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Renal blood oxygena...
Renal blood oxygenation level-dependent magnetic resonance imaging to measure renal tissue oxygenation : a statement paper and systematic review
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- Pruijm, Menno (författare)
- Univ Hosp Lausanne CHUV, Dept Med, Serv Nephrol & Hypertens, Lausanne, Switzerland
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- Mendichovszky, Iosif A. (författare)
- Cambridge Univ Hosp NHS Fdn Trust, Addenbrookes Hosp, Dept Radiol, Cambridge, England
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- Liss, Per, 1960- (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Radiologi
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- Van der Niepen, Patricia (författare)
- Univ Ziekenhuis Brussel VUB, Dept Nephrol & Hypertens, Brussels, Belgium
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- Textor, Stephen C. (författare)
- Mayo Clin, Div Nephrol & Hypertens, Rochester, MN USA
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- Lerman, Lilach O. (författare)
- Mayo Clin, Div Nephrol & Hypertens, Rochester, MN USA
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- Krediet, C. T. Paul (författare)
- Univ Amsterdam, Acad Med Ctr, Div Nephrol, Dept Internal Med, Amsterdam, Netherlands
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- Caroli, Anna (författare)
- Ist Ric Farmacol Mario Negri, IRCCS, Dept Bioengn, Med Imaging Unit, Bergamo, Italy
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- Burnier, Michel (författare)
- Univ Hosp Lausanne CHUV, Dept Med, Serv Nephrol & Hypertens, Lausanne, Switzerland
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- Prasad, Pottumarthi Vara (författare)
- NorthShore Univ HealthSyst, Dept Radiol, Evanston, IL USA
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(creator_code:org_t)
- 2018-08-23
- 2018
- Engelska.
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Ingår i: Nephrology, Dialysis and Transplantation. - : Oxford University Press. - 0931-0509 .- 1460-2385. ; 33, s. II22-II28
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Abstract
Ämnesord
Stäng
- Tissue hypoxia plays a key role in the development and progression of many kidney diseases. Blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) is the most promising imaging technique to monitor renal tissue oxygenation in humans. BOLD-MRI measures renal tissue deoxyhaemoglobin levels voxel by voxel. Increases in its outcome measure R2* (transverse relaxation rate expressed as per second) correspond to higher deoxyhaemoglobin concentrations and suggest lower oxygenation, whereas decreases in R2* indicate higher oxygenation. BOLD-MRI has been validated against micropuncture techniques in animals. Its reproducibility has been demonstrated in humans, provided that physiological and technical conditions are standardized. BOLD-MRI has shown that patients suffering from chronic kidney disease (CKD) or kidneys with severe renal artery stenosis have lower tissue oxygenation than controls. Additionally, CKD patients with the lowest cortical oxygenation have the worst renal outcome. Finally, BOLD-MRI has been used to assess the influence of drugs on renal tissue oxygenation, and may offer the possibility to identify drugs with nephroprotective or nephrotoxic effects at an early stage. Unfortunately, different methods are used to prepare patients, acquire MRI data and analyse the BOLD images. International efforts such as the European Cooperation in Science and Technology (COST) action 'Magnetic Resonance Imaging Biomarkers for Chronic Kidney Disease' (PARENCHIMA) are aiming to harmonize this process, to facilitate the introduction of this technique in clinical practice in the near future. This article represents an extensive overview of the studies performed in this field, summarizes the strengths and weaknesses of the technique, provides recommendations about patient preparation, image acquisition and analysis, and suggests clinical applications and future developments.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- BOLD-MRI
- chronic kidney disease
- functional MRI
- kidney
- renal artery stenosis
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Pruijm, Menno
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Mendichovszky, I ...
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Liss, Per, 1960-
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Van der Niepen, ...
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Textor, Stephen ...
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Lerman, Lilach O ...
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visa fler...
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Krediet, C. T. P ...
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Caroli, Anna
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Burnier, Michel
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Prasad, Pottumar ...
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