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Toward designing hu...
Toward designing human intervention studies to prevent osteoarthritis after knee injury : A report from an interdisciplinary OARSI 2023 workshop
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- Whittaker, Jackie L. (författare)
- University of British Columbia,Arthritis Research Canada
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- Kalsoum, Raneem (författare)
- Imperial College London
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- Bilzon, James (författare)
- University of Bath
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- Conaghan, Philip G. (författare)
- Leeds School of Medicine
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- Crossley, Kay (författare)
- La Trobe University
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- Dodge, George R. (författare)
- University of Pennsylvania
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Getgood, Alan (författare)
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- Li, Xiaojuan (författare)
- Cleveland Clinic Foundation
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- Losina, Elena (författare)
- Brigham and Women's Hospital / Harvard Medical School,Harvard Medical School
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- Mason, Deborah J. (författare)
- Cardiff University: Brain Research Imaging Centre (CUBRIC)
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- Pietrosimone, Brian (författare)
- University of North Carolina
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- Risberg, May Arna (författare)
- Oslo university hospital,Norwegian School of Sport Sciences
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- Roemer, Frank (författare)
- Friedrich-Alexander University Erlangen-Nürnberg,Boston University
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- Felson, David (författare)
- Boston University
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- Culvenor, Adam G. (författare)
- La Trobe University
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- Meuffels, Duncan (författare)
- Erasmus University Medical Center
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Gerwin, Nicole (författare)
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Simon, Lee S. (författare)
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- Lohmander, L. Stefan (författare)
- Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund OsteoArthritis Division - Nedbrytning av ledbrosk: en biologisk process som leder till artros,Forskargrupper vid Lunds universitet,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund OsteoArthritis Division - Molecular marker research group,Lund University Research Groups
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- Englund, Martin (författare)
- Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund OsteoArthritis Division - Clinical Epidemiology Unit,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas
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- Watt, Fiona E. (författare)
- Imperial College London,Kennedy Institute of Rheumatology
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: Osteoarthritis and Cartilage Open. - 2665-9131. ; 6:2
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective: The global impact of osteoarthritis is growing. Currently no disease modifying osteoarthritis drugs/therapies exist, increasing the need for preventative strategies. Knee injuries have a high prevalence, distinct onset, and strong independent association with post-traumatic osteoarthritis (PTOA). Numerous groups are embarking upon research that will culminate in clinical trials to assess the effect of interventions to prevent knee PTOA despite challenges and lack of consensus about trial design in this population. Our objectives were to improve awareness of knee PTOA prevention trial design and discuss state-of-the art methods to address the unique opportunities and challenges of these studies. Design: An international interdisciplinary group developed a workshop, hosted at the 2023 Osteoarthritis Research Society International Congress. Here we summarize the workshop content and outputs, with the goal of moving the field of PTOA prevention trial design forward. Results: Workshop highlights included discussions about target population (considering risk, homogeneity, and possibility of modifying osteoarthritis outcome); target treatment (considering delivery, timing, feasibility and effectiveness); comparators (usual care, placebo), and primary symptomatic outcomes considering surrogates and the importance of knee function and symptoms other than pain to this population. Conclusions: Opportunities to test multimodal PTOA prevention interventions across preclinical models and clinical trials exist. As improving symptomatic outcomes aligns with patient and regulator priorities, co-primary symptomatic (single or aggregate/multidimensional outcome considering function and symptoms beyond pain) and structural/physiological outcomes may be appropriate for these trials. To ensure PTOA prevention trials are relevant and acceptable to all stakeholders, future research should address critical knowledge gaps and challenges.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- Knee
- Osteoarthritis
- Post-traumatic osteoarthritis
- Prevention
- Randomised controlled trials
- Trial design
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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- Av författaren/redakt...
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Whittaker, Jacki ...
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Kalsoum, Raneem
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Bilzon, James
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Conaghan, Philip ...
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Crossley, Kay
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Dodge, George R.
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visa fler...
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Getgood, Alan
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Li, Xiaojuan
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Losina, Elena
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Mason, Deborah J ...
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Pietrosimone, Br ...
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Risberg, May Arn ...
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Roemer, Frank
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Felson, David
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Culvenor, Adam G ...
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Meuffels, Duncan
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Gerwin, Nicole
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Simon, Lee S.
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Lohmander, L. St ...
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Englund, Martin
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Watt, Fiona E.
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Osteoarthritis a ...
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