| 1. |
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| 2. |
- Böhm, M., et al.
(author)
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The conservation status of the world’s freshwater molluscs
- 2021
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In: Hydrobiologia. - : Springer Science and Business Media LLC. - 0018-8158 .- 1573-5117. ; 848, s. 3231-3254
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Journal article (peer-reviewed)abstract
- With the biodiversity crisis continuing unchecked, we need to establish levels and drivers of extinction risk, and reassessments over time, to effectively allocate conservation resources and track progress towards global conservation targets. Given that threat appears particularly high in freshwaters, we assessed the extinction risk of 1428 randomly selected freshwater molluscs using the IUCN Red List Categories and Criteria, as part of the Sampled Red List Index project. We show that close to one-third of species in our sample are estimated to be threatened with extinction, with highest levels of threat in the Nearctic, Palearctic and Australasia and among gastropods. Threat levels were higher in lotic than lentic systems. Pollution (chemical and physical) and the modification of natural systems (e.g. through damming and water abstraction) were the most frequently reported threats to freshwater molluscs, with some regional variation. Given that we found little spatial congruence between species richness patterns of freshwater molluscs and other freshwater taxa, apart from crayfish, new additional conservation priority areas emerged from our study. We discuss the implications of our findings for freshwater mollusc conservation, the adequacy of a sampled approach and important next steps to estimate trends in freshwater mollusc extinction risk over time. © 2020, Springer Nature Switzerland AG.
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| 3. |
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| 4. |
- Hwang, K-J, et al.
(author)
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Magnetic Reconnection Inside a Flux Rope Induced by Kelvin-Helmholtz Vortices
- 2020
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In: Journal of Geophysical Research - Space Physics. - 2169-9380 .- 2169-9402. ; 125:4
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Journal article (peer-reviewed)abstract
- On 5 May 2017, MMS observed a crater-type flux rope on the dawnside tailward magnetopause with fluctuations. The boundary-normal analysis shows that the fluctuations can be attributed to nonlinear Kelvin-Helmholtz (KH) waves. Reconnection signatures such as flow reversals and Joule dissipation were identified at the leading and trailing edges of the flux rope. In particular, strong northward electron jets observed at the trailing edge indicated midlatitude reconnection associated with the 3-D structure of the KH vortex. The scale size of the flux rope, together with reconnection signatures, strongly supports the interpretation that the flux rope was generated locally by KH vortex-induced reconnection. The center of the flux rope also displayed signatures of guide-field reconnection (out-of-plane electron jets, parallel electron heating, and Joule dissipation). These signatures indicate that an interface between two interlinked flux tubes was undergoing interaction, causing a local magnetic depression, resulting in an M-shaped crater flux rope, as supported by reconstruction.
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| 5. |
- Hwang, K. -J, et al.
(author)
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Microscale Processes Determining Macroscale Evolution of Magnetic Flux Tubes along Earth's Magnetopause
- 2021
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In: Astrophysical Journal. - : Institute of Physics Publishing (IOPP). - 0004-637X .- 1538-4357. ; 914:1
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Journal article (peer-reviewed)abstract
- An important process affecting solar wind-Earth's magnetosphere coupling is nonsteady dayside magnetic reconnection, observationally evidenced by a flux transfer event (FTE) that shows a bipolar variation of the magnetic field component normal to the magnetopause. FTEs often consist of two interlinked flux tubes, but, local kinetic processes between the flux tubes are not understood in the context of the FTE structuring, evolution, and impact. An FTE observed by the Magnetospheric Multiscale mission on 2017 December 18 consisted of two flux tubes of different topology. One includes field lines with ends connected to the northern and southern hemispheres while the other includes field lines with both ends connected to the magnetosheath. Reconnection occurring at the flux-tube interface indicates how interacting flux tubes evolve into a flux rope with helical magnetic topology that is either closed or open. This study demonstrates a new aspect of how micro- to meso-scale dynamics occurring within FTEs determines their macroscale characteristics and evolution.
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| 6. |
- Falster, Daniel, et al.
(author)
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AusTraits, a curated plant trait database for the Australian flora
- 2021
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In: Scientific Data. - : Nature Portfolio. - 2052-4463. ; 8:1
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Journal article (peer-reviewed)abstract
- We introduce the AusTraits database - a compilation of values of plant traits for taxa in the Australian flora (hereafter AusTraits). AusTraits synthesises data on 448 traits across 28,640 taxa from field campaigns, published literature, taxonomic monographs, and individual taxon descriptions. Traits vary in scope from physiological measures of performance (e.g. photosynthetic gas exchange, water-use efficiency) to morphological attributes (e.g. leaf area, seed mass, plant height) which link to aspects of ecological variation. AusTraits contains curated and harmonised individual- and species-level measurements coupled to, where available, contextual information on site properties and experimental conditions. This article provides information on version 3.0.2 of AusTraits which contains data for 997,808 trait-by-taxon combinations. We envision AusTraits as an ongoing collaborative initiative for easily archiving and sharing trait data, which also provides a template for other national or regional initiatives globally to fill persistent gaps in trait knowledge.
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| 7. |
- Hwang, K.-J., et al.
(author)
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Bifurcated Current Sheet Observed on the Boundary of Kelvin-Helmholtz Vortices
- 2021
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In: Frontiers in Astronomy and Space Sciences. - : Frontiers Media S.A.. - 2296-987X. ; 8
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Journal article (peer-reviewed)abstract
- On May 5, 2017 MMS observed a bifurcated current sheet at the boundary of Kelvin-Helmholtz vortices (KHVs) developed on the dawnside tailward magnetopause. We use the event to enhance our understanding of the formation and structure of asymmetric current sheets in the presence of density asymmetry, flow shear, and guide field, which have been rarely studied. The entire current layer comprises three separate current sheets, each corresponding to magnetosphere-side sunward separatrix region, central near-X-line region, and magnetosheath-side tailward separatrix region. Two off-center structures are identified as slow-mode discontinuities. All three current sheets have a thickness of ∼0.2 ion inertial length, demonstrating the sub-ion-scale current layer, where electrons mainly carry the current. We find that both the diamagnetic and electron anisotropy currents substantially support the bifurcated currents in the presence of density asymmetry and weak velocity shear. The combined effects of strong guide field, low density asymmetry, and weak flow shear appear to lead to asymmetries in the streamlines and the current-layer structure of the quadrupolar reconnection geometry. We also investigate intense electrostatics waves observed on the magnetosheath side of the KHV boundary. These waves may pre-heat a magnetosheath population that is to participate into the reconnection process, leading to two-step energization of the magnetosheath plasma entering into the magnetosphere via KHV-driven reconnection.
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| 8. |
- Hwang, K. -J, et al.
(author)
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Sequential Observations of Flux Transfer Events, Poleward-Moving Auroral Forms, and Polar Cap Patches
- 2020
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In: Journal of Geophysical Research - Space Physics. - : AMER GEOPHYSICAL UNION. - 2169-9380 .- 2169-9402. ; 125:6
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Journal article (peer-reviewed)abstract
- We report the observation of solar wind-magnetosphere-ionosphere interactions using a series of flux transfer events (FTEs) observed by Magnetospheric MultiScale (MMS) mission located near the dayside magnetopause on 18 December 2017. The FTEs were observed to propagate duskward and either southward or slightly northward, as predicted under duskward and southward interplanetary magnetic field (IMF). The Cooling model also predicted a significant dawnward propagation of northward-moving FTEs. Near the MMS footprint, a series of poleward-moving auroral forms (PMAFs) occurred almost simultaneously with those FTEs. They propagated poleward and westward, consistent with the modeled FTE propagation. The intervals between FTEs, relatively consistent with those between PMAFs, strongly suggest a one-to-one correspondence between the dayside transients and ionospheric responses. The FTEs embedded in continuous reconnection observed by MMS and corresponding PMAFs individually occurred during persistent auroral activity recorded by an all-sky imager strongly indicate that those FTEs/PMAFs resulted from the temporal modulation of the reconnection rate during continuous reconnection. With the decay of the PMAFs associated with the FTEs, patch-like plasma density enhancements were detected to form and propagate poleward and then dawnward. Propagation to the dawn was also suggested by the Super Dual Auroral Radar Network (SuperDARN) convection and Global Positioning System (GPS) total electron content data. We relate the temporal variation of the driving solar-wind and magnetospheric mechanism to that of the high-latitude and polar ionospheric responses and estimate the response time.
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| 9. |
- Kitamura, N., et al.
(author)
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Direct observations of energy transfer from resonant electrons to whistler-mode waves in magnetosheath of Earth
- 2022
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In: Nature Communications. - : Springer Nature. - 2041-1723. ; 13:1
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Journal article (peer-reviewed)abstract
- Excitation of whistler-mode waves by cyclotron instability is considered as the likely generation process of the waves. Here, the authors show direct observational evidence for locally ongoing secular energy transfer from the resonant electrons to the whistler-mode waves in Earth's magnetosheath. Electromagnetic whistler-mode waves in space plasmas play critical roles in collisionless energy transfer between the electrons and the electromagnetic field. Although resonant interactions have been considered as the likely generation process of the waves, observational identification has been extremely difficult due to the short time scale of resonant electron dynamics. Here we show strong nongyrotropy, which rotate with the wave, of cyclotron resonant electrons as direct evidence for the locally ongoing secular energy transfer from the resonant electrons to the whistler-mode waves using ultra-high temporal resolution data obtained by NASA's Magnetospheric Multiscale (MMS) mission in the magnetosheath. The nongyrotropic electrons carry a resonant current, which is the energy source of the wave as predicted by the nonlinear wave growth theory. This result proves the nonlinear wave growth theory, and furthermore demonstrates that the degree of nongyrotropy, which cannot be predicted even by that nonlinear theory, can be studied by observations.
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| 10. |
- Lundberg, T. R., et al.
(author)
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The International Olympic Committee framework on fairness, inclusion and nondiscrimination on the basis of gender identity and sex variations does not protect fairness for female athletes
- 2024
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In: Scandinavian Journal of Medicine and Science in Sports. - : Wiley. - 0905-7188 .- 1600-0838. ; 34:3
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Journal article (peer-reviewed)abstract
- The International Olympic Committee (IOC) recently published a framework on fairness, inclusion, and nondiscrimination on the basis of gender identity and sex variations. Although we appreciate the IOC's recognition of the role of sports science and medicine in policy development, we disagree with the assertion that the IOC framework is consistent with existing scientific and medical evidence and question its recommendations for implementation. Testosterone exposure during male development results in physical differences between male and female bodies; this process underpins male athletic advantage in muscle mass, strength and power, and endurance and aerobic capacity. The IOC's “no presumption of advantage” principle disregards this reality. Studies show that transgender women (male-born individuals who identify as women) with suppressed testosterone retain muscle mass, strength, and other physical advantages compared to females; male performance advantage cannot be eliminated with testosterone suppression. The IOC's concept of “meaningful competition” is flawed because fairness of category does not hinge on closely matched performances. The female category ensures fair competition for female athletes by excluding male advantages. Case-by-case testing for transgender women may lead to stigmatization and cannot be robustly managed in practice. We argue that eligibility criteria for female competition must consider male development rather than relying on current testosterone levels. Female athletes should be recognized as the key stakeholders in the consultation and decision-making processes. We urge the IOC to reevaluate the recommendations of their Framework to include a comprehensive understanding of the biological advantages of male development to ensure fairness and safety in female sports.
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| 11. |
- Perri, S., et al.
(author)
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On the deviation from Maxwellian of the ion velocity distribution functions in the turbulent magnetosheath
- 2020
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In: Journal of Plasma Physics. - : CAMBRIDGE UNIV PRESS. - 0022-3778 .- 1469-7807. ; 86:1
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Journal article (peer-reviewed)abstract
- The deviation from thermodynamic equilibrium of the ion velocity distribution functions (VDFs), as measured by the Magnetospheric Multiscale (MMS) mission in the Earth's turbulent magnetosheath, is quantitatively investigated. Making use of the unprecedented high-resolution MMS ion data, and together with Vlasov-Maxwell simulations, this analysis aims at investigating the relationship between deviation from Maxwellian equilibrium and typical plasma parameters. Correlations of the non-Maxwellian features with plasma quantities such as electric fields, ion temperature, current density and ion vorticity are found to be similar in magnetosheath data and numerical experiments, with a poor correlation between distortions of ion VDFs and current density, evidence that questions the occurrence of VDF departure from Maxwellian at the current density peaks. Moreover, strong correlation has been observed with the magnitude of the electric field in the turbulent magnetosheath, while a certain degree of correlation has been found in the numerical simulations and during a magnetopause crossing by MMS. This work could help shed light on the influence of electrostatic waves on the distortion of the ion VDFs in space turbulent plasmas.
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| 12. |
- Yao, S. T., et al.
(author)
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Low-frequency Whistler Waves Modulate Electrons and Generate Higher-frequency Whistler Waves in the Solar Wind
- 2021
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In: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 923:2
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Journal article (peer-reviewed)abstract
- The role of whistler-mode waves in the solar wind and the relationship between their electromagnetic fields and charged particles is a fundamental question in space physics. Using high-temporal-resolution electromagnetic field and plasma data from the Magnetospheric MultiScale spacecraft, we report observations of low-frequency whistler waves and associated electromagnetic fields and particle behavior in the Earth's foreshock. The frequency of these whistler waves is close to half the lower-hybrid frequency (similar to 2 Hz), with their wavelength close to the ion gyroradius. The electron bulk flows are strongly modulated by these waves, with a modulation amplitude comparable to the solar wind velocity. At such a spatial scale, the electron flows are forcibly separated from the ion flows by the waves, resulting in strong electric currents and anisotropic ion distributions. Furthermore, we find that the low-frequency whistler wave propagates obliquely to the background magnetic field ( B (0)), and results in spatially periodic magnetic gradients in the direction parallel to B (0). Under such conditions, large pitch-angle electrons are trapped in wave magnetic valleys by the magnetic mirror force, and may provide free perpendicular electron energy to excite higher-frequency whistler waves. This study offers important clues and new insights into wave-particle interactions, wave generation, and microscale energy conversion processes in the solar wind.
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| 13. |
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| 14. |
- Chen, L-J, et al.
(author)
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Lower-Hybrid Drift Waves Driving Electron Nongyrotropic Heating and Vortical Flows in a Magnetic Reconnection Layer
- 2020
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In: Physical Review Letters. - : American Physical Society (APS). - 0031-9007 .- 1079-7114. ; 125:2
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Journal article (peer-reviewed)abstract
- We report measurements of lower-hybrid drift waves driving electron heating and vortical flows in an electron-scale reconnection layer under a guide field. Electrons accelerated by the electrostatic potential of the waves exhibit perpendicular and nongyrotropic heating. The vortical flows generate magnetic field perturbations comparable to the guide field magnitude. The measurements reveal a new regime of electron-wave interaction and how this interaction modifies the electron dynamics in the reconnection layer.
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| 15. |
- Gumz, Michelle L, et al.
(author)
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Toward Precision Medicine : Circadian Rhythm of Blood Pressure and Chronotherapy for Hypertension - 2021 NHLBI Workshop Report
- 2023
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In: Hypertension. - : Wolters Kluwer. - 0194-911X .- 1524-4563. ; 80:3, s. 503-522
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Journal article (peer-reviewed)abstract
- Healthy individuals exhibit blood pressure variation over a 24-hour period with higher blood pressure during wakefulness and lower blood pressure during sleep. Loss or disruption of the blood pressure circadian rhythm has been linked to adverse health outcomes, for example, cardiovascular disease, dementia, and chronic kidney disease. However, the current diagnostic and therapeutic approaches lack sufficient attention to the circadian rhythmicity of blood pressure. Sleep patterns, hormone release, eating habits, digestion, body temperature, renal and cardiovascular function, and other important host functions as well as gut microbiota exhibit circadian rhythms, and influence circadian rhythms of blood pressure. Potential benefits of nonpharmacologic interventions such as meal timing, and pharmacologic chronotherapeutic interventions, such as the bedtime administration of antihypertensive medications, have recently been suggested in some studies. However, the mechanisms underlying circadian rhythm-mediated blood pressure regulation and the efficacy of chronotherapy in hypertension remain unclear. This review summarizes the results of the National Heart, Lung, and Blood Institute workshop convened on October 27 to 29, 2021 to assess knowledge gaps and research opportunities in the study of circadian rhythm of blood pressure and chronotherapy for hypertension.
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| 16. |
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| 17. |
- Kitamura, N., et al.
(author)
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Observations of the Source Region of Whistler Mode Waves in Magnetosheath Mirror Structures
- 2020
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In: Journal of Geophysical Research - Space Physics. - : American Geophysical Union (AGU). - 2169-9380 .- 2169-9402. ; 125:5
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Journal article (peer-reviewed)abstract
- In the magnetosheath, intense whistler mode waves, called "Lion roars," are often detected in troughs of magnetic field intensity in mirror mode structures. Using data obtained by the four Magnetospheric Multiscale (MMS) spacecraft, we show that reversals of gradient of magnetic field intensity along the magnetic field correspond to reversals of the field-aligned component of Poynting flux of whistler mode waves in the troughs. Such a characteristic is consistent with the idea that the whistler mode waves are effectively generated near the local minima of magnetic field intensity because of the smallest cyclotron resonance velocity and propagate toward regions of larger magnetic field intensity along the magnetic field lines on both sides. We use the reversal of the Poynting flux as an indicator of wave source regions. In these regions, we find that pancake or an outer edge of butterfly electron distributions above similar to 100 eV are good candidates for wave generation. Unclear correlations of phase difference and amplitude variations of whistler mode waves in cases of similar to 40 km spacecraft separation indicate that a simple plane wave approximation with a constant amplitude is not valid at this spatial scale that is much smaller than the ion gyroradius. The whistler mode waves consist of small coherent wave packets from multiple sources with spatial scales smaller than tens of electron gyroradii transverse to the background magnetic field in a mirror mode structure.
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| 18. |
- Pollock, C. J., et al.
(author)
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Dynamics of Earth's bow shock under near-radial interplanetary magnetic field conditions
- 2022
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In: Physics of Plasmas. - : AIP Publishing. - 1070-664X .- 1089-7674. ; 29:11
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Journal article (peer-reviewed)abstract
- We investigate the dynamics of Earth's quasi-parallel terrestrial bow shock based on measurements from the Magnetospheric MultiScale (MMS) spacecraft constellation during a period of near-radial interplanetary magnetic conditions, when the interplanetary magnetic field and the solar wind (SW) velocity are nearly anti-parallel. High-speed earthward ion flows with properties that are similar to those of the pristine SW are observed to be embedded within the magnetosheath-like plasma. These flows are accompanied by Interplanetary Magnetic Field (IMF) intensity of less than about 10 nT, compared to nearby magnetosheath intensities of generally greater than 10 nT. The high-speed flow intervals are bounded at their leading and trailing edges by intense fluxes of more energetic ions and large amplitude quasi-sinusoidal magnetic oscillations, similar to ultra-low frequency waves known to steepen and pileup on approach toward Earth to form the quasi-parallel bow shock. The MMS string-of-pearls configuration is aligned with the outbound trajectory and provides inter-spacecraft separations of several hundred km along its near 10(3) length, allowing sequential observation of the plasma and magnetic field signatures during the event by the four spacecraft. The SW-like interval is most distinct at the outer-most MMS-2 and sequentially less distinct at each of the trailing MMS spacecraft. We discuss the interpretation of this event alternatively as MMS having observed a quasi-rigid bow shock contraction/expansion cycle, ripples or undulations propagating on the bow shock surface, or a more spatially local evolution in the context of either a deeply deformed shock surface or a porous shock surface, as in the three-dimensional patchwork concept of the quasi-parallel bow shock, under the extant near-radial IMF condition. Published under an exclusive license by AIP Publishing.
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| 20. |
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| 21. |
- Bagaria, Sanjay P., et al.
(author)
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Morbidity and Outcomes After Distal Pancreatectomy for Primary Retroperitoneal Sarcoma : An Analysis by the Trans-Atlantic Australasian Retroperitoneal Sarcoma Working Group
- 2021
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In: Annals of Surgical Oncology. - : Springer Science and Business Media LLC. - 1068-9265 .- 1534-4681. ; 28:11, s. 6882-6889
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Journal article (peer-reviewed)abstract
- Background: Multi-visceral resection often is used in the treatment of retroperitoneal sarcoma (RPS). The morbidity after distal pancreatectomy for primary pancreatic cancer is well-documented, but the outcomes after distal pancreatectomy for primary RPS are not. This study aimed to evaluate morbidity and oncologic outcomes after distal pancreatectomy for primary RPS. Methods: In this study, 26 sarcoma centers that are members of the Trans-Atlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG) retrospectively identified consecutive patients who underwent distal pancreatectomy for primary RPS from 2008 to 2017. The outcomes measured were 90-day severe complications (Clavien-Dindo ≥ 3), postoperative pancreatic fistula (POPF) rate, and oncologic outcomes. Results: Between 2008 and 2017, 280 patients underwent distal pancreatectomy for primary RPS. The median tumor size was 25 cm, and the median number of organs resected, including the pancreas, was three. In 96% of the operations, R0/R1 resection was achieved. The 90-day severe complication rate was 40 %. The grades B and C POPF complication rates were respectively 19% and 5% and not associated with worse overall survival. Administration of preoperative radiation and factors to mitigate POPF did not have an impact on the risk for the development of a POPF. The RPS invaded the pancreas in 38% of the patients, and local recurrence was doubled for the patients who had a microscopic, positive pancreas margin (hazard ratio, 2.0; p = 0.042). Conclusion: Distal pancreatectomy for primary RPS has acceptable morbidity and oncologic outcomes and is a reasonable approach to facilitate complete tumor resection.
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| 22. |
- Dulvy, Nicholas K., et al.
(author)
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Overfishing drives over one-third of all sharks and rays toward a global extinction crisis
- 2021
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In: Current Biology. - : Cell Press. - 0960-9822 .- 1879-0445. ; 31:21, s. 4773-4787
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Journal article (peer-reviewed)abstract
- The scale and drivers of marine biodiversity loss are being revealed by the International Union for Conservation of Nature (IUCN) Red List assessment process. We present the first global reassessment of 1,199 species in Class Chondrichthyes-sharks, rays, and chimeras. The first global assessment (in 2014) concluded that one-quarter (24%) of species were threatened. Now, 391 (32.6%) species are threatened with extinction. When this percentage of threat is applied to Data Deficient species, more than one-third (37.5%) of chondrichthyans are estimated to be threatened, with much of this change resulting from new information. Three species are Critically Endangered (Possibly Extinct), representing possibly the first globalmarine fish extinctions due to overfishing. Consequently, the chondrichthyan extinction rate is potentially 25 extinctions per million species years, comparable to that of terrestrial vertebrates. Overfishing is the universal threat affecting all 391 threatened species and is the sole threat for 67.3% of species and interacts with three other threats for the remaining third: loss and degradation of habitat (31.2% of threatened species), climate change (10.2%), and pollution (6.9%). Species are disproportionately threatened in tropical and subtropical coastal waters. Science-based limits on fishing, effective marine protected areas, and approaches that reduce or eliminate fishing mortality are urgently needed to minimize mortality of threatened species and ensure sustainable catch and trade of others. Immediate action is essential to prevent further extinctions and protect the potential for food security and ecosystem functions provided by this iconic lineage of predators.
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| 28. |
- Lee, Justin H., et al.
(author)
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Application of Cold and Hot Plasma Composition Measurements to Investigate Impacts on Dusk-Side Electromagnetic Ion Cyclotron Waves
- 2021
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In: Journal of Geophysical Research - Space Physics. - : American Geophysical Union (AGU). - 2169-9380 .- 2169-9402. ; 126:1
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Journal article (peer-reviewed)abstract
- An extended interval of perturbed magnetospheric conditions in November 2016 supported increased convection and sunward transport of plasmaspheric material. During this period of time the Magnetospheric Multiscale satellites, with their apogees along Earth's dusk-side outer magnetosphere, encountered several cold plasma density structures at the same time as plasma bulk flows capable of accelerating hidden cold plasma occurred. Investigating the charged particle and fields data during two subintervals showed that the satellites made direct measurements of cold plasmaspheric ions embedded within multicomponent hot plasmas as well as electromagnetic emissions consistent with electromagnetic ion cyclotron (EMIC) waves. The complex in situ ion composition measurements were applied to linear wave modeling to interpret the impacts of cold and hot ion species on wave growth and band structure. Although the waves for both intervals were predicted to have peak growth rate below omega(He+), substantial differences were observed among all other dispersive properties. The modeling also showed EMIC waves generated in the presence of heavy ions had growth rates and unstable wave numbers always smaller than predicted for a pure proton-electron plasma. The results provide implications for future investigation of EMIC wave generation with and without direct measurements of the cold and hot plasma composition as well as of subsequent wave-particle interactions.
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| 33. |
- Sanchez, Erlan, et al.
(author)
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Association of plasma biomarkers with cognition, cognitive decline, and daily function across and within neurodegenerative diseases: Results from the Ontario Neurodegenerative Disease Research Initiative
- 2024
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In: Alzheimer's and Dementia. - 1552-5260 .- 1552-5279. ; 20:3, s. 1753-1770
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Journal article (peer-reviewed)abstract
- INTRODUCTION: We investigated whether novel plasma biomarkers are associated with cognition, cognitive decline, and functional independence in activities of daily living across and within neurodegenerative diseases. METHODS: Glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), phosphorylated tau (p-tau)181 and amyloid beta (Aβ)42/40 were measured using ultra-sensitive Simoa immunoassays in 44 healthy controls and 480 participants diagnosed with Alzheimer's disease/mild cognitive impairment (AD/MCI), Parkinson's disease (PD), frontotemporal dementia (FTD) spectrum disorders, or cerebrovascular disease (CVD). RESULTS: GFAP, NfL, and/or p-tau181 were elevated among all diseases compared to controls, and were broadly associated with worse baseline cognitive performance, greater cognitive decline, and/or lower functional independence. While GFAP, NfL, and p-tau181 were highly predictive across diseases, p-tau181 was more specific to the AD/MCI cohort. Sparse associations were found in the FTD and CVD cohorts and for Aβ42/40. DISCUSSION: GFAP, NfL, and p-tau181 are valuable predictors of cognition and function across common neurodegenerative diseases, and may be useful in specialized clinics and clinical trials.
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