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Children with Plasm...
Children with Plasmodium vivax infection previously observed in Namibia, were Duffy negative and carried a c.136G > A mutation
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- Haiyambo, Daniel Hosea (författare)
- University of Namibia
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- Aleksenko, Larysa (författare)
- Lund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Enheten för translationell obstetrisk forskning,Forskargrupper vid Lunds universitet,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Unit for translational obstetric research,Lund University Research Groups
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- Mumbengegwi, Davies (författare)
- University of Namibia
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- Bock, Ronnie (författare)
- University of Namibia
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- Uusiku, Petrina (författare)
- Ministry of Health and Social Services, Namibia
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- Malleret, Benoit (författare)
- National University of Singapore,A*STAR Singapore Immunology Network (SIgN)
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- Rénia, Laurent (författare)
- Nanyang Technological University
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- Quaye, Isaac Kweku (författare)
- Regent University College of Science and Technology
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(creator_code:org_t)
- 2021-08-21
- 2021
- Engelska.
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Ingår i: BMC Infectious Diseases. - : Springer Science and Business Media LLC. - 1471-2334. ; 21:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://bmcinfectdis...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: In a previous study, using a molecular approach, we reported the presence of P. vivax in Namibia. Here, we have extended our investigation to the Duffy antigen genetic profile of individuals of the same cohort with and without Plasmodium infections. Methods: Participants with P. vivax (n = 3), P. falciparum (n = 23) mono-infections and co-infections of P. vivax/P. falciparum (n = 4), and P. falciparum/P. ovale (n = 3) were selected from seven regions. Participants with similar age but without any Plasmodium infections (n = 47) were also selected from all the regions. Duffy allelic profile was examined using standard PCR followed by sequencing of amplified products. Sequenced samples were also examined for the presence or absence of G125A mutation in codon 42, exon 2. Results: All individuals tested carried the − 67 T > C mutation. However, while all P. vivax infected participants carried the c.G125A mutation, 7/28 P. falciparum infected participants and 9/41 of uninfected participants did not have the c.G125A mutation. The exon 2 region surrounding codon 42, had a c.136G > A mutation that was present in all P. vivax infections. The odds ratio for lack of this mutation with P. vivax infections was (OR 0.015, 95% CI 0.001–0.176; p = 0.001). Conclusion: We conclude that P. vivax infections previously reported in Namibia, occurred in Duffy negative participants, carrying the G125A mutation in codon 42. The role of the additional mutation c.136 G > A in exon 2 in P. vivax infections, will require further investigations.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Duffy gene mutations
- Namibia
- Plasmodium vivax
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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