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- Abrahamsson, Lena, et al.
(författare)
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Ungdomar och kvinnor utvecklar en konceptfabrik : ett annorlunda projekt
- 2008
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Denna rapport beskriver projektplanen för projektet Framtidsfabriken - en konceptfabrik utformad av kvinnor och ungdomar. Syftet med projektet är att bidra till utvecklingen av arbetsformer som ger en bättre arbetsmiljö för både kvinnor och män i industriellt arbete samt att ta fram uppdaterade principer för ett modernt industriellt produktionssystem. Vi utgår från de krav på det goda industri¬arbetet som ungdomar och kvinnor i dagens samhälle ställer. Vår metodidé är att försöka bryta gängse mönster i utformning av produktions¬system genom att låta grupper som i vanliga fall inte deltar i produk¬tionsutveckling (ungdomar och kvinnor) praktiskt medverka. Projektet genomförs 2008-2010 och har fyra faser: 1) kunskapsöversikt kring produktionssystem, arbetsmiljö och genus, 2) förstudie - en empirisk kartläggning av problem och preferenser kring produktionsmiljö, främst hos kvinnor i industrin och ungdomar, men också andra aktörer, 3) "projektering" - projektets interaktiva del där arbetsgrupper bestående av ungdomar och kvinnor med hjälp av forskarna arbetar fram en attraktiv och samtidigt effektiv "konceptfabrik", dvs. en visualiserad modell över ett framtida produktionssystem, och en uppsättning uppdaterade kriterier för det goda industriarbetet på systemnivå. 4) Summerande analys.
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| 2. |
- Eriksson, Maria A, 1965-, et al.
(författare)
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Sex-related differences in the associations between hyperleptinemia, insulin resistance and dysfibrinolysis
- 2008
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Ingår i: Blood Coagulation and Fibrinolysis. - : Lippincott Williams & Wilkins. - 1473-5733 .- 0957-5235. ; 19:7, s. 625-632
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Tidskriftsartikel (refereegranskat)abstract
- The adipocyte-derived hormone leptin is associated with insulin resistance and reduced fibrinolytic status - or dysfibrinolysis - in humans. As leptin associates differentially to the development of cardiovascular disease and diabetes in men and women, we hypothesized that leptin and insulin sensitivity are related to dysfibrinolysis in a sex-dependent manner. Thirty-two men and 40 women were recruited from the Monitoring of trends and determinants in Cardiovascular disease (MONICA) population sample, representing the highest and lowest quartiles of fasting insulin levels. Lipids, fibrinolytic status [plasminogen activator inhibitor 1 (PAI-1) activity, tissue plasminogen activator (tPA) mass and activity, and tPA-PAI complex], leptin, testosterone and sex-hormone-binding globulin were measured. Insulin sensitivity was estimated using the euglycaemic clamp technique. Body composition was determined by bioimpedance. Determinants for circulating levels of fibrinolytic factors were explored in a multivariate linear regression analysis. Levels of fibrinolytic variables and estimated insulin sensitivity did not differ between men and women. Leptin was independently associated with reduced fibrinolytic status high PAI-1 activity, low tPA activity, high tPA mass, and high tPA-PAI complex) in men (P<0.001-0.002). In women, fat mass and/or insulin sensitivity were related to these factors (P<0.001-0.03), and leptin only to reduced tPA activity (P = 0.002). Hyperleptinemia, dysfibrinolysis, insulin sensitivity and androgenicity associate differentially in men and women. Blood Coagul Fibrinolysis 19:625-632 (C) 2008 Wolters Kluwer Health | Lippincott Williams & Wilkins.
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| 3. |
- Mattsson, Cecilia, et al.
(författare)
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Gender-specific links between hepatic 11beta reduction of cortisone and adipokines
- 2007
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Ingår i: Obesity. - : Wiley. - 1930-7381 .- 1930-739X. ; 15:4, s. 887-894
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: Reduction of cortisone to cortisol is mediated by 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1), a putative key enzyme in obesity-related complications. Experimental studies suggest that adipokines, notably leptin and tumor necrosis factor-alpha (TNF-alpha), are of importance for 11betaHSD1 activity. We hypothesized that the regulation of hepatic preceptor glucocorticoid metabolism is gender-specific and associated with circulating levels of leptin and TNF-alpha receptors and/or sex hormones. RESEARCH METHODS AND PROCEDURES: A total of 34 males and 38 women (14 premenopausal and 22 postmenopausal) underwent physical examination and fasting blood sampling. Insulin sensitivity was tested by euglycemic hyperinsulinemic clamps, and hepatic 11betaHSD1 enzyme activity was estimated by the conversion of orally-ingested cortisone to cortisol. RESULTS: Hepatic 11betaHSD1 activity was negatively associated with leptin and soluble TNF (sTNF) r1 and sTNFr2 in males. These correlations remained significant after adjustment for age and insulin sensitivity, and for sTNF-alpha receptors also after adjustment of BMI and waist circumference. In contrast, 11beta reduction of cortisone was positively associated to leptin in females after adjustment for BMI and waist circumference. DISCUSSION: Hepatic 11beta reduction shows different links to circulating adipocyte-derived hormones in males and females. This emphasizes the need for further studies on tissue-specific regulation of 11betaHSD1 in both genders.
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| 4. |
- Rask, Kjell, et al.
(författare)
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Similarities and differences between lean production, tayloristic and socio-technical systems revealed in the methodology characteristics map
- 2008
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Ingår i: Proceedings of the 18th International Conference on Flexible Automation and Intelligent Manufacturing. - 9789163327575 ; , s. 995-1001
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Konferensbidrag (refereegranskat)abstract
- In this paper we illustrate similarities and differences between Lean Production, Sociotechnical System Theory and Taylorism (Scientific Management) in the methodology characteristics map. 10 categories are extracted from basic literature and classified for each of the methodologies, for the construction of the chart. 4 of the categories relate to division of work, where we discuss integration and segregation of work. 2 categories relate to instructions and information, while the remaining 4 are related to the general focus of the methodology. With reflections to the illustrated results in the chart, we discuss sources to disagreement about similarities and differences between the methodologies.
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