| 1. |
- Aad, G., et al.
(författare)
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The ATLAS Experiment at the CERN Large Hadron Collider
- 2008
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Ingår i: Journal of Instrumentation. - 1748-0221. ; 3:S08003
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Forskningsöversikt (refereegranskat)abstract
- The ATLAS detector as installed in its experimental cavern at point 1 at CERN is described in this paper. A brief overview of the expected performance of the detector when the Large Hadron Collider begins operation is also presented.
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| 2. |
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| 3. |
- Ramstedt, Madeleine, et al.
(författare)
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Bacterial and mammalian cell response to poly(3-sulfopropyl methacrylate) brushes loaded with silver halide salts
- 2009
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Ingår i: Biomaterials. - : Elsevier BV. - 0142-9612 .- 1878-5905. ; 30:8, s. 1524-31
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Tidskriftsartikel (refereegranskat)abstract
- This study investigates the antibacterial and cytotoxic effect of surfaces with sulphonate brushes containing silver salts. By using the same type of samples for both cytotoxicity and antibacterial studies, these two parameters could be compared in a controlled way. The silver was incorporated into the brush in four different forms to enable release of silver ions at different concentrations and different rates. It was found that although the surfaces displayed very good antibacterial properties in buffer solutions, this effect disappeared in systems with high protein content. Similarly, the silver-containing surfaces displayed cytotoxic effects in the absence of serum proteins but this effect was reduced in the presence of serum. The speciation of silver in the different solutions is discussed. Cytotoxic and antibacterial effects are compared at the different silver concentrations released. The implications of a concentration range where silver could be used to kill bacterial without harmful effects on mammalian cells are also discussed and questioned.
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| 4. |
- Ramstedt, Madeleine, et al.
(författare)
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Synthesis and characterization of poly(3-sulfopropylmethacrylate) brushes for potential antibacterial applications
- 2007
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Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 23:6, s. 3314-21
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Tidskriftsartikel (refereegranskat)abstract
- This article describes the aqueous atom transfer radical polymerization synthesis of poly(3-sulfopropylmethacrylate) brushes onto gold and Si/SiO2 surfaces in a controlled manner. The effect of Cu(I)/Cu(II) ratio was examined, and a quartz crystal microbalance was used to study the kinetics of the brush synthesis. The synthesized brushes displayed a thickness from a few nanometers to several hundred nanometers and were characterized using atomic force microscopy, ellipsometry, Fourier transform infrared spectroscopy (FTIR), contact angle measurements, and X-ray photoelectron spectroscopy (XPS). The as-synthesized sulfonate brushes had very good ion-exchange properties for the ions tested in this study, i.e., Na+, K+, Cu2+, and Ag+. FTIR and XPS show that the metal ions are coordinating to sulfonate moieties inside the brushes. The brushes were easily loaded with silver ions, and the effect of silver ion concentration on silver loading of the brush was examined. The silver-loaded brushes were shown to be antibacterial toward both gram negative and gram positive bacteria. The silver leaching was studied through leaching experiments into water, NaNO3, and NaCl (physiological medium). The results from these leaching experiments are compared and discussed in the article.
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| 5. |
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| 6. |
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| 7. |
- Ramstedt, S., et al.
(författare)
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The Physics and Chemistry of Circumstellar Envelopes of S Stars on the AGB
- 2007
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Ingår i: Proceedings of " Why galaxies care about stars: their importance as actors and probes", eds. F. Kerschbaum, C. Charbonnel and R.F. Wing, Vienna, August 2006, ASP Conference Series. - 9781583813188 ; 378, s. 335-336
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 8. |
- Trmcic-Cvitas, Jelena, et al.
(författare)
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Biofunctionalized protein resistant oligo(ethylene glycol)-derived polymer brushes as selective immobilization and sensing platforms
- 2009
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Ingår i: Biomacromolecules. - : American Chemical Society. - 1526-4602 .- 1525-7797. ; 10:10, s. 2885-94
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Tidskriftsartikel (refereegranskat)abstract
- Poly(oligo(ethylene glycol) methacrylate) (POEGMA) brushes are extremely protein resistant polymer coatings that can reduce nonspecific adsorption of proteins from complex mixtures such as blood, sera and plasma. These coatings can be prepared via atom transfer radical polymerization with excellent control of their thickness and grafting density. We studied their direct functionalization with streptavidin and developed an assay for determining which coupling conditions afford the highest streptavidin loading efficiency. Disuccinimidyl carbonate was found to be the most efficient activating agent for covalent capture of the receptor. Using infrared and X-ray photoelectron spectroscopy, fluorescence microscopy, surface plasmon resonance, and ellipsometry, we examined how structural parameters such as the length of the oligo(ethylene glycol) side chain affect streptavidin functionalization, but also immobilization of biotinylated antibodies, subsequent selective secondary recognition and nonspecific binding of proteins. We found evidence that large macromolecules cannot infiltrate dense polymer brushes and that bulky antibody recognition occurs in the upper part of these coatings.
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| 9. |
- van Poll, Maaike L, et al.
(författare)
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A self-assembly approach to chemical micropatterning of poly(dimethylsiloxane)
- 2007
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Ingår i: Angewandte Chemie International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 46:35, s. 6634-7
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Tidskriftsartikel (refereegranskat)abstract
- The surface of a silicone elastomer (poly(dimethylsiloxane); PDMS) can be selectively modified through minimization of interfacial free energy and self-assembly of functional molecules at the surface by mirroring the distribution of template surface energies (see scheme for formation of POEGMA brushes; SAM=self-assembled monolayer, bipy=2,2′-bipyridyl, POEGMA=poly[oligo(ethylene glycol) methacrylate]).
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| 10. |
- van Poll, Maaike L, et al.
(författare)
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Surface modification of PDMS via self-organization of vinyl-terminated small molecules
- 2009
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Ingår i: Soft Matter. - : RSC Publishing. - 1744-683X .- 1744-6848. ; 5:11, s. 2286-2293
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Tidskriftsartikel (refereegranskat)abstract
- Polydimethylsiloxane (PDMS) elastomers are widely used in soft lithography, microfluidics and biomedical applications as they combine a range of desirable chemical and physical properties. We studied the surface of PDMS modified using surface enrichment with long-chain alkenes. These alkenes were immobilized during crosslinking of the PDMS pre-polymer mixture cast against a template of matching surface energy. A range of different functional groups was introduced, including perfluorinated and oligoethylene glycol groups, alkyl chains and initiators for controlled radical polymerization. A detailed analysis of the composition of the modified PDMS surfaces was carried out using contact angle measurements, AFM, SIMS and XPS. The results demonstrate that the PDMS was enriched with small molecules near the surface and show that the functional molecules follow the template surface energy on patterned surfaces with edge resolutions equal to the template. By introducing hydrophilic alkenes receding contact angles on PDMS can be lowered below 5°, and we investigated how these surfaces rearrange in air due to the chain mobility of the PDMS backbone and PDMS short-chain fragments.
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