| 1. |
- Eichelmann, Fabian, et al.
(författare)
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Lipidome changes due to improved dietary fat quality inform cardiometabolic risk reduction and precision nutrition
- 2024
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Ingår i: Nature Medicine. - 1078-8956 .- 1546-170X. ; In Press
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Tidskriftsartikel (refereegranskat)abstract
- Current cardiometabolic disease prevention guidelines recommend increasing dietary unsaturated fat intake while reducing saturated fats. Here we use lipidomics data from a randomized controlled dietary intervention trial to construct a multilipid score (MLS), summarizing the effects of replacing saturated fat with unsaturated fat on 45 lipid metabolite concentrations. In the EPIC-Potsdam cohort, a difference in the MLS, reflecting better dietary fat quality, was associated with a significant reduction in the incidence of cardiovascular disease (−32%; 95% confidence interval (95% CI): −21% to −42%) and type 2 diabetes (−26%; 95% CI: −15% to −35%). We built a closely correlated simplified score, reduced MLS (rMLS), and observed that beneficial rMLS changes, suggesting improved dietary fat quality over 10 years, were associated with lower diabetes risk (odds ratio per standard deviation of 0.76; 95% CI: 0.59 to 0.98) in the Nurses’ Health Study. Furthermore, in the PREDIMED trial, an olive oil-rich Mediterranean diet intervention primarily reduced diabetes incidence among participants with unfavorable preintervention rMLS levels, suggestive of disturbed lipid metabolism before intervention. Our findings indicate that the effects of dietary fat quality on the lipidome can contribute to a more precise understanding and possible prediction of the health outcomes of specific dietary fat modifications.
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| 2. |
- Lagergren, Fredrik, et al.
(författare)
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Kilometre-scale simulations over Fennoscandia reveal a large loss of tundra due to climate warming
- 2024
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Ingår i: Biogeosciences. - 1726-4170 .- 1726-4189. ; 21:5, s. 1093-1116
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Tidskriftsartikel (refereegranskat)abstract
- The Fennoscandian boreal and mountain regions harbour a wide range of vegetation types, from boreal forest to high alpine tundra and barren soils. The area is facing a rise in air temperature above the global average and changes in temperature and precipitation patterns. This is expected to alter the Fennoscandian vegetation composition and change the conditions for areal land use such as forestry, tourism and reindeer husbandry. In this study we used a unique high-resolution (3 km) climate scenario with considerable warming resulting from strongly increasing carbon dioxide emissions to investigate how climate change can alter the vegetation composition, biodiversity and availability of suitable reindeer forage. Using a dynamical vegetation model, including a new implementation of potential reindeer grazing, resulted in simulated vegetation maps of unprecedented high resolution for such a long time period and spatial extent. The results were evaluated at the local scale using vegetation inventories and for the whole area against satellite-based vegetation maps. A deeper analysis of vegetation shifts related to statistics of threatened species was performed in six “hotspot” areas containing records of rare and threatened species. In this high-emission scenario, the simulations show dramatic shifts in the vegetation composition, accelerating at the end of the century. Alarmingly, the results suggest the southern mountain alpine region in Sweden will be completely covered by forests at the end of the 21st century, making preservation of many rare and threatened species impossible. In the northern alpine regions, most vegetation types will persist but shift to higher elevations with reduced areal extent, endangering vulnerable species. Simulated potential for reindeer grazing indicates latitudinal differences, with higher potential in the south in the current climate. In the future these differences will diminish, as the potentials will increase in the north, especially for the summer grazing grounds. These combined results suggest significant shifts in vegetation composition over the present century for this scenario, with large implications for nature conservation, reindeer husbandry and forestry.
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| 3. |
- Meister, Philip, et al.
(författare)
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A global compilation of diatom silica oxygen isotope records from lake sediment - trends and implications for climate reconstruction
- 2024
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Ingår i: Climate of the Past. - 1814-9324. ; 20:2, s. 363-392
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Tidskriftsartikel (refereegranskat)abstract
- Oxygen isotopes in biogenic silica (δ18OBSi) from lake sediments allow for quantitative reconstruction of past hydroclimate and proxy-model comparison in terrestrial environments. The signals of individual records have been attributed to different factors, such as air temperature (Tair), atmospheric circulation patterns, hydrological changes, and lake evaporation. While every lake has its own local set of drivers of δ18O variability, here we explore the extent to which regional or even global signals emerge from a series of paleoenvironmental records. This study provides a comprehensive compilation and combined statistical evaluation of the existing lake sediment δ18OBSi records, largely missing in other summary publications (i.e. PAGES network). For this purpose, we have identified and compiled 71 down-core records published to date and complemented these datasets with additional lake basin parameters (e.g. lake water residence time and catchment size) to best characterize the signal properties. Records feature widely different temporal coverage and resolution, ranging from decadal-scale records covering the past 150 years to records with multi-millennial-scale resolution spanning glacial-interglacial cycles. The best coverage in number of records (NCombining double low line37) and data points (NCombining double low line2112) is available for Northern Hemispheric (NH) extratropical regions throughout the Holocene (roughly corresponding to Marine Isotope Stage 1; MIS 1). To address the different variabilities and temporal offsets, records were brought to a common temporal resolution by binning and subsequently filtered for hydrologically open lakes with lake water residence times <100 years. For mid- to high-latitude (>45°N) lakes, we find common δ18OBSi patterns among the lake records during both the Holocene and Common Era (CE). These include maxima and minima corresponding to known climate episodes, such as the Holocene Thermal Maximum (HTM), Neoglacial Cooling, Medieval Climate Anomaly (MCA) and the Little Ice Age (LIA). These patterns are in line with long-term air temperature changes supported by previously published climate reconstructions from other archives, as well as Holocene summer insolation changes. In conclusion, oxygen isotope records from NH extratropical lake sediments feature a common climate signal at centennial (for CE) and millennial (for Holocene) timescales despite stemming from different lakes in different geographic locations and hence constitute a valuable proxy for past climate reconstructions.
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