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| 2. |
- Aström, S, et al.
(författare)
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Attitudes of health care personnel toward demented patients.
- 1987
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Ingår i: Comprehensive gerontology. Section B, Behavioural, social, and applied sciences. - 0902-008X. ; 1:3, s. 94-9
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Tidskriftsartikel (refereegranskat)abstract
- Health care personnel (n = 724) working in psychogeriatric care, somatic and psychiatric long-term care, somatic and psychiatric general care and in homes for the aged, were interviewed by means of questionnaires evaluating attitudes and intentions regarding work with demented patients and education in their care. The overall attitude towards demented patients was positive. The largest numbers of personnel with positive attitudes were found in psychogeriatric care and somatic long-term care and the lowest in general medical and psychiatric care. The figure for positive attitudes in relation to education showed a similar figure for all categories. Given a free choice only 4% of the respondents had the intention of working solely with demented patients. A majority of the respondents reported that their knowledge of the care of demented patients came from clinical work. There is a strong need for further education.
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| 3. |
- Johnsson, Rolf S., 1946-
(författare)
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Jordbrukspolitiska stödformer : en studie av SR-, A- och B-stödens lokala effekter 1961-1981
- 1987
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The aim of this study has been to analyse the effects of state subsidies within agriculture. The goal of these policies was to build up long-term sound and profitable farms by means of both general and selective support measures. The investments affecting structure gave rise to the following questions: (a) What were the effects on a farm of a given type of aid? (b) How were the farms and the surrounding community affected? (c) In what respect was a desirable effect achieved, and in what respect were the results problematical? The investigation was carried out in three municipalities in Norrland, and considered three different forms of subsidy (SR-, A- and B-support) which were utilized during the years 1961-1978. In addition to these so-called "subsidized farms", a similar number of "comparative farms" that had not received support were selected. In all, 650 farms were investigated.The evaluation was mainly divided into five areas of interest: (a) Farm reconstruction, (b) Farm development, (c) The farmers, (d) Economic effects, (e) Social effects in the locality.The principal findings were as follows: (1) SR- and A-supported farms were characterized by farmers who were relatively young, had good education and who used a portion of their working-hours for carrying out organizational measures. The comparative farms were distinguished rather by older farmers with less education and with a higher degree of employment outside the farm. (2) All of the SR-and B-supported farms had survived. Some A-supported farms were abandoned, while the number of comparative farms was greatly reduced. (3) All types of subsidized farms exhibited growth in their areas of arable land and forest and in their stock of milk cows, whereas the comparative farms were relatively unchanged. (4) Improved production results within crop husbandry could be derived simultaneously from the increased use of pipe drainage, shorter periods between ploughing, new methods of harvesting, etc. Within all these areas the subsidized farms had higher proportions of improvements than the comparative farms. (5) Since SR-farms in particular (but even A-farms) financed their rationalization measures by means of bank loans, they all became extremely sensitive to risks. In thi s way they all too easily ended up with economic difficulties when major increases in interest rates or changes in costs or revenues occurred. (6) In the short term the rationalization of the size of subsidized farms had little effect on outmigration from the areas concerned. (7) The households were larger on subsidized farms than in the comparative group. This meant that the subsidized farms, which were increasing their relative share of the population, also comprised a stabilizing factor in a locally-dependent service sector.
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| 5. |
- Sellin, L C, et al.
(författare)
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Membrane and biochemical alterations after denervation and during reinnervation of mouse skeletal muscle
- 1980
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Ingår i: Acta Physiologica Scandinavica. ; 110:2, s. 181-186
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Tidskriftsartikel (refereegranskat)abstract
- Denervation of the extensor digitorum longus (EDL) muscle of the mouse by either nerve crush or nerve section produced: a reduction of the resting membrane potential (Em), alterations in the properties of muscle fibre action potentials and the development of tetrodotoxin (TTX)-resistant action potentials. These changes in membrane electrical properties were accompanied by an increase in the endocytic activity of the muscle and an increase in the activities of the lysosomal enzymes cathepsin D and N-acetylglucosaminidase (NAGA). Reinnervation of muscle was indicated at 9 days after nerve crush by the presence of miniature end-plate potentials. The recovery of membrane electrical properties, beginning with the onset of reinnervation, were not temporally related. The Em increased in two stages: an early rapid repolarization and a later slower repolarization. The muscle fibers were sensitive to the blocking action of TTX by 12 days after nerve crush, whereas the rate of rise (dV/dt) of the action potential did not approach values of innervated muscles until 21 days. Reinnervation resulted in a decrease in endocytosis and a decrease in the activities of cathepsin D and NAGA toward innervated values by 21 days after nerve crush. The results suggest that membrane alterations after denervation and during reinnervation may occur by endo- and exocytosis of membrane constituents and that the lysosomal system may play a role in the breakdown and/or recycling of these structures.
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| 6. |
- Tågerud, Sven, et al.
(författare)
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An ultrastructural study of the segmental uptake of horseradish peroxidase in the endplate region of denervated skeletal muscle fibres
- 1986
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Ingår i: Journal of the Neurological Sciences. - 0022-510X .- 1878-5883. ; 75:2, s. 141-157
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Tidskriftsartikel (refereegranskat)abstract
- The segmental uptake of horseradish peroxidase (HRP) in the endplate region of denervated skeletal muscle fibres has been studied ultrastructurally using a method for selecting single muscle fibres with high segmental peroxidase staining from denervated mouse tibialis anterior muscle.Segments containing large peroxidase positive phagosomes could already be seen 10–15 min after i.v. injection of HRP. Such segments were still present 24 h after HRP injection. The localization of phagosomes, deep in the fibres rather than immediately under the sarcolemma, suggests that the uptake occurs from t-tubuli. Vivid proliferation of t-tubuli, consisting of vesiculation, enlargement and encircling of cytoplasmic components, was also observed. The HRP accumulates in phagosomes of varying size and shape. Similar membrane-limited bodies without or with very weak peroxidase staining were also observed. The peroxidase-positive phagosomes participate in autophagic processes as suggested by their content of undegraded cellular material. Golgi profiles, which occurred deep in the muscle fibres, and enlarged components of the sarcoplasmic reticulum were frequently encountered in the segments. Myofibrillar degeneration occurs in the segments and progresses with time after denervation.The described segments may be related to the increased membrane turnover in denervated muscle fibres and/or they may be related to processes aimed at establishing new synaptic contacts.
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| 7. |
- Tågerud, Sven, et al.
(författare)
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Effects of botulinum toxin induced muscle paralysis on endocytosis and lysosomal enzyme activities in mouse skeletal muscle
- 1986
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Ingår i: Pflügers Archive European Journal of Physiology. - 0031-6768. ; 407:3, s. 275-278
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Tidskriftsartikel (refereegranskat)abstract
- The effects of botulinum toxin (type A) induced muscle paralysis on endocytosis and lysosomal enzyme activities in skeletal muscle were compared with the effects of surgical denervation. Muscle atrophy, measured as decrease in total muscle protein content, was as large or larger after botulinum toxin treatment as after denervation. Endocytic activity, measured as the in vitro uptake of horseradish peroxidase, and the specific activities of the lysosomal enzymes N-acetyl--d-glucosaminidase and cathepsin D were all increased six days after denervation. Only the specific activity of cathepsin D was increased six days after botulinum toxin poisoning. The uptake of horseradish peroxidase and the specific activity of N-acetyl--d-glucosamidase were also increased eleven days after poisoning. Transverse sections of eleven days botulinum poisoned muscles from animals injected with horseradish peroxidase showed fibres with dense peroxidase staining similar to those seen in denervated muscle although they seemed to occur less frequently.The results show that increases in endocytic activity and lysosomal enzyme activities may occur in skeletal muscle without the presence of degenerating axons. The differences in effects of surgical denervation and botulinum toxin induced paralysis are discussed in terms of what is known about the mechanism of action of botulinum toxin and the possible functional roles of the two lysosomal enzymes studied.
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| 8. |
- Wester, P, et al.
(författare)
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Monoamine metabolite concentrations and cholinesterase activities in cerebrospinal fluid of progressive dementia patients : relation to clinical parameters.
- 1988
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Ingår i: Acta Neurologica Scandinavica. - 0001-6314 .- 1600-0404. ; 77:1, s. 12-21
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Tidskriftsartikel (refereegranskat)abstract
- Forty-five well clinically characterized patients with progressive dementia were investigated for lumbar cerebrospinal fluid (CSF) monoamine metabolites and cholinesterase activities. Monoamine concentrations were determined by reverse phase liquid chromatography with electrochemical detection and the cholinergic enzymes were measured photometrically. Firstly, all clinical and CSF parameters were studied in statistical cluster analyses to detect groups of variables which demonstrated a high correlation with respect to each other. The CSF transmitter markers were then used in multiple regression models to explain the variance of clinical variables as chosen from the cluster analyses. The degree of dementia, as assessed by global deterioration score (GDS) and activity in daily life (ADL) status, as well as the Alzheimer-related symptoms dyspraxia and dysphasia, were associated with low AChE activities in CSF. A presumed subgroup of dementia patients clinically characterized by asymmetry of neurological signs, increased unilateral tonus, stepwise progression, and high Hachinski score, showed low HVA concentrations in CSF. These data suggest a coupling of clinical/neurological parameters to different CSF transmitter profils and, thus, that CSF biochemical parameters are of use as antemortem markers in dementia conditions.
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