| 1. |
- Keogan, Katharine, et al.
(författare)
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Global phenological insensitivity to shifting ocean temperatures among seabirds
- 2018
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Ingår i: Nature Climate Change. - : Springer Science and Business Media LLC. - 1758-678X .- 1758-6798. ; 8:4, s. 313-318
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Tidskriftsartikel (refereegranskat)abstract
- Reproductive timing in many taxa plays a key role in determining breeding productivity(1), and is often sensitive to climatic conditions(2). Current climate change may alter the timing of breeding at different rates across trophic levels, potentially resulting in temporal mismatch between the resource requirements of predators and their prey(3). This is of particular concern for higher-trophic-level organisms, whose longer generation times confer a lower rate of evolutionary rescue than primary producers or consumers(4). However, the disconnection between studies of ecological change in marine systems makes it difficult to detect general changes in the timing of reproduction(5). Here, we use a comprehensive meta-analysis of 209 phenological time series from 145 breeding populations to show that, on average, seabird populations worldwide have not adjusted their breeding seasons over time (-0.020 days yr(-1)) or in response to sea surface temperature (SST) (-0.272 days degrees C-1) between 1952 and 2015. However, marked between-year variation in timing observed in resident species and some Pelecaniformes and Suliformes (cormorants, gannets and boobies) may imply that timing, in some cases, is affected by unmeasured environmental conditions. This limited temperature-mediated plasticity of reproductive timing in seabirds potentially makes these top predators highly vulnerable to future mismatch with lower-trophic-level resources(2).
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| 2. |
- Reinke, Beth A, et al.
(författare)
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Diverse aging rates in ectothermic tetrapods provide insights for the evolution of aging and longevity
- 2022
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Ingår i: Science. - : American Association for the Advancement of Science. - 0036-8075 .- 1095-9203. ; 376:6600, s. 1459-1466
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Tidskriftsartikel (refereegranskat)abstract
- Comparative studies of mortality in the wild are necessary to understand the evolution of aging; yet, ectothermic tetrapods are underrepresented in this comparative landscape, despite their suitability for testing evolutionary hypotheses. We present a study of aging rates and longevity across wild tetrapod ectotherms, using data from 107 populations (77 species) of nonavian reptiles and amphibians. We test hypotheses of how thermoregulatory mode, environmental temperature, protective phenotypes, and pace of life history contribute to demographic aging. Controlling for phylogeny and body size, ectotherms display a higher diversity of aging rates compared with endotherms and include phylogenetically widespread evidence of negligible aging. Protective phenotypes and life-history strategies further explain macroevolutionary patterns of aging. Analyzing ectothermic tetrapods in a comparative context enhances our understanding of the evolution of aging.
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| 3. |
- Asensio Ramos, A., et al.
(författare)
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Inference of the chromospheric magnetic field orientation in the Ca II 8542 angstrom line fibrils
- 2017
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 599
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Tidskriftsartikel (refereegranskat)abstract
- Context. Solar chromospheric fibrils, as observed in the core of strong chromospheric spectral lines, extend from photospheric field concentrations suggesting that they trace magnetic field lines. These images have been historically used as proxies of magnetic fields for many purposes.Aims. Use statistical analysis to test whether the association between fibrils and magnetic field lines is justified.Methods. We use a Bayesian hierarchical model to analyze several tens of thousands of pixels in spectro- polarimetric chromospheric images of penumbrae and chromospheric fibrils. We compare the alignment between the field azimuth inferred from the linear polarization signals through the transverse Zeeman effect and the direction of the fibrils in the image.Results. We conclude that, in the analyzed fields of view, fibrils are often well aligned with the magnetic field azimuth. Despite this alignment, the analysis also shows that there is a non-negligible dispersion. In penumbral filaments, we find a dispersion with a standard deviation of similar to 16 degrees, while this dispersion goes up to similar to 34 degrees in less magnetized regions.
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| 4. |
- Asensio Ramos, A., et al.
(författare)
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Inversion of Stokes profiles with systematic effects
- 2016
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 590
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Tidskriftsartikel (refereegranskat)abstract
- Quantitative thermodynamical, dynamical and magnetic properties of the solar and stellar plasmas are obtained by interpreting their emergent non-polarized and polarized spectrum. This inference requires the selection of a set of spectral lines that are particularly sensitive to the physical conditions in the plasma and a suitable parametric model of the solar/stellar atmosphere. Nonlinear inversion codes are then used to fit the model to the observations. However, the presence of systematic effects, like nearby or blended spectral lines, telluric absorption, or incorrect correction of the continuum, among others, can strongly affect the results. We present an extension to current inversion codes that can deal with these effects in a transparent way. The resulting algorithm is very simple and can be applied to any existing inversion code with the addition of a few lines of code as an extra step in each iteration.
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| 5. |
- Asensio Ramos, A., et al.
(författare)
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Real-time, multiframe, blind deconvolution of solar images
- 2018
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 620
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Tidskriftsartikel (refereegranskat)abstract
- The quality of images of the Sun obtained from the ground are severely limited by the perturbing effect of the Earth's turbulent atmosphere. The post-facto correction of the images to compensate for the presence of the atmosphere require the combination of high-order adaptive optics techniques, fast measurements to freeze the turbulent atmosphere, and very time-consuming blind deconvolution algorithms. Under mild seeing conditions, blind deconvolution algorithms can produce images of astonishing quality. They can be very competitive with those obtained from space, with the huge advantage of the flexibility of the instrumentation thanks to the direct access to the telescope. In this contribution we make use of deep learning techniques to significantly accelerate the blind deconvolution process and produce corrected images at a peak rate of similar to 100 images per second. We present two different architectures that produce excellent image corrections with noise suppression while maintaining the photometric properties of the images. As a consequence, polarimetric signals can be obtained with standard polarimetric modulation without any significant artifact. With the expected improvements in computer hardware and algorithms, we anticipate that on-site real-time correction of solar images will be possible in the near future.
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| 6. |
- Asensio Ramos, A., et al.
(författare)
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Sparse inversion of Stokes profiles I. Two-dimensional Milne-Eddington inversions
- 2015
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 577
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Tidskriftsartikel (refereegranskat)abstract
- Context. Inversion codes are numerical tools used to infer physical properties from observations. Despite their success, the quality of current spectropolarimetric observations and those expected in the near future presents a challenge to current inversion codes. Aims. The pixel-by-pixel strategy of inverting spectropolarimetric data that we currently use needs to be surpassed and improved. The inverted physical parameters have to take into account the spatial correlation that is present in the data and that contains valuable physical information. Methods. We used the concept of sparsity or compressibility to develop a new generation of inversion codes for the Stokes parameters. The inversion code uses numerical optimization techniques based on the idea of proximal algorithms to impose sparsity. In so doing, we allow for the first time exploiting the spatial correlation on the maps of physical parameters. Sparsity also regularizes the solution by reducing the number of unknowns. Results. We compare the results of the new inversion code with pixel-by-pixel inversions to demonstrate the increased robustness of the solution. We also show how the method can easily compensate for the effect of the telescope point spread function, producing solutions with an enhanced contrast.
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| 7. |
- Bentham, James, et al.
(författare)
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A century of trends in adult human height
- 2016
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Ingår i: eLIFE. - 2050-084X. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.522.7) and 16.5 cm (13.319.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
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| 8. |
- Bentham, James, et al.
(författare)
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A century of trends in adult human height
- 2016
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Ingår i: eLIFE. - : eLife Sciences Publications Ltd. - 2050-084X. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.5–22.7) and 16.5 cm (13.3– 19.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8– 144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
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| 9. |
- Campos, Ana R., et al.
(författare)
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How do Robins Erithacus rubecula resident in Iberia respond to seasonal flooding by conspecific migrants?
- 2011
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Ingår i: Bird Study. - : Informa UK Limited. - 0006-3657 .- 1944-6705. ; 58:4, s. 435-442
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Tidskriftsartikel (refereegranskat)abstract
- Capsule The majority of Robins in Iberia are sedentary and stay in their nesting areas despite the pre- sumed increased competition that results from the seasonal flooding of the area by conspecific migrants. Aims To evaluate if Robins in Iberia are displaced from their nesting areas by the presence of large num- bers of competitors originating from higher latitudes. Methods Data from constant effort ringing sites were used to estimate the proportion of Robins that are strictly sedentary and the seasonal variation in Robin numbers. Hydrogen stable isotope ratios (d2H) in feathers, and sex ratios determined through molecular techniques, allowed an insight into the numerical importance of invading Robins from higher latitudes. Results Robins were more numerous outside the breeding season, with clear influxes in autumn. Around half of the locally nesting Robins were captured during winter, indicating they are truly sedentary. d2H in feathers suggests that a wide mixture of Robins from all European latitudes were present in winter, and these data, together with sex ratios, suggest that there may be similar numbers of local and foreign individ- uals in winter at the main study site. Conclusion Despite the occupation of their range by migrants, local birds are largely sedentary.
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| 10. |
- Catry, Paulo, et al.
(författare)
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Provenance does matter : links between winter trophic segregation and the migratory origins of European robins
- 2016
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Ingår i: Oecologia. - : Springer Science and Business Media LLC. - 0029-8549 .- 1432-1939. ; 182:4, s. 985-994
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Tidskriftsartikel (refereegranskat)abstract
- Amongst migratory species, it is common to find individuals from different populations or geographical origins sharing staging or wintering areas. Given their differing life histories, ecological theory would predict that the different groups of individuals should exhibit some level of niche segregation. This has rarely been investigated because of the difficulty in assigning migrating individuals to breeding areas. Here, we start by documenting a broad geographical gradient of hydrogen isotopes (δ2H) in robin Erithacus rubecula feathers across Europe. We then use δ2H, as well as wing-tip shape, as surrogates for broad migratory origin of birds wintering in Iberia, to investigate the ecological segregation of populations. Wintering robins of different sexes, ages and body sizes are known to segregate between habitats in Iberia. This has been attributed to the despotic exclusion of inferior competitors from the best patches by dominant individuals. We find no segregation between habitats in relation to δ2H in feathers, or to wing-tip shape, which suggests that no major asymmetries in competitive ability exist between migrant robins of different origins. Trophic level (inferred from nitrogen isotopes in blood) correlated both with δ2H in feathers and with wing-tip shape, showing that individuals from different geographic origins display a degree of ecological segregation in shared winter quarters. Isotopic mixing models indicate that wintering birds originating from more northerly populations consume more invertebrates. Our multi-scale study suggests that trophic-niche segregation may result from specializations (arising in the population-specific breeding areas) that are transported by the migrants into the shared wintering grounds.
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| 11. |
- Danaei, Goodarz, et al.
(författare)
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Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331288 participants
- 2015
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Ingår i: The Lancet Diabetes & Endocrinology. - 2213-8595 .- 2213-8587. ; 3:8, s. 624-637
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Tidskriftsartikel (refereegranskat)abstract
- Background Diabetes has been defined on the basis of different biomarkers, including fasting plasma glucose (FPG), 2-h plasma glucose in an oral glucose tolerance test (2hOGTT), and HbA(1c). We assessed the effect of different diagnostic definitions on both the population prevalence of diabetes and the classification of previously undiagnosed individuals as having diabetes versus not having diabetes in a pooled analysis of data from population-based health examination surveys in different regions. Methods We used data from 96 population-based health examination surveys that had measured at least two of the biomarkers used for defining diabetes. Diabetes was defined using HbA(1c) (HbA(1c) >= 6 . 5% or history of diabetes diagnosis or using insulin or oral hypoglycaemic drugs) compared with either FPG only or FPG-or-2hOGTT definitions (FPG >= 7 . 0 mmol/L or 2hOGTT >= 11 . 1 mmol/L or history of diabetes or using insulin or oral hypoglycaemic drugs). We calculated diabetes prevalence, taking into account complex survey design and survey sample weights. We compared the prevalences of diabetes using different definitions graphically and by regression analyses. We calculated sensitivity and specificity of diabetes diagnosis based on HbA1c compared with diagnosis based on glucose among previously undiagnosed individuals (ie, excluding those with history of diabetes or using insulin or oral hypoglycaemic drugs). We calculated sensitivity and specificity in each survey, and then pooled results using a random-effects model. We assessed the sources of heterogeneity of sensitivity by meta-regressions for study characteristics selected a priori. Findings Population prevalence of diabetes based on FPG- or-2hOGTT was correlated with prevalence based on FPG alone (r= 0 . 98), but was higher by 2-6 percentage points at different prevalence levels. Prevalence based on HbA(1c) was lower than prevalence based on FPG in 42 . 8% of age-sex-survey groups and higher in another 41 . 6%; in the other 15 . 6%, the two definitions provided similar prevalence estimates. The variation across studies in the relation between glucose-based and HbA(1c)-based prevalences was partly related to participants' age, followed by natural logarithm of per person gross domestic product, the year of survey, mean BMI, and whether the survey population was national, subnational, or from specific communities. Diabetes defined as HbA(1c) 6 . 5% or more had a pooled sensitivity of 52 . 8% (95% CI 51 . 3-54 . 3%) and a pooled specificity of 99 . 74% (99 . 71-99 . 78%) compared with FPG 7 . 0 mmol/L or more for diagnosing previously undiagnosed participants; sensitivity compared with diabetes defined based on FPG-or-2hOGTT was 30 . 5% (28 . 7-32 . 3%). None of the preselected study-level characteristics explained the heterogeneity in the sensitivity of HbA(1c) versus FPG. Interpretation Different biomarkers and definitions for diabetes can provide different estimates of population prevalence of diabetes, and differentially identify people without previous diagnosis as having diabetes. Using an HbA(1c)-based definition alone in health surveys will not identify a substantial proportion of previously undiagnosed people who would be considered as having diabetes using a glucose-based test.
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| 12. |
- de la Cruz Rodriguez, Jaime, et al.
(författare)
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NON-LTE INVERSIONS OF THE Mg II h & k AND UV TRIPLET LINES
- 2016
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Ingår i: Astrophysical Journal Letters. - 2041-8205 .- 2041-8213. ; 830:2
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Tidskriftsartikel (refereegranskat)abstract
- The Mg II h & k lines are powerful diagnostics for studying the solar chromosphere. They have become particularly popular with the launch of the Interface Region Imaging Spectrograph (IRIS) satellite, and a number of studies that include these lines have lead to great progress in understanding chromospheric heating, in many cases thanks to the support from 3D MHD simulations. In this study, we utilize another approach to analyze observations: non-LTE inversions of the Mg II h & k and UV triplet lines including the effects of partial redistribution. Our inversion code attempts to construct a model atmosphere that is compatible with the observed spectra. We have assessed the capabilities and limitations of the inversions using the FALC atmosphere and a snapshot from a 3D radiation-MHD simulation. We find that Mg II h & k allow reconstructing a model atmosphere from the middle photosphere to the transition region. We have also explored the capabilities of a multi-line/multi-atom setup, including the Mg IIh & k, the Ca II 854.2. nm, and the Fe I. 630.25 lines to recover the full stratification of physical parameters, including the magnetic field vector, from the photosphere to the chromosphere. Finally, we present the first inversions of observed IRIS spectra from quiet-Sun, plage, and sunspot, with very promising results.
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| 13. |
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| 14. |
- Díaz Baso, Carlos José, et al.
(författare)
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Bayesian Stokes inversion with normalizing flows
- 2022
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 659
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Tidskriftsartikel (refereegranskat)abstract
- Stokes inversion techniques are very powerful methods for obtaining information on the thermodynamic and magnetic properties of solar and stellar atmospheres. In recent years, highly sophisticated inversion codes have been developed that are now routinely applied to spectro-polarimetric observations. Most of these inversion codes are designed to find an optimum solution to the nonlinear inverse problem. However, to obtain the location of potentially multimodal cases (ambiguities), the degeneracies and the uncertainties of each parameter inferred from the inversions algorithms – such as Markov chain Monte Carlo (MCMC) – require evaluation of the likelihood of the model thousand of times and are computationally costly. Variational methods are a quick alternative to Monte Carlo methods, and approximate the posterior distribution by a parametrized distribution. In this study, we introduce a highly flexible variational inference method to perform fast Bayesian inference, known as normalizing flows. Normalizing flows are a set of invertible, differentiable, and parametric transformations that convert a simple distribution into an approximation of any other complex distribution. If the transformations are conditioned on observations, the normalizing flows can be trained to return Bayesian posterior probability estimates for any observation. We illustrate the ability of the method using a simple Milne-Eddington model and a complex non-local thermodynamic equilibrium (NLTE) inversion. The method is extremely general and other more complex forward models can be applied. The training procedure need only be performed once for a given prior parameter space and the resulting network can then generate samples describing the posterior distribution several orders of magnitude faster than existing techniques.
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| 15. |
- Díaz Baso, Carlos José, et al.
(författare)
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Diagnostic potential of the Ca II 8542 Ångstrom line for solar filaments
- 2019
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 623
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Tidskriftsartikel (refereegranskat)abstract
- Aims. In this study we explore the diagnostic potential of the chromospheric Ca II line at 8542 angstrom for studying the magnetic and dynamic properties of solar filaments. We have acquired high spatial resolution spectropolarimetric observations in the Ca II 8542 angstrom line using the CRISP instrument at the Swedish 1 m Solar Telescope. Methods. We used the NICOLE inversion code to infer physical properties from observations of a solar filament. We discuss the validity of the results due to the assumption of hydrostatic equilibrium. We have used observations from other telescopes such as CHROTEL and SDO, in order to study large scale dynamics and the long term evolution of the filament. Results. We show that the Ca II 8542 angstrom line encodes information of the temperature, line-of-sight velocity and magnetic field vector from the region where the filament is located. The current noise levels only allow us to estimate an upper limit of 260 G for the total magnetic field of the filament. Our study also reveals that if we consider information from the aforementioned spectral line alone, the geometric height, the temperature and the density could be degenerated parameters outside the hydrostatic equilibrium approach.
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| 16. |
- Gato, Jorge, et al.
(författare)
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Psychosocial Effects of the COVID-19 Pandemic and Mental Health Among LGBTQ plus Young Adults : A Cross-Cultural Comparison Across Six Nations
- 2022
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Ingår i: International Journal of Sexual Health. - : Taylor & Francis. - 1931-7611 .- 1931-762X. ; 34:Suppl. 1, s. 105-105
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Across the world, people have seen their lives interrupted by the COVID-19 pandemic. Using an online survey, we explored how the psychosocial effects of the pandemic affected the mental health of LGBTQþ young adults who were confined with their parents during the lockdown period (N ¼ 1,934), from six countries: Portugal, UK, Italy, Brazil, Chile, and Sweden.South American participants experienced more negative psychosocial effects of the pandemic. Depression and anxiety were higher among participants who were younger, not working, living in Europe and who reported feeling more emotionally affected by the pandemic, uncomfortable at home, or isolated from non-LGBTQ friends.Not attending higher education predicted depression while not being totally confined at home, residing habitually with parents, and fearing more future infec-tion predicted anxiety. LGBTQþ community groups, as well as health and educational services should remain particularly attentive to the needs of LGBTQþ young adults during health crises.Conflict of Interest and Disclosure Statement: No conflict of interest
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| 17. |
- Gato, Jorge, et al.
(författare)
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Psychosocial Effects of the COVID-19 Pandemic and Mental Health among LGBTQ+ Young Adults : A Cross-Cultural Comparison across Six Nations
- 2021
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Ingår i: Journal of Homosexuality. - : Haworth Press. - 0091-8369 .- 1540-3602. ; 68:4, s. 612-630
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Tidskriftsartikel (refereegranskat)abstract
- Across the world, people have seen their lives interrupted by the COVID-19 pandemic. Using an online survey, we explored how the psychosocial effects of the pandemic affected the mental health of LGBTQ+ young adults who were confined with their parents during the lockdown period (N = 1,934), from six countries: Portugal, UK, Italy, Brazil, Chile, and Sweden. South American participants experienced more negative psychosocial effects of the pandemic. Depression and anxiety were higher among participants who were younger, not working, living in Europe and who reported feeling more emotionally affected by the pandemic, uncomfortable at home, or isolated from non-LGBTQ friends. Not attending higher education predicted depression while not being totally confined at home, residing habitually with parents, and fearing more future infection predicted anxiety. LGBTQ+ community groups, as well as health and educational services should remain particularly attentive to the needs of LGBTQ+ young adults during health crises.
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| 18. |
- Jacobs, Tovia, et al.
(författare)
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The neutrophil to lymphocyte ratio associates with markers of Alzheimer's disease pathology in cognitively unimpaired elderly people.
- 2024
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Ingår i: Research square.
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Tidskriftsartikel (refereegranskat)abstract
- An elevated neutrophil-lymphocyte ratio (NLR) in blood has been associated with Alzheimer's disease (AD). However, an elevated NLR has also been implicated in many other conditions that are risk factors for AD, prompting investigation into whether the NLR is directly linked with AD pathology or a result of underlying comorbidities. Herein, we explored the relationship between the NLR and AD biomarkers in the cerebrospinal fluid (CSF) of cognitively unimpaired (CU) subjects. Adjusting for sociodemographics, APOE4, and common comorbidities, we investigated these associations in two cohorts: the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the M.J. de Leon CSF repository at NYU. Specifically, we examined associations between the NLR and cross-sectional measures of amyloid-β42 (Aβ42), total tau (t-tau), and phosphorylated tau181 (p-tau), as well as the trajectories of these CSF measures obtained longitudinally.A total of 111 ADNI and 190 NYU participants classified as CU with available NLR, CSF, and covariate data were included. Compared to NYU, ADNI participants were older (73.79 vs. 61.53, p < 0.001), had a higher proportion of males (49.5% vs. 36.8%, p = 0.042), higher BMIs (27.94 vs. 25.79, p < 0.001), higher prevalence of hypertensive history (47.7% vs. 16.3%, p < 0.001), and a greater percentage of Aβ-positivity (34.2% vs. 20.0%, p = 0.009). In the ADNI cohort, we found cross-sectional associations between the NLR and CSF Aβ42 (β=-12.193, p = 0.021), but not t-tau or p-tau. In the NYU cohort, we found cross-sectional associations between the NLR and CSF t-tau (β = 26.812, p = 0.019) and p-tau (β = 3.441, p = 0.015), but not Aβ42. In the NYU cohort alone, subjects classified as Aβ+ (n = 38) displayed a stronger association between the NLR and t-tau (β = 100.476, p = 0.037) compared to Aβ- subjects or the non-stratified cohort. In both cohorts, the same associations observed in the cross-sectional analyses were observed after incorporating longitudinal CSF data.We report associations between the NLR and Aβ42 in the older ADNI cohort, and between the NLR and t-tau and p-tau181 in the younger NYU cohort. Associations persisted after adjusting for comorbidities, suggesting a direct link between the NLR and AD. However, changes in associations between the NLR and specific AD biomarkers may occur as part of immunosenescence.
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| 19. |
- Kampinga, Harm H., et al.
(författare)
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Function, evolution, and structure of J-domain proteins
- 2019
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Ingår i: Cell stress & chaperones (Print). - : Springer Science and Business Media LLC. - 1355-8145 .- 1466-1268. ; 24:1, s. 7-15
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Forskningsöversikt (refereegranskat)abstract
- Hsp70 chaperone systems are very versatile machines present in nearly all living organisms and in nearly all intracellular compartments. They function in many fundamental processes through their facilitation of protein (re)folding, trafficking, remodeling, disaggregation, and degradation. Hsp70 machines are regulated by co-chaperones. J-domain containing proteins (JDPs) are the largest family of Hsp70 co-chaperones and play a determining role functionally specifying and directing Hsp70 functions. Many features of JDPs are not understood; however, a number of JDP experts gathered at a recent CSSI-sponsored workshop in Gdansk (Poland) to discuss various aspects of J-domain protein function, evolution, and structure. In this report, we present the main findings and the consensus reached to help direct future developments in the field of Hsp70 research.
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| 20. |
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| 21. |
- Libbrecht, Tine, et al.
(författare)
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Observations of Ellerman bomb emission features in He I D-3 and He I 10 830 angstrom
- 2017
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 598
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Tidskriftsartikel (refereegranskat)abstract
- Context. Ellerman bombs (EBs) are short-lived emission features, characterised by extended wing emission in hydrogen Balmer lines. Until now, no distinct signature of EBs has been found in the He I 10 830 angstrom line, and conclusive observations of EBs in He I D-3 have never been reported.Aims. We aim to study the signature of EBs in neutral helium triplet lines. Methods. The observations consisted of ten consecutive SST/TRIPPEL raster scans close to the limb, featuring the H beta, He I D-3 and He I 10 830 angstrom spectral regions. We also obtained raster scans with IRIS and made use of the SDO/AIA 1700 angstrom channel. We used HAZEL to invert the neutral helium triplet lines.Results. Three EBs in our data show distinct emission signatures in neutral helium triplet lines, most prominently visible in the He I D-3 line. The helium lines have two components: a broad and blueshifted emission component associated with the EB, and a narrower absorption component formed in the overlying chromosphere. One of the EBs in our data shows evidence of strong velocity gradients in its emission component. The emission component of the other two EBs could be fitted using a constant slab. Our analysis hints towards thermal Doppler motions having a large contribution to the broadening for helium and IRIS lines. We conclude that the EBs must have high temperatures to exhibit emission signals in neutral helium triplet lines. An order of magnitude estimate places our observed EBs in the range of T similar to 2 x 10(4) 10(5) K.
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| 22. |
- Martinez Gonzalez, M. J., et al.
(författare)
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ON THE MAGNETISM AND DYNAMICS OF PROMINENCE LEGS HOSTING TORNADOES
- 2016
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Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 825:2
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Tidskriftsartikel (refereegranskat)abstract
- Solar tornadoes are dark vertical filamentary structures observed in the extreme ultraviolet associated with prominence legs and filament barbs. Their true nature and relationship to prominences requires an understanding of their magnetic structure and dynamic properties. Recently, a controversy has arisen: is the magnetic field organized forming vertical, helical structures or is it dominantly horizontal? And concerning their dynamics, are tornadoes really rotating or is it just a visual illusion? Here we analyze four consecutive spectro-polarimetric scans of a prominence hosting tornadoes on its legs, which helps us shed some light on their magnetic and dynamical properties. We show that the magnetic field is very smooth in all the prominence, which is probably an intrinsic property of the coronal field. The prominence legs have vertical helical fields that show slow temporal variation that is probably related to the motion of the fibrils. Concerning the dynamics, we argue that (1) if rotation exists, it is intermittent, lasting no more than one hour, and (2) the observed velocity pattern is also consistent with an oscillatory velocity pattern (waves).
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| 23. |
- Martinez Gonzalez, M. J., et al.
(författare)
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SPECTRO-POLARIMETRIC IMAGING REVEALS HELICAL MAGNETIC FIELDS IN SOLAR PROMINENCE FEET
- 2015
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Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 802:1
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Tidskriftsartikel (refereegranskat)abstract
- Solar prominences are clouds of cool plasma levitating above the solar surface and insulated from the million-degree corona by magnetic fields. They form in regions of complex magnetic topology, characterized by non-potential fields, which can evolve abruptly, disintegrating the prominence and ejecting magnetized material into the heliosphere. However, their physics is not yet fully understood because mapping such complex magnetic configurations and their evolution is extremely challenging, and must often be guessed by proxy from photometric observations. Using state-of-the-art spectro-polarimetric data, we reconstruct the structure of the magnetic field in a prominence. We find that prominence feet harbor helical magnetic fields connecting the prominence to the solar surface below.
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| 24. |
- Muller, Elodie, et al.
(författare)
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Conditions of emergence of the Sooty Bark Disease and aerobiology of Cryptostroma corticale in Europe
- 2023
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Ingår i: NeoBiota. - 1619-0033 .- 1314-2488. ; 84, s. 319-347
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Tidskriftsartikel (refereegranskat)abstract
- The sooty bark disease (SBD) is an emerging disease affecting sycamore maple trees (Acer pseudoplatanus) in Europe. Cryptostroma corticale, the causal agent, putatively native to eastern North America, can be also pathogenic for humans causing pneumonitis. It was first detected in 1945 in Europe, with markedly increasing reports since 2000. Pathogen development appears to be linked to heat waves and drought episodes. Here, we analyse the conditions of the SBD emergence in Europe based on a three-decadal time-series data set. We also assess the suitability of aerobiological samples using a species-specific quantitative PCR assay to inform the epidemiology of C. corticale, through a regional study in France comparing two-year aerobiological and epidemiological data, and a continental study including 12 air samplers from six countries (Czechia, France, Italy, Portugal, Sweden and Switzerland).We found that an accumulated water deficit in spring and summer lower than -132 mm correlates with SBD outbreaks. Our results suggest that C. corticale is an efficient airborne pathogen which can disperse its conidia as far as 310 km from the site of the closest disease outbreak. Aerobiology of C. corticale followed the SBD distribution in Europe. Pathogen detection was high in countries within the host native area and with longer disease presence, such as France, Switzerland and Czech Republic, and sporadic in Italy, where the pathogen was reported just once. The pathogen was absent in samples from Portugal and Sweden, where the disease has not been reported yet. We conclude that aerobiological surveillance can inform the spatial distribution of the SBD, and contribute to early detection in pathogen-free countries.
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| 25. |
- Norte, Ana Cláudia, et al.
(författare)
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Host dispersal shapes the population structure of a tick-borne bacterial pathogen
- 2020
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Ingår i: Molecular Ecology. - : Wiley. - 0962-1083 .- 1365-294X. ; 29:3, s. 485-501
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Tidskriftsartikel (refereegranskat)abstract
- Birds are hosts for several zoonotic pathogens. Because of their high mobility, especially of longdistance migrants, birds can disperse these pathogens, affecting their distribution and phylogeography. We focused on Borrelia burgdorferi sensu lato, which includes the causative agents of Lyme borreliosis, as an example for tick-borne pathogens, to address the role of birds as propagation hosts of zoonotic agents at a large geographical scale. We collected ticks from passerine birds in 11 European countries. B. burgdorferi s.l. prevalence in Ixodes spp. was 37% and increased with latitude. The fieldfare Turdus pilaris and the blackbird T. merula carried ticks with the highest Borrelia prevalence (92 and 58%, respectively), whereas robin Erithacus rubecula ticks were the least infected (3.8%). Borrelia garinii was the most prevalent genospecies (61%), followed by B. valaisiana (24%), B. afzelii (9%), B. turdi (5%) and B. lusitaniae (0.5%). A novel Borrelia genospecies “Candidatus Borrelia aligera” was also detected. Multilocus sequence typing (MLST) analysis of B. garinii isolates together with the global collection of B. garinii genotypes obtained from the Borrelia MLST public database revealed that: (a) there was little overlap among genotypes from different continents, (b) there was no geographical structuring within Europe, and (c) there was no evident association pattern detectable among B. garinii genotypes from ticks feeding on birds, questing ticks or human isolates. These findings strengthen the hypothesis that the population structure and evolutionary biology of tick-borne pathogens are shaped by their host associations and the movement patterns of these hosts.
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| 26. |
- Paleti, Sri Harish Kumar, et al.
(författare)
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Correlating Acceptor Structure and Blend Nanostructure with the Photostability of Nonfullerene Organic Solar Cells
- 2022
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Ingår i: Solar RRL. - : Wiley. - 2367-198X. ; 6:10
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Tidskriftsartikel (refereegranskat)abstract
- The formation of photoinduced traps resulting in the loss of electron mobility deteriorates the performance of organic solar cells under continuous light soaking. The genesis of these loss mechanisms is elucidated by examining the structural stability of halogenated ITIC derivative films and the phase behavior of the respective binary systems by blending with the donor polymer PBDBT-2F. Under constant illumination, ITIC-4Cl is found to maintain its structural integrity, whereas fluorine on the peripheral moieties of ITIC-4F undergoes chemical substitution to form a mixture of ITIC and ITIC-4F. Thermal analysis of the light-soaked binary films reveals that ITIC-4Cl loses its crystalline phase while the crystallinity of ITIC-4F does not undergo changes. Further, it is shown that the addition of a small amount of ITIC-4F as a third component hinders the loss of ITIC-4Cl crystalline phase in bulk heterojunction blends through the formation of cocrystals. These results suggest that long-range ordering of NFAs does not necessarily improve the photostability of organic solar cells and that the addition of a third component, irrespective of the crystalline nature, can prevent changes in bulk heterojunction blend nanostructure.
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| 27. |
- Pardal, Sara, et al.
(författare)
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Characterization of MHC class I in a long distance migratory wader, the Icelandic black-tailed godwit
- 2017
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Ingår i: Immunogenetics. - : Springer Science and Business Media LLC. - 0093-7711 .- 1432-1211. ; 69:7, s. 463-478
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Tidskriftsartikel (refereegranskat)abstract
- The major histocompatibility complex (MHC) encodes proteins that are central for antigen presentation and pathogen elimination. MHC class I (MHC-I) genes have attracted a great deal of interest among researchers in ecology and evolution and have been partly characterized in a wide range of bird species. So far, the main focus has been on species within the bird orders Galliformes and Passeriformes, while Charadriiformes remain vastly underrepresented with only two species studied to date. These two Charadriiformes species exhibit striking differences in MHC-I characteristics and MHC-I diversity. We therefore set out to study a third species within Charadriiformes, the Icelandic subspecies of black-tailed godwits (Limosa limosa islandica). This subspecies is normally confined to parasite-poor environments, and we hence expected low MHC diversity. MHC-I was partially characterized first using Sanger sequencing and then using high-throughput sequencing (MiSeq) in 84 individuals. We verified 47 nucleotide alleles in open reading frame with classical MHC-I characteristics, and each individual godwit had two to seven putatively classical MHC alleles. However, in contrast to previous MHC-I data within Charadriiformes, we did not find any evidence of alleles with low sequence diversity, believed to represent non-classical MHC genes. The diversity and divergence of the godwits MHC-I genes to a large extent fell between the previous estimates within Charadriiformes. However, the MHC genes of the migratory godwits had few sites subject to positive selection, and one possible explanation could be a low exposure to pathogens.
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| 28. |
- Pardal, Sara, et al.
(författare)
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Dressed to impress : breeding plumage as a reliable signal of innate immunity
- 2018
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Ingår i: Journal of Avian Biology. - : Wiley. - 0908-8857 .- 1600-048X. ; 49:7
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Tidskriftsartikel (refereegranskat)abstract
- Animal signals involved in sexual selection are often indicators of individual quality. The assumption that sexual characters such as breeding plumage may indicate immune state has rarely been tested in free-living migratory birds, particularly in relation to innate immunity. If sexual characters indeed reflect immune condition, then these could be used to evaluate individual quality. Melanin is a common pigment used in animal communication that mitigates the effects of oxidative stress and has positive effects on energy homeostasis, important functions during the strenuous activity of long-distance flights. However, melanin is also immunosuppressive, and the melanised patches of breeding plumage may to some extent compromise immune responsiveness. We studied melanin-based secondary sexual characters (SSC) in a long-distance migratory wader, the black-tailed godwit Limosa limosa, and found that breeding plumage features of male and female godwits are linked to components of innate immunity. Males with a larger colour extension had higher circulating levels of haptoglobin and hemolysis activity, while they also presented a lower body condition; whereas females presented a negative trend between colour and bar extension and hemolysis activity, and a positive trend for natural antibodies. The association between signal, immune state and physical condition in males suggests a cost for signal production and immune condition during prenuptial migration. Sex differences in how signals relate with immune capacity are a likely consequence of sex-specific signalling roles and energy demands. Our results indicate that male godwit breeding plumage reflects innate immunity state, and is therefore a likely signal for females to use during mate choice as an honest indicator of male's capacity to allocate energy/resources to both expensive traits during periods of energetic constraint.
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| 29. |
- Pillai, Anilkumar, et al.
(författare)
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Complement component 3 levels in the cerebrospinal fluid of cognitively intact elderly individuals with major depressive disorder.
- 2019
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Ingår i: Biomarkers in neuropsychiatry. - : Elsevier BV. - 2666-1446. ; 1
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Tidskriftsartikel (refereegranskat)abstract
- Late-life major depression (LLMD) is a risk factor for the development of mild cognitive impairment and dementia, including Alzheimer's disease (AD) and vascular dementia. Immune dysregulation and changes in innate immune responses in particular, have been implicated in the pathophysiology of both LLMD and AD. Complement system, a key component of the innate immune mechanism, is known to play an important role in synaptic plasticity and cognitive functions. However, its role in LLMD remains unknown. In the present study, we examined the levels of complement component 3 (C3, the convergence point of all complement activation pathways) in the cerebrospinal fluid (CSF) of elderly depressed subjects compared to healthy controls; as well as the relationship of CSF C3 levels with amyloid-beta (Aβ42 and Aβ40), total tau (T-tau) and phosphorylated tau (P-tau) proteins and cognition scores. CSF was obtained from 50 cognitively intact volunteers (major depression group, N = 30; comparison group, N = 20) and analyzed for levels of C3 by ELISA. C3 levels were marginally lower in the major depression group relative to the comparison group. We did not find any significant association of C3 with the AD biomarkers Aβ42 reflecting plaque pathology, P-tau related to tau pathology or the neurodegeneration biomarker T-tau. In contrast, C3 was positively correlated with CSF Aβ40, which may reflect Aβ deposition in cerebral vessel walls. We observed a negative correlation between C3 levels and Total Recall on the Buschke Selective Reminding Test (BSRT) for memory performance in the depressed subjects when controlling for education. This initial evidence on C3 status in LLMD subjects may have implications for our understanding of the pathophysiology of major depression especially in late life.
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| 30. |
- Pomara, Nunzio, et al.
(författare)
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Evidence of upregulation of the cholinergic anti-inflammatory pathway in late-life depression.
- 2021
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Ingår i: Journal of affective disorders. - : Elsevier BV. - 1573-2517 .- 0165-0327. ; 286, s. 275-281
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Tidskriftsartikel (refereegranskat)abstract
- Decreased cholinergic tone associated with increased proinflammatory cytokines has been observed in several human diseases associated with low-grade inflammation. We examined if this attenuated cholinergic anti-inflammatory pathway (CAP) mechanism contributed to increased neuroinflammation observed in depression.We measured cerebrospinal fluid (CSF) cholinergic markers (AChE and BChE activities) in 28 individuals with longstanding late-life major depression (LLMD) and 19 controls and their relationship to central and peripheral levels of pro-inflammatory cytokines (IL-6 and IL-8). Additionally, we examined if these cholinergic indices were related to CSF markers of microglial activation and neuroinflammation (sTREM2 and complement C3).Compared with controls, LLMD patients had a significant reduction in CSF BChE levels. Lower CSF BChE and AChE activities were associated with lower CSF markers of microglial and neuroinflammation (sTREM2 and C3). In addition, in LLMD patients we found an inverse relationship between peripheral marker of inflammation (plasma IL-6) and CSF BChE and AChE levels.Our results suggest an upregulation of the CAP mechanism in LLMD with an elevation in peripheral markers of inflammation and concomitant reduction in markers of glial activation associated with a higher cholinergic tone. Future studies should confirm these findings in a larger sample including individuals with acute and more severe depressive episodes and across all ages.
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| 31. |
- Pozuelo, S. Esteban, et al.
(författare)
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Estimating the longitudinal magnetic field in the chromosphere of quiet-Sun magnetic concentrations
- 2023
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 672
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Tidskriftsartikel (refereegranskat)abstract
- Context. Details of the magnetic field in the quiet-Sun chromosphere are key to our understanding of essential aspects of the solar atmosphere. However, the strength and orientation of this magnetic field have not been thoroughly studied at high spatial resolution.Aims. We aim to determine the longitudinal magnetic field component (B∥) of quiet-Sun regions depending on their size.Methods. We estimated B∥ by applying the weak-field approximation to high-spatial-resolution Ca II 854.2 nm data taken with the Swedish 1 m Solar Telescope. Specifically, we analyzed the estimates inferred for different spectral ranges using the data at the original cadence and temporally integrated signals.Results. The longitudinal magnetic field in each considered plasma structure correlates with its size. Using a spectral range restricted to the line core leads to chromospheric longitudinal fields varying from ∼50 G at the edges to 150–500 G at the center of the structure. These values increase as the spectral range widens due to the photospheric contribution. However, the difference between this contribution and the chromospheric one is not uniform for all structures. Small and medium-sized concentrations show a steeper height gradient in B∥ compared to their chromospheric values, so estimates for wider ranges are less trustworthy. Signal addition does not alleviate this situation as the height gradients in B∥ are consistent with time. Finally, despite the amplified noise levels that deconvolving processes may cause, data restored with the destretching technique show similar results, though are affected by smearing.Conclusions. We obtained B∥ estimates similar to those previously found, except for large concentrations and wide spectral ranges. In addition, we report a correlation between the height variation of B∥ compared to the chromospheric estimates and the concentration size. This correlation affects the difference between the photospheric and chromospheric magnetic flux values and the reliability of the estimates for wider spectral ranges.
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| 32. |
- Ramos, Jaime, 1960
(författare)
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YBa2Cu3O7-δ Biepitaxial and Step Edge Josephson Junctions on MgO Substrates. SQUID Amplifier
- 1996
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis concerns the preparation of Josephson junctions and their applications in Superconducting Quantum Interference Devices (SQUIDs). High temperature superconductors were used for operation at 77 K, the boiling temperature of liquid nitrogen. To perform the study, high quality superconducting films had to be deposited and low noise junctions had to be prepared. This thesis treats the optimization process for the preparation of superconducting films, Josephson junctions and dc SQUIDs. The preparation of YBa2Cu3O7 (YBaCuO), high-TC superconducting films has been investigated. The optimization of the deposition parameters was performed by using the pulsed laser deposition technique. The superconducting films were prepared on (100)MgO and r-cut sapphire substrates. It has been shown that an annealing process of the MgO substrates at 950 °C, prior to the deposition of YBaCuO, improved substantially the reproducibility of the experiments. The deposition of a thin (10 nm thick) homoepitaxial MgO buffer layer improved the epitaxy of the YBaCuO thin films. Under certain deposition parameters, the application of CeO2 buffer layers improved the epitaxy of the YBaCuO layers on r-cut sapphire. Critical current density values of 1-2x106 A/cm2 have been measured at 77 K in microbridges prepared on MgO and CeO2-buffered sapphire substrates. MgO substrates have been covered with an structured photoresist mask and shortly (
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| 33. |
- Ramos, Saioa, et al.
(författare)
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SENSE tool: easy-to-use web-based tool to calculate food product environmental impact
- 2016
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Ingår i: The International Journal of Life Cycle Assessment. - : Springer Ferlag. - 0948-3349 .- 1614-7502. ; 21:5, s. 710-721
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: The purpose of the European SENSE project was to define an integral system to assess and communicate the environmental impacts of food products and to develop a web-based tool for Small and Medium size Enterprises (SMEs). The tool has been tested in salmon, beef-and-dairy, and fruit juice production sectors. Methods: The SENSE project has evaluated several existing methodologies for environmental impact assessment over the life cycle including also social aspects, in order to deliver a new integral system for the environmental and social assessment of agricultural and aquaculture food products. Results and discussion: The system includes a standardization of a data gathering system, a selection of relevant key environmental performance indicators for food supply chains and a common methodology to perform simplified life cycle impact assessment. The results are based on collected information on the use of resources and emissions generated along the supply chain of food or drink products. The main result is a web-based software tool that is based on a summation of the partial impacts of the different steps in food supply chains. In this software, different actors in the supply chain can enter their own data and link them to the data of other companies. The results obtained in the tool could be used for at least six different approaches: (i) environmental impact assessment of the product, (ii) food chain hot spot identification, (iii) comparison of hypothetical or real improvement scenarios, (iv) assessment of the environmental impact development over the years, (v) benchmarking opportunity for the companies, and (vi) a business to business communication strategy. The scientific robustness of the tool has been tested comparing the obtained results with the same analysis with commercial software. Conclusions: The SENSE tool is a simplified tool designed for food and drink SMEs to assess their sustainability on their own. This cannot be fully compared to a complete LCA study. The testing with SMEs showed that they need additional support for filling in the questionnaires correctly and interpret the results. The simplified evaluation of environmental impacts based on a life cycle approach could lead to benefits to SMEs within the food industry. The future application and development of the tool will be focused on adapting the tool to the Product Environmental Footprint initiative requirements and self-assessment opportunities.
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| 34. |
- Socas-Navarro, H., et al.
(författare)
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An open-source, massively parallel code for non-LTE synthesis and inversion of spectral lines and Zeeman-induced Stokes profiles
- 2015
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 577
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Tidskriftsartikel (refereegranskat)abstract
- With the advent of a new generation of solar telescopes and instrumentation, interpreting chromospheric observations (in particular, spectropolarimetry) requires new, suitable diagnostic tools. This paper describes a new code, NICOLE, that has been designed for Stokes non-LTE radiative transfer, for synthesis and inversion of spectral lines and Zeeman-induced polarization profiles, spanning a wide range of atmospheric heights from the photosphere to the chromosphere. The code features a number of unique features and capabilities and has been built from scratch with a powerful parallelization scheme that makes it suitable for application on massive datasets using large supercomputers. The source code is written entirely in Fortran 90/2003 and complies strictly with the ANSI standards to ensure maximum compatibility and portability. It is being publicly released, with the idea of facilitating future branching by other groups to augment its capabilities.
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| 35. |
- Vázquez, Inês, et al.
(författare)
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Psychological Adjustment Profiles of LGBTQ+ Young Adults Residing with Their Parents during the COVID-19 Pandemic : An International Study
- 2023
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Ingår i: International Journal of Environmental Research and Public Health. - : MDPI. - 1661-7827 .- 1660-4601. ; 20:4
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Tidskriftsartikel (refereegranskat)abstract
- The COVID-19 pandemic has been associated with poor mental health symptoms, particularly among vulnerable populations such as LGBTQ+ individuals. In the present study, we aimed to (i) identify different psychological adjustment profiles among LGBTQ+ young adults during the COVID-19 pandemic and compare LGBTQ+ young adults in relation to (ii) sociodemographic characteristics and COVID-19-related experiences and (iii) the internal and external protective resources associated with each adjustment profile. An online questionnaire was administered to 1699 LGBTQ+ young adults from six countries (Brazil, Chile, Italy, Portugal, Sweden, and the UK). A cluster analysis was conducted, and four profiles of psychological adjustment were identified: unchallenged, resilient, distressed, and at-risk. The at-risk cluster scored lowest in social support (particularly from family). The profiles of participants who experienced the highest levels of pandemic adversity (at-risk and resilient) comprised mostly South American participants, those under lockdown at the time of survey completion, those who self-identified as transgender and non-binary, and those with a plurisexual sexual orientation. Interventions should consider strategies to help young adults maintain support systems and reinforce the value of positive family relationships. Specific groups within the LGBTQ+ community that seem to be in a particularly vulnerable situation may need additional tailored support.
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| 36. |
- Xu, Han, et al.
(författare)
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Dissecting the structure-stability relationship of Y-series electron acceptors for real-world solar cell applications
- 2023
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Ingår i: Joule. - 2542-4351. ; 7:9, s. 2135-2151
-
Tidskriftsartikel (refereegranskat)abstract
- Despite striking progress toward improving the photovoltaic (PV) performance of organic solar cells (OSCs) with recent Y-series non-fullerene acceptors (Y-NFAs), knowledge about their outdoor performance under real-world conditions and photodegradation mechanisms remains elusive, which is urgently needed to close the lab-to-fab gap of OSCs. Herein, for the first time, we study the structure-outdoor-stability relationship of Y-NFAs. We show that Y-NFAs with long internal side-chains exhibit high energy barriers for photoisomerization, and fluorinated end-groups can enhance the structural confinement to inhibit the photodegradation pathway and thereby improve device stability. Furthermore, the performance loss of Y-NFA-based OSCs under illumination is mainly driven by increased trap-assisted recombination over time. The structure-stability correlation and demonstration of outdoor performance of these state-of-the-art Y-NFA cells provided in this study highlight molecular engineering of device stability control to minimize power output losses in real-world climates.
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| 37. |
- Yadav, Rahul, et al.
(författare)
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Three-dimensional magnetic field structure of a flux-emerging region in the solar atmosphere
- 2019
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 632
-
Tidskriftsartikel (refereegranskat)abstract
- We analyze high-resolution spectropolarimetric observations of a flux-emerging region (FER) in order to understand its magnetic and kinematic structure. Our spectropolarimetric observations in the HeI 10830 angstrom spectral region of a FER were recorded with GRIS at the 1.5 m aperture GREGOR telescope. A Milne-Eddington-based inversion code was employed to extract the photospheric information of the SiI spectral line, whereas the HeI triplet line was analyzed with the Hazel inversion code, which takes into account the joint action of the Hanle and the Zeeman effects. The spectropolarimetric analysis of the SiI line reveals a complex magnetic structure near the vicinity of the FER, where a weak (350-600 G) and horizontal magnetic field was observed. In contrast to the photosphere, the analysis of the HeI triplet presents a smooth variation of the magnetic field vector (ranging from 100 to 400 G) and velocities across the FER. Moreover, we find supersonic downflows of similar to 40 km s(-1) appearing near the foot points of loops connecting two pores of opposite polarity, whereas strong upflows of 22 km s(-1) appear near the apex of the loops. At the location of supersonic downflows in the chromosphere, we observed downflows of 3 km s(-1) in the photosphere. Furthermore, nonforce-free field extrapolations were performed separately at two layers in order to understand the magnetic field topology of the FER. We determine, using extrapolations from the photosphere and the observed chromospheric magnetic field, that the average formation height of the HeI triplet line is similar to 2 Mm from the solar surface. The reconstructed loops using photospheric extrapolations along an arch filament system have a maximum height of similar to 10.5 Mm from the solar surface with a foot-point separation of similar to 19 Mm, whereas the loops reconstructed using chromospheric extrapolations reach around similar to 8.4 Mm above the solar surface with a foot-point separation of similar to 16 Mm at the chromospheric height. The magnetic topology in the FER suggests the presence of small-scale loops beneath the large loops. Under suitable conditions, due to magnetic reconnection, these loops can trigger various heating events in the vicinity of the FER.
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| 38. |
- Zhou, Bin, et al.
(författare)
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Worldwide trends in diabetes since 1980: A pooled analysis of 751 population-based studies with 4.4 million participants
- 2016
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Ingår i: The Lancet. - : Elsevier B.V.. - 0140-6736 .- 1474-547X. ; 387:10027, s. 1513-1530
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Tidskriftsartikel (refereegranskat)abstract
- Background: One of the global targets for non-communicable diseases is to halt, by 2025, the rise in the age standardised adult prevalence of diabetes at its 2010 levels. We aimed to estimate worldwide trends in diabetes, how likely it is for countries to achieve the global target, and how changes in prevalence, together with population growth and ageing, are aff ecting the number of adults with diabetes.Methods: We pooled data from population-based studies that had collected data on diabetes through measurement of its biomarkers. We used a Bayesian hierarchical model to estimate trends in diabetes prevalence-defined as fasting plasma glucose of 7.0 mmol/L or higher, or history of diagnosis with diabetes, or use of insulin or oral hypoglycaemic drugs-in 200 countries and territories in 21 regions, by sex and from 1980 to 2014. We also calculated the posterior probability of meeting the global diabetes target if post-2000 trends continue.Findings: We used data from 751 studies including 4372000 adults from 146 of the 200 countries we make estimates for. Global age-standardised diabetes prevalence increased from 4.3% (95% credible interval 2.4-17.0) in 1980 to 9.0% (7.2-11.1) in 2014 in men, and from 5.0% (2.9-7.9) to 7.9% (6.4-9.7) in women. The number of adults with diabetes in the world increased from 108 million in 1980 to 422 million in 2014 (28.5% due to the rise in prevalence, 39.7% due to population growth and ageing, and 31.8% due to interaction of these two factors). Age-standardised adult diabetes prevalence in 2014 was lowest in northwestern Europe, and highest in Polynesia and Micronesia, at nearly 25%, followed by Melanesia and the Middle East and north Africa. Between 1980 and 2014 there was little change in age-standardised diabetes prevalence in adult women in continental western Europe, although crude prevalence rose because of ageing of the population. By contrast, age-standardised adult prevalence rose by 15 percentage points in men and women in Polynesia and Micronesia. In 2014, American Samoa had the highest national prevalence of diabetes (>30% in both sexes), with age-standardised adult prevalence also higher than 25% in some other islands in Polynesia and Micronesia. If post-2000 trends continue, the probability of meeting the global target of halting the rise in the prevalence of diabetes by 2025 at the 2010 level worldwide is lower than 1% for men and is 1% for women. Only nine countries for men and 29 countries for women, mostly in western Europe, have a 50% or higher probability of meeting the global target.Interpretation: Since 1980, age-standardised diabetes prevalence in adults has increased, or at best remained unchanged, in every country. Together with population growth and ageing, this rise has led to a near quadrupling of the number of adults with diabetes worldwide. The burden of diabetes, both in terms of prevalence and number of adults aff ected, has increased faster in low-income and middle-income countries than in high-income countries.
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