| 1. |
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| 2. |
- Aad, G, et al.
(författare)
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- 2015
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swepub:Mat__t
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| 3. |
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| 4. |
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| 5. |
- Ruilope, LM, et al.
(författare)
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Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial
- 2019
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Ingår i: American journal of nephrology. - : S. Karger AG. - 1421-9670 .- 0250-8095. ; 50:5, s. 345-356
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Tidskriftsartikel (refereegranskat)abstract
- <b><i>Background:</i></b> Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. <b><i>Patients and</i></b> <b><i>Methods:</i></b> The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate ≥25 mL/min/1.73 m<sup>2</sup> and albuminuria (urinary albumin-to-creatinine ratio ≥30 to ≤5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level α = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. <b><i>Conclusions:</i></b> FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049.
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| 6. |
- Aaltonen, T., et al.
(författare)
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Tevatron Run II combination of the effective leptonic electroweak mixing angle
- 2018
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Ingår i: Physical Review D. - : AMER PHYSICAL SOC. - 2470-0010 .- 2470-0029. ; 97:11
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Tidskriftsartikel (refereegranskat)abstract
- Drell-Yan lepton pairs produced in the process p (p) over bar -> l(+)l(-) + X through an intermediate gamma*/Z boson have an asymmetry in their angular distribution related to the spontaneous symmetry breaking of the electroweak force and the associated mixing of its neutral gauge bosons. The CDF and D0 experiments have measured the effective-leptonic electroweak mixing parameter sin(2) theta(lept)(eff) using electron and muon pairs selected from the full Tevatron proton-antiproton data sets collected in 2001-2011, corresponding to 9-10 fb(-1) of integrated luminosity. The combination of these measurements yields the most precise result from hadron colliders, sin(2)theta(lept)(eff) = 0.23148 +/- 0.00033. This result is consistent with, and approaches in precision, the best measurements from electron-positron colliders. The standard model inference of the on-shell electroweak mixing parameter sin(2) theta(W), or equivalently the W-boson mass M-W, using the ZFITTER software package yields sin(2) theta(W) = 0.22324 +/- 0.00033 or equivalently, M-W = 80.367 +/- 0.017 GeV/c(2).
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| 7. |
- Aaltonen, T., et al.
(författare)
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Combined Forward-Backward Asymmetry Measurements in Top-Antitop Quark Production at the Tevatron
- 2018
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Ingår i: Physical Review Letters. - : AMER PHYSICAL SOC. - 0031-9007 .- 1079-7114. ; 120:4
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Tidskriftsartikel (refereegranskat)abstract
- The CDF and D0 experiments at the Fermilab Tevatron have measured the asymmetry between yields of forward- and backward-produced top and antitop quarks based on their rapidity difference and the asymmetry between their decay leptons. These measurements use the full data sets collected in proton-antiproton collisions at a center-of-mass energy of root s = 1.96 TeV. We report the results of combinations of the inclusive asymmetries and their differential dependencies on relevant kinematic quantities. The combined inclusive asymmetry is A(FB)(t (t) over bar) = 0.128 +/- 0.025. The combined inclusive and differential asymmetries are consistent with recent standard model predictions.
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| 8. |
- Aaltonen, T., et al.
(författare)
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Tevatron Combination of Single-Top-Quark Cross Sections and Determination of the Magnitude of the Cabibbo-Kobayashi-Maskawa Matrix Element V-tb
- 2015
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 115:15
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Tidskriftsartikel (refereegranskat)abstract
- We present the final combination of CDF and D0 measurements of cross sections for single-top-quark production in proton-antiproton collisions at a center-of-mass energy of 1.96 TeV. The data correspond to total integrated luminosities of up to 9.7 fb(-1) per experiment. The t-channel cross section is measured to be sigma(t) = 2.25(-0.31)(+0.29) pb. We also present the combinations of the two-dimensional measurements of the s- vs t-channel cross section. In addition, we give the combination of the s + t channel cross section measurement resulting in sigma(s+t) = 3.30(-0.40)(+0.52) pb, without assuming the standard model value for the ratio sigma(s)/sigma(t). The resulting value of the magnitude of the top-to-bottom quark coupling is vertical bar V-tb vertical bar = 1.02(-0.05)(+0.06), corresponding to vertical bar V-tb vertical bar > 0.92 at the 95% C. L.
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| 9. |
- Aaltonen, T., et al.
(författare)
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Tevatron Constraints on Models of the Higgs Boson with Exotic Spin and Parity Using Decays to Bottom-Antibottom Quark Pairs
- 2015
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 114:15
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Tidskriftsartikel (refereegranskat)abstract
- Combined constraints from the CDF and D0 Collaborations on models of the Higgs boson with exotic spin J and parity P are presented and compared with results obtained assuming the standard model value J(P) = 0(+). Both collaborations analyzed approximately 10 fb(-1) of proton-antiproton collisions with a center-of-mass energy of 1.96 TeV collected at the Fermilab Tevatron. Two models predicting exotic Higgs bosons with J(P) = 0(-) and J(P) = 2(+) are tested. The kinematic properties of exotic Higgs boson production in association with a vector boson differ from those predicted for the standard model Higgs boson. Upper limits at the 95% credibility level on the production rates of the exotic Higgs bosons, expressed as fractions of the standard model Higgs boson production rate, are set at 0.36 for both the J(P) = 0(-) hypothesis and the J(P) = 2(+) hypothesis. If the production rate times the branching ratio to a bottom-antibottom pair is the same as that predicted for the standard model Higgs boson, then the exotic bosons are excluded with significances of 5.0 standard deviations and 4.9 standard deviations for the J(P) = 0(-) and J(P) = 2(+) hypotheses, respectively.
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| 10. |
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| 11. |
- Bousquet, Jean, et al.
(författare)
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Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018) : Change management in allergic rhinitis and asthma multimorbidity using mobile technology
- 2019
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Ingår i: Journal of Allergy and Clinical Immunology. - : Elsevier. - 0091-6749 .- 1097-6825. ; 143:3, s. 864-879
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Tidskriftsartikel (refereegranskat)abstract
- Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline by using the best approach to integrated care pathways using mobile technology in patients with allergic rhinitis (AR) and asthma multimorbidity. The proposed next phase of ARIA is change management, with the aim of providing an active and healthy life to patients with rhinitis and to those with asthma multimorbidity across the lifecycle irrespective of their sex or socioeconomic status to reduce health and social inequities incurred by the disease. ARIA has followed the 8-step model of Kotter to assess and implement the effect of rhinitis on asthma multimorbidity and to propose multimorbid guidelines. A second change management strategy is proposed by ARIA Phase 4 to increase self-medication and shared decision making in rhinitis and asthma multimorbidity. An innovation of ARIA has been the development and validation of information technology evidence-based tools (Mobile Airways Sentinel Network [MASK]) that can inform patient decisions on the basis of a self-care plan proposed by the health care professional.
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| 12. |
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- 2019
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Tidskriftsartikel (refereegranskat)
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| 13. |
- Menditto, Enrica, et al.
(författare)
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Adherence to treatment in allergic rhinitis using mobile technology : The MASK Study
- 2019
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Ingår i: Clinical and Experimental Allergy. - : WILEY. - 0954-7894 .- 1365-2222. ; 49:4, s. 442-460
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Tidskriftsartikel (refereegranskat)abstract
- Background: Mobile technology may help to better understand the adherence to treatment. MASK-rhinitis (Mobile Airways Sentinel NetworK for allergic rhinitis) is a patient-centred ICT system. A mobile phone app (the Allergy Diary) central to MASK is available in 22 countries. Objectives: To assess the adherence to treatment in allergic rhinitis patients using the Allergy Diary App. Methods: An observational cross-sectional study was carried out on all users who filled in the Allergy Diary from 1 January 2016 to 1 August 2017. Secondary adherence was assessed by using the modified Medication Possession Ratio (MPR) and the Proportion of days covered (PDC) approach. Results: A total of 12143 users were registered. A total of 6949 users reported at least one VAS data recording. Among them, 1887 users reported >= 7 VAS data. About 1195 subjects were included in the analysis of adherence. One hundred and thirty-six (11.28%) users were adherent (MPR >= 70% and PDC <= 1.25), 51 (4.23%) were partly adherent (MPR >= 70% and PDC = 1.50) and 176 (14.60%) were switchers. On the other hand, 832 (69.05%) users were non-adherent to medications (MPR <70%). Of those, the largest group was non-adherent to medications and the time interval was increased in 442 (36.68%) users. Conclusion and clinical relevance: Adherence to treatment is low. The relative efficacy of continuous vs on-demand treatment for allergic rhinitis symptoms is still a matter of debate. This study shows an approach for measuring retrospective adherence based on a mobile app. This also represents a novel approach for analysing medication-taking behaviour in a real-world setting.
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| 14. |
- Abazov, V. M., et al.
(författare)
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B-s(0) lifetime measurement in the CP-odd decay channel B-s(0) -> J/Psi f(0)(980)
- 2016
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Ingår i: PHYSICAL REVIEW D. - 2470-0010. ; 94:1
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Tidskriftsartikel (refereegranskat)abstract
- The lifetime of the B-s(0) meson is measured in the decay channel B-s(0) -> J/Psi pi(+)pi(-) with 880 <= M pi+pi- <= 1080 MeV/c(2), which is mainly a CP-odd state and dominated by the f(0)(980) resonance. In 10.4 fb(-1) of data collected with the D0 detector in Run II of the Tevatron, the lifetime of the B-s(0) meson is measured to be tau(B-s(0)) = 1.70 +/- 0.14(stat) +/- 0.05(syst) ps. Neglecting CP violation in B-s(0)/(B) over bar (0)(s) mixing, the measurement can be translated into the width of the heavy mass eigenstate of the B-s(0), Gamma(H) = 0.59 +/- 0.05(stat) +/- 0.02(syst) ps(-1).
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| 15. |
- Abazov, V. M., et al.
(författare)
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Combination of D0 measurements of the top quark mass
- 2017
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Ingår i: Physical Review D. - : AMER PHYSICAL SOC. - 2470-0010 .- 2470-0029. ; 95:11
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Tidskriftsartikel (refereegranskat)abstract
- We present a combination of measurements of the top quark mass by the D0 experiment in the lepton + jets and dilepton channels. We use all the data collected in Run I (1992-1996) at root s = 1.8 TeV and Run II (2001-2011) at root s = 1.96 TeV of the Tevatron p (p) over bar collider, corresponding to integrated luminosities of 0.1 fb(-1) and 9.7 fb(-1), respectively. The combined result is: m(t) = 174.95 +/- 0.40(stat)+/- 0.64(syst) GeV = 174.95 +/- 0.75 GeV.
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| 16. |
- Abazov, V. M., et al.
(författare)
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Evidence for a B-s(0)pi(+/-) State
- 2016
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 117:2
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Tidskriftsartikel (refereegranskat)abstract
- We report evidence for a narrow structure, X(5568), in the decay sequence X(5568) -> B-s(0)pi(+/-), B-s(0) -> J/psi phi, J/psi -> mu(+)mu(-), phi -> K+K-. This is evidence for the first instance of a hadronic state with valence quarks of four different flavors. The mass and natural width of this state are measured to be m = 5567.8 +/- 2.9(stat)(-1.9)(+0.9) (syst) MeV/c(2) and Gamma = 21.9 +/- 6.4(stat)(-2.5)(+5.0) (syst) MeV/c(2). If the decay is X(5568) -> B-s*pi(+/-). B-s(0)gamma pi(+/-) with an unseen gamma, m(X(5568)) will be shifted up by m(B-s*) - m(B-s(0)) similar to 49 MeV/c(2). This measurement is based on 10.4 fb(-1) of p (p) over bar collision data at root s = 1.96 TeV collected by the D0 experiment at the Fermilab Tevatron collider.
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| 17. |
- Abazov, V. M., et al.
(författare)
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Evidence for Simultaneous Production of J/psi and Upsilon Mesons
- 2016
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 116:8
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Tidskriftsartikel (refereegranskat)abstract
- We report evidence for the simultaneous production of J/psi and Upsilon mesons in 8.1 fb(-1) of data collected at root s = 1.96 TeV by the D0 experiment at the Fermilab p (p) over bar Tevatron Collider. Events with these characteristics are expected to be produced predominantly by gluon-gluon interactions. In this analysis, we extract the effective cross section characterizing the initial parton spatial distribution, sigma(eff) = 2.2 +/- 0.7(stat) +/- 0.9(syst) mb.
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| 18. |
- Abazov, V. M., et al.
(författare)
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Evidence for Z(c)(+/-)(3900) in semi-inclusive decays of b-flavored hadrons
- 2018
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Ingår i: Physical Review D. - : AMER PHYSICAL SOC. - 2470-0010 .- 2470-0029. ; 98:5
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Tidskriftsartikel (refereegranskat)abstract
- We present evidence for the exotic charged charmoniumlike state Z(c)(+/-)(3900) decaying to J/psi pi(+/-) in semi-inclusive weak decays of b-flavored hadrons. The signal is correlated with a parent J/psi pi(+)pi(-) system in the invariant-mass range 4.2-4.7 GeV that would include the exotic structure Y(4260). The study is based on 10.4 fb(-1) of p (p) over bar collision data collected by the D0 experiment at the Fermilab Tevatron collider.
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| 19. |
- Abazov, V. M., et al.
(författare)
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Inclusive Production of the X(4140) State in p(p)over-bar Collisions at D0
- 2015
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 115:23
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Tidskriftsartikel (refereegranskat)abstract
- We present a study of the inclusive production of the X(4140) state with the decay to the J/psi phi final state in hadronic collisions. Based on 10.4 fb(-1) of p (p) over bar collision data collected by the D0 experiment at the Fermilab Tevatron collider, we report the first evidence for the prompt production of an X(4140) state and find the fraction of X(4140) events originating from b hadrons to be f(b) = 0.39 +/- 0.07 (stat) +/- 0.10 (syst). The ratio of the nonprompt X(4140) production rate to the B-s(0) yield in the same channel is R = 0.19 +/- 0.05 (stat) +/- 0.07 (syst). The values of the mass M = 4152.5 +/- 1.7 (stat)(-5.4)(+/- 6.2)(syst) MeV and width Gamma = 16.3 +/- 5.6 (stat) +/- 11.4 (syst) MeV are consistent with previous measurements.
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| 20. |
- Abazov, V. M., et al.
(författare)
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Measurement of spin correlation between top and antitop quarks produced in p(p)over-bar collisions at root s=1.96 TeV
- 2016
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 757, s. 199-206
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Tidskriftsartikel (refereegranskat)abstract
- We present a measurement of the correlation between the spins of t and (t) over bar quarks produced in proton-antiproton collisions at the Tevatron Collider at a center-of-mass energy of 1.96 TeV. We apply a matrix element technique to dilepton and single-lepton+jets final states in data accumulated with the DO detector that correspond to an integrated luminosity of 9.7 fb(-1). The measured value of the correlation coefficient in the off-diagonal basis, O-off = 0.89 +/- 0.22 (stat + syst), is in agreement with the standard model prediction, and represents evidence for a top-antitop quark spin correlation difference from zero at a level of 4.2 standard deviations.
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| 21. |
- Abazov, V. M., et al.
(författare)
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Measurement of the B-s(0) Lifetime in the Flavor-Specific Decay Channel B-s(0)-> D-s(-)mu(+)nu X
- 2015
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 114:6
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Tidskriftsartikel (refereegranskat)abstract
- We present an updated measurement of the B-s(0) lifetime using the semileptonic decays B-s(0) -> D-s(-)mu(+)nu X, with D-s(-) -> phi pi(-) and phi -> K+K- (and the charge conjugate process). This measurement uses the full Tevatron Run II sample of proton-antiproton collisions at root s = 1.96 TeV, comprising an integrated luminosity of 10.4 fb(-1). We find a flavor-specific lifetime tau(fs)(B-s(0)) = 1.479 +/- 0.010(stat) +/- 0.021(syst) ps. This technique is also used to determine the B-0 lifetime using the analogous B-0 -> D- mu(+)nu X decay with D- -> phi pi(-) and phi -> K+K-, yielding tau(B-0) = 1.534 +/- 0.019(stat) +/- 0.021(syst) ps. Both measurements are consistent with the current world averages, and the B-s(0) lifetime measurement is one of the most precise to date. Taking advantage of the cancellation of systematic uncertainties, we determine the lifetime ratio tau(fs)(B-s(0))/tau(B-0) = 0.964 +/- 0.013(stat) +/- 0.007(syst).
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| 22. |
- Abazov, V. M., et al.
(författare)
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Measurement of the direct CP violating charge asymmetry in B-+/- -> mu(+/-)nu D-mu(0) decays
- 2017
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Ingår i: Physical Review D. - 2470-0010 .- 2470-0029. ; 95:3
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Tidskriftsartikel (refereegranskat)abstract
- We present the first measurement of the CP violating charge asymmetry in B-+/- -> mu(+/-)nu D-mu(0) decays using the full Run II integrated luminosity of 10.4 fb(-1) in proton-antiproton collisions collected with the D0 detector at the Fermilab Tevatron Collider. We measure a difference in the yield of B- and B+ mesons in these decays by fitting the reconstructed invariant mass distributions. This results in an asymmetry of A(mu D0) = [-0.14 +/- 0.20] %, which is consistent with standard model predictions.
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| 23. |
- Abazov, V. M., et al.
(författare)
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Measurement of the Effective Weak Mixing Angle in p(p)over-bar -> Z/gamma* -> e(+)e(-) Events
- 2015
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 115:4
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Tidskriftsartikel (refereegranskat)abstract
- We present a measurement of the fundamental parameter of the standard model, the weak mixing angle sin(2)theta(l)(eff) which determines the relative strength of weak and electromagnetic interactions, in p (p) over bar -> Z/gamma* -> e(+)e(-) events at a center of mass energy of 1.96 TeV, using data corresponding to 9.7 fb(-1) of integrated luminosity collected by the D0 detector at the Fermilab Tevatron. The effective weak mixing angle is extracted from the forward-backward charge asymmetry as a function of the invariant mass around the Z boson pole. The measured value of sin(2)theta(l)(eff) = 0.23147 +/- 0.00047 is the most precise measurement from light quark interactions to date, with a precision close to the best LEP and SLD results.
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| 24. |
- Abazov, V. M., et al.
(författare)
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Measurement of the Effective Weak Mixing Angle in p¯p→Z/γ∗→ℓ+ℓ− Events
- 2018
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 120:24
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Tidskriftsartikel (refereegranskat)abstract
- We present a measurement of the effective weak mixing angle parameter sin(2)theta(l)(eff) in p (p) over bar -> Z/gamma* -> mu(+)mu(-) events at a center-of-mass energy of 1.96 TeV, collected by the D0 detector at the Fermilab Tevatron Collider and corresponding to 8.6 fb(-1) of integrated luminosity. The measured value of sin(2)theta(l)(eff)[mu mu] = 0.23016 +/- 0.00064 is further combined with the result from the D0 measurement in p (p) over bar -> Z/gamma* -> e(+)e(-) events, resulting in sin(2)theta(l)(eff)[comb] = 0.23095 +/- 0.00040. This combined result is the most precise measurement from a single experiment at a hadron collider and is the most precise determination using the coupling of the Z/gamma* to light quarks.
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| 25. |
- Abazov, V. M., et al.
(författare)
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Measurement of the electron charge asymmetry in p(p)over-bar -> W + X -> ev plus X decays in p(p)over-bar collisions at root S=1.96 TeV
- 2015
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Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 91:3
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Tidskriftsartikel (refereegranskat)abstract
- We present a measurement of the electron charge asymmetry in p (p) over bar -> W + X -> ev + X events at a center-of-mass energy of 1.96 TeV, using data corresponding to 9.7 fb(-1) of integrated luminosity collected with the D0 detector at the Fermilab Tevatron Collider. The asymmetry is measured as a function of the electron pseudorapidity and is presented in five kinematic bins based on the electron transverse energy and the missing transverse energy in the event. The measured asymmetry is compared with next-to-leading-order predictions in perturbative quantum chromodynamics and provides accurate information for the determination of parton distribution functions of the proton. This is the most precise lepton charge asymmetry measurement to date.
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| 26. |
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| 27. |
- Abazov, V. M., et al.
(författare)
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Measurement of the forward-backward asymmetry in Lambda(0)(b) and (Lambda)over-bar(b)(0) baryon production in p(p)over-bar collisions at root s=1.96 TeV
- 2015
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Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 91:7
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Tidskriftsartikel (refereegranskat)abstract
- We measure the forward-backward asymmetry in the production of Lambda(0)(b) and (Lambda) over bar (0)(b) baryons as a function of rapidity in p (p) over bar collisions at root s = 1.96 TeV using 10.4 fb(-1) of data collected with the D0 detector at the Fermilab Tevatron collider. The asymmetry is determined by the preference of Lambda(0)(b) or (Lambda) over bar (0)(b) particles to be produced in the direction of the beam protons or antiprotons, respectively. The measured asymmetry integrated over rapidity y in the range 0.1 < vertical bar y vertical bar < 2.0 is A = 0.04 +/- 0.07(stat) +/- 0.02(syst).
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| 28. |
- Abazov, V. M., et al.
(författare)
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Measurement of the Forward-Backward Asymmetry in the Production lof B-+/- Mesons in p(p)over-bar Collisions at root s=1.96 TeV
- 2015
-
Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 114:5
-
Tidskriftsartikel (refereegranskat)abstract
- We present a measurement of the forward-backward asymmetry in the production of B-+/- mesons, A(FB)(B-+/-) using B-+/- -> J/ Psi K-+/- decays in 10.4 fb(-1) of p (p) over bar collisions at root s = 1.96 TeV collected by the D0 experiment during Run II of the Tevatron collider. A nonzero asymmetry would indicate a preference for a particular flavor, i.e., b quark or (b) over bar antiquark, to be produced in the direction of the proton beam. We extract A(FB) (B-+/-) from a maximum likelihood fit to the difference between the numbers of forward-and backward-produced B-+/- mesons. We measure an asymmetry consistent with zero: A(FB) (B-+/-) = [-0.24 +/- 0.41 (stat) +/- 0.19 (syst)] %.
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| 29. |
- Abazov, V. M., et al.
(författare)
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Measurement of the forward-backward asymmetry of Lambda and (Lambda)over-bar production in p(p)over-bar collisions
- 2016
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Ingår i: PHYSICAL REVIEW D. - 2470-0010. ; 93:3
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Tidskriftsartikel (refereegranskat)abstract
- We study Lambda and (Lambda) over bar production asymmetries in p (p) over bar -> Lambda((Lambda) over bar )X, p (p) over bar -> J/psi Lambda((Lambda) over bar )X, and p (p) over bar -> mu(+/-)Lambda((Lambda) over bar )X events recorded by the D0 detector at the Fermilab Tevatron collider at root s = 1.96 TeV. We find an excess of Lambda's ((Lambda) over bar 's) produced in the proton (antiproton) direction. This forward-backward asymmetry is measured as a function of rapidity. We confirm that the (Lambda) over bar/Lambda production ratio, measured by several experiments with various targets and a wide range of energies, is a universal function of "rapidity loss," i.e., the rapidity difference of the beam proton and the lambda.
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| 30. |
- Abazov, V. M., et al.
(författare)
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Measurement of the inclusive t(t)over-bar production cross section in p(p)over-bar collisions at root s=1.96 TeV and determination of the top quark pole mass
- 2016
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Ingår i: PHYSICAL REVIEW D. - 2470-0010. ; 94:9
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Tidskriftsartikel (refereegranskat)abstract
- The inclusive cross section of top quark-antiquark pairs produced in p (p) over bar collisions at root s = 1.96 TeV is measured in the lepton + jets and dilepton decay channels. The data sample corresponds to 9.7 fb(-1) of integrated luminosity recorded with the D0 detector during Run II of the Fermilab Tevatron Collider. Employing multivariate analysis techniques we measure the cross section in the two decay channels and we perform a combined cross section measurement. For a top quark mass of 172.5 GeV, we measure a combined inclusive top quark-antiquark pair production cross section of sigma(t<(t)over bar) = 7.26 +/- 0.13(stat)(-0.50)(+0.57) (syst) pb which is consistent with standard model predictions. We also perform a likelihood fit to the measured and predicted top quark mass dependence of the inclusive cross section, which yields a measurement of the pole mass of the top quark. The extracted value is m(t) = 172.8 +/- 1.1(theo)(-3.1)(+3.3) (exp) GeV.
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| 31. |
- Abazov, V. M., et al.
(författare)
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Measurement of the phi(eta)* distribution of muon pairs with masses between 30 and 500 GeV in 10.4 fb(-1) of p(p)over-bar collisions
- 2015
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Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 91:7
-
Tidskriftsartikel (refereegranskat)abstract
- We present a measurement of the distribution of the variable phi(eta)* for muon pairs with masses between 30 and 500 GeV, using the complete run II data set collected by the D0 detector at the Fermilab Tevatron proton-antiproton collider. This corresponds to an integrated luminosity of 10.4 fb(-1) at root s = 1.96 TeV. The data are corrected for detector effects and presented in bins of dimuon rapidity and mass. The variable phi(eta)* probes the same physical effects as the Z/gamma* boson transverse momentum, but is less susceptible to the effects of experimental resolution and efficiency. These are the first measurements at any collider of the phi(eta)* distributions for dilepton masses away from the Z --> l(+)l(-) boson mass peak. The data are compared to QCD predictions based on the resummation of multiple soft gluons.
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| 32. |
- Abazov, V. M., et al.
(författare)
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Measurement of the ratio of inclusive cross sections sigma(p(p)over-bar) -> Z+2b jets/sigma(p((p)over-bar) -> Z+2 jets) in p((p)over-bar) collisions at root s=1.96 TeV
- 2015
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Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 91:5
-
Tidskriftsartikel (refereegranskat)abstract
- We measure the ratio of cross sections, σ(pp¯→Z+2b jets)/σ(pp¯→Z+2 jets), for associated production of a Z boson with at least two jets with transverse momentum pjetT>20 GeV and pseudorapidity |ηjet|<2.5. This measurement uses data corresponding to an integrated luminosity of 9.7 fb−1 collected by the D0 experiment in Run II of Fermilab’s Tevatron pp¯ Collider at a center-of-mass energy of 1.96 TeV. The measured integrated ratio of 0.0236±0.0032 (stat)±0.0035 (syst) is in agreement with predictions from next-to-leading-order perturbative QCD and the Monte Carlo event generators pythia and alpgen.
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| 33. |
- Abazov, V. M., et al.
(författare)
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Measurement of the top quark mass using the matrix element technique in dilepton final states
- 2016
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Ingår i: PHYSICAL REVIEW D. - 2470-0010. ; 94:3
-
Tidskriftsartikel (refereegranskat)abstract
- We present a measurement of the top quark mass in p (p) over bar collisions at a center-of-mass energy of 1.96 TeV at the Fermilab Tevatron collider. The data were collected by the D0 experiment corresponding to an integrated luminosity of 9.7 fb(-1). The matrix element technique is applied to t (t) over bar events in the final state containing leptons (electrons or muons) with high transverse momenta and at least two jets. The calibration of the jet energy scale determined in the lepton + jets final state of t (t) over bar decays is applied to jet energies. This correction provides a substantial reduction in systematic uncertainties. We obtain a top quark mass of m(t) = 173.93 +/- 1.84 GeV.
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| 34. |
- Abazov, V. M., et al.
(författare)
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Measurement of the W plus b-jet and W plus c-jet differential production cross sections in p (p)over-bar collisions at root s=1.96 TeV
- 2015
-
Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 743, s. 6-14
-
Tidskriftsartikel (refereegranskat)abstract
- We present a measurement of the cross sections for the associated production of a W boson with at least one heavy quark jet, b or c, in proton-antiproton collisions. Data corresponding to an integrated luminosity of 8.7 fb(-1) recorded with the D0 detector at the Fermilab Tevatron p (p) over bar Collider at root s = 1.96 TeV are used to measure the cross sections differentially as a function of the jet transverse momenta in the range 20 to 150 GeV. These results are compared to calculations of perturbative QCD theory as well as predictions from Monte Carlo generators.
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| 35. |
- Abazov, V. M., et al.
(författare)
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Measurement of top quark polarization in t(t)over-bar lepton+jets final states
- 2017
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Ingår i: PHYSICAL REVIEW D. - 2470-0010. ; 95:1
-
Tidskriftsartikel (refereegranskat)abstract
- We present a measurement of top quark polarization in t (t) over bar pair production in p (p) over bar collisions at root s = 1.96 TeV using data corresponding to 9.7 fb(-1) of integrated luminosity recorded with the D0 detector at the Fermilab Tevatron Collider. We consider final states containing a lepton and at least three jets. The polarization is measured through the distribution of lepton angles along three axes: the beam axis, the helicity axis, and the transverse axis normal to the t (t) over bar production plane. This is the first measurement of top quark polarization at the Tevatron using lepton + jet final states and the first measurement of the transverse polarization in t (t) over bar production. The observed distributions are consistent with standard model predictions of nearly no polarization.
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| 36. |
- Abazov, V. M., et al.
(författare)
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Precise measurement of the top quark mass in dilepton decays using optimized neutrino weighting
- 2016
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Ingår i: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 752, s. 18-26
-
Tidskriftsartikel (refereegranskat)abstract
- We measure the top quark mass in dilepton final states of t (t) over bar events in p (p) over bar collisions at root s = 1.96 TeV, using data corresponding to an integrated luminosity of 9.7 fb(-1) at the Fermilab Tevatron Collider. The analysis features a comprehensive optimization of the neutrino weighting method to minimize the statistical uncertainties. We also improve the calibration of jet energies using the calibration determined in t (t) over bar -> lepton + jets events, which reduces the otherwise limiting systematic uncertainty from the jet energy scale. The measured top quark mass is m(t) = 173.32 +/- 1.36(stat) +/- 0.85(syst) GeV.
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| 37. |
- Abazov, V. M., et al.
(författare)
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Precision measurement of the top-quark mass in lepton plus jets final states
- 2015
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Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 91:11
-
Tidskriftsartikel (refereegranskat)abstract
- We measure the mass of the top quark in lepton + jets final states using the full sample of p (p) over bar collision data collected by the D0 experiment in Run II of the Fermilab Tevatron Collider at root s = 1.96 TeV, corresponding to 9.7 fb(-1) of integrated luminosity. We use a matrix element technique that calculates the probabilities for each event to result from t (t) over bar production or background. The overall jet energy scale is constrained in situ by the mass of the W boson. We measure m(t) = 174.98 +/- 0.76 GeV. This constitutes the most precise single measurement of the top-quark mass.
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| 38. |
- Abazov, V. M., et al.
(författare)
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Search for Violation of CPT and Lorentz Invariance in B-s(0) Meson Oscillations
- 2015
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 115:16
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Tidskriftsartikel (refereegranskat)abstract
- We present the first search for CPT-violating effects in the mixing of B-s(0) mesons using the full Run II data set with an integrated luminosity of 10.4 fb(-1) of proton-antiproton collisions collected using the D0 detector at the Fermilab Tevatron Collider. We measure the CPT-violating asymmetry in the decay B-s(0) -> mu D-+/-(s)+/- as a function of celestial direction and sidereal phase. We find no evidence for CPT-violating effects and place limits on the direction and magnitude of flavor-dependent CPT- and Lorentz-invariance violating coupling coefficients. We find 95% confidence intervals of Delta a(perpendicular to) < 1.2 x 10(-12) GeV and (-0.8 < Delta a(T) - 0.396 Delta a(Z) < 3.9) x 10(-13) GeV.
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| 39. |
- Abazov, V. M., et al.
(författare)
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Simultaneous measurement of forward-backward asymmetry and top polarization in dilepton final states from t(t)over-bar production at the Tevatron
- 2015
-
Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 92:5
-
Tidskriftsartikel (refereegranskat)abstract
- We present a simultaneous measurement of the forward-backward asymmetry and the top-quark polarization in t (t) over bar production in dilepton final states using 9.7 fb(-1) of proton-antiproton collisions at root s = 1.96 TeV with the D0 detector. To reconstruct the distributions of kinematic observables we employ a matrix element technique that calculates the likelihood of the possible t (t) over bar kinematic configurations. After accounting for the presence of background events and for calibration effects, we obtain a forward-backward asymmetry of A(t (t) over bar) = (15.0 +/- 6.4(stat) +/- 4.9(syst)) % and a top-quark polarization times spin analyzing power in the beam basis of kappa P = (7.2 +/- 10.5(stat) +/- 4.2(syst)) %, with a correlation of -56% between the measurements. If we constrain the forward-backward asymmetry to its expected standard model value, we obtain a measurement of the top polarization of kappa P = (11.3 +/- 9.1(stat) +/- 1.9(syst)) %. If we constrain the top polarization to its expected standard model value, we measure a forward-backward asymmetry of A(t (t) over bar) = (17.5 +/- 5.6(stat) +/- 3.1(syst)) %. A combination with the D0 A(t (t) over bar) measurement in the lepton + jets final state yields an asymmetry of A(t (t) over bar) = (11.8 +/- 2.5(stat) +/- 1.3(syst)) %. Within their respective uncertainties, all these results are consistent with the standard model expectations.
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| 40. |
- Abazov, V. M., et al.
(författare)
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Study of double parton interactions in diphoton plus dijet events in p<(p)over bar> collisions at root s = 1.96 TeV
- 2016
-
Ingår i: PHYSICAL REVIEW D. - 2470-0010. ; 93:5
-
Tidskriftsartikel (refereegranskat)abstract
- We use a sample of diphoton + dijet events to measure the effective cross section of double parton interactions, which characterizes the area containing the interacting partons in proton-antiproton collisions, and find it to be sigma(eff) = 19.3 +/- 1.4(stat) +/- 7.8(syst) mb. The sample was collected by the D0 detector at the Fermilab Tevatron collider in p (p) over bar collisions at root s = 1.96 TeV and corresponds to an integrated luminosity of 8.7 fb(-1).
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| 41. |
- Abazov, V. M., et al.
(författare)
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Study of the X-+/-(5568) state with semileptonic decays of the B-s(0) meson
- 2018
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Ingår i: Physical Review D. - : AMER PHYSICAL SOC. - 2470-0010 .- 2470-0029. ; 97:9
-
Tidskriftsartikel (refereegranskat)abstract
- We present a study of the X-+/-(5568) using semileptonic decays of the B-s(0) meson using the full run II integrated luminosity of 10.4 fb(-1) in proton-antiproton collisions at a center of mass energy of 1.96 TeV collected with the DO detector at the Fermilab Tevatron Collider. We report evidence for a narrow structure, X-+/-(5568), in the decay sequence X-+/-(5568) -> B-s(0) pi(+/-) where B-s(0)-> mu(-/+) (DsX)-X-+/-, D-s(+/-)-> phi pi(+/-)which is consistent with the previous measurement by the DO Collaboration in the hadronic decay mode, X-+/-(5568) -> B-s(0)pi(+/-) where B-s(0 )-> J/psi phi. The mass and width of this state are measured using a combined fit of the hadronic and semileptonic data, yielding m = 5566.9(-3.1)(+3.2)(stat)(-1.2)(+0.6)(syst) MeV/c(2), Gamma = 18.6(-6.1)(+7.9)(stat)(-3.8)(+3.5) (syst) McV/c(2) with a significance of 6.7 sigma.
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| 42. |
- Forouzanfar, Mohammad H, et al.
(författare)
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Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013 : a systematic analysis for the Global Burden of Disease Study 2013.
- 2015
-
Ingår i: The Lancet. - 0140-6736 .- 1474-547X. ; 386:10010, s. 2287-2323
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) is the first of a series of annual updates of the GBD. Risk factor quantification, particularly of modifiable risk factors, can help to identify emerging threats to population health and opportunities for prevention. The GBD 2013 provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution.METHODS: Attributable deaths, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs) have been estimated for 79 risks or clusters of risks using the GBD 2010 methods. Risk-outcome pairs meeting explicit evidence criteria were assessed for 188 countries for the period 1990-2013 by age and sex using three inputs: risk exposure, relative risks, and the theoretical minimum risk exposure level (TMREL). Risks are organised into a hierarchy with blocks of behavioural, environmental and occupational, and metabolic risks at the first level of the hierarchy. The next level in the hierarchy includes nine clusters of related risks and two individual risks, with more detail provided at levels 3 and 4 of the hierarchy. Compared with GBD 2010, six new risk factors have been added: handwashing practices, occupational exposure to trichloroethylene, childhood wasting, childhood stunting, unsafe sex, and low glomerular filtration rate. For most risks, data for exposure were synthesised with a Bayesian meta-regression method, DisMod-MR 2.0, or spatial-temporal Gaussian process regression. Relative risks were based on meta-regressions of published cohort and intervention studies. Attributable burden for clusters of risks and all risks combined took into account evidence on the mediation of some risks such as high body-mass index (BMI) through other risks such as high systolic blood pressure and high cholesterol.FINDINGS: All risks combined account for 57·2% (95% uncertainty interval [UI] 55·8-58·5) of deaths and 41·6% (40·1-43·0) of DALYs. Risks quantified account for 87·9% (86·5-89·3) of cardiovascular disease DALYs, ranging to a low of 0% for neonatal disorders and neglected tropical diseases and malaria. In terms of global DALYs in 2013, six risks or clusters of risks each caused more than 5% of DALYs: dietary risks accounting for 11·3 million deaths and 241·4 million DALYs, high systolic blood pressure for 10·4 million deaths and 208·1 million DALYs, child and maternal malnutrition for 1·7 million deaths and 176·9 million DALYs, tobacco smoke for 6·1 million deaths and 143·5 million DALYs, air pollution for 5·5 million deaths and 141·5 million DALYs, and high BMI for 4·4 million deaths and 134·0 million DALYs. Risk factor patterns vary across regions and countries and with time. In sub-Saharan Africa, the leading risk factors are child and maternal malnutrition, unsafe sex, and unsafe water, sanitation, and handwashing. In women, in nearly all countries in the Americas, north Africa, and the Middle East, and in many other high-income countries, high BMI is the leading risk factor, with high systolic blood pressure as the leading risk in most of Central and Eastern Europe and south and east Asia. For men, high systolic blood pressure or tobacco use are the leading risks in nearly all high-income countries, in north Africa and the Middle East, Europe, and Asia. For men and women, unsafe sex is the leading risk in a corridor from Kenya to South Africa.INTERPRETATION: Behavioural, environmental and occupational, and metabolic risks can explain half of global mortality and more than one-third of global DALYs providing many opportunities for prevention. Of the larger risks, the attributable burden of high BMI has increased in the past 23 years. In view of the prominence of behavioural risk factors, behavioural and social science research on interventions for these risks should be strengthened. Many prevention and primary care policy options are available now to act on key risks.FUNDING: Bill & Melinda Gates Foundation.
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| 43. |
- Meyer, H.F., et al.
(författare)
-
Overview of physics studies on ASDEX Upgrade
- 2019
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 59:11
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Forskningsöversikt (refereegranskat)abstract
- The ASDEX Upgrade (AUG) programme, jointly run with the EUROfusion MST1 task force, continues to significantly enhance the physics base of ITER and DEMO. Here, the full tungsten wall is a key asset for extrapolating to future devices. The high overall heating power, flexible heating mix and comprehensive diagnostic set allows studies ranging from mimicking the scrape-off-layer and divertor conditions of ITER and DEMO at high density to fully non-inductive operation (q 95 = 5.5, ) at low density. Higher installed electron cyclotron resonance heating power 6 MW, new diagnostics and improved analysis techniques have further enhanced the capabilities of AUG. Stable high-density H-modes with MW m-1 with fully detached strike-points have been demonstrated. The ballooning instability close to the separatrix has been identified as a potential cause leading to the H-mode density limit and is also found to play an important role for the access to small edge-localized modes (ELMs). Density limit disruptions have been successfully avoided using a path-oriented approach to disruption handling and progress has been made in understanding the dissipation and avoidance of runaway electron beams. ELM suppression with resonant magnetic perturbations is now routinely achieved reaching transiently . This gives new insight into the field penetration physics, in particular with respect to plasma flows. Modelling agrees well with plasma response measurements and a helically localised ballooning structure observed prior to the ELM is evidence for the changed edge stability due to the magnetic perturbations. The impact of 3D perturbations on heat load patterns and fast-ion losses have been further elaborated. Progress has also been made in understanding the ELM cycle itself. Here, new fast measurements of and E r allow for inter ELM transport analysis confirming that E r is dominated by the diamagnetic term even for fast timescales. New analysis techniques allow detailed comparison of the ELM crash and are in good agreement with nonlinear MHD modelling. The observation of accelerated ions during the ELM crash can be seen as evidence for the reconnection during the ELM. As type-I ELMs (even mitigated) are likely not a viable operational regime in DEMO studies of 'natural' no ELM regimes have been extended. Stable I-modes up to have been characterised using -feedback. Core physics has been advanced by more detailed characterisation of the turbulence with new measurements such as the eddy tilt angle - measured for the first time - or the cross-phase angle of and fluctuations. These new data put strong constraints on gyro-kinetic turbulence modelling. In addition, carefully executed studies in different main species (H, D and He) and with different heating mixes highlight the importance of the collisional energy exchange for interpreting energy confinement. A new regime with a hollow profile now gives access to regimes mimicking aspects of burning plasma conditions and lead to nonlinear interactions of energetic particle modes despite the sub-Alfvénic beam energy. This will help to validate the fast-ion codes for predicting ITER and DEMO.
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| 44. |
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| 45. |
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| 46. |
- Naghavi, Mohsen, et al.
(författare)
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Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013
- 2015
-
Ingår i: The Lancet. - 1474-547X .- 0140-6736. ; 385:9963, s. 117-171
-
Tidskriftsartikel (refereegranskat)abstract
- Background Up-to-date evidence on levels and trends for age-sex-specifi c all-cause and cause-specifi c mortality is essential for the formation of global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013) we estimated yearly deaths for 188 countries between 1990, and 2013. We used the results to assess whether there is epidemiological convergence across countries. Methods We estimated age-sex-specifi c all-cause mortality using the GBD 2010 methods with some refinements to improve accuracy applied to an updated database of vital registration, survey, and census data. We generally estimated cause of death as in the GBD 2010. Key improvements included the addition of more recent vital registration data for 72 countries, an updated verbal autopsy literature review, two new and detailed data systems for China, and more detail for Mexico, UK, Turkey, and Russia. We improved statistical models for garbage code redistribution. We used six different modelling strategies across the 240 causes; cause of death ensemble modelling (CODEm) was the dominant strategy for causes with sufficient information. Trends for Alzheimer's disease and other dementias were informed by meta-regression of prevalence studies. For pathogen-specifi c causes of diarrhoea and lower respiratory infections we used a counterfactual approach. We computed two measures of convergence (inequality) across countries: the average relative difference across all pairs of countries (Gini coefficient) and the average absolute difference across countries. To summarise broad findings, we used multiple decrement life-tables to decompose probabilities of death from birth to exact age 15 years, from exact age 15 years to exact age 50 years, and from exact age 50 years to exact age 75 years, and life expectancy at birth into major causes. For all quantities reported, we computed 95% uncertainty intervals (UIs). We constrained cause-specific fractions within each age-sex-country-year group to sum to all-cause mortality based on draws from the uncertainty distributions. Findings Global life expectancy for both sexes increased from 65.3 years (UI 65.0-65.6) in 1990, to 71.5 years (UI 71.0-71.9) in 2013, while the number of deaths increased from 47.5 million (UI 46.8-48.2) to 54.9 million (UI 53.6-56.3) over the same interval. Global progress masked variation by age and sex: for children, average absolute diff erences between countries decreased but relative diff erences increased. For women aged 25-39 years and older than 75 years and for men aged 20-49 years and 65 years and older, both absolute and relative diff erences increased. Decomposition of global and regional life expectancy showed the prominent role of reductions in age-standardised death rates for cardiovascular diseases and cancers in high-income regions, and reductions in child deaths from diarrhoea, lower respiratory infections, and neonatal causes in low-income regions. HIV/AIDS reduced life expectancy in southern sub-Saharan Africa. For most communicable causes of death both numbers of deaths and age-standardised death rates fell whereas for most non-communicable causes, demographic shifts have increased numbers of deaths but decreased age-standardised death rates. Global deaths from injury increased by 10.7%, from 4.3 million deaths in 1990 to 4.8 million in 2013; but age-standardised rates declined over the same period by 21%. For some causes of more than 100 000 deaths per year in 2013, age-standardised death rates increased between 1990 and 2013, including HIV/AIDS, pancreatic cancer, atrial fibrillation and flutter, drug use disorders, diabetes, chronic kidney disease, and sickle-cell anaemias. Diarrhoeal diseases, lower respiratory infections, neonatal causes, and malaria are still in the top five causes of death in children younger than 5 years. The most important pathogens are rotavirus for diarrhoea and pneumococcus for lower respiratory infections. Country-specific probabilities of death over three phases of life were substantially varied between and within regions. Interpretation For most countries, the general pattern of reductions in age-sex specifi c mortality has been associated with a progressive shift towards a larger share of the remaining deaths caused by non-communicable disease and injuries. Assessing epidemiological convergence across countries depends on whether an absolute or relative measure of inequality is used. Nevertheless, age-standardised death rates for seven substantial causes are increasing, suggesting the potential for reversals in some countries. Important gaps exist in the empirical data for cause of death estimates for some countries; for example, no national data for India are available for the past decade.
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| 47. |
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| 48. |
- Vos, Theo, et al.
(författare)
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Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013
- 2015
-
Ingår i: The Lancet. - 1474-547X .- 0140-6736. ; 386:9995, s. 743-800
-
Tidskriftsartikel (refereegranskat)abstract
- Background Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013), we estimated these quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013. Methods Estimates were calculated for disease and injury incidence, prevalence, and YLDs using GBD 2010 methods with some important refinements. Results for incidence of acute disorders and prevalence of chronic disorders are new additions to the analysis. Key improvements include expansion to the cause and sequelae list, updated systematic reviews, use of detailed injury codes, improvements to the Bayesian meta-regression method (DisMod-MR), and use of severity splits for various causes. An index of data representativeness, showing data availability, was calculated for each cause and impairment during three periods globally and at the country level for 2013. In total, 35 620 distinct sources of data were used and documented to calculated estimates for 301 diseases and injuries and 2337 sequelae. The comorbidity simulation provides estimates for the number of sequelae, concurrently, by individuals by country, year, age, and sex. Disability weights were updated with the addition of new population-based survey data from four countries. Findings Disease and injury were highly prevalent; only a small fraction of individuals had no sequelae. Comorbidity rose substantially with age and in absolute terms from 1990 to 2013. Incidence of acute sequelae were predominantly infectious diseases and short-term injuries, with over 2 billion cases of upper respiratory infections and diarrhoeal disease episodes in 2013, with the notable exception of tooth pain due to permanent caries with more than 200 million incident cases in 2013. Conversely, leading chronic sequelae were largely attributable to non-communicable diseases, with prevalence estimates for asymptomatic permanent caries and tension-type headache of 2.4 billion and 1.6 billion, respectively. The distribution of the number of sequelae in populations varied widely across regions, with an expected relation between age and disease prevalence. YLDs for both sexes increased from 537.6 million in 1990 to 764.8 million in 2013 due to population growth and ageing, whereas the age-standardised rate decreased little from 114.87 per 1000 people to 110.31 per 1000 people between 1990 and 2013. Leading causes of YLDs included low back pain and major depressive disorder among the top ten causes of YLDs in every country. YLD rates per person, by major cause groups, indicated the main drivers of increases were due to musculoskeletal, mental, and substance use disorders, neurological disorders, and chronic respiratory diseases; however HIV/AIDS was a notable driver of increasing YLDs in sub-Saharan Africa. Also, the proportion of disability-adjusted life years due to YLDs increased globally from 21.1% in 1990 to 31.2% in 2013. Interpretation Ageing of the world's population is leading to a substantial increase in the numbers of individuals with sequelae of diseases and injuries. Rates of YLDs are declining much more slowly than mortality rates. The non-fatal dimensions of disease and injury will require more and more attention from health systems. The transition to non-fatal outcomes as the dominant source of burden of disease is occurring rapidly outside of sub-Saharan Africa. Our results can guide future health initiatives through examination of epidemiological trends and a better understanding of variation across countries.
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| 49. |
- Locke, Adam E, et al.
(författare)
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Genetic studies of body mass index yield new insights for obesity biology.
- 2015
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401
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Tidskriftsartikel (refereegranskat)abstract
- Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
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| 50. |
- Figlioli, G, et al.
(författare)
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The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer
- 2019
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Ingår i: NPJ breast cancer. - : Springer Science and Business Media LLC. - 2374-4677. ; 5, s. 38-
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Tidskriftsartikel (refereegranskat)abstract
- Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a breast cancer predisposition gene, with greater effects for the ER-negative and triple-negative breast cancer (TNBC) subtypes. We tested the three recurrent protein-truncating variants FANCM:p.Arg658*, p.Gln1701*, and p.Arg1931* for association with breast cancer risk in 67,112 cases, 53,766 controls, and 26,662 carriers of pathogenic variants of BRCA1 or BRCA2. These three variants were also studied functionally by measuring survival and chromosome fragility in FANCM−/− patient-derived immortalized fibroblasts treated with diepoxybutane or olaparib. We observed that FANCM:p.Arg658* was associated with increased risk of ER-negative disease and TNBC (OR = 2.44, P = 0.034 and OR = 3.79; P = 0.009, respectively). In a country-restricted analysis, we confirmed the associations detected for FANCM:p.Arg658* and found that also FANCM:p.Arg1931* was associated with ER-negative breast cancer risk (OR = 1.96; P = 0.006). The functional results indicated that all three variants were deleterious affecting cell survival and chromosome stability with FANCM:p.Arg658* causing more severe phenotypes. In conclusion, we confirmed that the two rare FANCM deleterious variants p.Arg658* and p.Arg1931* are risk factors for ER-negative and TNBC subtypes. Overall our data suggest that the effect of truncating variants on breast cancer risk may depend on their position in the gene. Cell sensitivity to olaparib exposure, identifies a possible therapeutic option to treat FANCM-associated tumors.
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