Sökning: WFRF:(Röhl Maria)
> (2011-2014) >
Increased cell-medi...
Increased cell-mediated immune responses in patients with recurrent herpes simplex virus type 2 meningitis.
-
- Franzen-Röhl, Elisabeth (författare)
- Karolinska Institutet
-
- Schepis, Danika (författare)
- Karolinska Institutet
-
Lagrelius, Maria (författare)
-
visa fler...
-
Franck, Kristina (författare)
-
Jones, Petra (författare)
-
- Liljeqvist, Jan-Åke, 1954 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
-
- Bergström, Tomas, 1950 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
-
- Aurelius, Elisabeth (författare)
- Karolinska Institutet
-
- Kärre, Klas (författare)
- Karolinska Institutet
-
- Berg, Louise (författare)
- Karolinska Institutet
-
Gaines, Hans (författare)
-
visa färre...
-
(creator_code:org_t)
- 2011
- 2011
- Engelska.
-
Ingår i: Clinical and vaccine immunology : CVI. - 1556-679X. ; 18:4, s. 655-60
- Relaterad länk:
-
https://gup.ub.gu.se...
-
visa fler...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- The clinical picture of herpes simplex virus type 2 (HSV-2) infection includes genital blisters and less frequently meningitis, and some individuals suffer from recurrent episodes of these manifestations. We hypothesized that adaptive and/or innate immune functional deficiencies may be a major contributing factor in susceptibility to recurrent HSV-2 meningitis. Ten patients with recurrent HSV-2 meningitis were studied during clinical remission. For comparison, 10 patients with recurrent genital HSV infections as well as 21 HSV-seropositive and 19 HSV-seronegative healthy blood donors were included. HSV-specific T cell blasting and cytokine secretion were evaluated in whole blood cultures. HSV-2-induced NK cell gamma interferon production, dendritic cell Toll-like receptor (TLR) expression, and TLR agonist-induced alpha interferon secretion were analyzed. Patients with recurrent HSV-2 meningitis had elevated T cell blasting and Th1 and Th2 cytokine production in response to HSV antigens compared to those of patients with recurrent genital infections. A somewhat increased NK cell response, increased dendritic cell expression of TLR3 and -9, and increased TLR-induced alpha interferon responses were also noted. Contrary to our expectation, recurrent HSV-2 meningitis patients have increased HSV-specific adaptive and innate immune responses, raising the possibility of immune-mediated pathology in the development of recurrent HSV2 meningitis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- Adult
- Cytokines
- secretion
- Dendritic Cells
- immunology
- Female
- Gene Expression
- Herpes Simplex
- immunology
- Herpesvirus 2
- Human
- immunology
- Humans
- Immunity
- Cellular
- Killer Cells
- Natural
- immunology
- Male
- Meningitis
- Viral
- immunology
- Middle Aged
- Recurrence
- T-Lymphocytes
- immunology
- Toll-Like Receptors
- immunology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Franzen-Röhl, El ...
-
Schepis, Danika
-
Lagrelius, Maria
-
Franck, Kristina
-
Jones, Petra
-
Liljeqvist, Jan- ...
-
visa fler...
-
Bergström, Tomas ...
-
Aurelius, Elisab ...
-
Kärre, Klas
-
Berg, Louise
-
Gaines, Hans
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Mikrobiologi ino ...
- Artiklar i publikationen
-
Clinical and vac ...
- Av lärosätet
-
Göteborgs universitet
-
Karolinska Institutet