| 1. |
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| 2. |
- Glasbey, JC, et al.
(författare)
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- 2021
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swepub:Mat__t
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| 3. |
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| 4. |
- Drake, TM, et al.
(författare)
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Surgical site infection after gastrointestinal surgery in children: an international, multicentre, prospective cohort study
- 2020
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Ingår i: BMJ global health. - : BMJ. - 2059-7908. ; 5:12
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Tidskriftsartikel (refereegranskat)abstract
- Surgical site infection (SSI) is one of the most common healthcare-associated infections (HAIs). However, there is a lack of data available about SSI in children worldwide, especially from low-income and middle-income countries. This study aimed to estimate the incidence of SSI in children and associations between SSI and morbidity across human development settings.MethodsA multicentre, international, prospective, validated cohort study of children aged under 16 years undergoing clean-contaminated, contaminated or dirty gastrointestinal surgery. Any hospital in the world providing paediatric surgery was eligible to contribute data between January and July 2016. The primary outcome was the incidence of SSI by 30 days. Relationships between explanatory variables and SSI were examined using multilevel logistic regression. Countries were stratified into high development, middle development and low development groups using the United Nations Human Development Index (HDI).ResultsOf 1159 children across 181 hospitals in 51 countries, 523 (45·1%) children were from high HDI, 397 (34·2%) from middle HDI and 239 (20·6%) from low HDI countries. The 30-day SSI rate was 6.3% (33/523) in high HDI, 12·8% (51/397) in middle HDI and 24·7% (59/239) in low HDI countries. SSI was associated with higher incidence of 30-day mortality, intervention, organ-space infection and other HAIs, with the highest rates seen in low HDI countries. Median length of stay in patients who had an SSI was longer (7.0 days), compared with 3.0 days in patients who did not have an SSI. Use of laparoscopy was associated with significantly lower SSI rates, even after accounting for HDI.ConclusionThe odds of SSI in children is nearly four times greater in low HDI compared with high HDI countries. Policies to reduce SSI should be prioritised as part of the wider global agenda.
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| 5. |
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| 6. |
- Barucca, G., et al.
(författare)
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The potential of Λ and Ξ- studies with PANDA at FAIR
- 2021
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Ingår i: European Physical Journal A. - : Springer Nature. - 1434-6001 .- 1434-601X. ; 57:4
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Tidskriftsartikel (refereegranskat)abstract
- The antiproton experiment PANDA at FAIR is designed to bring hadron physics to a new level in terms of scope, precision and accuracy. In this work, its unique capability for studies of hyperons is outlined. We discuss ground-state hyperons as diagnostic tools to study non-perturbative aspects of the strong interaction, and fundamental symmetries. New simulation studies have been carried out for two benchmark hyperon-antihyperon production channels: p¯ p→ Λ¯ Λ and p¯ p→ Ξ¯ +Ξ-. The results, presented in detail in this paper, show that hyperon-antihyperon pairs from these reactions can be exclusively reconstructed with high efficiency and very low background contamination. In addition, the polarisation and spin correlations have been studied, exploiting the weak, self-analysing decay of hyperons and antihyperons. Two independent approaches to the finite efficiency have been applied and evaluated: one standard multidimensional efficiency correction approach, and one efficiency independent approach. The applicability of the latter was thoroughly evaluated for all channels, beam momenta and observables. The standard method yields good results in all cases, and shows that spin observables can be studied with high precision and accuracy already in the first phase of data taking with PANDA.
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| 7. |
- Barucca, G., et al.
(författare)
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Study of excited Ξ baryons with the P¯ ANDA detector
- 2021
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Ingår i: European Physical Journal A. - : Springer Nature. - 1434-6001 .- 1434-601X. ; 57:4
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Tidskriftsartikel (refereegranskat)abstract
- The study of baryon excitation spectra provides insight into the inner structure of baryons. So far, most of the world-wide efforts have been directed towards N∗ and Δ spectroscopy. Nevertheless, the study of the double and triple strange baryon spectrum provides independent information to the N∗ and Δ spectra. The future antiproton experiment P¯ANDA will provide direct access to final states containing a Ξ¯ Ξ pair, for which production cross sections up to μb are expected in p¯p reactions. With a luminosity of L= 10 31 cm- 2 s- 1 in the first phase of the experiment, the expected cross sections correspond to a production rate of ∼106events/day. With a nearly 4 π detector acceptance, P¯ANDA will thus be a hyperon factory. In this study, reactions of the type p¯p → Ξ¯ +Ξ∗ - as well as p¯p → Ξ¯ ∗ +Ξ- with various decay modes are investigated. For the exclusive reconstruction of the signal events a full decay tree fit is used, resulting in reconstruction efficiencies between 3 and 5%. This allows high statistics data to be collected within a few weeks of data taking.
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| 8. |
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| 9. |
- van Rheenen, W, et al.
(författare)
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Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
- 2021
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Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 53:12, s. 1636-
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Tidskriftsartikel (refereegranskat)abstract
- Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a lifetime risk of one in 350 people and an unmet need for disease-modifying therapies. We conducted a cross-ancestry genome-wide association study (GWAS) including 29,612 patients with ALS and 122,656 controls, which identified 15 risk loci. When combined with 8,953 individuals with whole-genome sequencing (6,538 patients, 2,415 controls) and a large cortex-derived expression quantitative trait locus (eQTL) dataset (MetaBrain), analyses revealed locus-specific genetic architectures in which we prioritized genes either through rare variants, short tandem repeats or regulatory effects. ALS-associated risk loci were shared with multiple traits within the neurodegenerative spectrum but with distinct enrichment patterns across brain regions and cell types. Of the environmental and lifestyle risk factors obtained from the literature, Mendelian randomization analyses indicated a causal role for high cholesterol levels. The combination of all ALS-associated signals reveals a role for perturbations in vesicle-mediated transport and autophagy and provides evidence for cell-autonomous disease initiation in glutamatergic neurons.
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| 10. |
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| 11. |
- Tedersoo, L., et al.
(författare)
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The Global Soil Mycobiome consortium dataset for boosting fungal diversity research
- 2021
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Ingår i: Fungal Diversity. - : Springer Science and Business Media LLC. - 1560-2745 .- 1878-9129. ; 111, s. 573-588
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Tidskriftsartikel (refereegranskat)abstract
- Fungi are highly important biotic components of terrestrial ecosystems, but we still have a very limited understanding about their diversity and distribution. This data article releases a global soil fungal dataset of the Global Soil Mycobiome consortium (GSMc) to boost further research in fungal diversity, biogeography and macroecology. The dataset comprises 722,682 fungal operational taxonomic units (OTUs) derived from PacBio sequencing of full-length ITS and 18S-V9 variable regions from 3200 plots in 108 countries on all continents. The plots are supplied with geographical and edaphic metadata. The OTUs are taxonomically and functionally assigned to guilds and other functional groups. The entire dataset has been corrected by excluding chimeras, index-switch artefacts and potential contamination. The dataset is more inclusive in terms of geographical breadth and phylogenetic diversity of fungi than previously published data. The GSMc dataset is available over the PlutoF repository.
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| 12. |
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| 13. |
- Addazi, A., et al.
(författare)
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New high-sensitivity searches for neutrons converting into antineutrons and/or sterile neutrons at the HIBEAM/NNBAR experiment at the European Spallation Source
- 2021
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Ingår i: Journal of Physics G. - : Institute of Physics Publishing (IOPP). - 0954-3899 .- 1361-6471. ; 48:7
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Tidskriftsartikel (refereegranskat)abstract
- The violation of baryon number, , is an essential ingredient for the preferential creation of matter over antimatter needed to account for the observed baryon asymmetry in the Universe. However, such a process has yet to be experimentally observed. The HIBEAM/NNBAR program is a proposed two-stage experiment at the European Spallation Source to search for baryon number violation. The program will include high-sensitivity searches for processes that violate baryon number by one or two units: free neutron–antineutron oscillation () via mixing, neutron–antineutron oscillation via regeneration from a sterile neutron state (), and neutron disappearance (n → n'); the effective process of neutron regeneration () is also possible. The program can be used to discover and characterize mixing in the neutron, antineutron and sterile neutron sectors. The experiment addresses topical open questions such as the origins of baryogenesis and the nature of dark matter, and is sensitive to scales of new physics substantially in excess of those available at colliders. A goal of the program is to open a discovery window to neutron conversion probabilities (sensitivities) by up to three orders of magnitude compared with previous searches. The opportunity to make such a leap in sensitivity tests should not be squandered. The experiment pulls together a diverse international team of physicists from the particle (collider and low energy) and nuclear physics communities, while also including specialists in neutronics and magnetics.
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| 14. |
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| 15. |
- Pasquier, J. T., et al.
(författare)
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The Ny-Ålesund Aerosol Cloud Experiment (NASCENT) : Overview and First Results
- 2022
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Ingår i: Bulletin of The American Meteorological Society - (BAMS). - 0003-0007 .- 1520-0477. ; 103:11, s. e2533-E2558
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Tidskriftsartikel (refereegranskat)abstract
- The Arctic is warming at more than twice the rate of the global average. This warming is influenced by clouds, which modulate the solar and terrestrial radiative fluxes and, thus, determine the surface energy budget. However, the interactions among clouds, aerosols, and radiative fluxes in the Arctic are still poorly understood. To address these uncertainties, the Ny-Ålesund Aerosol Cloud Experiment (NASCENT) study was conducted from September 2019 to August 2020 in Ny-Ålesund, Svalbard. The campaign’s primary goal was to elucidate the life cycle of aerosols in the Arctic and to determine how they modulate cloud properties throughout the year. In situ and remote sensing observations were taken on the ground at sea level, at a mountaintop station, and with a tethered balloon system. An overview of the meteorological and the main aerosol seasonality encountered during the NASCENT year is introduced, followed by a presentation of first scientific highlights. In particular, we present new findings on aerosol physicochemical and molecular properties. Further, the role of cloud droplet activation and ice crystal nucleation in the formation and persistence of mixed-phase clouds, and the occurrence of secondary ice processes, are discussed and compared to the representation of cloud processes within the regional Weather Research and Forecasting Model. The paper concludes with research questions that are to be addressed in upcoming NASCENT publications.
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| 16. |
- Rinaldi, P., et al.
(författare)
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MIDIS : Strong (H beta plus [OIII]) and Ha Emitters at Redshift z similar or equal to 7-8 Unveiled with JWST NIRCam and MIRI Imaging in the Hubble eXtreme Deep Field
- 2023
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Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 952:2
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Tidskriftsartikel (refereegranskat)abstract
- We make use of JWST medium-band and broadband NIRCam imaging, along with ultradeep MIRI 5.6 mu m imaging, in the Hubble eXtreme Deep Field to identify prominent line emitters at z similar or equal to 7-8. Out of a total of 58 galaxies at z similar or equal to 7-8, we find 18 robust candidates ( similar or equal to 31%) for (H beta + [O III]) emitters, based on their enhanced fluxes in the F430M and F444W filters, with EW0(H beta +[O III]) similar or equal to 87-2100 angstrom. Among these emitters, 16 lie in the MIRI coverage area and 12 exhibit a clear flux excess at 5.6 mu m, indicating the simultaneous presence of a prominent Ha emission line with EW0(H alpha) similar or equal to 200-3000 angstrom. This is the first time that H alpha emission can be detected in individual galaxies at z > 7. The Ha line, when present, allows us to separate the contributions of H beta and [O III] to the (H beta +[O III]) complex and derive Ha-based star formation rates (SFRs). We find that in most cases [O III]/ H beta > 1. Instead, two galaxies have [O III]/H beta < 1, indicating that the NIRCam flux excess is mainly driven by H beta. Most prominent line emitters are very young starbursts or galaxies on their way to/from the starburst cloud. They make for a cosmic SFR density log(10)( rho(SFRH alpha) (M-circle dot yr(-1) Mpc))similar or equal to - 2.351 3 which is about a quarter of the total value (log(10)( SFR (M-circle dot yr(-1) Mpc))similar or equal to - 1.761 3 ) at z similar or equal to 7-8. Therefore, the strong Ha emitters likely had a significant role in reionization.
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| 17. |
- Bartling, Andrew W., et al.
(författare)
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Techno-economic analysis and life cycle assessment of a biorefinery utilizing reductive catalytic fractionation
- 2021
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Ingår i: Energy & Environmental Science. - : Royal Society of Chemistry (RSC). - 1754-5692 .- 1754-5706. ; 14:8, s. 4147-4168
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Tidskriftsartikel (refereegranskat)abstract
- Reductive catalytic fractionation (RCF) is a promising approach to fractionate lignocellulose and convert lignin to a narrow product slate. To guide research towards commercialization, cost and sustainability must be considered. Here we report a techno-economic analysis (TEA), life cycle assessment (LCA), and air emission analysis of the RCF process, wherein biomass carbohydrates are converted to ethanol and the RCF oil is the lignin-derived product. The base-case process, using a feedstock supply of 2000 dry metric tons per day, methanol as a solvent, and H-2 gas as a hydrogen source, predicts a minimum selling price (MSP) of crude RCF oil of $1.13 per kg when ethanol is sold at $2.50 per gallon of gasoline-equivalent ($0.66 per liter of gasoline-equivalent). We estimate that the RCF process accounts for 57% of biorefinery installed capital costs, 77% of positive life cycle global warming potential (GWP) (excluding carbon uptake), and 43% of positive cumulative energy demand (CED). Of $563.7 MM total installed capital costs, the RCF area accounts for $323.5 MM, driven by high-pressure reactors. Solvent recycle and water removal via distillation incur a process heat demand equivalent to 73% of the biomass energy content, and accounts for 35% of total operating costs. In contrast, H-2 cost and catalyst recycle are relatively minor contributors to operating costs and environmental impacts. In the carbohydrate-rich pulps, polysaccharide retention is predicted not to substantially affect the RCF oil MSP. Analysis of cases using different solvents and hemicellulose as an in situ hydrogen donor reveals that reducing reactor pressure and the use of low vapor pressure solvents could reduce both capital costs and environmental impacts. Processes that reduce the energy demand for solvent separation also improve GWP, CED, and air emissions. Additionally, despite requiring natural gas imports, converting lignin as a biorefinery co-product could significantly reduce non-greenhouse gas air emissions compared to burning lignin. Overall, this study suggests that research should prioritize ways to lower RCF operating pressure to reduce capital expenses associated with high-pressure reactors, minimize solvent loading to reduce reactor size and energy required for solvent recovery, implement condensed-phase separations for solvent recovery, and utilize the entirety of RCF oil to maximize value-added product revenues.
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| 18. |
- Grenville, Z. S., et al.
(författare)
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Diet and BMI Correlate with Metabolite Patterns Associated with Aggressive Prostate Cancer
- 2022
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Ingår i: Nutrients. - : MDPI AG. - 2072-6643. ; 14:16
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Tidskriftsartikel (refereegranskat)abstract
- Three metabolite patterns have previously shown prospective inverse associations with the risk of aggressive prostate cancer within the European Prospective Investigation into Cancer and Nutrition (EPIC). Here, we investigated dietary and lifestyle correlates of these three prostate cancer-related metabolite patterns, which included: 64 phosphatidylcholines and three hydroxysphingomyelins (Pattern 1), acylcarnitines C18:1 and C18:2, glutamate, ornithine, and taurine (Pattern 2), and 8 lysophosphatidylcholines (Pattern 3). In a two-stage cross-sectional discovery (n = 2524) and validation (n = 518) design containing 3042 men free of cancer in EPIC, we estimated the associations of 24 dietary and lifestyle variables with each pattern and the contributing individual metabolites. Associations statistically significant after both correction for multiple testing (False Discovery Rate = 0.05) in the discovery set and at p < 0.05 in the validation set were considered robust. Intakes of alcohol, total fish products, and its subsets total fish and lean fish were positively associated with Pattern 1. Body mass index (BMI) was positively associated with Pattern 2, which appeared to be driven by a strong positive BMI-glutamate association. Finally, both BMI and fatty fish were inversely associated with Pattern 3. In conclusion, these results indicate associations of fish and its subtypes, alcohol, and BMI with metabolite patterns that are inversely associated with risk of aggressive prostate cancer.
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| 19. |
- Abu-Omar, Mahdi M., et al.
(författare)
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Guidelines for performing lignin-first biorefining
- 2021
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Ingår i: Energy & Environmental Science. - : Royal Society of Chemistry (RSC). - 1754-5692 .- 1754-5706. ; 14:1, s. 262-292
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Forskningsöversikt (refereegranskat)abstract
- The valorisation of the plant biopolymer lignin is now recognised as essential to enabling the economic viability of the lignocellulosic biorefining industry. In this context, the lignin-first biorefining approach, in which lignin valorisation is considered in the design phase, has demonstrated the fullest utilisation of lignocellulose. We define lignin-first methods as active stabilisation approaches that solubilise lignin from native lignocellulosic biomass while avoiding condensation reactions that lead to more recalcitrant lignin polymers. This active stabilisation can be accomplished by solvolysis and catalytic conversion of reactive intermediates to stable products or by protection-group chemistry of lignin oligomers or reactive monomers. Across the growing body of literature in this field, there are disparate approaches to report and analyse the results from lignin-first approaches, thus making quantitative comparisons between studies challenging. To that end, we present herein a set of guidelines for analysing critical data from lignin-first approaches, including feedstock analysis and process parameters, with the ambition of uniting the lignin-first research community around a common set of reportable metrics. These guidelines comprise standards and best practices or minimum requirements for feedstock analysis, stressing reporting of the fractionation efficiency, product yields, solvent mass balances, catalyst efficiency, and the requirements for additional reagents such as reducing, oxidising, or capping agents. Our goal is to establish best practices for the research community at large primarily to enable direct comparisons between studies from different laboratories. The use of these guidelines will be helpful for the newcomers to this field and pivotal for further progress in this exciting research area.
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| 20. |
- Bianchi, F., et al.
(författare)
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The SALTENA Experiment : Comprehensive Observations of Aerosol Sources, Formation, and Processes in the South American Andes
- 2022
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Ingår i: Bulletin of The American Meteorological Society - (BAMS). - 0003-0007 .- 1520-0477. ; 103:2, s. E212-E229
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents an introduction to the Southern Hemisphere High Altitude Experiment on Particle Nucleation and Growth (SALTENA). This field campaign took place between December 2017 and June 2018 (wet to dry season) at Chacaltaya (CHC), a GAW (Global Atmosphere Watch) station located at 5,240 m MSL in the Bolivian Andes. Concurrent measurements were conducted at two additional sites in El Alto (4,000 m MSL) and La Paz (3,600 m MSL). The overall goal of the campaign was to identify the sources, understand the formation mechanisms and transport, and characterize the properties of aerosol at these stations. State-of-the-art instruments were brought to the station complementing the ongoing permanent GAW measurements, to allow a comprehensive description of the chemical species of anthropogenic and biogenic origin impacting the station and contributing to new particle formation. In this overview we first provide an assessment of the complex meteorology, airmass origin, and boundary layer-free troposphere interactions during the campaign using a 6-month high-resolution Weather Research and Forecasting (WRF) simulation coupled with Flexible Particle dispersion model (FLEXPART). We then show some of the research highlights from the campaign, including (i) chemical transformation processes of anthropogenic pollution while the air masses are transported to the CHC station from the metropolitan area of La Paz-El Alto, (ii) volcanic emissions as an important source of atmospheric sulfur compounds in the region, (iii) the characterization of the compounds involved in new particle formation, and (iv) the identification of long-range-transported compounds from the Pacific or the Amazon basin. We conclude the article with a presentation of future research foci. The SALTENA dataset highlights the importance of comprehensive observations in strategic high-altitude locations, especially the undersampled Southern Hemisphere.
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| 21. |
- Colina, L., et al.
(författare)
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Uncovering the stellar structure of the dusty star-forming galaxy GN20 at z=4.055 with MIRI/JWST
- 2023
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Ingår i: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 673
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Tidskriftsartikel (refereegranskat)abstract
- Luminous infrared galaxies at high redshifts (z > 4) include extreme starbursts that build their stellar mass over short periods of time, that is, of 100 Myr or less. These galaxies are considered to be the progenitors of massive quiescent galaxies at intermediate redshifts (z similar to 2) but their stellar structure and buildup is unknown. Here, we present the first spatially resolved near-infrared (rest-frame 1.1 mu m) imaging of GN20, one of the most luminous dusty star-forming galaxies known to date, observed at an epoch when the Universe was only 1.5 Gyr old. The 5.6 mu m image taken with the JWST Mid-Infrared Instrument (MIRI/JWST) shows that GN20 is a very luminous galaxy (M-1.1 mu m,M- AB = 25.01, uncorrected for internal extinction), with a stellar structure composed of a conspicuous central source and an extended envelope. The central source is an unresolved nucleus that carries 9% of the total flux. The nucleus is co-aligned with the peak of the cold dust emission, and offset by 3.9 kpc from the ultraviolet stellar emission. The diffuse stellar envelope is similar in size (3.6 kpc effective radius) to the clumpy CO molecular gas distribution. The centroid of the stellar envelope is offset by 1 kpc from the unresolved nucleus, suggesting GN20 is involved in an interaction or merger event supported by its location as the brightest galaxy in a proto-cluster. Additional faint stellar clumps appear to be associated with some of the UV- and CO-clumps. The stellar size of GN20 is larger by a factor of about 3 to 5 than known spheroids, disks, and irregulars at z similar to 4, while its size and low Sersic index are similar to those measured in dusty, infrared luminous galaxies at redshift 2 of the same mass (similar to 10(11) M-circle dot). GN20 has all the ingredients necessary for evolving into a massive spheroidal quiescent galaxy at intermediate redshift: it is a large, luminous galaxy at z = 4.05 involved in a short and massive starburst centred in the stellar nucleus and extended over the entire galaxy, out to radii of 4 kpc, and likely induced by the interaction or merger with a member of the proto-cluster.
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| 22. |
- Fehmi, Janev, et al.
(författare)
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Contactin-1 links autoimmune neuropathy and membranous glomerulonephritis
- 2023
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 18:3 March
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Tidskriftsartikel (refereegranskat)abstract
- Membranous glomerulonephritis (MGN) is a common cause of nephrotic syndrome in adults, mediated by glomerular antibody deposition to an increasing number of newly recognised antigens. Previous case reports have suggested an association between patients with anti-contactin-1 (CNTN1)-mediated neuropathies and MGN. In an observational study we investigated the pathobiology and extent of this potential cause of MGN by examining the association of antibodies against CNTN1 with the clinical features of a cohort of 468 patients with suspected immune-mediated neuropathies, 295 with idiopathic MGN, and 256 controls. Neuronal and glomerular binding of patient IgG, serum CNTN1 antibody and protein levels, as well as immune-complex deposition were determined. We identified 15 patients with immune-mediated neuropathy and concurrent nephrotic syndrome (biopsy proven MGN in 12/12), and 4 patients with isolated MGN from an idiopathic MGN cohort, all seropositive for IgG4 CNTN1 antibodies. CNTN1-containing immune complexes were found in the renal glomeruli of patients with CNTN1 antibodies, but not in control kidneys. CNTN1 peptides were identified in glomeruli by mass spectroscopy. CNTN1 seropositive patients were largely resistant to first-line neuropathy treatments but achieved a good outcome with escalation therapies. Neurological and renal function improved in parallel with suppressed antibody titres. The reason for isolated MGN without clinical neuropathy is unclear. We show that CNTN1, found in peripheral nerves and kidney glomeruli, is a common target for autoantibody-mediated pathology and may account for between 1 and 2% of idiopathic MGN cases. Greater awareness of this cross-system syndrome should facilitate earlier diagnosis and more timely use of effective treatment.
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| 23. |
- Ferrari, P., et al.
(författare)
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Model-Based Stealth Attack to Networked Control System Based on Real-Time Ethernet
- 2021
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Ingår i: IEEE Transactions on Industrial Electronics. - : Institute of Electrical and Electronics Engineers Inc.. - 0278-0046 .- 1557-9948. ; 68:8, s. 7672-7683
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Tidskriftsartikel (refereegranskat)abstract
- In this article, industrial control systems include networked control systems (NCS), which use real-time Ethernet (RTE) protocols since many years, well before the time sensitive networking initiative debut. Today, ethernet-based control systems are used all across Industry 4.0, including in critical applications, allowing for straight integration with information technology layers. Even if it is known that current RTE protocols do not have strong authentication or ciphering options, it is still very challenging to perform undetected cyber-attacks to these protocols while the NSC is in operation, in particular because such attacks must comply with very strict and small temporal constraints. In this article, a model-based attack is proposed for service degradation of NCS. The attack is carried out in real-time and it can remain undetected for the entire plant life. The attack can be applied to any RTE protocols and, without loss of generality, a detailed analysis of stealth techniques is provided for a specific real use case based on PROFINET. The experimental results demonstrate the feasibility of the proposed attack and its high effectiveness. The article also points out some possible future investigation directions in order to mitigate the attack. © 1982-2012 IEEE.
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| 24. |
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| 25. |
- Keddie, Stephen, et al.
(författare)
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Peripherin is a biomarker of axonal damage in peripheral nervous system disease
- 2023
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Ingår i: Brain. - 0006-8950 .- 1460-2156. ; 146:11, s. 4562-4573
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Tidskriftsartikel (refereegranskat)abstract
- Valid, responsive blood biomarkers specific to peripheral nerve damage would improve management of peripheral nervous system (PNS) diseases. Neurofilament light chain (NfL) is sensitive for detecting axonal pathology but is not specific to PNS damage, as it is expressed throughout the PNS and CNS. Peripherin, another intermediate filament protein, is almost exclusively expressed in peripheral nerve axons. We postulated that peripherin would be a promising blood biomarker of PNS axonal damage. We demonstrated that peripherin is distributed in sciatic nerve, and to a lesser extent spinal cord tissue lysates, but not in brain or extra-neural tissues. In the spinal cord, anti-peripherin antibody bound only to the primary cells of the periphery (anterior horn cells, motor axons and primary afferent sensory axons). In vitro models of antibody-mediated axonal and demyelinating nerve injury showed marked elevation of peripherin levels only in axonal damage and only a minimal rise in demyelination. We developed an immunoassay using single molecule array technology for the detection of serum peripherin as a biomarker for PNS axonal damage. We examined longitudinal serum peripherin and NfL concentrations in individuals with Guillain-Barr © syndrome (GBS, n = 45, 179 time points), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP, n = 35, 70 time points), multiple sclerosis (n = 30), dementia (as non-inflammatory CNS controls, n = 30) and healthy individuals (n = 24). Peak peripherin levels were higher in GBS than all other groups (median 18.75 pg/ml versus < 6.98 pg/ml, P < 0.0001). Peak NfL was highest in GBS (median 220.8 pg/ml) and lowest in healthy controls (median 5.6 pg/ml), but NfL did not distinguish between CIDP (17.3 pg/ml), multiple sclerosis (21.5 pg/ml) and dementia (29.9 pg/ml). While peak NfL levels were higher with older age (rho = +0.39, P < 0.0001), peak peripherin levels did not vary with age. In GBS, local regression analysis of serial peripherin in the majority of individuals with three or more time points of data (16/25) displayed a rise-and-fall pattern with the highest value within the first week of initial assessment. Similar analysis of serial NfL concentrations showed a later peak at 16 days. Group analysis of serum peripherin and NfL levels in GBS and CIDP patients were not significantly associated with clinical data, but in some individuals with GBS, peripherin levels appeared to better reflect clinical outcome measure improvement. Serum peripherin is a promising new, dynamic and specific biomarker of acute PNS axonal damage.
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| 26. |
- Mehta, Vishal S., et al.
(författare)
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Machine learning-derived major adverse event prediction of patients undergoing transvenous lead extraction : Using the ESC EHRA EORP European lead extraction ConTRolled ELECTRa registry
- 2022
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Ingår i: Heart Rhythm. - : Elsevier. - 1547-5271 .- 1556-3871. ; 19:6, s. 885-893
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND Transvenous lead extraction (TLE) remains a high-risk procedure. OBJECTIVE The purpose of this study was to develop a machine learning (ML)-based risk stratification system to predict the risk of major adverse events (MAEs) after TLE. A MAE was defined as procedure-related major complication and procedure-related death. METHODS We designed and evaluated an ML-based risk stratification system trained using the European Lead Extraction ConTRolled (ELECTRa) registry to predict the risk of MAEs in 3555 patients undergoing TLE and tested this on an independent registry of 1171 patients. ML models were developed, including a self-normalizing neural network (SNN), stepwise logistic regression model ("stepwise model"), support vector machines, and random forest model. These were compared with the ELECTRa Registry Outcome Score (EROS) for MAEs. RESULTS There were 53 MAEs (1.7%) in the training cohort and 24 (2.4%) in the test cohort. Thirty-two clinically important features were used to train the models. ML techniques were similar to EROS by balanced accuracy (stepwise model: 0.74 vs EROS: 0.70) and superior by area under the curve (support vector machines: 0.764 vs EROS: 0.677). The SNN provided a finite risk for MAE and accurately identified MAE in 14 of 169 "high (<80%) risk" patients (8.3%) and no MAEs in all 198 "low (,20%) risk" patients (100%). CONCLUSION ML models incrementally improved risk prediction for identifying those at risk of MAEs. The SNN has the additional advantage of providing a personalized finite risk assessment for patients. This may aid patient decision making and allow better preoperative risk assessment and resource allocation.
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| 27. |
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| 28. |
- Rinaldi, S., et al.
(författare)
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A Cognitive Strategy for Renovation and Maintenance of Buildings through IoT Technology
- 2020
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Ingår i: Proceedings. - : IEEE Computer Society. - 9781728154145 ; , s. 1949-1954
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Konferensbidrag (refereegranskat)abstract
- Recently, designers of the home automation framework are looking to the Internet of Things (IoT) model to make it easier to deploy devices capable of gathering data from various plants. This situation is pushing a further evolution: from the conventional building automation, where the logic is determined by the installer or by the customer, to a cognitive system, capable of learning from the customers' preferences what the best plant configuration would be. The aim of this research work is to identify issues related to the implementation of cognitive solutions during the renovation process of buildings. The paper proposes a cognitive framework to help the operation and management phases of buildings, by means of the digitalization of the supply chain of the construction industry, from the single building aspect to the entire construction cycle. The paper presents the design of smart building elements with integrated capability to generate a massive amount of data for monitoring the energy and maintenance status of renovated buildings. The IoT paradigm has been used to link the physical word of building elements with the cognitive layer. The proposed approach has been applied and validated into a real test case. © 2020 IEEE.
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| 29. |
- Sisinni, Emiliano, et al.
(författare)
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A new LoRaWAN adaptive strategy for smart metering applications
- 2020
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Ingår i: Proceedings. - : Institute of Electrical and Electronics Engineers Inc.. - 9781728148922 ; , s. 690-695
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Konferensbidrag (refereegranskat)abstract
- One of the most widespread applications of IoT technologies is smart metering. Despite remote metering in smart grids is not a novelty, the advent of Low Power Wide Area Network (LPWAN) wireless technologies allowed to extend the concept to gas and water distribution. However, these battery-supplied meters must ensure an operating lifetime longer than 10 years without any maintenance, thus leading to battery oversizing. This work focuses on LoRaWAN and proposes an innovative adaptive strategy for equalizing the message time duration in order to maximize the battery exploitation. A simulator has been purposely designed to evaluate the performance in a real-world scenario, considering a node density of hundreds of nodes per square km. The simulation results demonstrate that a better exploitation of the battery is possible, ensuring an increase by 10 times of the amount of the amount of useful user data bytes transferred by meters. © 2020 IEEE.
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| 30. |
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| 31. |
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| 32. |
- Verissimo, T., et al.
(författare)
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Decreased Renal Gluconeogenesis Is a Hallmark of Chronic Kidney Disease
- 2022
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Ingår i: Journal of the American Society of Nephrology. - : Ovid Technologies (Wolters Kluwer Health). - 1046-6673 .- 1533-3450. ; 33:4, s. 810-827
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Tidskriftsartikel (refereegranskat)abstract
- Introduction CKD is associated with alterations of tubular function. Renal gluconeogenesis is responsible for 40% of systemic gluconeogenesis during fasting, but how and why CKD affects this process and the repercussions of such regulation are unknown.Methods We used data on the renal gluconeogenic pathway from more than 200 renal biopsies performed on CKD patients and from 43 kidney allograft patients, and studied three mouse models, of proteinuric CKD (POD-ATTAC), of ischemic CKD, and of unilateral urinary tract obstruction. We analyzed a cohort of patients who benefitted from renal catheterization and a retrospective cohort of patients hospitalized in the intensive care unit.Results Renal biopsies of CKD and kidney allograft patients revealed a stage-dependent decrease in the renal gluconeogenic pathway. Two animal models of CKD and one model of kidney fibrosis confirm gluconeogenic downregulation in injured proximal tubule cells. This shift resulted in an alteration of renal glucose production and lactate clearance during an exogenous lactate load. The isolated perfused kidney technique in animal models and renal venous catheterization in CKD patients confirmed decreased renal glucose production and lactate clearance. In CKD patients hospitalized in the intensive care unit, systemic alterations of glucose and lactate levels were more prevalent and associated with increased mortality and a worse renal prognosis at follow-up. Decreased expression of the gluconeogenesis pathway and its regulators predicted faster histologic progression of kidney disease in kidney allograft biopsies.Conclusion Renal gluconeogenic function is impaired in CKD. Altered renal gluconeogenesis leads to systemic metabolic changes with a decrease in glucose and increase in lactate level, and is associated with a worse renal prognosis.
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| 33. |
- Castro-Espin, Carlota, et al.
(författare)
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Dietary patterns related to biological mechanisms and survival after breast cancer diagnosis : results from a cohort study
- 2023
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Ingår i: British Journal of Cancer. - : Nature Publishing Group. - 0007-0920 .- 1532-1827. ; 128, s. 1301-1310
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Tidskriftsartikel (refereegranskat)abstract
- Background: Inflammatory, insulin and oestrogenic pathways have been linked to breast cancer (BC). We aimed to examine the relationship between pre-diagnostic dietary patterns related to these mechanisms and BC survival.Methods: The diabetes risk reduction diet (DRRD), inflammatory score of diet (ISD) and oestrogen-related dietary pattern (ERDP) were calculated using dietary data from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to assess associations between dietary patterns and overall mortality and competing risk models for associations with BC-specific mortality.Results: We included 13,270 BC cases with a mean follow-up after diagnosis of 8.6 years, representing 2340 total deaths, including 1475 BC deaths. Higher adherence to the DRRD score was associated with lower overall mortality (HR1–SD 0.92; 95%CI 0.87–0.96). Greater adherence to pro-inflammatory diets was borderline associated with 6% higher mortality HR1–SD 1.06; 95%CI 1.00–1.12. No significant association with the oestrogen-related dietary pattern was observed. None of the dietary patterns were associated with BC-specific mortality.Conclusions: Greater adherence to an anti-diabetic and anti-inflammatory diet prior to diagnosis is associated with lower overall mortality among BC survivors. Long-term adherence to these dietary patterns could be a means to improve the prognosis of BC survivors.
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| 34. |
- Christakoudi, Sofia, et al.
(författare)
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A body shape index (ABSI) is associated inversely with post-menopausal progesterone-receptor-negative breast cancer risk in a large European cohort
- 2023
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Ingår i: BMC Cancer. - 1471-2407. ; 23:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Associations of body shape with breast cancer risk, independent of body size, are unclear because waist and hip circumferences are correlated strongly positively with body mass index (BMI). Methods: We evaluated body shape with the allometric “a body shape index” (ABSI) and hip index (HI), which compare waist and hip circumferences, correspondingly, among individuals with the same weight and height. We examined associations of ABSI, HI, and BMI (per one standard deviation increment) with breast cancer overall, and according to menopausal status at baseline, age at diagnosis, and oestrogen and progesterone receptor status (ER+/-PR+/-) in multivariable Cox proportional hazards models using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Results: During a mean follow-up of 14.0 years, 9011 incident breast cancers were diagnosed among 218,276 women. Although there was little evidence for association of ABSI with breast cancer overall (hazard ratio HR = 0.984; 95% confidence interval: 0.961–1.007), we found borderline inverse associations for post-menopausal women (HR = 0.971; 0.942-1.000; n = 5268 cases) and breast cancers diagnosed at age ≥ 55 years (HR = 0.976; 0.951–1.002; n = 7043) and clear inverse associations for ER + PR- subtypes (HR = 0.894; 0.822–0.971; n = 726) and ER-PR- subtypes (HR = 0.906; 0.835–0.983 n = 759). There were no material associations with HI. BMI was associated strongly positively with breast cancer overall (HR = 1.074; 1.049–1.098), for post-menopausal women (HR = 1.117; 1.085–1.150), for cancers diagnosed at age ≥ 55 years (HR = 1.104; 1.076–1.132), and for ER + PR + subtypes (HR = 1.122; 1.080–1.165; n = 3101), but not for PR- subtypes. Conclusions: In the EPIC cohort, abdominal obesity evaluated with ABSI was not associated with breast cancer risk overall but was associated inversely with the risk of post-menopausal PR- breast cancer. Our findings require validation in other cohorts and with a larger number of PR- breast cancer cases.
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| 35. |
- Depari, A., et al.
(författare)
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Exploitation of precise timing capabilities of single board computer for transcranial magnetic stimulation
- 2020
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Ingår i: Proceedings. - : Institute of Electrical and Electronics Engineers Inc.. - 9781728148427
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Konferensbidrag (refereegranskat)abstract
- An early Alzheimer Disease (AD) diagnosis is fundamental for maximizing the effectiveness of treatment administration. Unfortunately, distinguish AD from other neurodegenerative dementias, such as Frontotemporal Dementia (FTD) is not trivial. Transcranial Magnetic Stimulation (TMS) emerged as an effective non-invasive, easy to apply and not time-consuming solution. TMS-based techniques generally require expensive ad hoc clinical equipment that suffer from poor flexibility and user friendliness in defining the specific diagnostic protocol. In this work, a low-cost BeagleBone Black single board computer (BBB-SBC) has been used to implement all the functionalities required to manage a TMS-based instrument. Timeliness of signal generation is guaranteed by dedicated programmable real-time units hosted by the BBB-SBC System on Chip. Web-based interface, complemented by IoT-like features, provide a high degree of versatility and permit the execution of many different diagnostic protocols. In particular, the experimental validation confirms timing error in the sub-microsecond range, more than enough for the considered application. © 2020 IEEE.
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| 36. |
- Depari, A., et al.
(författare)
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Simple and robust microcontroller-based acquisition system for differential capacitive sensors
- 2021
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Ingår i: Conference Record - IEEE Instrumentation and Measurement Technology Conference. - : Institute of Electrical and Electronics Engineers Inc.. - 9781728195391
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Konferensbidrag (refereegranskat)abstract
- Differential capacitive sensors, especially if implemented as MEMS (Micro Electro Mechanical Systems) are a widely employed sensor solution, especially after the widespread adoption of the IoT (Internet of things) paradigm. These sensors target very different applications, including accelerometers, gyroscopes, barometers, just to mention a few, because they can take advantage from lower power consumption, better temperature coefficient and manufacturability. The readout circuit plays a central and fundamental role in ensuring optimal overall performance. In this paper, a frontend for interfacing differential capacitive sensors with microcontroller-based systems is discussed and performance is evaluated. In particular, the use of voltage mode is considered and, consequently, the stray capacitance can deeply affect the readouts. The proposed interface evaluates the mismatch between the current flowing in the two sensor equivalent capacitors and estimates the parasitic value. Additionally, the information about the current unbalance is used to improve the measurand estimation. In particular, the proposed approach is able to decrease of one order of magnitude the measurand estimation error, when large stray capacitance affects the sensor. © 2021 IEEE.
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| 37. |
- Depari, A., et al.
(författare)
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Versatile and low-cost sensor interface for IoT-ready odor monitoring in wastewater management
- 2021
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Ingår i: 2021 IEEE Sensors Applications Symposium, SAS 2021 - Proceedings. - : Institute of Electrical and Electronics Engineers Inc.. - 9781728194318
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Konferensbidrag (refereegranskat)abstract
- The monitoring of pollutants in industrial plants is a major concern, in order to satisfy the requirements dictated by the related norms. Recently, the problem of odor monitoring gained importance since, despite the generally low dangerous nature of the emission, people usually correlate bad smell to unhealthy air condition. In this paper, we focus on the wastewater treatment application scenario and propose a versatile air pollution control solution. In particular, a distributed eNose, based on low-cost, but highly configurable sensing probes, is suggested. The Internet of Things (IoT) paradigm has been followed, thanks to the adoption of a communication infrastructure based on the widely adopted LoRaWAN technology. Such an approach, on one hand, would allow to easily cope with the administration and local population; on the other hand, it paves the way to use analytics to predict emission events in advance. The need for managing multiple transducers per each probe has been solved using an innovative acquisition strategy, exploiting both the volt-amperometric and resistance-to-time (integral) approaches, implemented by low-cost microcontroller and ancillary electronics. A proof-of-concept prototype has been realized and preliminary experiments have been carried out. Experimental results have demonstrated the solidity of the proposed approach, with relative error below 1% and relative standard deviation below 0.5% over the whole considered resistive range of more than two decades. © 2021 IEEE.
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| 38. |
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| 39. |
- Fernandes, C. D., et al.
(författare)
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Hybrid indoor and outdoor localization for elderly care applications with LoRaWAN
- 2020
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Ingår i: Proceedings. - : Institute of Electrical and Electronics Engineers Inc.. - 9781728153865
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Konferensbidrag (refereegranskat)abstract
- It is common for elderly to experience a decrease in health conditions, limiting independence. Very often, hospitalization is not required and at home assistance is a more effective solution. Ambient assisted living technologies can help in mitigating the need for continuous supervision, enabling the elderly to easily look for help in case of emergency. In this work, the well-known and widespread LoRaWAN communication infrastructure is evaluated for possible complementing indoor and outdoor positioning solutions, in order to alert a remotely-connected caregiver about accidents (e.g., falls). The choice of LoRaWAN is dictated by the capability to implement both private and public infrastructures. Satellite-based systems are addressed for outdoor localization, whereas the demanding task of indoor localization is solved by means of Ultra Wide Band technology. Results demonstrated sub-meter error in a typical indoor scenario, with average communication latency on the order of 700 ms. © 2020 IEEE.
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| 40. |
- Ferrari, P., et al.
(författare)
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Evaluation of the impact of Cloud Database services on Industrial IoT Applications
- 2020
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Ingår i: Proceedings. - : Institute of Electrical and Electronics Engineers Inc.. - 9781728144603
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Konferensbidrag (refereegranskat)abstract
- The Internet of Things applied to Industry (IIoT) is one of the pillars of Industry 4.0. The connection to Internet of all the industrial devices, and the storage (sharing) of enormous amount of data inside Cloud database, enable the development of analysis algorithms for the delivery of new "high value" services. However, the industrial market may require response with short predictable latency (real-time response) even for supervision and optimization functions. Often today, the estimation of the latency of new services is not taken into account. For all these reasons, this work introduces an experimental measurement procedure for investigating the impact of Cloud database services on the communication delay from the production line to the Cloud and the way back (feedback). In this paper, a use case demonstrates the feasibility of the proposed test methodology. In details, the considered use case is a predictive maintenance system with Siemens S7 industrial automation controller sending data to a Cloudant database inside the IBM Bluemix platform. The use case results show that the IIoT solutions based on Cloud database services can be easily evaluated, compared (and optimized) thanks to the proposed approach. © 2020 IEEE.
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| 41. |
- Ferrari, P., et al.
(författare)
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Evaluation of the impact on industrial applications of NTP Used by IoT devices
- 2020
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Ingår i: Proceedings. - : Institute of Electrical and Electronics Engineers Inc.. - 9781728148922 ; , s. 223-228
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Konferensbidrag (refereegranskat)abstract
- The requirements of distributed systems implemented using IoT paradigms include the sharing of a common time reference. When the applications are intended for industrial scenarios, the desired time synchronization uncertainty decreases, due to the real-time needs of this kind of systems. Currently, the most diffused way to obtain a time reference for an Internet connected device is to use NTP (Network Time Protocol) for querying time servers. This paper is focused on industrial IoT applications and it is aimed to evaluate the impact that NTP synchronization performance and NTP throughput may have on the real-time host network. Analytical formulas for estimating the NTP impact are introduced. The work is complemented by the presentation of a use case that shows the use of NTP for the synchronization of a large industrial plant at field level. The results highlight the threat to the real-time behavior of the automation system caused by the uncontrolled peaks of traffic due to NTP. Last, some design considerations for mitigation of the impact are discussed. © 2020 IEEE.
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| 42. |
- Ferrari, P., et al.
(författare)
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Experimental characterization of an IoV framework leveraging mobile wireless technologies
- 2021
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Ingår i: Conference Record - IEEE Instrumentation and Measurement Technology Conference. - : Institute of Electrical and Electronics Engineers Inc.. - 9781728195391
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Konferensbidrag (refereegranskat)abstract
- The advent of the Internet of Things (IoT) paradigm highlighted the importance of core technologies at the root of any distributed systems, as wireless communications, cloud computing and big data analysis. Today, companies and organizations, pursuing the so-called Industry 4.0 (r)evolution, are moving toward smart factories, smart workforce, and intelligent transportation. The use of IoT technologies for connecting smart vehicles is identified by the IoV acronym, i.e. the Internet of Vehicle. In this work, the authors address the characterization of a distributed measurement platform for vehicle fleet management, focusing on time-related performance. In particular, a commercially available solution has been considered and real-world use cases have been identified, showing obtainable performance: with default configuration, an average overall delay less than 11 s has been estimated. © 2021 IEEE.
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| 43. |
- Ferrari, P., et al.
(författare)
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On the performance of cloud services and databases for industrial IoT scalable applications
- 2020
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Ingår i: Electronics. - : MDPI AG. - 2079-9292. ; 9:9, s. 1-17
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Tidskriftsartikel (refereegranskat)abstract
- In the Industry 4.0 the communication infrastructure is derived from the Internet of Things (IoT), and it is called Industrial IoT or IIoT. Smart objects deployed on the field collect a large amount of data which is stored and processed in the Cloud to create innovative services. However, differently from most of the consumer applications, the industrial scenario is generally constrained by time-related requirements and its needs for real-time behavior (i.e., bounded and possibly short delays). Unfortunately, timeliness is generally ignored by traditional service provider, and the Cloud is treated as a black box. For instance, Cloud databases (generally seen as “Database as a service”—DBaaS) have unknown or hard-to-compare impact on applications. The novelty of this work is to provide an experimental measurement methodology based on an abstract view of IIoT applications, in order to define some easy-to-evaluate metrics focused on DBaaS latency (no matter the actual implementation details are). In particular, the focus is on the impact of DBaaS on the overall communication delays in a typical IIoT scalable context (i.e., from the field to the Cloud and the way back). In order to show the effectiveness of the proposed approach, a real use case is discussed (it is a predictive maintenance application with a Siemens S7 industrial controller transmitting system health status information to a Cloudant DB inside the IBM Bluemix platform). Experiments carried on in this use case provide useful insights about the DBaaS performance: evaluation of delays, effects of involved number of devices (scalability and complexity), constraints of the architecture, and clear information for comparing with other implementations and for optimizing configuration. In other words, the proposed evaluation strategy helps in finding out the peculiarities of Cloud Database service implementations. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
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| 44. |
- Ferrari, P., et al.
(författare)
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Resilient time synchronization opportunistically exploiting UWB RTLS infrastructure
- 2022
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Ingår i: IEEE Transactions on Instrumentation and Measurement. - : Institute of Electrical and Electronics Engineers Inc.. - 0018-9456 .- 1557-9662. ; 71, s. 1-10
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Tidskriftsartikel (refereegranskat)abstract
- Ultra Wide Band (UWB) based solutions for real time localization are starting to be widely diffused. They use two-way ranging scheme achieving indoor positioning accuracy well below ten centimeters. These wireless devices are based on counters with picosecond resolution, which could be used also for nodes time synchronization. This work aims to propose an opportunistic approach for transparently obtaining multiple accurate time synchronization from low-cost infrastructure of Real Time Location Systems (RTLS). After the description of the proposed approach, the idea is demonstrated using off-the-shelf Ultra Wide Band (UWB) modules from Decawave and their related software. Thanks to hardware timestamping support inside the core architecture, the realized wireless station is able to simultaneously lock and track several time references generated by the UWB module. The extensive experimental characterization evaluates both the uncertainty of the reference signal generated by the UWB receiver, and the time synchronization uncertainty of the whole host system running a Proportional Integrative (PI) control loop for locking the master reference clock. The time reference pulses are delivered by the UWB modules with a maximum jitter on the order of 40 ns, whereas the synchronization uncertainty is less than 10 ns. IEEE
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| 45. |
- Ferrari, P., et al.
(författare)
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Turning old into new : Adding LoRaWAN connectivity to PLC in brownfield installations
- 2021
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Ingår i: 2021 IEEE International Workshop on Metrology for Industry 4.0 and IoT, MetroInd 4.0 and IoT 2021 - Proceedings. - : Institute of Electrical and Electronics Engineers Inc.. - 9781665419802 ; , s. 665-670
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Konferensbidrag (refereegranskat)abstract
- Industry 4.0 paradigm improves industrial automation systems efficiency leveraging on the Industrial Internet of Things (IIoT), offering pervasive connectivity with field devices and paving the way to innovative services. Updating legacy machines in brownfield installations is needed for preserving investments. This paper discusses the design and the experimental validation in a real-world use case of a low-cost solution aiming at providing LoRaWAN Class A connectivity to a Programmable Logic Controller (PLC). Widespread modules, offering full compatibility with the standard, are considered. They behave as 'modems' controlled by AT-like commands via simple serial links (RS232), minimizing the need for additional glue logic. The developed solution has been connected to a public LoRaWAN infrastructure, showing average uplink delays in the order of 300-500 ms; on the contrary, downlink messages are constrained by uplink interarrival time. The experiments also highlighted strong correlation between the LoRaWAN network congestion and the end-to-end delay. © 2021 IEEE.
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| 46. |
- Guida, Florence, et al.
(författare)
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The blood metabolome of incident kidney cancer: A case-control study nested within the MetKid consortium
- 2021
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Ingår i: PLoS Medicine. - : Public Library of Science (PLOS). - 1549-1277 .- 1549-1676. ; 18:9
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Tidskriftsartikel (refereegranskat)abstract
- Background: Excess bodyweight and related metabolic perturbations have been implicated in kidney cancer aetiology, but the specific molecular mechanisms underlying these relationships are poorly understood. In this study, we sought to identify circulating metabolites that predispose kidney cancer and to evaluate the extent to which they are influenced by body mass index (BMI).Methods and findings: We assessed the association between circulating levels of 1,416 metabolites and incident kidney cancer using pre-diagnostic blood samples from up to 1,305 kidney cancer case–control pairs from 5 prospective cohort studies. Cases were diagnosed on average 8 years after blood collection. We found 25 metabolites robustly associated with kidney cancer risk. In particular, 14 glycerophospholipids (GPLs) were inversely associated with risk, including 8 phosphatidylcholines (PCs) and 2 plasmalogens. The PC with the strongest association was PC ae C34:3 with an odds ratio (OR) for 1 standard deviation (SD) increment of 0.75 (95% confidence interval [CI]: 0.68 to 0.83, p = 2.6 × 10−8). In contrast, 4 amino acids, including glutamate (OR for 1 SD = 1.39, 95% CI: 1.20 to 1.60, p = 1.6 × 10−5), were positively associated with risk. Adjusting for BMI partly attenuated the risk association for some—but not all—metabolites, whereas other known risk factors of kidney cancer, such as smoking and alcohol consumption, had minimal impact on the observed associations. A mendelian randomisation (MR) analysis of the influence of BMI on the blood metabolome highlighted that some metabolites associated with kidney cancer risk are influenced by BMI. Specifically, elevated BMI appeared to decrease levels of several GPLs that were also found inversely associated with kidney cancer risk (e.g., −0.17 SD change [ßBMI] in 1-(1-enyl-palmitoyl)-2-linoleoyl-GPC (P-16:0/18:2) levels per SD change in BMI, p = 3.4 × 10−5). BMI was also associated with increased levels of glutamate (ßBMI: 0.12, p = 1.5 × 10−3). While our results were robust across the participating studies, they were limited to study participants of European descent, and it will, therefore, be important to evaluate if our findings can be generalised to populations with different genetic backgrounds.Conclusions: This study suggests a potentially important role of the blood metabolome in kidney cancer aetiology by highlighting a wide range of metabolites associated with the risk of developing kidney cancer and the extent to which changes in levels of these metabolites are driven by BMI - the principal modifiable risk factor of kidney cancer.
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| 47. |
- Jones, Geraint H., et al.
(författare)
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The Comet Interceptor Mission
- 2024
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Ingår i: Space Science Reviews. - : Springer Nature. - 0038-6308 .- 1572-9672. ; 220:1
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Tidskriftsartikel (refereegranskat)abstract
- Here we describe the novel, multi-point Comet Interceptor mission. It is dedicated to the exploration of a little-processed long-period comet, possibly entering the inner Solar System for the first time, or to encounter an interstellar object originating at another star. The objectives of the mission are to address the following questions: What are the surface composition, shape, morphology, and structure of the target object? What is the composition of the gas and dust in the coma, its connection to the nucleus, and the nature of its interaction with the solar wind? The mission was proposed to the European Space Agency in 2018, and formally adopted by the agency in June 2022, for launch in 2029 together with the Ariel mission. Comet Interceptor will take advantage of the opportunity presented by ESA’s F-Class call for fast, flexible, low-cost missions to which it was proposed. The call required a launch to a halo orbit around the Sun-Earth L2 point. The mission can take advantage of this placement to wait for the discovery of a suitable comet reachable with its minimum Δ V capability of 600 ms − 1 . Comet Interceptor will be unique in encountering and studying, at a nominal closest approach distance of 1000 km, a comet that represents a near-pristine sample of material from the formation of the Solar System. It will also add a capability that no previous cometary mission has had, which is to deploy two sub-probes – B1, provided by the Japanese space agency, JAXA, and B2 – that will follow different trajectories through the coma. While the main probe passes at a nominal 1000 km distance, probes B1 and B2 will follow different chords through the coma at distances of 850 km and 400 km, respectively. The result will be unique, simultaneous, spatially resolved information of the 3-dimensional properties of the target comet and its interaction with the space environment. We present the mission’s science background leading to these objectives, as well as an overview of the scientific instruments, mission design, and schedule.
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| 48. |
- Kliemann, Nathalie, et al.
(författare)
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Predicted basal metabolic rate and cancer risk in the European Prospective Investigation into Cancer and Nutrition
- 2020
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 147:3, s. 648-661
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Tidskriftsartikel (refereegranskat)abstract
- Emerging evidence suggests that a metabolic profile associated with obesity may be a more relevant risk factor for some cancers than adiposity per se. Basal metabolic rate (BMR) is an indicator of overall body metabolism and may be a proxy for the impact of a specific metabolic profile on cancer risk. Therefore, we investigated the association of predicted BMR with incidence of 13 obesity-related cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). BMR at baseline was calculated using the WHO/FAO/UNU equations and the relationships between BMR and cancer risk were investigated using multivariable Cox proportional hazards regression models. A total of 141,295 men and 317,613 women, with a mean follow-up of 14 years were included in the analysis. Overall, higher BMR was associated with a greater risk for most cancers that have been linked with obesity. However, among normal weight participants, higher BMR was associated with elevated risks of esophageal adenocarcinoma (hazard ratio per 1-standard deviation change in BMR [HR1-SD]: 2.46; 95% CI 1.20; 5.03) and distal colon cancer (HR1-SD: 1.33; 95% CI 1.001; 1.77) among men and with proximal colon (HR1-SD: 1.16; 95% CI 1.01; 1.35), pancreatic (HR1-SD: 1.37; 95% CI 1.13; 1.66), thyroid (HR1-SD: 1.65; 95% CI 1.33; 2.05), postmenopausal breast (HR1-SD: 1.17; 95% CI 1.11; 1.22) and endometrial (HR1-SD: 1.20; 95% CI 1.03; 1.40) cancers in women. These results indicate that higher BMR may be an indicator of a metabolic phenotype associated with risk of certain cancer types, and may be a useful predictor of cancer risk independent of body fatness.
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| 49. |
- Pasetti, M., et al.
(författare)
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Evaluation of the use of class B LoraWAn for the coordination of distributed interface protection systems in smart grids
- 2020
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Ingår i: Journal of Sensor and Actuator Networks. - : MDPI AG. - 2224-2708. ; 9:1
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Tidskriftsartikel (refereegranskat)abstract
- The adoption of the distributed generation paradigm is introducing several changes in the design and operation of modern distribution networks. Modern grid codes are becoming more and more complex, and the adoption of smart protection systems is becoming mandatory. However, the adoption of newer and smarter units is only half of the story. Proper communication networks must be provided as well, and the overall costs may become critical. In this work, the adoption of the Long-Range Wide Area Network (LoRaWAN) technology is suggested as a viable approach to implement the coordination of Interface Protection Systems. A proper communication architecture based on the LoRaWAN Class B technology was proposed and evaluated in order to assess its feasibility for the considered application. A scalability analysis was carried out, by computing the number of devices that can be handled by a single LoRaWAN Gateway (GW) and the maximum expected time of response between a triggering event and the arrival of the related coordination command. The results of the study showed that up to 312 devices can be managed by a single GW, by assuring a maximum response time of 22.95 s. A faster maximum response time of 6.2 s is also possible by reducing the number of managed devices to 12. © 2020 by the authors.
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- Pasetti, M., et al.
(författare)
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Impact of the Measurement Time Resolution on Energy Key Performance Indicators for Distributed Energy Resources : An Experimental Analysis
- 2021
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Ingår i: AMPS 2021 - 2021 11th IEEE International Workshop on Applied Measurements for Power Systems, Proceedings. - : Institute of Electrical and Electronics Engineers Inc.. - 9781728169231
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Konferensbidrag (refereegranskat)abstract
- The growing presence of Renewable Energy Sources (RESs) is heavily affecting the control and management of distribution grids. Battery Energy Storage Systems (BESSs) are increasingly adopted to mitigate the adverse impacts caused by the uncertainty of RES generators. Most of the existing works in the literature aims at using BESSs to maximize the self-consumption of energy provided by RES generators or focuses on the mitigation of voltage and/or frequency drift effects. More recently, some research works also studied the effects that BESSs have on the active power flows at the Point of Common Coupling (PCC) of prosumers. All these studies are based on the definition of proper energy Key Performance Indicators (KPIs) based on heterogeneous information collected from several measurement devices deployed in the field. This also means that the results of such studies could be significantly affected by the quality of data, particularly concerning the time resolution of the measurements. To better highlight this concern, this paper proposes an analysis of the impact of the time resolution of measurements on the evaluation of the absolute power ramp reduction at the PCC of prosumers in presence of BESS installations. The analysis was performed on real data collected from the eLUX lab of the University of Brescia, Italy, by varying the time resolution from 5 s to 15 min. The results of the analysis demonstrated that the time resolution has a great impact on the evaluation of the considered KPI, by leading to completely different performance assessments. © 2021 IEEE.
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