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- Gusev, A, et al.
(författare)
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Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation
- 2016
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7, s. 10979-
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Tidskriftsartikel (refereegranskat)abstract
- Although genome-wide association studies have identified over 100 risk loci that explain ∼33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data from 59,089 men of European and African American ancestries combined with cell-type-specific epigenetic data to build a genomic atlas of single-nucleotide polymorphism (SNP) heritability in PrCa. We find significant differences in heritability between variants in prostate-relevant epigenetic marks defined in normal versus tumour tissue as well as between tissue and cell lines. The majority of SNP heritability lies in regions marked by H3k27 acetylation in prostate adenoc7arcinoma cell line (LNCaP) or by DNaseI hypersensitive sites in cancer cell lines. We find a high degree of similarity between European and African American ancestries suggesting a similar genetic architecture from common variation underlying PrCa risk. Our findings showcase the power of integrating functional annotation with genetic data to understand the genetic basis of PrCa.
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- Riska, K., et al.
(författare)
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Brash ice growth model : development and validation
- 2019
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Ingår i: Cold Regions Science and Technology. - : Elsevier. - 0165-232X .- 1872-7441. ; 157, s. 30-41
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Tidskriftsartikel (refereegranskat)abstract
- Brash ice growth in frequently navigated areas like fairways or ports is quick due to the ‘freezing – breaking’ cycle induced by sub-zero temperatures and ship traffic. This problem is very acute in ports in Arctic areas where the temperatures are very low for long durations and the ship traffic is frequent. In order to take adequate action in managing the brash ice, the forecasts of the amount of brash ice expected should be reliable. The aim of this work is to develop and validate these prediction methods.The growth model developed is based on extension of earlier growth models which modify the Stefan type growth modelling. The improvement on the earlier models is that the brash ice layer is divided into three layers (instead of two in earlier models): The consolidated layer just below the water level, the brash ice over the water level and the unfrozen brash ice below the consolidated layer. The thermodynamic model follows the Stefan formulation including only the heat flux from latent heat release upon freezing (Stefan, 1891 and e.g. Anderson, 1961). The modelling includes the cyclic breaking and refreezing.The validation of the model is made using measurements carried out in winter 2013 in Luleå port and in winter 2015 in Sabetta in the Yamal peninsula. Luleå data suggests that the sideways motion of brash ice due to ship motion and wake should be taken into account when assessing the brash ice thickness. The analytical calculation over-estimates the brash ice thickness in the actual channel but under-estimates the total amount of broken ice. When applied to Sabetta data, the analytical calculation predicts well the observed brash ice thickness. It can be concluded that the analytical method that does not take into account any radiation heat fluxes can be applied in the high Arctic where solar radiation plays a minor role and ice surface is clearly below zero.
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