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Sökning: WFRF:(Pepin X.) > (2020)

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1.
  • Abrahamsson, B., et al. (författare)
  • Six years of progress in the oral biopharmaceutics area - A summary from the IMI OrBiTo project
  • 2020
  • Ingår i: European journal of pharmaceutics and biopharmaceutics. - : ELSEVIER. - 0939-6411 .- 1873-3441. ; 152, s. 236-247
  • Tidskriftsartikel (refereegranskat)abstract
    • OrBiTo was a precompetitive collaboration focused on the development of the next generation of Oral Biopharmaceutics Tools. The consortium included world leading scientists from nine universities, one regulatory agency, one non-profit research organisation, three small/medium sized specialist technology companies together with thirteen pharmaceutical companies. The goal of the OrBiTo project was to deliver a framework for rational application of predictive biopharmaceutics tools for oral drug delivery. This goal was achieved through novel prospective investigations to define new methodologies or refinement of existing tools. Extensive validation has been performed of novel and existing biopharmaceutics tools using historical datasets supplied by industry partners as well as laboratory ring studies. A combination of high quality in vitro and in vivo characterizations of active drugs and formulations have been integrated into physiologically based in silico biopharmaceutics models capturing the full complexity of gastrointestinal drug absorption and some of the best practices has been highlighted. This approach has given an unparalleled opportunity to deliver transformational change in European industrial research and development towards model based pharmaceutical product development in accordance with the vision of model-informed drug development.
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2.
  • Grandadam, M., et al. (författare)
  • Electronic spectral function in the fractionalized pair density wave scenario
  • 2020
  • Ingår i: Physical Review B. - : AMER PHYSICAL SOC. - 2469-9950 .- 2469-9969. ; 102:12
  • Tidskriftsartikel (refereegranskat)abstract
    • Studies of the electronic spectral function in cuprates by angle-resolved photoemission spectroscopy (ARPES) reveal unusual features in the pseudogap phase that persist in the superconducting phase. Here we address these observations based on the recently proposed idea that the pseudogap is due to the fractionalization of modulated particle-particle pairs (a pair density wave) into uniform particle-particle and modulated particle-hole pairs. The constraint that appears between these two types of pairs can be seen has an amplitude for the pseudogap energy scale. This constraint directly modifies the electronic spectral function in the pseudogap phase. We derive a self-consistent equation for the pseudogap amplitude and show that it leads to the formation of Fermi arcs. The band dispersion obtained in the antinodal region is in good agreement with experimental ARPES observations in Pb0.55Bi1.5Sr1.6La0.4CuO6+delta (Bi2201) and present a back-bending that goes to the Fermi level as we go away from the antinodal region. We also discuss the temperature dependence of the ARPES spectrum in the pseudogap and in the superconducting state.
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