Sökning: WFRF:(Reizenstein Johan A)
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Electroporation the...
Electroporation therapy for T1 and T2 oral tongue cancer
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- Landström, Fredrik J., 1966- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Örebro University Hospital, Örebro, Sweden
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- Nilsson, Christer O. S. (författare)
- Örebro University Hospital, Örebro, Sweden
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- Reizenstein, Johan A. (författare)
- Örebro University Hospital, Örebro, Sweden
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- Nordqvist, Kent (författare)
- Örebro University Hospital, Örebro, Sweden
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- Adamsson, Gun-Britt (författare)
- Örebro University Hospital, Örebro, Sweden
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- Löfgren, Lennart A., 1939- (författare)
- Dept Head & Neck, Center for Oncology, Örebro Univ Hospital, Örebro, Sweden
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(creator_code:org_t)
- 2010-12-29
- 2011
- Engelska.
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Ingår i: Acta Oto-Laryngologica. - : Informa Healthcare. - 0001-6489 .- 1651-2251. ; 131:6, s. 660-664
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Conclusion: Electroporation therapy appears to be a safe treatment achieving excellent local tumor control and very good functional results in our study and it should be further clinically evaluated.Objectives: The objectives of this study were to assess local tumor control, survival, and effects on speech and eating after treatment of tongue cancer with electroporation therapy, a new local therapeutic modality. In this approach intracellular accumulation of a chemotherapeutic agent is achieved by using a locally applied electrical field.Methods: Fifteen patients with primary T1 and T2 oral tongue cancer were treated with electroporation therapy with intratumorally administered bleomycin. Postoperative radiotherapy was performed when the tumor infiltration was 5 mm or more. The follow-up time was 24 months for the surviving patients and 20.4 months overall. The effects on eating and speech were assessed using the PSS-HN scale and voice recordings.Results: No local recurrence was recorded in any patient during the follow-up. Three patients died, two from progressive regional disease. Of the 12 surviving patients, 2 patients had regional recurrence and 10 patients including the 5 patients treated with EPT alone were tumor-free both locally and regionally at the last follow-up. The functional outcome for speech and eating were very good.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)
Nyckelord
- Electrochemotherapy
- bleomycin
- local control
- survival
- speech
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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