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Hippocampal subfiel...
Hippocampal subfield volumetry from structural isotropic 1 mm3 MRI scans : A note of caution
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- Wisse, Laura E.M. (författare)
- Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,University of Pennsylvania
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- Chételat, Gaël (författare)
- University of Caen Normandy
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- Daugherty, Ana M. (författare)
- Wayne State University
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- de Flores, Robin (författare)
- University of Caen Normandy
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- la Joie, Renaud (författare)
- University of California, San Francisco
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- Mueller, Susanne G. (författare)
- Veterans Health Administration,University of California, San Francisco
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- Stark, Craig E.L. (författare)
- University of California, Irvine
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- Wang, Lei (författare)
- Northwestern University
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- Yushkevich, Paul A. (författare)
- University of Pennsylvania
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- Berron, David (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Raz, Naftali (författare)
- Wayne State University,Max Planck Institute for Human Development
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- Bakker, Arnold (författare)
- Johns Hopkins University
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- Olsen, Rosanna K. (författare)
- Rotman Research Institute
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- Carr, Valerie A. (författare)
- San Jose State University
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(creator_code:org_t)
- 2020-10-15
- 2021
- Engelska.
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Ingår i: Human Brain Mapping. - : Wiley. - 1065-9471 .- 1097-0193. ; 42:2, s. 539-550
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://onlinelibrar...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Spurred by availability of automatic segmentation software, in vivo MRI investigations of human hippocampal subfield volumes have proliferated in the recent years. However, a majority of these studies apply automatic segmentation to MRI scans with approximately 1 × 1 × 1 mm3 resolution, a resolution at which the internal structure of the hippocampus can rarely be visualized. Many of these studies have reported contradictory and often neurobiologically surprising results pertaining to the involvement of hippocampal subfields in normal brain function, aging, and disease. In this commentary, we first outline our concerns regarding the utility and validity of subfield segmentation on 1 × 1 × 1 mm3 MRI for volumetric studies, regardless of how images are segmented (i.e., manually or automatically). This image resolution is generally insufficient for visualizing the internal structure of the hippocampus, particularly the stratum radiatum lacunosum moleculare, which is crucial for valid and reliable subfield segmentation. Second, we discuss the fact that automatic methods that are employed most frequently to obtain hippocampal subfield volumes from 1 × 1 × 1 mm3 MRI have not been validated against manual segmentation on such images. For these reasons, we caution against using volumetric measurements of hippocampal subfields obtained from 1 × 1 × 1 mm3 images.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- 1 mm
- FreeSurfer
- hippocampal subfields
- MRI
- volumetry
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Wisse, Laura E.M ...
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Chételat, Gaël
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Daugherty, Ana M ...
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de Flores, Robin
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la Joie, Renaud
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Mueller, Susanne ...
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visa fler...
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Stark, Craig E.L ...
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Wang, Lei
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Yushkevich, Paul ...
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Berron, David
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Raz, Naftali
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Bakker, Arnold
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Olsen, Rosanna K ...
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Carr, Valerie A.
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visa färre...
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