| 1. |
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| 2. |
- Feroci, M., et al.
(författare)
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The large observatory for x-ray timing
- 2014
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Ingår i: Proceedings of SPIE - The International Society for Optical Engineering. - : SPIE. - 9780819496126
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Konferensbidrag (refereegranskat)abstract
- The Large Observatory For x-ray Timing (LOFT) was studied within ESA M3 Cosmic Vision framework and participated in the final downselection for a launch slot in 2022-2024. Thanks to the unprecedented combination of effective area and spectral resolution of its main instrument, LOFT will study the behaviour of matter under extreme conditions, such as the strong gravitational field in the innermost regions of accretion flows close to black holes and neutron stars, and the supranuclear densities in the interior of neutron stars. The science payload is based on a Large Area Detector (LAD, 10 m2 effective area, 2-30 keV, 240 eV spectral resolution, 1° collimated field of view) and a Wide Field Monitor (WFM, 2-50 keV, 4 steradian field of view, 1 arcmin source location accuracy, 300 eV spectral resolution). The WFM is equipped with an on-board system for bright events (e.g. GRB) localization. The trigger time and position of these events are broadcast to the ground within 30 s from discovery. In this paper we present the status of the mission at the end of its Phase A study.
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| 3. |
- Feroci, M., et al.
(författare)
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LOFT - The large observatory for x-ray timing
- 2012
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Ingår i: Proceedings of SPIE - The International Society for Optical Engineering. - : SPIE - International Society for Optical Engineering. - 9780819491442 ; , s. 84432D-
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Konferensbidrag (refereegranskat)abstract
- The LOFT mission concept is one of four candidates selected by ESA for the M3 launch opportunity as Medium Size missions of the Cosmic Vision programme. The launch window is currently planned for between 2022 and 2024. LOFT is designed to exploit the diagnostics of rapid X-ray flux and spectral variability that directly probe the motion of matter down to distances very close to black holes and neutron stars, as well as the physical state of ultradense matter. These primary science goals will be addressed by a payload composed of a Large Area Detector (LAD) and a Wide Field Monitor (WFM). The LAD is a collimated (<1 degree field of view) experiment operating in the energy range 2-50 keV, with a 10 m2 peak effective area and an energy resolution of 260 eV at 6 keV. The WFM will operate in the same energy range as the LAD, enabling simultaneous monitoring of a few-steradian wide field of view, with an angular resolution of <5 arcmin. The LAD and WFM experiments will allow us to investigate variability from submillisecond QPO's to yearlong transient outbursts. In this paper we report the current status of the project.
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| 4. |
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| 5. |
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| 6. |
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| 7. |
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| 8. |
- Yusuf, D, et al.
(författare)
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The transcription factor encyclopedia
- 2012
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Ingår i: Genome biology. - : Springer Science and Business Media LLC. - 1474-760X .- 1465-6906. ; 13:3, s. R24-
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Tidskriftsartikel (refereegranskat)
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| 9. |
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| 10. |
- Hamadani, Mehdi, et al.
(författare)
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Early Failure of Frontline Rituximab-Containing Chemo-immunotherapy in Diffuse Large B Cell Lymphoma Does Not Predict Futility of Autologous Hematopoietic Cell Transplantation
- 2014
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Ingår i: Biology of blood and marrow transplantation. - : Elsevier BV. - 1083-8791 .- 1523-6536. ; 20:11, s. 1729-1736
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Tidskriftsartikel (refereegranskat)abstract
- The poor prognosis for patients with diffuse large B cell lymphoma (DLBCL) who relapse within 1 year of initial diagnosis after first-line rituximab-based chemo-immunotherapy has created controversy about the role of autologous transplantation (HCT) in this setting. We compared autologous HCT outcomes for chemosensitive DLBCL patients between 2000 and 2011 in 2 cohorts based on time to relapse from diagnosis. The early rituximab failure (ERF) cohort consisted of patients with primary refractory disease or those with first relapse within 1 year of initial diagnosis. The ERF cohort was compared with those relapsing >1 year after initial diagnosis (late rituximab failure [LRF] cohort). ERF and LRF cohorts included 300 and 216 patients, respectively. Nonrelapse mortality (NRM), progression/relapse, progression-free survival (PFS), and overall survival (OS) of ERF versus LRF cohorts at 3 years were 9% (95% confidence interval [CI], 6% to 13%) versus 9% (95% CI, 5% to 13%), 47% (95% CI, 41% to 52%) versus 39% (95% CI, 33% to 46%), 44% (95% CI, 38% to 50%) versus 52% (95% CI, 45% to 59%), and 50% (95% CI, 44% to 56%) versus 67% (95% CI, 60% to 74%), respectively. On multivariate analysis, ERF was not associated with higher NRM (relative risk [RR], 1.31; P = .34). The ERF cohort had a higher risk of treatment failure (progression/relapse or death) (RR, 2.08; P < .001) and overall mortality (RR, 3.75; P < .001) within the first 9 months after autologous HCT. Beyond this period, PFS and OS were not significantly different between the ERF and LRF cohorts. Autologous HCT provides durable disease control to a sizeable subset of DLBCL despite ERF (3-year PFS, 44%) and remains the standard-of-care in chemosensitive DLBCL regardless of the timing of disease relapse.
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| 11. |
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| 14. |
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| 15. |
- Ay, Hakan, et al.
(författare)
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Pathogenic Ischemic Stroke Phenotypes in the NINDS-Stroke Genetics Network
- 2014
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Ingår i: Stroke. - 0039-2499. ; 45:12, s. 3589-3596
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND AND PURPOSE: NINDS (National Institute of Neurological Disorders and Stroke)-SiGN (Stroke Genetics Network) is an international consortium of ischemic stroke studies that aims to generate high-quality phenotype data to identify the genetic basis of pathogenic stroke subtypes. This analysis characterizes the etiopathogenetic basis of ischemic stroke and reliability of stroke classification in the consortium. METHODS: Fifty-two trained and certified adjudicators determined both phenotypic (abnormal test findings categorized in major pathogenic groups without weighting toward the most likely cause) and causative ischemic stroke subtypes in 16954 subjects with imaging-confirmed ischemic stroke from 12 US studies and 11 studies from 8 European countries using the web-based Causative Classification of Stroke System. Classification reliability was assessed with blinded readjudication of 1509 randomly selected cases. RESULTS: The distribution of pathogenic categories varied by study, age, sex, and race (P<0.001 for each). Overall, only 40% to 54% of cases with a given major ischemic stroke pathogenesis (phenotypic subtype) were classified into the same final causative category with high confidence. There was good agreement for both causative (κ 0.72; 95% confidence interval, 0.69-0.75) and phenotypic classifications (κ 0.73; 95% confidence interval, 0.70-0.75). CONCLUSIONS: This study demonstrates that pathogenic subtypes can be determined with good reliability in studies that include investigators with different expertise and background, institutions with different stroke evaluation protocols and geographic location, and patient populations with different epidemiological characteristics. The discordance between phenotypic and causative stroke subtypes highlights the fact that the presence of an abnormality in a patient with stroke does not necessarily mean that it is the cause of stroke.
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| 16. |
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| 17. |
- Zhu, C. H., et al.
(författare)
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Topological Ferroelectric Bistability in a Polarization-Modulated Orthogonal Smectic Liquid Crystal
- 2012
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Ingår i: Journal of the American Chemical Society. - : American Chemical Society (ACS). - 1520-5126 .- 0002-7863. ; 134:23, s. 9681-9687
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Tidskriftsartikel (refereegranskat)abstract
- We report a bent-core liquid crystal (LC) compound exhibiting two fluid smectic phases in which two-dimensional, polar, orthorhombic layers order into three-dimensional ferroelectric states. The lower-temperature phase has a uniform polarization field which responds in an analog fashion to applied electric field. The higher-temperature phase is a new smectic state with periodic undulation of the polarization, structurally modulated layers, and a bistable response to applied electric field which originates in the periodically splay-modulated bulk of the LC rather than by surface stabilization at the cell boundaries.
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| 18. |
- Baxtera, Shannon A., et al.
(författare)
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Regulation of the lymphatic endothelial cell cycle by the PROX1 homeodomain protein
- 2011
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Ingår i: Biochimica et Biophysica Acta. Molecular Cell Research. - : Elsevier. - 0167-4889 .- 1879-2596. ; 1813:1, s. 201-212
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Tidskriftsartikel (refereegranskat)abstract
- The homeobox transcription factor PROX1 is essential for the development and maintenance of lymphatic vasculature. How PROX1 regulates lymphatic endothelial cell fate remains undefined. PROX1 has been shown to upregulate the expression of Cyclin E, which mediates the G1 to S transition of the cell cycle. Here we demonstrate that PROX1 activates the mouse Cyclin E1 (Ccne1) promoter via two proximal E2F-binding sites. We have determined that the N-terminal region of PROX1 is sufficient to activate a 1-kb Ccne1 promoter, whereas the homeodomain is dispensable for activation. We have identified that the Prospero domain 1 (PD1) is required for the nuclear localization of PROX1. Our comparison of two DNA-binding-deficient constructs of PROX1 showed a cell-type-specific difference between these two proteins in both their localization and function. We demonstrated that siRNA-mediated knockdown of PROX1 in lymphatic endothelial cells decreases progression from G1 to S phase of the cell cycle. We conclude that PROX1 activates the Ccne1 promoter independent of DNA binding, and our results illustrate a novel role for PROX1 in the regulation of lymphatic endothelial cell proliferation.
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| 19. |
- Bhowal, S., et al.
(författare)
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Development of collective structures over noncollective excitations in Nd-139
- 2011
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Ingår i: Physical Review C (Nuclear Physics). - 0556-2813. ; 84:2
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Tidskriftsartikel (refereegranskat)abstract
- High-spin states in Nd-139 were investigated using the reaction Zr-96(Ca-48,5n) at a beam energy of 195 MeV and gamma-ray coincidences were acquired with the Euroball spectrometer. Apart from several dipole bands at medium excitation energy, three quadrupole bands have been observed at high spin. Linking transitions connecting two of the high-spin bands to low-energy states have been observed. Calculations based on the cranked-Nilsson-Strutinsky formalism have been used to assign configurations for the high-spin quadrupole bands.
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| 20. |
- Brannon, A Rose, et al.
(författare)
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Molecular Stratification of Clear Cell Renal Cell Carcinoma by Consensus Clustering Reveals Distinct Subtypes and Survival Patterns.
- 2010
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Ingår i: Genes & cancer. - : Sage. - 1947-6027 .- 1947-6019. ; 1:2, s. 152-163
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Tidskriftsartikel (refereegranskat)abstract
- Clear cell renal cell carcinoma (ccRCC) is the predominant RCC subtype, but even within this classification, the natural history is heterogeneous and difficult to predict. A sophisticated understanding of the molecular features most discriminatory for the underlying tumor heterogeneity should be predicated on identifiable and biologically meaningful patterns of gene expression. Gene expression microarray data were analyzed using software that implements iterative unsupervised consensus clustering algorithms to identify the optimal molecular subclasses, without clinical or other classifying information. ConsensusCluster analysis identified two distinct subtypes of ccRCC within the training set, designated clear cell type A (ccA) and B (ccB). Based on the core tumors, or most well-defined arrays, in each subtype, logical analysis of data (LAD) defined a small, highly predictive gene set that could then be used to classify additional tumors individually. The subclasses were corroborated in a validation data set of 177 tumors and analyzed for clinical outcome. Based on individual tumor assignment, tumors designated ccA have markedly improved disease-specific survival compared to ccB (median survival of 8.6 vs 2.0 years, P = 0.002). Analyzed by both univariate and multivariate analysis, the classification schema was independently associated with survival. Using patterns of gene expression based on a defined gene set, ccRCC was classified into two robust subclasses based on inherent molecular features that ultimately correspond to marked differences in clinical outcome. This classification schema thus provides a molecular stratification applicable to individual tumors that has implications to influence treatment decisions, define biological mechanisms involved in ccRCC tumor progression, and direct future drug discovery.
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| 21. |
- Carrizo, Daniel, et al.
(författare)
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Compound-specific bromine isotope compositions of one natural and six = dustrially synthesised organobromine substances
- 2011
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Ingår i: Environmental Chemistry. - 1448-2517 .- 1449-8979. ; 8:2, s. 127-132
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Tidskriftsartikel (refereegranskat)abstract
- AB The stable bromine isotopic composition (delta(81)Br) was determined for six industrially synthesised brominated organic compounds (BOCs) and one natural BOC by gas-chromatography multi-collector inductively coupled plasma mass spectrometry (GC-mcICP-MS). The delta(81)Br compositions of brominated benzenes, phenols (both natural and industrial), anisoles, and naphthalenes were constrained with the standard differential measurement approach using as reference a monobromobenzene sample with an independently determined delta(81)Br value (-0.39 parts per thousand v. Standard Mean Ocean Bromide, SMOB). The delta(81)Br values for the industrial BOCs ranged from -4.3 to -0.4 parts per thousand. The average delta(81)Br value for the natural compound (2,4-dibromophenol) was 0.2 +/- 1.6% (1 s.d.), and for the identical industrial compound (2,4-dibromophenol) -1.1 +/- 0.9 parts per thousand (1 s.d.), with a statistically significant difference of similar to 1.4 (P<0.05). The delta(81)Br of four out of six industrial compounds was found to be significantly different from that of the natural sample. These novel results establish the bromine isotopic variability among the industrially produced BOCs in relation to a natural sample.
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| 22. |
- Filippov, Stanislav, et al.
(författare)
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Effects of Ni-coating on ZnO nanowires : A Raman scattering study
- 2013
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Ingår i: Journal of Applied Physics. - : American Institute of Physics (AIP). - 0021-8979 .- 1089-7550. ; 113:21, s. 214302-1-214302-6
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Tidskriftsartikel (refereegranskat)abstract
- Structural properties of ZnO/Ni core/shell nanowires (NWs) are studied in detail by means of Raman spectroscopy. It is shown that formation of the Ni shell leads to passivation of surface states responsible for the observed enhanced intensity of the A1(LO) Raman mode of the bare ZnO NWs. It also causes appearance of 490 cm−1 and 710 cm−1 modes that are attributed to local vibrational modes of a defect/impurity (or defects/impurities). This defect is concluded to be preferably formed in annealed ZnO/Ni NWs and is unlikely to contain a Ni atom, as the same Raman modes were also reported for the Ni-free ZnO nanostructures. From our resonant Raman studies, we also show that the ZnO/Ni core/shell NWs exhibit an enhanced Raman signal with a multiline structure involving A1(LO). This observation is attributed to combined effects of an enhanced Fröhlich interaction at the ZnO/Ni heterointerface and coupling of the scattered light with local surface plasmons excited in the Ni shell. The plasmonic effect is also suggested to allow detection of carbon-related species absorbed at the surface of a single ZnO/Ni NW, promising for applications of such structures as efficient nano-sized gas sensors.
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| 23. |
- Jesorka, Aldo, 1967, et al.
(författare)
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Water coordinated zinc dioxo-chlorin and porphyrin self-assemblies as chlorosomal mimics: Variability of supramolecular interactions
- 2012
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Ingår i: Photochemical and Photobiological Sciences. - : Springer Science and Business Media LLC. - 1474-9092 .- 1474-905X. ; 11:6, s. 1069-1080
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Tidskriftsartikel (refereegranskat)abstract
- Semisynthetic zinc chlorins are shown for the first time to self-assemble in the absence of an intrinsic hydroxy group, which is always present in the chlorosomal bacteriochlorophylls (BChl's) c, d and e. Instead, the presently studied compounds have carbonyl groups. These cannot function as hydrogen bond donating groups. However due to interspacing water molecules bound to the zinc ion, double hydrogen bonding can occur to adjacent tetrapyrrolic macrocycles equipped with carbonyl recognition groups. Solution studies comprising UV-Vis absorption, electronic circular dichroism (ECD) and FT-IR show that different aggregates are formed in hydrated solvents in comparison to dry nonpolar solvents. Single crystal X-ray studies show variable supramolecular interactions either with interspacing water molecules coordinating the Zn ion within a porphyrin or with the 17 2 carbonyl group of a chlorin ligating the Zn ion. Our findings have implications for a minimalistic design of self-assembling chromophores, which can act as efficient light-harvesting units.
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| 24. |
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| 25. |
- Krampert, Monika, et al.
(författare)
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Smad7 Regulates the Adult Neural Stem/Progenitor Cell Pool in a Transforming Growth Factor β- and Bone Morphogenetic Protein-Independent Manner
- 2010
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Ingår i: Molecular and Cellular Biology. - : American Society for Microbiology. - 0270-7306 .- 1098-5549. ; 30:14, s. 3685-3694
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Tidskriftsartikel (refereegranskat)abstract
- Members of the transforming growth factor beta (TGF-beta) family of proteins modulate the proliferation, differentiation, and survival of many different cell types. Neural stem and progenitor cells (NPCs) in the adult brain are inhibited in their proliferation by TGF-beta and by bone morphogenetic proteins (BMPs). Here, we investigated neurogenesis in a hypomorphic mouse model for the TGF-beta and BMP inhibitor Smad7, with the hypothesis that NPC proliferation might be reduced due to increased TGF-beta and BMP signaling. Unexpectedly, we found enhanced NPC proliferation as well as an increased number of label-retaining cells in vivo. The enhanced proliferation potential of mutant cells was retained in vitro in neurosphere cultures. We observed a higher sphere-forming capacity as well as faster growth and cell cycle progression. Use of specific inhibitors revealed that these effects were independent of TGF-beta and BMP signaling. The enhanced proliferation might be at least partially mediated by elevated signaling via epidermal growth factor (EGF) receptor, as mutant cells showed higher expression and activation levels of the EGF receptor. Conversely, an EGF receptor inhibitor reduced the proliferation of these cells. Our data indicate that endogenous Smad7 regulates neural stem/progenitor cell proliferation in a TGF-beta- and BMP-independent manner.
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| 26. |
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| 27. |
- Ren, Qijun, et al.
(författare)
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Evidence for coupling between exciton emissions and surface plasmon in Ni-coated ZnO nanowires
- 2012
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Ingår i: Nanotechnology. - : Institute of Physics Publishing (IOPP). - 0957-4484 .- 1361-6528. ; 23:42, s. 425201-
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Tidskriftsartikel (refereegranskat)abstract
- We show that coating ZnO nanowires (NWs) with a transition metal, such as Ni, can increase the efficiency of light emission at room temperature. Based on detailed structural and optical studies, this enhancement is attributed to energy transfer between near-band-edge emission in ZnO and surface plasmons in the Ni film which leads to an increased rate of the spontaneous emission. It is also shown that the Ni coating leads to an enhanced non-radiative recombination via surface states, which becomes increasingly important at low measurement temperatures and in annealed ZnO/Ni NWs.
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| 28. |
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| 29. |
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| 30. |
- Ssembatya, Martin, et al.
(författare)
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Simulation studies on performance of solar cooling system in UAE conditions
- 2014
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Ingår i: Energy Procedia 48. - : Elsevier. ; , s. 1007-1016
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Konferensbidrag (refereegranskat)abstract
- The abundance of solar radiation makes the approach of solar cooling the most sustainable cooling solutions for the Gulf countries like UAE. In this article, the performance of a 10 TR solar absorption cooling system was evaluated by TRNSYS simulation. The system used for simulation studies was developed at SOLAB of CSEM-uae for the purpose of assessing the potential of applying solar cooling systems in this region. Simulation results show that the solar cooling system operates with a COP in the range of 0.60 - 0.80. The simulation results closely match a typical day performance validating the model. The currently installed system can meet its cooling requirement for almost 2/3rd of year without back up heating and/or cooling.
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| 31. |
- Stehr, Jan Eric, et al.
(författare)
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Defect properties of ZnO nanowires
- 2014
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Ingår i: AIP Conference Proceedings. - : AIP Publishing LLC. - 0094-243X .- 1551-7616. ; 1583, s. 272-276
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Tidskriftsartikel (refereegranskat)abstract
- In this work we examined optical and defect properties of as-grown and Ni-coated ZnO nanowires (NWs) grown by rapid thermal chemical vapor deposition by means of optically detected magnetic resonance (ODMR). Several grown-in defects are revealed by monitoring visible photoluminescence (PL) emissions and are attributed to Zn vacancies, O vacancies, a shallow (but not effective mass) donor and exchange-coupled pairs of a Zn vacancy and a Zn interstitial. It is also found that the same ODMR signals are detected in the as-grown and Ni-coated NWs, indicating that metal coatings does not significantly affect formation of the aforementioned defects and that the observed defects are located in the bulk of the NWs.
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| 32. |
- Stehr, Jan Eric, et al.
(författare)
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Defect properties of ZnO nanowires revealed from an optically detected magnetic resonance study
- 2013
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Ingår i: Nanotechnology. - : Institute of Physics. - 0957-4484 .- 1361-6528. ; 24:1, s. 015701-
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Tidskriftsartikel (refereegranskat)abstract
- Optically detected magnetic resonance (ODMR) complemented by photoluminescence measurements is used to evaluate optical and defect properties of ZnO nanowires (NWs) grown by rapid thermal chemical vapor deposition. By monitoring visible emissions, several grown-in defects are revealed and attributed to Zn vacancies, shallow (but not effective mass) donor and exchange-coupled pairs of Zn vacancies and Zn interstitials. It is also found that the intensity of the donor-related ODMR signals is substantially lower in the NWs compared with that in bulk ZnO. This may indicate that formation of native donors is suppressed in NWs, which is beneficial for achieving p-type conductivity.
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| 33. |
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