| 1. |
- Petersson, Malin, et al.
(författare)
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Patient-reported symptom severity in a nationwide myasthenia gravis cohort : cross-sectional analysis of the Swedish GEMG study
- 2021
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Ingår i: Neurology. - : Lippincott Williams & Wilkins. - 0028-3878 .- 1526-632X. ; 97:14, s. e1382-e1391
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Tidskriftsartikel (refereegranskat)abstract
- Background and Objectives: To describe myasthenia gravis activities of daily living (MG-ADL) in relation to clinical characteristics in a large Swedish nationwide cohort.Methods: In a cross-sectional prevalence cohort study, the Genes and Environment in Myasthenia Gravis study, performed from November 2018 through August 2019, patients with myasthenia gravis (MG) were invited to submit an extensive 106-item life environment questionnaire, including the MG-ADL score. Patients were classified into early-onset MG (EOMG, <50 years), late-onset MG (LOMG, >= 50 years), or thymoma-associated MG (TAMG). Comparisons of disease-specific characteristics were made between subgroups, sexes, and different MG-ADL scores.Results: A total of 1,077 patients were included, yielding a 74% response rate: 505 (47%) were classified as EOMG, 520 (48%) LOMG, and 45 (4%) TAMG. Mean age at inclusion was 64.3 years (SD 15.7) and mean disease duration was 14.6 years (SD 14.0). Complete MG-ADL scores (n = 1,035) ranged from 0p to 18p, where 26% reported a score of 0p. Higher MG-ADL scores were associated with female sex, obesity, and diagnostic delay (odds ratio [OR] 1.62, 1.72, and 1.69; p(adj) = 0.017, 0.013, and 0.008) and inversely correlated with high educational attainment (OR 0.59; p(adj) = 0.02), but not with age at inclusion, disease subtype, or disease duration. Almost half of the population (47%) reported MG-ADL >= 3p, corresponding to an unsatisfactory symptom state.Discussion: In this nationwide study, comprising more than 40% of the prevalent MG population in Sweden, almost half of the patients reported current disease symptoms associated with an unsatisfactory symptom state, indicating the need for improved treatment options.
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| 2. |
- Andersson, Anton, et al.
(författare)
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A Method for Synthesizing Iron Silicate Slags to Evaluate Their Performance as Supplementary Cementitious Materials
- 2023
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Ingår i: Applied Sciences. - : Mdpi. - 2076-3417. ; 13:14
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Tidskriftsartikel (refereegranskat)abstract
- Utilizing iron silicate copper slag as supplementary cementitious material (SCM) is a means to improve resource efficiency and lower the carbon dioxide emissions from cement production. Despite multiple studies on the performance of these slags in SCM applications, the variations in cooling procedure, grinding, and methods for evaluating reactivity limit the ability to assess the influence of chemical composition on reactivity from the literature data. In this study, a methodology was developed to synthesize iron silicate slags, which were then evaluated for their inherent reactivity using the R-3 calorimeter-based experiments. The results demonstrated that laboratory-scale granulation produced the same reactivity as industrially granulated slag. Furthermore, a synthesized triplicate sample showed high repeatability. Based on these two aspects, this method can be used to systematically study the influence of chemical composition on the inherent reactivity of iron silicate slags while producing results that are directly translatable to industrial slags.
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| 3. |
- Andersson, Anton, et al.
(författare)
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Ground granulated iron silicate slag as supplementary cementitious material: Effect of prolonged grinding and granulation temperature
- 2023
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Ingår i: Cleaner Materials. - : Elsevier. - 2772-3976. ; 10
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Tidskriftsartikel (refereegranskat)abstract
- The metallurgical and cement industries contribute significantly to anthropogenic carbon dioxide emissions. Utilizing oxidic by-products from the metallurgical industry as supplementary cementitious materials (SCMs) can improve resource efficiency and reduce emissions from cement production. Iron silicate copper slags have been studied as SCMs, but mainly in systems where Portland cement is used as an activator. There is limited research on the inherent reactivity of the slag under changing processing conditions. The present study offers insight into the effect of granulation temperature and grinding on the inherent reactivity of an industrially produced iron silicate copper slag. The results showed that granulation temperature had an insignificant effect on reactivity, while grinding generated substantial improvements. The latter effect was concluded to stem from the increased specific surface area, increased number of sites for nucleation and growth of hydrates, and changes in the inherent reactivity owing to structural changes induced by the grinding.
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| 4. |
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| 5. |
- Henriksson, Manne, 1987-, et al.
(författare)
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Optimal Freewheeling Control of a Heavy-Duty Vehicle Using Mixed Integer Quadratic Programming
- 2020
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Ingår i: IFAC PAPERSONLINE. - : Elsevier BV. - 2405-8963. ; , s. 13809-13815
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Konferensbidrag (refereegranskat)abstract
- Improving the powertrain control of heavy-duty vehicles can be an efficient way to reduce the fuel consumption and thereby reduce both the operating cost and the environmental impact. One way of doing so is by using information about the upcoming driving conditions, known as look-ahead information, in order to coast in gear or to use freewheeling. Controllers using such techniques today mainly exist for vehicles in highway driving. This paper therefore targets how such control can be applied to vehicles with more variations in their velocity. The driving mission of such a vehicle is here formulated as an optimal control problem. The control variables are the tractive force, the braking force, and a Boolean variable representing closed or open powertrain. The problem is solved by a model predictive controller, which at each iteration solves a mixed integer quadratic program. The fuel consumption is compared for four different control policies: a benchmark following the reference of the driving cycle, look-ahead control without freewheeling, freewheeling with the engine idling, and freewheeling with the engine turned off. Simulations on a driving cycle with a varying velocity profile show the potential of saving 11 %, 19 %, and 23% respectively for the control policies compared with the benchmark, in all cases without increasing the trip time. Copyright
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| 6. |
- Mark-Herbert, Cecilia, et al.
(författare)
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Urban Planners’ Perspectives on Public Private Partnership for Wooden Multistorey Construction
- 2023
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Ingår i: Journal of Forest Economics. - : Now Publishers. - 1104-6899 .- 1618-1530. ; 38, s. 7-35
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Tidskriftsartikel (refereegranskat)abstract
- Increased awareness of sustainable development in the construction industry and current housing shortages have contributed to market opportunities for wooden multi-storey construction (WMC) in the Nordic countries. However, the market development has been slow despite access to forest products and a political ambition to transform to a low carbon society. The aim of this study is to explain enabling factors for municipalities in Sweden to create institutional conditions that stimulate local market development of WMC. A comparative case study of municipal efforts to establish WMC norms has been conducted pointing to the importance of relationships, in so-called public private partnerships (PPP). These partnerships serve as long-lasting relations in which development processes can manage challenges relating to, for example, lack of professional experience in WMC and dated material understandings of wood as a construction material. In the Sustainable Development Goals, PPP represent enabling conditions for sustainable system transformations.
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| 7. |
- Roos, Anders, et al.
(författare)
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Impact of prospective residents dwelling requirements on preferences for house construction materials
- 2023
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Ingår i: Wood Material Science & Engineering. - : Taylor & Francis Ltd. - 1748-0272 .- 1748-0280. ; 18:4, s. 1275-1284
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Tidskriftsartikel (refereegranskat)abstract
- This study investigated peoples requirements for multi-story housing attributes and preferences for apartments in wooden-structure versus steel/concrete-structure multi-story buildings. Data came from an online survey conducted in Finland and Sweden that screened for respondents who expressed a preference for living in an apartment, as compared with a low-rise dwelling. Responses were analyzed using exploratory factor and regression analyses. Swedish respondents assigned significantly higher requirements to factors related to environmental and social sustainability performance than Finnish respondents. Requirements in both countries were described across three factors: environmental and social sustainability, quality, and design. Factor scores differed between socioeconomic sub-groups, particularly regarding quality, between urban and non-urban respondents. Preferences to live in an apartment in a wooden building were positively associated with respondents requirements for environmental and social sustainability, and negatively with requirements for quality-related attributes. Opposite relationships were found in the Swedish sample for apartments in non-wooden structure houses. Design requirements had no significant association with preferences for a specific material in load-bearing structures for multi-story buildings, in either country. The findings can contribute toward enhanced marketing efforts and customized value propositions to increase the social acceptability of multi-story wooden buildings and advance climate-related goals within the housing sector.
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| 8. |
- Strandberg, Kristin, et al.
(författare)
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Blood-derived biomarkers correlate with clinical progression in Duchenne muscular dystrophy
- 2020
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Ingår i: Journal of Neuromuscular Diseases. - : IOS Press. - 2214-3599 .- 2214-3602. ; 7:3, s. 231-246
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Tidskriftsartikel (refereegranskat)abstract
- Background: Duchenne Muscular Dystrophy is a severe, incurable disorder caused by mutations in the dystrophin gene. The disease is characterized by decreased muscle function, impaired muscle regeneration and increased inflammation. In a clinical context, muscle deterioration, is evaluated using physical tests and analysis of muscle biopsies, which fail to accurately monitor the disease progression. Objectives: This study aims to confirm and asses the value of blood protein biomarkers as disease progression markers using one of the largest longitudinal collection of samples. Methods: A total of 560 samples, both serum and plasma, collected at three clinical sites are analyzed using a suspension bead array platform to assess 118 proteins targeted by 250 antibodies in microliter amount of samples. Results: Nine proteins are confirmed as disease progression biomarkers in both plasma and serum. Abundance of these biomarkers decreases as the disease progresses but follows different trajectories. While carbonic anhydrase 3, microtubule associated protein 4 and collagen type I alpha 1 chain decline rather constantly over time, myosin light chain 3, electron transfer flavoprotein A, troponin T, malate dehydrogenase 2, lactate dehydrogenase B and nestin plateaus in early teens. Electron transfer flavoprotein A, correlates with the outcome of 6-minutes-walking-test whereas malate dehydrogenase 2 together with myosin light chain 3, carbonic anhydrase 3 and nestin correlate with respiratory capacity. Conclusions: Nine biomarkers have been identified that correlate with disease milestones, functional tests and respiratory capacity. Together these biomarkers recapitulate different stages of the disorder that, if validated can improve disease progression monitoring.
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