this study, we examined the stability of some drug-LDL complexes in blood and plasma as this is an important prerequisite to achieve a selective therapy. The in vitro dialysis of N-trifluoroacetyl-adriamycin-14-valerat-LDL (AD-32-LDL) against plasma revealed a slow dissociation of the complex. The same method showed a fast and total leakage of paclitaxel from paclitaxel-LDL into the plasma chamber. The dissociation of paclitaxel was confirmed by an autoradiographic study of the distribution of paclitaxel-LDL in tumour-bearing mice. In patients with leukemia the rapid plasma dissociation of AD-32 from LDL illustrated a much higher in vivo instability of this complex. With this method, cholesteryl-linoleate only could be incorporated into LDL in a stable manner as shown by dialysis and autoradiography results. The incorporation of cytotoxic drug derivatives, containing lipophilic anchors, is now under study in order to obtain LDL complexes with better plasma stability.
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| 3. |
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| 4. |
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| 5. |
- Palsson, S
(författare)
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Microsatellite variation in Daphnia pulex from both sides of the Baltic Sea
- 2000
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Ingår i: MOLECULAR ECOLOGY. - : BLACKWELL SCIENCE LTD. - 0962-1083. ; 9:8, s. 1075-1088
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Tidskriftsartikel (refereegranskat)abstract
- Despite large genetic differentiation among neighbouring populations of many freshwater zooplankton species, a macrogeographical homogeneity of allozyme variation is generally observed. A study on breeding systems in Scandinavian populations of Daphnia pu
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| 6. |
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| 7. |
- Palsson, S
(författare)
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The effects of deleterious mutations in cyclically parthenogenetic organisms
- 2001
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Ingår i: JOURNAL OF THEORETICAL BIOLOGY. - : ACADEMIC PRESS LTD. - 0022-5193. ; 208:2, s. 201-214
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Tidskriftsartikel (refereegranskat)abstract
- Cyclically parthenogenetic organisms experience benefits of both sexual and asexual reproductive modes in a constant environment. Sexual reproduction generates new genotypes and may facilitate the purging of deleterious mutations whereas asexuality has a
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| 8. |
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