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The aminoterminal-t...
The aminoterminal-type-III procollagen pepetide and proteoglycans in serum and synovial fluid in patients with rheumatoid arthritis or reactive arthritis.
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- Hörslev-Pedersen, Kim (författare)
- University of Copenhagen
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- Saxne, Tore (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Haar, D (författare)
- King Christian the Xth Hospital
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visa fler...
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- Thomsen, BS (författare)
- Copenhagen University Hospital
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- Bentsen, KD (författare)
- Copenhagen University Hospital
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- Junker, Peter (författare)
- University of Southern Denmark
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- Lorenzen, Ib (författare)
- Copenhagen University Hospital
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visa färre...
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(creator_code:org_t)
- 1988
- 1988
- Engelska.
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Ingår i: Rheumatology International. - 1437-160X. ; 8, s. 1-9
- Relaterad länk:
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https://lup.lub.lu.s...
Abstract
Ämnesord
Stäng
- The concentrations of aminoterminal-type-III procollagen (procollagen N-) peptide, and of proteoglycans were measured in knee-joint synovial fluid and serum from patients with rheumatoid arthritis or reactive arthritis. All synovial fluids contained large amounts of intact propeptide. The synovial fluid: serum propeptide ratios were high, suggesting local propeptide liberation. A correlation was demonstrated between the propeptide concentration in synovial fluid and in serum. In rheumatoid arthritis, the propeptide concentration in synovial fluid was related to local inflammatory activity, and the serum concentration was correlated with the presence of nonspecific markers of inflammation. The presence of smaller propeptide fragments in synovial fluid indicated that some degradation occurred locally. The local metabolic changes were most prominent in patients with joint erosions. Patients with nonerosive rheumatoid arthritis and reactive arthritis had similar synovial fluid propeptide concentrations. The proteoglycan content of synovial fluid was inversely related to the degree of joint destruction, and was highest in patients with reactive arthritis. No correlation was observed between the concentrations of propeptide and proteoglycan in synovial fluid. Intraarticular glucocorticoid injection reduced the levels of propeptide and proteoglycan in synovial fluid
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- Arthritis, Rheumatoid/drug therapy
- Proteoglycans/analysis
- Prospective studies
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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