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PlanHab(*) :
PlanHab(*) : hypoxia does not worsen the impairment of skeletal muscle oxidative function induced by bed rest alone
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- Salvadego, Desy (author)
- Univ Udine, Dept Med, Piazzale M Kolbe 4, I-33100 Udine, Italy.
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- Keramidas, Michail E. (author)
- KTH,Omgivningsfysiologi,Centrum för flyg- och rymdfysiologi, SAPC
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- Kölegård, Roger (author)
- KTH,Omgivningsfysiologi,Centrum för flyg- och rymdfysiologi, SAPC
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- Brocca, Lorenza (author)
- Univ Pavia, Dept Mol Med, Pavia, Italy.
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- Lazzer, Stefano (author)
- Univ Udine, Dept Med, Piazzale M Kolbe 4, I-33100 Udine, Italy.
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- Mavelli, Irene (author)
- Univ Udine, Dept Med, Piazzale M Kolbe 4, I-33100 Udine, Italy.
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- Rittweger, Joern (author)
- German Aerosp Ctr, Inst Aerosp Med, Cologne, Germany.;Univ Cologne, Fac Med, Dept Pediat & Adolescent Med, Cologne, Germany.
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- Eiken, Ola (author)
- KTH,Omgivningsfysiologi,Centrum för flyg- och rymdfysiologi, SAPC
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- Mekjavic, Igor B. (author)
- Jozef Stefan Inst, Dept Automat Biocybernet & Robot, Ljubljana, Slovenia.;Simon Fraser Univ, Dept Biomed Physiol & Kinesiol, Burnaby, BC, Canada.
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- Grassi, Bruno (author)
- Univ Udine, Dept Med, Piazzale M Kolbe 4, I-33100 Udine, Italy.;CNR, Inst Bioimaging & Mol Physiol, Milan, Italy.
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Univ Udine, Dept Med, Piazzale M Kolbe 4, I-33100 Udine, Italy Omgivningsfysiologi (creator_code:org_t)
- Wiley, 2018
- 2018
- English.
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In: Journal of Physiology. - : Wiley. - 0022-3751 .- 1469-7793. ; 596:15, s. 3341-3355
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Skeletal muscle oxidative function was evaluated in 11 healthy males (mean +/- SD age 27 +/- 5years) prior to (baseline data collection, BDC) and following a 21day horizontal bed rest (BR), carried out in normoxia (P-IO2=133 mmHg; N-BR) and hypoxia (P-IO2=90 mmHg; H-BR). H-BR was aimed at simulating reduced gravity habitats. The effects of a 21day hypoxic ambulatory confinement (P-IO2=90 mmHg; H-AMB) were also assessed. Pulmonary O-2 uptake (<(V) over dot>O-2), vastus lateralis fractional O-2 extraction (changes in deoxygenated haemoglobin+myoglobin concentration, Delta[deoxy(Hb+Mb)]; near-infrared spectroscopy) and femoral artery blood flow (ultrasound Doppler) were evaluated during incremental one-leg knee-extension exercise (reduced constraints to cardiovascular O-2 delivery) carried out to voluntary exhaustion in a normoxic environment. Mitochondrial respiration was evaluated ex vivo by high-resolution respirometry in permeabilized vastus lateralis fibres. <(V) over dot>(O2peak) decreased (P<0.05) after N-BR (0.98 +/- 0.13 L min(-1)) and H-BR (0.96 +/- 0.17 L min(-1)) vs. BDC (1.05 +/- 0.14 L min(-1)). In the presence of a decreased (by similar to 6-8%) thigh muscle volume, <(V) over dot>(O2peak) normalized per unit of muscle mass was not affected by both interventions. Delta[deoxy(Hb+Mb)](peak) decreased (P<0.05) after N-BR (65 +/- 13% of limb ischaemia) and H-BR (62 +/- 12%) vs. BDC (73 +/- 13%). H-AMB did not alter <(V) over dot>(O2peak) or Delta[deoxy(Hb+Mb)](peak). An overshoot of Delta[deoxy(Hb+Mb)] was evident during the first minute of unloaded exercise after N-BR and H-BR. Arterial blood flow to the lower limb during both unloaded and peak knee extension was not affected by any intervention. Maximal ADP-stimulated mitochondrial respiration decreased (P<0.05) after all interventions vs. control. In 21day N-BR, a significant impairment of oxidative metabolism occurred downstream of cardiovascular O-2 delivery, affecting both mitochondrial respiration and presumably the intramuscular matching between O-2 supply and utilization. Superposition of H on BR did not worsen the impairment induced by BR alone.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- planetary habitats
- microgravity
- hypoxia
- mitochondrial respiration
- skeletal muscle oxidative metabolism
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Salvadego, Desy
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Keramidas, Micha ...
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Kölegård, Roger
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Brocca, Lorenza
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Lazzer, Stefano
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Mavelli, Irene
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show more...
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Rittweger, Joern
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Eiken, Ola
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Mekjavic, Igor B ...
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Grassi, Bruno
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Journal of Physi ...
- By the university
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Royal Institute of Technology