| 1. |
- Tuskan, G A, et al.
(författare)
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The genome of black cottonwood, Populus trichocarpa (Torr. & Gray).
- 2006
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 313:5793, s. 1596-604
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Tidskriftsartikel (refereegranskat)abstract
- We report the draft genome of the black cottonwood tree, Populus trichocarpa. Integration of shotgun sequence assembly with genetic mapping enabled chromosome-scale reconstruction of the genome. More than 45,000 putative protein-coding genes were identified. Analysis of the assembled genome revealed a whole-genome duplication event; about 8000 pairs of duplicated genes from that event survived in the Populus genome. A second, older duplication event is indistinguishably coincident with the divergence of the Populus and Arabidopsis lineages. Nucleotide substitution, tandem gene duplication, and gross chromosomal rearrangement appear to proceed substantially more slowly in Populus than in Arabidopsis. Populus has more protein-coding genes than Arabidopsis, ranging on average from 1.4 to 1.6 putative Populus homologs for each Arabidopsis gene. However, the relative frequency of protein domains in the two genomes is similar. Overrepresented exceptions in Populus include genes associated with lignocellulosic wall biosynthesis, meristem development, disease resistance, and metabolite transport.
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| 2. |
- Harrington, Robert A., et al.
(författare)
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The Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRA.CER) trial : study design and rationale
- 2009
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Ingår i: American Heart Journal. - : Elsevier BV. - 0002-8703 .- 1097-6744. ; 158:3, s. 327-334
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Tidskriftsartikel (refereegranskat)abstract
- Background The protease-activated receptor 1 (PAR-1), the main platelet receptor for thrombin, represents a novel target for treatment of arterial thrombosis, and SCH 530348 is an orally active, selective, competitive PAR-1 antagonist. We designed TRA.CER to evaluate the efficacy and safety of SCH 530348 compared with placebo in addition to standard of care in patients with non-ST-segment elevation (NSTE) acute coronary syndromes (ACS) and high-risk features. Trial design TRA.CER is a prospective, randomized, double-blind, multicenter, phase III trial with an original estimated sample size of 10,000 subjects. Our primary objective is to demonstrate that SCH 530348 in addition to standard of care will reduce the incidence of the composite of cardiovascular death, myocardial infarction (MI), stroke, recurrent ischemia with rehospitalization, and urgent coronary revascularization compared with standard of care alone. Our key secondary objective is to determine whether SCH 530348 will reduce the composite of cardiovascular death, MI, or stroke compared with standard of care alone. Secondary objectives related to safety are the composite of moderate and severe GUSTO bleeding and clinically significant TIMI bleeding. The trial will continue until a predetermined minimum number of centrally adjudicated primary and key secondary end point events have occurred and all subjects have participated in the study for at least I year. The TRA.CER trial is part of the large phase III SCH 530348 development program that includes a concomitant evaluation in secondary prevention. Conclusion TRA.CER will define efficacy and safety of the novel platelet PAR-1 inhibitor SCH 530348 in the treatment of high-risk patients with NSTE ACS in the setting of current treatment strategies.
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| 3. |
- Richards, Stephen, et al.
(författare)
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The genome of the model beetle and pest Tribolium castaneum.
- 2008
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Ingår i: Nature. - 1476-4687. ; 452:7190, s. 949-55
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Tidskriftsartikel (refereegranskat)abstract
- Tribolium castaneum is a representative of earth’s most numerous eukaryotic order, a powerful model organism for the study of generalized insect development, and also an important pest of stored agricultural products. We describe its genome sequence here. This omnivorous beetle has evolved an ability to interact with a diverse chemical environment as evidenced by large expansions in odorant and gustatory receptors, as well as p450 and other detoxification enzymes. Developmental patterns in Tribolium are more representative of other arthropods than those found in Drosophila, a fact represented in gene content and function. For one, Tribolium has retained more ancestral genes involved in cell-cell communication than Drosophila, and some are expressed in the growth zone crucial for axial elongation in short germ development. Systemic RNAi in T. castaneum appears to use mechanisms distinct from those found in C. elegans, but nevertheless offers similar power for the elucidation of gene function and identification of targets for selective insect control.
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| 4. |
- Morcos, Sameh K., et al.
(författare)
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Reducing the risk of iodine-based and MRI contrast media administration : recommendation for a questionnaire at the time of booking
- 2008
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Ingår i: European Journal of Radiology. - : Elsevier BV. - 0720-048X .- 1872-7727. ; 66:2, s. 225-229
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents a practical questionnaire to be used when a contrast medium examination is requested. The questionnaire is based on the guidelines from the European Society of Urogenital Radiology. Its aim is to identify patients at increased risk of clinically relevant renal and non-renal adverse reactions to iodine-based and MRI contrast agents. The questionnaire should be completed by the referring physician when the examination is requested.
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| 5. |
- Juncker, Agnieszka S, et al.
(författare)
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Sequence-based feature prediction and annotation of proteins
- 2009
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Ingår i: Genome biology. - : Springer Science and Business Media LLC. - 1465-6914 .- 1465-6906. ; 10:2, s. 206-
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Tidskriftsartikel (refereegranskat)abstract
- A recent trend in computational methods for annotation of protein function is that many prediction tools are combined in complex workflows and pipelines to facilitate the analysis of feature combinations, for example, the entire repertoire of kinase-binding motifs in the human proteome.
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| 6. |
- Pe'er, Asaf, et al.
(författare)
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A new method of determining the initial size and Lorentz factor of gamma-ray burst fireballs using a thermal emission component
- 2007
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 664:1, s. L1-L4
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Tidskriftsartikel (refereegranskat)abstract
- In recent years, increasing evidence has emerged for a thermal component in the gamma- and X- ray spectrum of the prompt emission phase in gamma- ray bursts. The temperature and flux of the thermal component show a characteristic break in the temporal behavior after a few seconds. We show here that measurements of the temperature and flux of the thermal component at early times ( before the break) allow the determination of the values of two of the least restricted fireball model parameters: the size at the base of the flow and the outflow bulk Lorentz factor. Relying on the thermal emission component only, this measurement is insensitive to the inherent uncertainties of previous estimates of the bulk motion Lorentz factor. We give specific examples of the use of this method: for GRB 970828 at redshift z = 0.9578, we show that the physical size at the base of the flow is r(0) = (2.9 +/- 1.8) x 10(8) Y-0(-3/2) cm and the Lorentz factor of the flow is Gamma = (305 +/- 28) Y-0(1/4), and for GRB 990510 at z= 1.619, r(0) = (1.7 +/- 1.7) x 10(8)Y(0)(-3/2) cm and Gamma = (384 +/- 71)y(0)(1/4), where Y= 1Y(0) is the between the total fireball energy and the energy emitted in g- rays.
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| 7. |
- Pe’Er, A., et al.
(författare)
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Theoretical Implications of Thermal Emission from Gamma-Ray Bursts
- 2009
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Ingår i: GAMMA-RAY BURST. - : AIP. ; , s. 317-322
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Recent analysis show evidence for a thermal emission component that accompanies the non-thermal emission during the prompt phase of GRBs. We show that this component is naturally explained by considering emission from the photosphere. The photosphere of a relativistically expanding plasma wind strongly depends on the angle to the line of sight, θs. As a result, thermal emission can be seen after tens of seconds. Using probability density function P(r,θs) to describe photon escape at radius r and angle θs, we show that the thermal flux is expected to decay at late times as F$_BB$~t$^-2$, and the observed temperature decays as T~t$^-α$, with α~1/2-2/3. We discuss the relation between thermal emission and high energy, non-thermal spectra observed by FERMI. We show how thermal emission can be used to directly measure the Lorentz factor of the flow and the initial radius of the jet.
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