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1.	Kam, K., et al. (författare) Sleep oscillation-specific associations with Alzheimer's disease CSF biomarkers: novel roles for sleep spindles and tau 2019 Ingår i: Molecular Neurodegeneration. - : Springer Science and Business Media LLC. - 1750-1326. ; 14 Tidskriftsartikel (refereegranskat)abstract BackgroundBased on associations between sleep spindles, cognition, and sleep-dependent memory processing, here we evaluated potential relationships between levels of CSF A(42), P-tau, and T-tau with sleep spindle density and other biophysical properties of sleep spindles in a sample of cognitively normal elderly individuals.MethodsOne-night in-lab nocturnal polysomnography (NPSG) and morning to early afternoon CSF collection were performed to measure CSF A(42), P-tau and T-tau. Seven days of actigraphy were collected to assess habitual total sleep time.ResultsSpindle density during NREM stage 2 (N2) sleep was negatively correlated with CSF A(42), P-tau and T-tau. From the three, CSF T-tau was the most significantly associated with spindle density, after adjusting for age, sex and ApoE4. Spindle duration, count and fast spindle density were also negatively correlated with T-tau levels. Sleep duration and other measures of sleep quality were not correlated with spindle characteristics and did not modify the associations between sleep spindle characteristics and the CSF biomarkers of AD.ConclusionsReduced spindles during N2 sleep may represent an early dysfunction related to tau, possibly reflecting axonal damage or altered neuronal tau secretion, rendering it a potentially novel biomarker for early neuronal dysfunction. Given their putative role in memory consolidation and neuroplasticity, sleep spindles may represent a mechanism by which tau impairs memory consolidation, as well as a possible target for therapeutic interventions in cognitive decline.
2.	Wain, LV, et al. (författare) Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank 2015 Ingår i: The Lancet. Respiratory medicine. - 2213-2619. ; 3:10, s. 769-781 Tidskriftsartikel (refereegranskat)

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Typ av publikation: tidskriftsartikel (2)

Typ av innehåll: refereegranskat (2)

Författare/redaktör: Blennow, Kaj, 1958 (1); Lewin, M. (1); Chen, Z. (1); Zetterberg, Henrik, ... (1); McCarthy, M. (1); Postma, DS (1); visa fler...; Melen, E (1); Ramasamy, A (1); Shrine, N (1); Tobin, MD (1); Wain, LV (1); Deloukas, P. (1); Zeggini, E (1); Strachan, DP (1); Andrade, A (1); Morris, AP (1); Marchini, J (1); Mihailov, E (1); Artigas, MS (1); Miller, S (1); Kheirallah, AK (1); Ntalla, I (1); Obeidat, M (1); Bosse, Y (1); Sayers, I (1); Hall, IP (1); Hansell, AL (1); Hubbard, R (1); Jackson, VE (1); Pavord, I (1); Thomson, NC (1); Osorio, R. S. (1); Magi, R (1); Hao, K (1); Freeman, C (1); de Leon, M. J. (1); Delaneau, O (1); Mosconi, L (1); O'Connell, J (1); Frangou, E (1); Cook, JP (1); Kam, K. (1); Parekh, A. (1); Sharma, R. A. (1); Castillo, B. (1); Bubu, O. M. (1); Chua, N. J. (1); Miller, M. D. (1); Mullins, A. E. (1); Glodzik, L. (1); visa färre...

Lärosäte: Göteborgs universitet (1); Karolinska Institutet (1)

Språk: Engelska (2)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (1)

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