Sökning: WFRF:(Rugbjerg Peter 1988)
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Performance and rob...
Performance and robustness analysis reveals phenotypic trade-offs in yeast
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- Trivellin, Cecilia, 1993 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Rugbjerg, Peter, 1988 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Olsson, Lisbeth, 1963 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: Life Science Alliance. - 2575-1077. ; 7:1
- Relaterad länk:
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https://research.cha... (primary) (free)
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- To design strains that can function efficiently in complex industrial settings, it is crucial to consider their robustness, that is, the stability of their performance when faced with perturbations. In the present study, we cultivated 24 Saccharomyces cerevisiae strains under conditions that simulated perturbations encountered during lignocellulosic bioethanol production, and assessed the performance and robustness of multiple phenotypes simultaneously. The observed negative correlations confirmed a trade-off between performance and robustness of ethanol yield, biomass yield, and cell dry weight. Conversely, the specific growth rate performance positively correlated with the robustness, presumably because of evolutionary selection for robust, fast-growing cells. The Ethanol Red strain exhibited both high performance and robustness, making it a good candidate for bioproduction in the tested perturbation space. Our results experimentally map the robustness-performance trade-offs, previously demonstrated mainly by single-phenotype and computational studies.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Samhällsbyggnadsteknik -- Annan samhällsbyggnadsteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Civil Engineering -- Other Civil Engineering (hsv//eng)
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