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| 7. |
- Gustafsson, G, et al.
(författare)
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The electric field and wave experiment for the Cluster mission
- 1997
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Ingår i: Space Science Reviews. - 0038-6308 .- 1572-9672. ; 79, s. 137-156
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Tidskriftsartikel (refereegranskat)abstract
- The electric-field and wave experiment (EFW) on Cluster is designed to measure the electric-field and density fluctuations with sampling rates up to 36 000 samples s(-1). Langmuir probe sweeps can also be made to determine the electron density and temperature. The instrument has several important capabilities. These include (1) measurements of quasi-static electric fields of amplitudes lip to 700 mV m(-1) with high amplitude and time resolution, (2) measurements over short periods of time of up to five simualtaneous waveforms (two electric signals and three magnetic signals from the seach coil magnetometer sensors) of a bandwidth of 4 kHz with high time resolution, (3) measurements of density fluctuations in four points with high time resolution. Among the more interesting scientific objectives of the experiment are studies of nonlinear wave phenomena that result in acceleration of plasma as well as large- and small-scale interferometric measurements. By using four spacecraft for large-scale differential measurements and several Langmuir probes on one spacecraft for small-scale interferometry, it will be possible to study motion and shape of plasma structures on a wide range of spatial and temporal scales. This paper describes the primary scientific objectives of the EFW experiment and the technical capabilities of the instrument.
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| 8. |
- Gustafsson, G, et al.
(författare)
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The electric field and wave experiment for the Cluster mission
- 1997
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Ingår i: SPACE SCIENCE REVIEWS. - : KLUWER ACADEMIC PUBL. - 0038-6308. ; 79:1-2, s. 137-156
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Tidskriftsartikel (refereegranskat)abstract
- The electric-field and wave experiment (EFW) on Cluster is designed to measure the electric-field and density fluctuations with sampling rates up to 36 000 samples s(-1). Langmuir probe sweeps can also be made to determine the electron density and tempera
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| 15. |
- Crozier, R.H, et al.
(författare)
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Phylogenetic assessment of total biodiversity
- 1999
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Ingår i: Ponder, W. and Lunney, D. (eds). The other 99%. The conservation and biodiversity of invertebrates. - Mosman 2088 : Royal Zoological society of New south Wales. ; , s. 30-33
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 17. |
- Escoubet, C P, et al.
(författare)
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Density in the magnetosphere inferred from ISEE 1 spacecraft potential
- 1997
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Ingår i: JOURNAL OF GEOPHYSICAL RESEARCH-SPACE PHYSICS. - ROYAL INST TECHNOL,ALFVEN LAB,DIV PLASMA PHYS,S-10044 STOCKHOLM,SWEDEN.. ; 102:A8, s. 17595-17609
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Tidskriftsartikel (refereegranskat)abstract
- The potential of ISEE 1 spacecraft has been used to derive the plasma density in the magnetosphere and its environment. First, we show that using the equilibrium of currents flowing in and out of a spacecraft, we could numerically derive a relation between the spacecraft potential and the density of the surrounding plasma, After verifying: that this relation was in good agreement with the measurement of the density made by other instruments during selected periods of time, we apply this relation to the spacecraft potential measured continuously from 1977 to 1984 on ISEE 1, An image of the plasma density in the magnetosphere and its environment is obtained as a result, All principal magnetospheric regions are clearly identified: the solar wind with a density around 5 cm(-3) : the magnetosheath with a density around 50 cm(-3), the magnetosphere with a density around 1 cm(-3) the plasma sheet with a density around 0.5 cm(-3), and finally, the more tenuous tail lobes with a density below 0.1 cm(-3), The plasma density was observed slightly higher on the dawnside than on the duskside of the magnetosphere, In addition, the magnetosheath was closer to the Earth on the dawnside than on the duskside, When the magnetic activity increased (recorded by the AE index), the dayside magnetosphere was compressed/eroded by about 1 to 2 R-E, while the plasmasphere/inner magnetosphere became quite irregular and expanded in the dawn-midnight and in the dusk-noon sectors, In addition, during high magnetic activity, the plasma sheet at Y-GSM = 0 was thicker and slightly denser than at low-activity, On the other hand, the flanks of the plasma sheet were thinner and slightly less dense during high-activity than during low-activity.
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| 18. |
- Escoubet, C. P., et al.
(författare)
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Imaging the magnetosphere using ISEE-1 spacecraft potential
- 1996
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Ingår i: European Space Agency, (Special Publication) ESA SP. - 0379-6566. ; :392, s. 179-187
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Tidskriftsartikel (refereegranskat)abstract
- The potential of ISEE 1 spacecraft has been used to derived the plasma density in the magnetosphere and its environment. First we show that using the equilibrium of currents flowing in and out of a spacecraft, we could derive numerically a relation between the spacecraft potential and the density of the surrounding plasma. After verifying that this relation was in good agreement with the measurement of the density made by other instruments during selected periods of time, we apply this relation to the spacecraft potential measured continuously from 1977 to 1984 on ISEE-1. An image of the plasma density in the magnetosphere and its environment is obtained as a result. All principal magnetospheric regions are clearly identified, from the solar wind with a density around 5 cm-3 , the magnetosheath around 50 cm-3, the magnetosphere around 1 cm-3, the plasma sheet around 0.5 cm-3 and finally the more tenuous tail lobes below 0.1 cm-3. The plasma density was observed slightly higher on the dawnside than on the dusk side of the magnetosphere. In addition the magnetosheath was closer to the Earth on the dawnside than on the duskside. When the magnetic activity increased (recorded by the AE index), the dayside magnetosphere was compressed/eroded by about 1 to 2 RE while the plasmasphere/inner magnetosphere became quite irregular and expanded in the dawn-midnight and in the dusk-noon sectors. In addition, during high magnetic activity, the plasmasheet at Ygsm = 0 was thicker and denser than at low activity. On the other hand the flanks of the plasmasheet were thinner and less dense during high activity than during low activity.
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| 23. |
- Harvey, P, et al.
(författare)
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The electric field instrument on the Polar satellite
- 1995
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Ingår i: Space Science Reviews. - 0038-6308 .- 1572-9672. ; 71, s. 583-596
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Tidskriftsartikel (refereegranskat)abstract
- The Polar satellite carries a system of four wire booms in the spacecraft spin plane and two rigid booms along the spin axis. Each of the booms has a spherical sensor at its tip along with nearby guard and stub surfaces whose potentials relative to that of their sphere are controlled by associated electronics. The potential differences between opposite sphere pairs are measured to yield the three components of the DC to >1 MHz electric field. Spheres can also be operated in a mode in which their collected current is measured to give information on the plasma density and its fluctuations. The scientific studies to be performed by this experiment as well as the mechanical and electrical properties of the detector system are described.
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| 25. |
- Hoekx, JCM, et al.
(författare)
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Fluticasone propionate compared with budesonide: a double-blind trial in asthmatic children using powder devices at a dosage of 400 microg x day(-1)
- 1996
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Ingår i: The European respiratory journal. - : European Respiratory Society (ERS). - 0903-1936 .- 1399-3003. ; 9:11, s. 2263-2272
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Tidskriftsartikel (refereegranskat)abstract
- The aim of this study was to compare fluticasone propionate (FP) with budesonide (BUD) at a dose of 400 microg x day(-1) in the treatment of children with asthma. Two hundred and twenty nine children with mild-to-moderate asthma, currently receiving 200-400 microg x day(-1) of inhaled corticosteroid, were randomized to receive either 400 microg x day(-1) of FP from the Diskhaler (registered trade mark of the Glaxo Group of Companies) or 400 microg x day(-1) of BUD from the Turbuhaler (registered trade mark of Astra Pharmaceuticals Ltd) for 8 weeks, in a parallel-group, double-blind, double-dummy study. Primary efficacy was assessed by measurement of daily peak expiratory flow (PEF). In addition, pulmonary function tests were performed at each clinic visit and a self-administered patient-centred questionnaire was completed by one parent of each patient at the start and end of study treatment. Mean morning PEF increased following treatment both with FP and BUD, but was significantly higher following treatment with FP during Weeks 1-4 (p=0.015) and Weeks 1-8 (p=0.019). Similar results were found for mean evening PEF and percentage predicted morning and evening PEF. Children receiving FP experienced significantly less disruption in their physical activities (i.e. sports, games) because of their asthma compared to children treated with BUD (p=0.03). Mean cortisol levels increased in both groups, but the increase was significantly higher in the FP group at 4 weeks (p=0.022). Serum and urine markers of bone formation and resorption changed very little and showed no consistent pattern of change. Fluticasone propionate at a dosage of 400 microg x day(-1) from the Diskhaler provided a more rapid and greater improvement in lung function in children with mild-to-moderate asthma than BUD 400 microg day(-1) from the Turbuhaler. Both treatments were well-tolerated, with a similar safety profile.
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| 26. |
- Jahnson, S., et al.
(författare)
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p53 and Rb immunostaining in locally advanced bladder cancer : relation to prognostic variables and predictive value for the local response to radical radiotherapy
- 1995
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Ingår i: European Urology. - Basel, Switzerland : S. Karger. - 0302-2838 .- 1873-7560. ; 28:2, s. 135-142
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Tidskriftsartikel (refereegranskat)abstract
- The association between known prognostic variables and altered immunostaining for the nuclear proteins retinoblastoma (Rb) and p53 was studied in a homogeneous series of locally advanced bladder cancer. The predictive value of this immunostaining for the local response to intended radical radiotherapy was investigated. Among 262 patients treated with intended radical radiotherapy between 1967 and 1986, a total of 154 patients were evaluable with respect to local response to treatment. The paraffin-embedded specimen from the tumour prior to irradiation was immunostained with the monoclonal antibodies PMG3-245 for Rb and 1801 for p53 nuclear proteins after heating in a microwave oven for 40 min at 650 W. An altered expression of Rb and p53 was observed in 18 and 42% of the tumours, respectively. p53 overexpression was associated with higher tumour grade. However, the results of the p53 and Rb immunostaining procedures had no predictive value for tumor response to radiation treatment, local control or cancer-specific mortality.
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| 30. |
- Jorgensen, F S, et al.
(författare)
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MULTISCAN--a Scandinavian multicenter second trimester obstetric ultrasound and serum screening study
- 1999
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Ingår i: Acta Obstetricia et Gynecologica Scandinavica. - 1600-0412. ; 78:6, s. 501-510
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Tidskriftsartikel (refereegranskat)abstract
- AIM: To study the detection rates of second trimester ultrasound screening for neural tube defects (NTD), abdominal wall defects (AWD) and Down's syndrome (DS) in low risk populations at tertiary centers, and to compare the ultrasound screening detection rates with those that were obtainable by biochemical serum screening (double test: alpha-fetoprotein/human chorion gonadotrophin/age test). STUDY DESIGN: Prospective multicenter study with a three year inclusion period: 1/1/1989-31/12/1991. SUBJECTS: 27,844 low-risk women at 18-34 years of age who had a second trimester ultrasound screening examination. Of these, 10,264 also had a serum test. METHODS: An ultrasound malformation scan and a serum test were carried out at 17-19 weeks of gestation. Risk calculations regarding DS were based on alpha-fetoprotein, human chorion gonadotrophin and maternal age; performed retrospectively for the first two years. RESULTS: In total 73 cases were identified in the study population: NTD (n=34), AWD (n=7) and DS (n=32). The detection rates, (%, with 95% confidence interval) for ultrasound screening were: NTD: 79.4 (62.1-91.3); AWD: 85.7 (42.1-99.6); DS: 6.3 (0.8-20.8). In the subgroup of women who had both tests, the detection rates for ultrasound screening vs double test were: NTD: 62.5 (24.5-91.5) vs 75.0 (34.9-96.8); AWD: 66.7 (9.4-99.2) vs 100 (29.2-100.0); DS: 7.7 (0.2-36.0) vs 46.2 (19.2-74.9). The false positive rates (%) for ultrasound screening vs double test were: NTD: 0.01/3.3; AWD: 0.01/3.3; DS: 0.1/4.0. CONCLUSION: Second trimester ultrasound screening in a low risk population gave a low detection rate for fetal DS (6.3%) and an acceptable detection rate for NTD (79.4%) and AWD (85.7%). In the subgroup of women who had both tests, serum screening performed better than ultrasound as applied in the present study, especially regarding DS.
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| 31. |
- Jönsson, Bengt, et al.
(författare)
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Cost-effectiveness of cholesterol lowering. Results from the Scandinavian Simvastatin Survival Study (4S)
- 1996
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Ingår i: European heart journal. - : Oxford University Press. - 1522-9645 .- 0195-668X. ; 17:7, s. 1001-1007
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Tidskriftsartikel (refereegranskat)abstract
- An analysis of the cost-effectiveness of simvastatin was conducted, based on the Scandinavian Simvastatin Survival Study (4S). The total cost of hospitalization in the placebo group was 52.8 million Swedish kronor (SEK) (5.15 million pounds), compared with SEK 36.0 million (3.51 million pounds) in the simvastatin group. This amounts to a 32% reduction, or a saving of SEK 16.8 million (1.6 million pounds) or SEK 7560 (738 pounds) per patient. The net cost per patient for the duration of the study (5.4 years) was SEK 13,540 (1324 pounds). Simvastatin treatment saved an estimated 0.377 undiscounted life years (0.240 life years discounted at 5% per annum). The cost of simvastatin therapy per discounted life-year saved was therefore SEK 56,400 (5502 pounds). Sensitivity analysis, examining the effect of different life expectancies, costs of initiation and monitoring of simvastatin therapy, and discount rates, showed the results to be stable. Conclusion. The cost per life-year saved of simvastatin in the treatment of post-myocardial infarction and angina patients, as determined from 4S data, is well within the range normally considered cost-effective.
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| 32. |
- Jönsson, Bengt, et al.
(författare)
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Cost effectiveness of simvastatin treatment to lower cholesterol levels in patients with coronary heart disease
- 1997
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Ingår i: The New England journal of medicine. - : Massachusetts Medical Society. - 1533-4406 .- 0028-4793. ; 336:5, s. 332-336
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Tidskriftsartikel (refereegranskat)abstract
- Background The Scandinavian Simvastatin Survival Study (4S) showed that lowering cholesterol levels with simvastatin reduces mortality and morbidity in patients with angina pectoris or previous acute myocardial infarction. Before the widespread use of cholesterol-lowering drugs in such patients is recommended, its cost effectiveness should be demonstrated. We estimated the cost effectiveness of simvastatin treatment to lower cholesterol levels in relation to the age, sex, and cholesterol level before treatment of patients with coronary heart disease. Methods We estimated the cost per year of life gained with simvastatin therapy. To model the increased life expectancy, hazard functions from 4S were used. The costs studied included those of the intervention and the direct and indirect costs associated with morbidity from coronary causes. We prepared separate estimates for men and women at various ages (from 35 to 70 years) and total cholesterol levels before treatment (213 to 309 mg per deciliter). Results In the analysis limited to direct costs, the cost of each year of life gained ranged from $3,800 for 70-year-old men with 309 mg of cholesterol per deciliter to $27,400 for 35-year-old women with 213 mg of cholesterol per deciliter. When we included indirect costs, the results ranged from a savings in the youngest patients to a cost of $13,300 per year of life gained in 70-year-old women with 213 mg of cholesterol per deciliter. Conclusions In patients with coronary heart disease, simvastatin therapy is cost effective among both men and women at the ages and cholesterol levels studied.
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| 36. |
- McClearn, GE, et al.
(författare)
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Substantial genetic influence on cognitive abilities in twins 80 or more years old
- 1997
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Ingår i: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 276:5318, s. 1560-1563
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Tidskriftsartikel (refereegranskat)abstract
- General and specific cognitive abilities were studied in intact Swedish same-sex twin pairs 80 or more years old for whom neither twin had major cognitive, sensory, or motor impairment. Resemblance for 110 identical twin pairs significantly exceeded resemblance for 130 fraternal same-sex twin pairs for all abilities. Maximum-likelihood model-fitting estimates of heritability were 62 percent for general cognitive ability, 55 percent for verbal ability, 32 percent for spatial ability, 62 percent for speed of processing, and 52 percent for memory. There was also evidence for the significant influence of idiosyncratic experience as the environmental component that most determines individual differences in cognitive abilities late in life.
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| 37. |
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| 38. |
- Pedersen, A, et al.
(författare)
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The wave experiment consortium (WEC)
- 1997
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Ingår i: SPACE SCIENCE REVIEWS. - : KLUWER ACADEMIC PUBL. - 0038-6308. ; 79:1-2, s. 93-105
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- In order to get the maximum scientific return from available resources, the wave experimenters on Cluster established the Wave Experiment Consortium (WEC). The WEC's scientific objectives are described, together with its capability to achieve them in the
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| 39. |
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| 40. |
- Petrill, SA, et al.
(författare)
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The genetic and environmental relationship between general and specific cognitive abilities in twins age 80 and older
- 1998
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Ingår i: PSYCHOLOGICAL SCIENCE. - : SAGE Publications. - 0956-7976 .- 1467-9280. ; 9:3, s. 183-189
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- In the first twin study of the old-old, individuals 80 years old and older, we examined the relationship between general and specific cognitive abilities from a genetic perspective. That is, we examined the extent to which genetic and environmental factors influence major group factors of cognitive abilities, independent of general cognitive ability. As part of the OctoTwin project in Sweden, general and specific cognitive abilities were assessed in 52 monozygotic and 65 same-sex dizygotic twin pairs 80 years old and older using a battery of seven tests that assess verbal, spatial, speed-of-processing, and memory performance. Results suggest that genetic effects associated with general cognitive ability (g) account for the correlation between g and verbal, spatial, and speed-of-processing abilities. No genetic influences were found for these specific cognitive abilities separate from g. In contrast, memory ability appears to be more distinct genetically from g than are other cognitive abilities. Comparison with younger samples suggests that cognitive abilities relating to speed of processing may be genetically dedifferentiated in the old-old.
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