| 1. |
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| 2. |
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| 3. |
- Svanberg, Sune, et al.
(författare)
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Applications of terawatt lasers
- 1994
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Ingår i: LASER SPECTROSCOPY - XITH INTERNATIONAL CONFERENCE. - : AIP. - 1551-7616 .- 0094-243X. - 1563962624 ; :290, s. 264-269
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Konferensbidrag (refereegranskat)
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| 4. |
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| 5. |
- Berggård, T, et al.
(författare)
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Alpha1-microglobulin chromophores are located to three lysine residues semiburied in the lipocalin pocket and associated with a novel lipophilic compound
- 1999
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Ingår i: Protein Science. - : Wiley. - 0961-8368. ; 8:12, s. 20-2611
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Tidskriftsartikel (refereegranskat)abstract
- Alpha1-microglobulin (alpha1m) is an electrophoretically heterogeneous plasma protein. It belongs to the lipocalin superfamily, a group of proteins with a three-dimensional (3D) structure that forms an internal hydrophobic ligand-binding pocket. Alpha1m carries a covalently linked unidentified chromophore that gives the protein a characteristic brown color and extremely heterogeneous optical properties. Twenty-one different colored tryptic peptides corresponding to residues 88-94, 118-121, and 122-134 of human alpha1m were purified. In these peptides, the side chains of Lys92, Lys118, and Lys130 carried size heterogeneous, covalently attached, unidentified chromophores with molecular masses between 122 and 282 atomic mass units (amu). In addition, a previously unknown uncolored lipophilic 282 amu compound was found strongly, but noncovalently associated with the colored peptides. Uncolored tryptic peptides containing the same Lys residues were also purified. These peptides did not carry any additional mass (i.e., chromophore) suggesting that only a fraction of the Lys92, Lys118, and Lys130 are modified. The results can explain the size, charge, and optical heterogeneity of alpha1m. A 3D model of alpha1m, based on the structure of rat epididymal retinoic acid-binding protein (ERABP), suggests that Lys92, Lys118, and Lys130 are semiburied near the entrance of the lipocalin pocket. This was supported by the fluorescence spectra of alpha1m under native and denatured conditions, which indicated that the chromophores are buried, or semiburied, in the interior of the protein. In human plasma, approximately 50% of alpha1m is complex bound to IgA. Only the free alpha1m carried colored groups, whereas alpha1m linked to IgA was uncolored.
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| 6. |
- Campieri, M, et al.
(författare)
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Oral budesonide is as effective as oral prednisolone in active Crohn's disease. The Global Budesonide Study Group
- 1997
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Ingår i: Gut. - : BMJ. - 0017-5749 .- 1468-3288. ; 41:2, s. 209-214
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Tidskriftsartikel (refereegranskat)abstract
- Background—The use of corticosteroids in active Crohn’s disease often becomes limited by side effects. Budesonide is a potent corticosteroid with low systemic bioavailability due to an extensive first pass liver metabolism.Aims—To compare the efficacy and safety of two dosage regimens of budesonide and prednisolone in patients with active Crohn’s disease affecting the ileum and/or the ascending colon.Patients and methods—One hundred and seventy eight patients were randomised to receive budesonide controlled ileal release (CIR) capsules 9 mg once daily or 4.5 mg twice daily, or prednisolone tablets 40 mg once daily. The treatment period was 12 weeks. The primary efficacy variable was clinical remission, defined as a Crohn’s Disease Activity Index (CDAI) of 150 or less.Results—After eight weeks of treatment, remission occurred in 60% of patients receiving budesonide once daily or prednisolone and in 42% of those receiving budesonide twice daily (p=0.062). The presence of glucocorticoid associated side effects was similar in all groups; however, moon face was more common in the prednisolone group (p=0.0005). The highest frequency of impaired adrenal function, as measured by a short ACTH test, was found in the prednisolone group (p=0.0023).Conclusions—Budesonide CIR, administered at 9 mg once daily or 4.5 mg twice daily, is comparable to prednisolone in inducing remission in active Crohn’s disease. The single dose administration is as promptly effective as prednisolone and represents a simpler and safer therapeutic approach, with a considerable reduction in side effects.
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| 7. |
- Gadea, A., et al.
(författare)
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Spectroscopy at N=Z with EUROBALL III
- 1999
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Ingår i: AIP Conference Proceedings. - : AIP. - 1551-7616 .- 0094-243X. ; 495, s. 195-198
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Konferensbidrag (refereegranskat)abstract
- A complete study of the nuclear structure by means of gamma spectroscopy requires, in addition to the high resolution gamma measurement and accurate DCO's or angular distributions, the information concerning the Electric or Magnetic character of the transition. This information for transitions in nuclei far from stability valley is now reachable in the new generation of Ge-arrays based in composite detectors. EUROBALL III is a good example with the high polarization sensitivity of the 90 degrees ring of Clovers. The Polarization correlations PCO's measured in coincidence with the Cluster detectors permits to investigate transitions in weakly populated nuclei. In this contribution we present results on medium mass N=Z nuclei measured with EUROBALL III coupled with light particle ancillary detectors.
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| 8. |
- Korsgren, M, et al.
(författare)
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Natural killer cells determine development of allergen-induced eosinophilic airway inflammation in mice
- 1999
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Ingår i: The Journal of experimental medicine. - : Rockefeller University Press. - 0022-1007 .- 1540-9538. ; 189:3, s. 553-562
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Tidskriftsartikel (refereegranskat)abstract
- The earliest contact between antigen and the innate immune system is thought to direct the subsequent antigen-specific T cell response. We hypothesized that cells of the innate immune system, such as natural killer (NK) cells, NK1.1+ T cells (NKT cells), and γ/δ T cells, may regulate the development of allergic airway disease. We demonstrate here that depletion of NK1.1+ cells (NK cells and NKT cells) before immunization inhibits pulmonary eosinophil and CD3+ T cell infiltration as well as increased levels of interleukin (IL)-4, IL-5, and IL-12 in bronchoalveolar lavage fluid in a murine model of allergic asthma. Moreover, systemic allergen-specific immunoglobulin (Ig)E and IgG2a levels and the number of IL-4 and interferon γ–producing splenic cells were diminished in mice depleted of NK1.1+ cells before the priming regime. Depletion of NK1.1+ cells during the challenge period only did not influence pulmonary eosinophilic inflammation. CD1d1 mutant mice, deficient in NKT cells but with normal NK cells, developed lung tissue eosinophilia and allergen-specific IgE levels not different from those observed in wild-type mice. Mice deficient in γ/δ T cells showed a mild attenuation of lung tissue eosinophilia in this model. Taken together, these findings suggest a critical role of NK cells, but not of NKT cells, for the development of allergen-induced airway inflammation, and that this effect of NK cells is exerted during the immunization. If translatable to humans, these data suggest that NK cells may be critically important for deciding whether allergic eosinophilic airway disease will develop. These observations are also compatible with a pathogenic role for the increased NK cell activity observed in human asthma.
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| 9. |
- Kownacki, J, et al.
(författare)
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High-spin studies of the neutron deficient nuclei In-103, In-105, In-107, and In-109
- 1997
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Ingår i: Nuclear Physics A. - 0375-9474 .- 1873-1554. ; 627:2, s. 239-258
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Tidskriftsartikel (refereegranskat)abstract
- High-spin states of the isotopes 103,105,107,109In have been investigated using in-beam γ-ray spectroscopic methods. Results from three different experiments are presented. Targets of 54Fe, 50Cr, and 92Mo were bombarded by a 270 and 261 MeV 58Ni beam and by a 95 MeV 19F beam, respectively. Reaction channel separation was achieved with a charged-particle detector array and in the first two experiments also with a 1π neutron detector system. As a result of these experiments the level schemes of 103,105,107,109In were significantly extended. Excited states of these odd-A indium isotopes are discussed within the framework of the nuclear shell model and the hole-core coupling scheme. The systematics of excited states of light odd-A indium isotopes is also discussed.
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| 10. |
- Landin-Olsson, Mona, et al.
(författare)
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Immunoreactive trypsin(Ogen) in the sera of children with recent-onset insulin-dependent diabetes and matched controls
- 1990
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Ingår i: Pancreas. - : Ovid Technologies (Wolters Kluwer Health). - 0885-3177. ; 5:3, s. 241-247
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Tidskriftsartikel (refereegranskat)abstract
- To evaluate the exocrine pancreatic function at the time of diagnosis of insulin-dependent diabetes mellitus, we determined immunoreactive an-odal and cathodal trypsin(ogen) levels in sera from almost all children (n = 375) 0-14 years of age in Sweden in whom diabetes developed during 1 year, and in sex-, age-, and geographically matched control subjects (n = 312). The median level of anodal trypsin(ogen) was 5 (quartile range, 3-7) µg/L in children with newly diagnosed diabetes, compared with a median level of 7 (quartile range, 4-8) µg/L in control subjects (p < 0.0001). Similarly, the median level of cathodal trypsin(ogen) was 8 (quartile range, 4-10) µg/L in children with diabetes, compared with a median level of 11 (quartile range, 7-15) µg/L in control subjects (p < 0.0001). The median of the individual ratios between cathodal and anodal trypsin(ogen) was 1.4 in the diabetic patients and 1.7 in the control children (p < 0.001). In a multivariate test, however, only the decrease in cathodal trypsin(ogen) concentration was associated with diabetes. The levels of trypsin(ogen)s did not correlate with levels of islet cell antibodies, present in 81% of the diabetic children. Several mechanisms may explain our findings, for example, similar pathogenetic factors may affect both the endocrine and exocrine pancreas simultaneously, a failing local trophic stimulation by insulin on the exocrine cells may decrease the trypsinogen production, and there may be an increased elimination of trypsin(ogen) because of higher filtration through the kidneys in the hyperglycemic state.
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| 11. |
- Leonardson, L., et al.
(författare)
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Nitrogen Retention in Artificially Flooded Meadows
- 1994
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Ingår i: Ambio: a Journal of Human Environment. - 0044-7447. ; 23:6, s. 332-341
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Tidskriftsartikel (refereegranskat)abstract
- Investigations of nitrogen retention in artificially flooded wetlands were performed in southern Sweden during 1991-1993. The purpose of the study was to investigate whether artificial flooding of meadows would be a possible means of reducing the nitrogen content in streams and rivers. Two case studies are presented, one from a sandy/organic soil, one from a peaty soil. Overall nitrogen retention was estimated by mass balance. Denitrification activity and plant biomass incorporation of nitrogen were used to complement and verify the mass-balance data. The study shows that artificial flooding of meadows did not contribute significantly to nitrogen retention in the introduced river water under the irrigation regimes utilized. The technique stimulated mineralization of the soil nitrogen pool to an extent which corresponded to the reduction of nitrate caused by denitrification. In the sandy/organic soil, denitrification was enhanced by the artificial flooding, while in the peat area the activity was lower than in a nonflooded reference area. Plant uptake of nitrogen was stimulated by flooding.
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| 12. |
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| 13. |
- Palacz, M, et al.
(författare)
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In beam gamma-ray spectroscopy of very neutron deficient odd-cadmium isotopes
- 1997
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Ingår i: Acta Physica Polonica B. - : ACTA PHYSICA POLONICA B, JAGELLONIAN UNIV, INST PHYSICS. - 0587-4254 .- 1509-5770. ; 28:1-2, s. 309-313
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Tidskriftsartikel (refereegranskat)abstract
- Excited states in the very neutron deficient odd cadmium isotopes Cd-99, Cd-101 and Cd-103 are discussed in terms of the nuclear shell model. Systematics of excited states in Cd99-109 is presented.
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| 14. |
- Persson, J, et al.
(författare)
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In-beam gamma-ray spectroscopy of Cd-102
- 1997
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Ingår i: Nuclear Physics A. - : ELSEVIER SCIENCE BV. - 0375-9474 .- 1873-1554. ; 627:1, s. 101-118
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Tidskriftsartikel (refereegranskat)abstract
- Neutron deficient nuclei close to 100Sn have been studied using the NORDBALL Ge-detector array together with ancillary particle detectors. Evaporation residues from the compound nucleus 108Te were identified with charged particle and neutron detectors. In this paper a considerable extension of the level scheme of the nucleus 102Cd is presented. The strongest cascade of the new level scheme reveals an irregular sequence of dipole transitions above Iπ = 10+ extending up to spin 17. A strongly populated rather regular side band consisting of four quadrupole transitions ranging from spin 9 to spin 17 was also discovered. This band was tentatively assigned negative parity. Shell model calculations were performed and a very good agreement with the experimental results was found. The excited states could successfully be interpreted as neutron particle and proton hole excitations with respect to the doubly closed core 50100Sn50.
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| 15. |
- Persson, J, et al.
(författare)
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New spectroscopic data on Cd-102
- 1996
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Ingår i: Acta Physica Polonica B. - : POLISH ACAD SCIENCES INST PHYSICS. - 0587-4254 .- 1509-5770. ; 27:1-2, s. 171-178
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Tidskriftsartikel (refereegranskat)abstract
- Gamma ray spectroscopy of neutron deficient nuclei close to the doubly magic nucleus Sn-100 has been performed using a heavy-ion reaction and the NORDBALL Ge-detector array. Evaporation residues were identified by means of charged particle and neutron detection. Transitions in 31 different evaporation residues were identified. New results on Cd-102 are presented.
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| 16. |
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| 17. |
- Sundqvist, Bertil, et al.
(författare)
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Physical properties of pressure polymerized C60
- 1996
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Ingår i: Proceedings of the Symposium on Recent Advances in the Chemistry and Physics of Fullerenes and Related Materials. - Pennington, NJ : Electrochemical Society, Incorporated. - 1566771625 ; , s. 1014-1028
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Konferensbidrag (refereegranskat)
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| 18. |
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| 19. |
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| 20. |
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| 21. |
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| 22. |
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| 23. |
- Anderson, D, et al.
(författare)
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Analysis of profile effects on high Q subignited Tokamak fusion plasmas
- 1998
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Ingår i: PHYSICA SCRIPTA. - : ROYAL SWEDISH ACAD SCIENCES. - 0281-1847. ; 58:3, s. 256-261
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- An analysis is made of the maximum power multiplication factor Q, achievble in subignited Tokamak fusion plasmas where the burn is sustained by feedback controlled auxiliary heating. Using a 1-D model equation for the plasma temperature, simple analytical
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| 24. |
- Andersson, Eva, 1955, et al.
(författare)
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Mortality from asthma and cancer among sulfite mill workers.
- 1998
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Ingår i: Scandinavian journal of work, environment & health. - 0355-3140. ; 24:1, s. 12-7
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: The aims of the present case-referent study were to investigate whether sulfite workers show increased mortality from asthma, chronic obstructive pulmonary disease or certain malignancies of interest in relation to sulfite mill work. The main exposure from the pulping processes is from sulfur dioxide, wood dust and terpenes. METHODS: The subjects of the study were all the men who died between 1960 and 1989 and who were aged 40 to 75 years at death (N = 780) in the parishes surrounding 3 sulfite mills. The men who died from asthma (N = 13), COPD (N = 20), lung cancer (N = 33), stomach cancer (N = 35), or brain tumor (N = 10) formed the case group. All the subjects, except the cases in question, were used as referents. As a proxy variable of exposure, job titles from the registers of deaths and burials were used, and 24% of the subjects were classified as exposed. RESULTS: There was an increased mortality from asthma [odds ratio(OR) 2.8, 90% confidence interval (90% CI) 1.1-6.8] and brain tumors (OR 3.3, 90% CI 1.2-8.9) among the sulfite workers. The mortality due to lung cancer was not significantly increased (OR 1.4, 90% CI 0.7-2.6), and there was a reduced mortality from stomach cancer (OR 0.4, 90% CI 0.2-0.9). CONCLUSIONS: The increased asthma mortality may be due to accidental exposure to irritating gases, such as sulfur dioxide. The increased risk for brain tumors has no obvious explanation.
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| 25. |
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| 26. |
- Axelsson, A, et al.
(författare)
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Excited superdeformed band in Eu-143
- 1999
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Ingår i: European Physical Journal A. - : Springer Science and Business Media LLC. - 1434-6001 .- 1434-601X. ; 6:2, s. 175-183
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Tidskriftsartikel (refereegranskat)abstract
- A new superdeformed band has been discovered in a EUROBALL experiment and assigned to Eu-143. It has a maximum intensity of 35% of the Eu-143 yrast superdeformed band and the transition energies of the two bands are very similar. Based on comparison with cranked shell model calculations the new band is tentatively assigned the high-N intruder configuration pi 6(2)nu 7(0) and the parity and signature quantum numbers (pi, alpha) = (-1, +1/2). In addition to the already known high-energy transition at 3361 keV another discrete line at 2715 keV was found to be in coincidence with the yrast superdeformed band. However, it was not possible to connect the decay out of either of the superdeformed bands to, known normally deformed states.
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| 27. |
- Axelsson, A, et al.
(författare)
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Excited superdeformed band in Eu-143
- 1999
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Ingår i: EUROPEAN PHYSICAL JOURNAL A. - : SPRINGER VERLAG. - 1434-6001. ; 6:2, s. 175-183
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- A new superdeformed band has been discovered in a EUROBALL experiment and assigned to Eu-143. It has a maximum intensity of 35% of the Eu-143 yrast superdeformed band and the transition energies of the two bands are very similar. Based on comparison with
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| 28. |
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| 29. |
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| 30. |
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| 31. |
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| 32. |
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| 33. |
- Dale, S, et al.
(författare)
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A mobile tomographic gamma camera system for acute studies
- 1997
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Ingår i: IEEE TRANSACTIONS ON NUCLEAR SCIENCE. - : Institute of Electrical and Electronics Engineers (IEEE). - 0018-9499 .- 1558-1578. ; 44:2, s. 199-203
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 34. |
- De Angelis, G., et al.
(författare)
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Collective Excitations in the Vicinity of N=Z
- 1999. - 1 SUPPL. 1
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Ingår i: Proceedings INPC 1998. - 0375-9474. ; 654, s. 659-662
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Konferensbidrag (refereegranskat)abstract
- In our contribution to the INPC98 conference we reported on the experimental investigation of high spin collective states in medium and heavy mass N≈Z nuclei at LNL. The main purpose is to set light on the role of the proton-neutron interaction in the collective behavior of the nucleus. In medium mass N=Z nuclei, in contrast with the stable nuclei, valence protons and neutrons occupy the same orbitals and one may expect a reinforcement of neutron-proton T=0 (np) pairing correlations[1]. In this interesting subject, the medium mass N=Z=36 72Kr has been studied and completely reported in [2]. In this proceedings we will concentrate in unpublished results concerning the onset of collectivity on nearly spherical nuclei in the 100Sn region. In nuclei with Z=50 and Z=49 dipole bands have been found indicating the presence of "Magnetic Rotation" [3].
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| 35. |
- Dechevski, Ljubomir T., et al.
(författare)
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Sharp generalized Carleman inequalities with minimal information about the spectrum
- 1994
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Ingår i: Mathematische Nachrichten. - : Wiley. - 0025-584X .- 1522-2616. ; 168:1, s. 61-77
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Tidskriftsartikel (refereegranskat)abstract
- Let H and T: H → H denote a separable Hilbert space and an operator in a Schatten-von Neumann ideal Sp(H), respectively. Consider the resolvent operator (λI - T)−1, where I is the identity operator and λ belongs to the resolvent set of T. Some sharp bounds for the uniform operator norm of (λI - T)−1 are derived in some situations of particular interest for certain applications, namely when only partial or minimal information about the spectrum is available. The results obtained may also be regarded as generalizations of Carleman's inequality for quasinilpotent operators.
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| 36. |
- Dechevsky, Ljubomir T., et al.
(författare)
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On sharpness, applications and generalizations of some Carleman type inequalities
- 1996
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Ingår i: Tohoku mathematical journal. - : Mathematical Institute, Tohoku University. - 0040-8735. ; 48:1, s. 1-22
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Tidskriftsartikel (refereegranskat)abstract
- Carleman’s inequality for Hilbert-Schmidt operators and its generalizations for Schatten-von Neumann operator ideals (see [7]) are shown to be sharp in a certain sense. Explicit classes of extremizing operators are found on which the generalized Carleman inequalities turn to asymptotic equalities. Applications are made to a priori estimation of the solutions of Fredholm and Volterra first- and second kind integral equations and to perturbation and error analysis. Some further generalizations are considered which extend the applications to singular integral equations, pseudodifferential equations and analytic functions of operator argument.
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| 37. |
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| 38. |
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| 39. |
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| 40. |
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| 41. |
- FALKEBORN, M, et al.
(författare)
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Validity of information on gynecological operations in the Swedish in-patient registry
- 1995
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Ingår i: Scandinavian journal of social medicine. - : SAGE Publications. - 0300-8037. ; 23:3, s. 220-224
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Tidskriftsartikel (refereegranskat)abstract
- In order to validate information held at the Swedish Inpatient Registry on oophorectomy and/or hysterectomy procedures, the register codes were compared with data from the medical records in a random sample of 1,338 women. Only 1% of these codes were missing but 5% were erroneous, which in most cases meant that the oophorectomy had been misclassified. The positive predictive value of operation codes was high, ranging from 86 to 100% of the registered events. The actual procedures among women registered with a code for hysterectomy with or without oophorectomy comprised hysterectomy alone in 47% of the women and hysterectomy with a bilateral or unilateral oophorectomy in 30% and 20%, respectively. The reliability of register codes for major gynecological surgical procedures is good, but when the code for hysterectomy is used, medical record data are needed to ascertain the ovarian status. Revised codes are therefore recommended.
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| 42. |
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| 43. |
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| 44. |
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| 45. |
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| 46. |
- Frisk, J., et al.
(författare)
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Exercise and smoking habits among Swedish postmenopausal women
- 1997
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Ingår i: British Journal of Sports Medicine. - : BMJ Publishing Group Ltd. - 0306-3674 .- 1473-0480. ; 31:3, s. 217-223
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To assess exercise habits and their relation to smoking habits and social and medical factors in postmenopausal women.Methods: A cross-sectional study with a questionnaire to all 1324 55-56 year old women in Linkoping, Sweden.Results: Response rate was 85%. About a third of the women took part in some kind of quite strenuous exercise for at least one hour a week. About a quarter worked out once a week; fewer did swimming and jogging. One in four women smoked. Women who used hormone replacement therapy, who were not smoking and who had a physically light occupation more often took part in strenuous sports. Women who had been treated for malignancies or with back problems exercised to the same extent as women in the general population.Conclusion: About a third of the post-menopausal women exercised on a regular basis, if exercise involved in getting to and ti om work was not counted. Since regular physical exercise has many health benefits, more women should be encouraged to take part in regular physical exercise. Factors probably associated with level of education and general awareness of the importance of a healthy Lifestyle positively influenced the likelihood of these women to be physically active on a regular basis. A previous malignant disease or current back problems did not prevent women from taking part in exercise on a regular basis.
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| 47. |
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| 48. |
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| 49. |
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| 50. |
- Gorska, M, et al.
(författare)
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Cd-98(48)50 : The two-proton-hole spectrum in Sn-100(50)50
- 1997
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 79:13, s. 2415-2418
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Tidskriftsartikel (refereegranskat)abstract
- Excited states in Cd-98, two proton holes from Sn-100, were identified and studied for the first time, using in-beam spectroscopy with highly selective ancillary detectors. The structure of the (pi g(9/2))(-2) two-proton-hole spectrum below a T-1/2 = 0.48(16) mu s isomer is deduced and compared to shell-model predictions. A tentative I-pi = (8(+)) assignment, as suggested by systematics, yields a strongly reduced B(E2,8(+) --> 6(+)) = 0.44((+20)(-10)) W.u., corresponding to an effective proton charge of e(pi) = 0.85((+20)(-10))e, which is at variance with existing theoretical predictions.
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