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Träfflista för sökning "WFRF:(Rius M.) srt2:(2015-2019)"

Sökning: WFRF:(Rius M.) > (2015-2019)

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  • Lopez-Vicario, C, et al. (författare)
  • Association of a variant in the gene encoding for ERV1/ChemR23 with reduced inflammation in visceral adipose tissue from morbidly obese individuals
  • 2017
  • Ingår i: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7:1, s. 15724-
  • Tidskriftsartikel (refereegranskat)abstract
    • Obesity comorbidities are closely associated with chronic low-grade adipose tissue inflammation. A number of SNPs associated with inflammation has been identified, underscoring the impact of genetic determinants on this process. Here, we screened SNPs in genes with pro-inflammatory (IL-1β, IL-6, STAT3 and JAK2), anti-inflammatory (IL-10 and SOCS3) and pro-resolving (ERV1/ChemR23) properties in 101 obese and 99 non-obese individuals. Among the SNPs analyzed, we identified that individuals carrying a C allele in the rs1878022 polymorphism of the ERV1/ChemR23 gene, which encodes for the receptor of the pro-resolving mediator RvE1, had increased ERV1/ChemR23 protein expression and reduced levels of the inflammatory cytokine IL-6 in adipose tissue. Moreover, patients carrying the C allele in homozygosity had lower plasma levels of IL-6, IFN-α2, IL-15, IL-1ra, IL-10, GM-CSF, G-CSF and VEGF and enhanced leukocyte responsiveness to RvE1. C-carriers also exhibited decreased TAG to HDL ratio, a surrogate marker of insulin resistance and a predictor of incident fatty liver. Finally, we confirmed in vivo that the ERV1/ChemR23 receptor regulates systemic and tissue inflammation since mice lacking ERV1/ChemR23 expression showed increased IL-6 levels in adipose tissue and peritoneal macrophages. Together, our study identified an ERV1/ChemR23 variant that protects patients with obesity from excessive inflammatory burden.
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  • Herrero-Garcia, Juan, et al. (författare)
  • Testing the Zee-Babu model via neutrino data, lepton flavour violation and direct searches at the LHC
  • 2016
  • Ingår i: Nuclear and Particle Physics Proceedings. - : Elsevier. - 2405-6014. ; 273-275, s. 1678-1684
  • Tidskriftsartikel (refereegranskat)abstract
    • In this talk we discuss how the Zee-Babu model can be tested combining information from neutrino data, low-energy experiments and direct searches at the LHC. We update previous analysis in the light of the recent measurement of the neutrino mixing angle θ13 [1], the new MEG limits on μ→eγ [2], the lower bounds on doubly-charged scalars coming from LHC data [3, 4], and, of course, the discovery of a 125 GeV Higgs boson by ATLAS and CMS [5, 6]. In particular, we find that the new singly- and doubly-charged scalars are accessible at the second run of the LHC, yielding different signatures depending on the neutrino hierarchy and on the values of the phases. We also discuss in detail the stability of the potential.
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