1. |
- Schael, S, et al.
(författare)
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Precision electroweak measurements on the Z resonance
- 2006
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Ingår i: Physics Reports. - : Elsevier BV. - 0370-1573 .- 1873-6270. ; 427:5-6, s. 257-454
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Forskningsöversikt (refereegranskat)abstract
- We report on the final electroweak measurements performed with data taken at the Z resonance by the experiments operating at the electron-positron colliders SLC and LEP. The data consist of 17 million Z decays accumulated by the ALEPH, DELPHI, L3 and OPAL experiments at LEP, and 600 thousand Z decays by the SLID experiment using a polarised beam at SLC. The measurements include cross-sections, forward-backward asymmetries and polarised asymmetries. The mass and width of the Z boson, m(Z) and Gamma(Z), and its couplings to fermions, for example the p parameter and the effective electroweak mixing angle for leptons, are precisely measured: m(Z) = 91.1875 +/- 0.0021 GeV, Gamma(Z) = 2.4952 +/- 0.0023 GeV, rho(l) = 1.0050 +/- 0.0010, sin(2)theta(eff)(lept) = 0.23153 +/- 0.00016. The number of light neutrino species is determined to be 2.9840 +/- 0.0082, in agreement with the three observed generations of fundamental fermions. The results are compared to the predictions of the Standard Model (SM). At the Z-pole, electroweak radiative corrections beyond the running of the QED and QCD coupling constants are observed with a significance of five standard deviations, and in agreement with the Standard Model. Of the many Z-pole measurements, the forward-backward asymmetry in b-quark production shows the largest difference with respect to its SM expectation, at the level of 2.8 standard deviations. Through radiative corrections evaluated in the framework of the Standard Model, the Z-pole data are also used to predict the mass of the top quark, m(t) = 173(+10)(+13) GeV, and the mass of the W boson, m(W) = 80.363 +/- 0.032 GeV. These indirect constraints are compared to the direct measurements, providing a stringent test of the SM. Using in addition the direct measurements of m(t) and m(W), the mass of the as yet unobserved SM Higgs boson is predicted with a relative uncertainty of about 50% and found to be less than 285 GeV at 95% confidence level. (c) 2006 Elsevier B.V. All rights reserved.
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2. |
- Aaron, F. D., et al.
(författare)
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Multi-leptons with high transverse momentum at HERA
- 2009
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Ingår i: Journal of High Energy Physics. - : Springer Science and Business Media LLC. - 1029-8479. ; :10
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Tidskriftsartikel (refereegranskat)abstract
- Events with at least two high transverse momentum leptons (electrons or muons) are studied using the H1 and ZEUS detectors at HERA with an integrated luminosity of 0.94 fb(-1). The observed numbers of events are in general agreement with the Standard Model predictions. Seven di- and tri-lepton events are observed in e(+)p collision data with a scalar sum of the lepton transverse momenta above 100 GeV while 1.94 +/- 0.17 events are expected. Such events are not observed in e(-)p collisions for which 1.19 +/- 0.12 are predicted. Total visible and differential di-electron and di-muon photoproduction cross sections are extracted in a restricted phase space dominated by photon-photon collisions.
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3. |
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4. |
- Abat, E., et al.
(författare)
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Study of the response of the ATLAS central calorimeter to pions of energies from 3 to 9 GeV
- 2009
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Ingår i: Nuclear Instruments & Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment. - : Elsevier BV. - 0167-5087 .- 0168-9002 .- 1872-9576. ; 607:2, s. 372-386
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Tidskriftsartikel (refereegranskat)abstract
- A fully instrumented slice of the ATLAS central detector was exposed to test beams from the SPS (Super Proton Synchrotron) at CERN in 2004. in this paper, the response of the central calorimeters to pions with energies in the range between 3 and 9 GeV is presented. The linearity and the resolution of the combined calorimetry (electromagnetic and hadronic calorimeters) was measured and compared to the prediction of a detector simulation program using the toolkit Geant 4. (C) 2009 Elsevier B.V. All rights reserved.
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5. |
- Abdo, A. A., et al.
(författare)
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Fermi Observations of High-Energy Gamma-Ray Emission from GRB 080916C
- 2009
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 323:5922, s. 1688-1693
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Tidskriftsartikel (refereegranskat)abstract
- Gamma-ray bursts (GRBs) are highly energetic explosions signaling the death of massive stars in distant galaxies. The Gamma-ray Burst Monitor and Large Area Telescope onboard the Fermi Observatory together record GRBs over a broad energy range spanning about 7 decades of gamma-ray energy. In September 2008, Fermi observed the exceptionally luminous GRB 080916C, with the largest apparent energy release yet measured. The high-energy gamma rays are observed to start later and persist longer than the lower energy photons. A simple spectral form fits the entire GRB spectrum, providing strong constraints on emission models. The known distance of the burst enables placing lower limits on the bulk Lorentz factor of the outflow and on the quantum gravity mass.
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6. |
- Aaron, F. D., et al.
(författare)
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A general search for new phenomena at HERA
- 2009
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 674:4-5, s. 257-268
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Tidskriftsartikel (refereegranskat)abstract
- A model-independent search for deviations from the Standard Model prediction is performed using the full e(+/-) p data sample collected by the H1 experiment at HERA. All event topologies involving isolated electrons, photons, muons, neutrinos and jets with transverse momenta above 20 GeV are investigated in a single analysis. Events are assigned to exclusive classes according to their final state. A dedicated algorithm is used to search for deviations from the Standard Model in the distributions of the scalar sum of transverse momenta or the invariant mass of final state particles and to quantify their significance. Variables related to angular distributions and energy sharing between final state particles are also introduced to study the final state topologies. No significant deviation from the Standard Model expectation is observed in the phase space covered by this analysis. (C) 2009 Elsevier B.V. All rights reserved.
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7. |
- Aaron, F. D., et al.
(författare)
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A precision measurement of the inclusive ep scattering cross section at HERA
- 2009
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 64:4, s. 561-587
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Tidskriftsartikel (refereegranskat)abstract
- A measurement of the inclusive deep inelastic neutral current e(+) p scattering cross section is reported in the region of four-momentum transfer squared, 12GeV(2) <= Q(2) <= 150 GeV2, and Bjorken x, 2 x 10(-4) <= x <= 0.1. The results are based on data collected by the H1 Collaboration at the ep collider HERA at positron and proton beam energies of E-e = 27.6 GeV and E-p = 920 GeV, respectively. The data are combined with previously published data, taken at E-p = 820 GeV. The accuracy of the combined measurement is typically in the range of 1.3-2%. A QCD analysis at next-to-leading order is performed to determine the parton distributions in the proton based on H1 data.
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8. |
- Aaron, F. D., et al.
(författare)
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A search for excited neutrinos in e(-) p collisions at HERA
- 2008
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 663:5, s. 382-389
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Tidskriftsartikel (refereegranskat)abstract
- A search for first generation excited neutrinos is performed using the full e(-) p data sample collected by the HI experiment at HERA at a centre-of-mass energy of 319 GeV, corresponding to a total luminosity of 184 pb(-1). The electroweak decays of excited neutrinos nu* -> nu gamma, v* -> nu Z and nu* -> eW with subsequent hadronic or leptonic decays of the W and Z bosons are considered. No evidence for excited neutrino production is found. Mass dependent exclusion limits on nu* production cross sections and on the ratio of the coupling to the compositeness scale f/boolean AND are derived within gauge mediated models. A limit on f/boolean AND A, independent of the relative couplings to the SU(2) and U(1) gauge bosons, is also determined. These limits extend the excluded region to higher masses than has been possible in previous excited neutrino searches. (c) 2008 Elsevier B.V. All rights reserved.
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9. |
- Aaron, F. D., et al.
(författare)
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Deeply virtual Compton scattering and its beam charge asymmetry in e(+/-)p collisions at HERA
- 2009
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 681:5, s. 391-399
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Tidskriftsartikel (refereegranskat)abstract
- A measurement of elastic deeply virtual Compton scattering gamma*p --> gamma p using e(+) p and e(-) p collision data recorded with the HI detector at HERA is presented. The analysed data sample corresponds to an integrated luminosity of 306 pb(-1), almost equally shared between both beam charges. The cross section is measured as a function of the virtuality Q(2) of the exchanged photon and the centre-of-mass energy W of the gamma*p system in the kinematic domain 6.5 < Q(2) < 80 GeV2, 30 < W < 140 GeV and |t| < 1 GeV2, where t denotes the squared momentum transfer at the proton vertex. The cross section is determined differentially in t for different Q(2) and W values and exponential t-slope parameters are derived. Using e(+) p and e(-) p data samples, a beam charge asymmetry is extracted for the first time in the low Biorken x kinematic domain. The observed asymmetry is attributed to the interference between Bethe-Heitler and deeply virtual Compton scattering processes. Experimental results are discussed in the context of two different models, one based on generalised parton distributions and one based on the dipole approach. (C) 2009 Elsevier B.V. All rights reserved.
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10. |
- Aaron, F. D., et al.
(författare)
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Events with isolated leptons and missing transverse momentum and measurement of W production at HERA
- 2009
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 64:2, s. 251-271
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Tidskriftsartikel (refereegranskat)abstract
- Events with high energy isolated electrons, muons or tau leptons and missing transverse momentum are studied using the full e(+/-)p data sample collected by the H1 experiment at HERA, corresponding to an integrated luminosity of 474 pb(-1). Within the Standard Model, events with isolated leptons and missing transverse momentum mainly originate from the production of single W bosons. The total single W boson production cross section is measured as 1.14 +/- 0.25 (stat.) +/- 0.14 (sys.) pb, in agreement with the Standard Model expectation. The data are also used to establish limits on the WW gamma gauge couplings and for a measurement of the W boson polarisation.
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11. |
- Aaron, F. D., et al.
(författare)
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Inclusive photoproduction of rho(0), K*(0) and phi mesons at HERA H1 Collaboration
- 2009
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 673:2, s. 119-126
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Tidskriftsartikel (refereegranskat)abstract
- Inclusive non-diffractive photoproduction of rho(770)(0), K*(892)(0) and phi(1020) mesons is investigated with the H1 detector in ep collisions at HERA. The corresponding average gamma p centre-of-mass energy is 210 GeV. The mesons are measured in the transverse momentum range 0.5 < p(T) < 7 GeV and the rapidity range vertical bar y(lab)vertical bar < 1. Differential cross sections are presented as a function of transverse momentum and rapidity, and are compared to the predictions of hadroproduction models. (C) 2009 Elsevier B.V. All rights reserved.
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12. |
- Aaron, F. D., et al.
(författare)
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Measurement of the inclusive ep scattering cross section at low Q (2) and x at HERA
- 2009
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 63:4, s. 625-678
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Tidskriftsartikel (refereegranskat)abstract
- A measurement of the inclusive ep scattering cross section is presented in the region of low momentum transfers, 0.2 GeV2 a parts per thousand currency signQ (2)a parts per thousand currency sign12 GeV2, and low Bjorken x, 5a <...10(-6)a parts per thousand currency signxa parts per thousand currency sign0.02. The result is based on two data sets collected in dedicated runs by the H1 Collaboration at HERA at beam energies of 27.6 GeV and 920 GeV for positrons and protons, respectively. A combination with data previously published by H1 leads to a cross section measurement of a few percent accuracy. A kinematic reconstruction method exploiting radiative ep events extends the measurement to lower Q (2) and larger x. The data are compared with theoretical models which apply to the transition region from photoproduction to deep inelastic scattering.
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13. |
- Aaron, F. D., et al.
(författare)
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Observation of the hadronic final state charge asymmetry in high Q(2) deep-inelastic scattering at HERA
- 2009
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 681:2, s. 125-133
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Tidskriftsartikel (refereegranskat)abstract
- A first measurement is presented of the charge asymmetry in the hadronic final state from the hard interaction in deep-inelastic ep neutral current scattering at HERA. The measurement is performed in the range of negative squared four momentum transfer 100 < Q(2) < 8000 GeV2. The difference between the event normalised distributions of the scaled momentum, x(p), for positively and negatively charged particles, measured in the current region of the Breit frame, is studied together with its evolution as a function of Q. The results are compared to Monte Carlo models at the hadron and parton levels. (C) 2009 Elsevier B.V. All rights reserved.
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14. |
- Aaron, F. D., et al.
(författare)
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Search for excited quarks in ep collisions at HERA
- 2009
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 678:4, s. 335-343
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Tidskriftsartikel (refereegranskat)abstract
- A search for excited quarks is performed using the full e(+/-)p data sample collected by the HI experiment at HERA, corresponding to a total integrated luminosity of 475 pb(-1). The electroweak decays of excited quarks q* -> q gamma. q* -> qZ and q* - qW with Subsequent hadronic or leptonic decays of the W and Z bosons are considered. No evidence for first generation excited quark production is found. Mass dependent exclusion limits on q* production cross sections and on the ratio f/Lambda of the coupling to the compositeness scale are derived Within gauge mediated models. These limits extend the excluded region compared to previous excited quark searches. (C) 2009 Elsevier B.V. All rights reserved.
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15. |
- Aaron, F. D., et al.
(författare)
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Search for single top quark production at HERA
- 2009
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 678:5, s. 450-458
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Tidskriftsartikel (refereegranskat)abstract
- A search for single top quark production is performed in the full e(+/-)p data sample collected by the H1 experiment at HERA, corresponding to an integrated luminosity of 474 pb(-1). Decays of top quarks into a b quark and a W boson with Subsequent leptonic or hadronic decay of the W are investigated. A multivariate analysis is performed to discriminate top quark production from Standard Model background processes. An upper limit on the top quark production cross section via flavour changing neutral current processes sigma(ep -> et X) < 0.25 pb is established at 95% CL. Limits on the anomalous coupling K-tu gamma are derived. (C) 2009 Elsevier B.V. All rights reserved.
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16. |
- Aaron, F. D., et al.
(författare)
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Measurement of diffractive scattering of photons with large momentum transfer at HERA
- 2009
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 672:3, s. 219-226
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Tidskriftsartikel (refereegranskat)abstract
- The first measurement of diffractive scattering of quasi-real photons with large momentum transfer gamma p -> gamma Y, where Y is the proton dissociative system, is made using the H1 detector at HERA. The measurement is performed for initial photon virtualities Q(2) < 0.01 GeV2. Single differential cross sections are Measured as a function of W, the incident photon-proton centre of mass energy, and t, the square of the four-momentum transferred at the proton vertex, in the range 175 < W < 247 GeV and 4 < |t| < 36 GeV2. The W dependence is well described by a model based on perturbative QCD using a leading logarithmic approximation of the BFKL evolution. The measured |t| dependence is harder than that predicted by the model and those observed in exclusive vector meson production. (C) 2009 Published by Elsevier B.V.
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17. |
- Aaron, F. D., et al.
(författare)
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Measurement of the proton structure function F-L(x, Q(2)) at low x
- 2008
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 665:4, s. 139-146
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Tidskriftsartikel (refereegranskat)abstract
- A first measurement is reported of the longitudinal proton structure function FL(X, Q(2)) at the ep collider HERA. It is based on inclusive deep inelastic e(+)p scattering cross section measurements with a positron beam energy of 27.5 GeV and proton beam energies of 920, 575 and 460 GeV. Employing the energy dependence of the cross section, FL is measured in a range of squared four-momentum transfers 12 <= Q2 <=, 90 GeV2 and low Bjorken x 0.00024 <= x <= 0.0036. The F-L values agree with higher order QCD calculations based on parton densities obtained using cross section data previously measured at HERA. (C) 2008 Elsevier B.V. All rights reserved.
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18. |
- Aaron, F. D., et al.
(författare)
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Multi-lepton production at high transverse momenta in ep collisions at HERA
- 2008
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 668:4, s. 268-276
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Tidskriftsartikel (refereegranskat)abstract
- Processes leading to a final state with at least two high transverse momentum leptons (electrons or muons) are studied using the full e(+/-) p data sample collected by the H1 experiment at HERA. The data correspond to an integrated luminosity of 463 pb(-1). Di-lepton and tri-lepton event classes are investigated. Cross sections of the production of e(+)e(-) and mu(+)mu(-) pairs are derived in a restricted phase space dominated by photon-photon collisions. In general, good agreement is found with Standard Model predictions. Events are observed with a total scalar sum of lepton transverse momenta above 100 GeV where the Standard Model expectation is low. In this region, combining di-lepton and tri-lepton classes, five events are observed in e(+) p collisions, compared to a Standard Model expectation of 0.96 +/- 0.12, while no such event is observed in e(-) p data for 0.64 +/- 0.09 expected. (C) 2008 Elsevier B.V. All rights reserved.
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19. |
- Aaron, F. D., et al.
(författare)
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Search for excited electrons in ep collisions at HERA
- 2008
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Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 666:2, s. 131-139
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Tidskriftsartikel (refereegranskat)abstract
- A search for excited electrons is performed using the full e(+/-) p data sample collected by the HI experiment at HERA, corresponding to a total luminosity of 475 pb(-1). The electroweak decays of excited electrons e* -> e gamma, e* -> eZ and e* -> vW with subsequent hadronic or leptonic decays of the W and Z bosons are considered. No evidence for excited electron production is found. Mass dependent exclusion limits on e* production cross sections and on the ratio f/Lambda of the coupling to the compositeness scale are derived within gauge mediated models. These limits extend the excluded region compared to previous excited electron searches. The e* production via contact interactions is also addressed for the first time in ep collisions. (C) 2008 Elsevier B.V. All rights reserved.
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20. |
- Aaron, F. D., et al.
(författare)
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Strangeness production at low Q(2) in deep-inelastic ep scattering at HERA
- 2009
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 61:2, s. 185-205
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Tidskriftsartikel (refereegranskat)abstract
- The production of neutral strange hadrons is investigated using deep-inelastic scattering events measured with the H1 detector at HERA. The measurements are made in the phase space defined by the negative four-momentum transfer squared of the photon 2 < Q(2) < 100 GeV2 and the inelasticity 0.1 < y < 0.6. The K-s(0) s and Lambda((Lambda) over bar) production cross sections and their ratios are determined. K-s(0) s production is compared to the production of charged particles in the same region of phase space. The Lambda-(Lambda) over bar asymmetry is also measured and found to be consistent with zero. Predictions of leading order Monte Carlo programs are compared to the data.
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21. |
- Aaron, F. D., et al.
(författare)
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Study of charm fragmentation into D (* +/-) mesons in deep-inelastic scattering at HERA
- 2009
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 59:3, s. 589-606
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Tidskriftsartikel (refereegranskat)abstract
- The process of charm quark fragmentation is studied using D (* +/-) meson production in deep-inelastic scattering as measured by the H1 detector at HERA. The parameters of fragmentation functions are extracted for QCD models based on leading order matrix elements and DGLAP or CCFM evolution of partons together with string fragmentation and particle decays. Additionally, they are determined for a next-to-leading order QCD calculation in the fixed flavour number scheme using the independent fragmentation of charm quarks to D (* +/-) mesons. Two different regions of phase space are investigated defined by the presence or absence of a jet containing the D (* +/-) meson in the event. The fragmentation parameters extracted for the two phase space regions are found to be different.
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22. |
- Abdo, A. A., et al.
(författare)
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A limit on the variation of the speed of light arising from quantum gravity effects
- 2009
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 462:7271, s. 331-334
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Tidskriftsartikel (refereegranskat)abstract
- A cornerstone of Einstein’s special relativity is Lorentz invariance—the postulate that all observers measure exactly the same speed of light in vacuum, independent of photon-energy. While special relativity assumes that there is no fundamental length-scale associated with such invariance, there is a fundamental scale (the Planck scale, lPlanck~1.62×10-33cm or EPlanck = MPlanckc2~1.22×1019GeV), at which quantum effects are expected to strongly affect the nature of space–time. There is great interest in the (not yet validated) idea that Lorentz invariance might break near the Planck scale. A key test of such violation of Lorentz invariance is a possible variation of photon speed with energy. Even a tiny variation in photon speed, when accumulated over cosmological light-travel times, may be revealed by observing sharp features in γ-ray burst (GRB) light-curves. Here we report the detection of emission up to ~31GeV from the distant and short GRB090510. We find no evidence for the violation of Lorentz invariance, and place a lower limit of 1.2EPlanck on the scale of a linear energy dependence (or an inverse wavelength dependence), subject to reasonable assumptions about the emission (equivalently we have an upper limit of lPlanck/1.2 on the length scale of the effect). Our results disfavour quantum-gravity theories in which the quantum nature of space–time on a very small scale linearly alters the speed of light.
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23. |
- Elsik, Christine G., et al.
(författare)
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The Genome Sequence of Taurine Cattle : A Window to Ruminant Biology and Evolution
- 2009
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 324:5926, s. 522-528
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Tidskriftsartikel (refereegranskat)abstract
- To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
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24. |
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25. |
- Villa, Luisa L., et al.
(författare)
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Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions
- 2007
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Ingår i: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 356:19, s. 1915-1927
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Human papillomavirus types 16 (HPV-16) and 18 (HPV-18) cause approximately 70% of cervical cancers worldwide. A phase 3 trial was conducted to evaluate a quadrivalent vaccine against HPV types 6, 11, 16, and 18 (HPV-6/11/16/18) for the prevention of high-grade cervical lesions associated with HPV-16 and HPV-18. METHODS: In this randomized, double-blind trial, we assigned 12,167 women between the ages of 15 and 26 years to receive three doses of either HPV-6/11/16/18 vaccine or placebo, administered at day 1, month 2, and month 6. The primary analysis was performed for a per-protocol susceptible population that included 5305 women in the vaccine group and 5260 in the placebo group who had no virologic evidence of infection with HPV-16 or HPV-18 through 1 month after the third dose (month 7). The primary composite end point was cervical intraepithelial neoplasia grade 2 or 3, adenocarcinoma in situ, or cervical cancer related to HPV-16 or HPV-18. RESULTS: Subjects were followed for an average of 3 years after receiving the first dose of vaccine or placebo. Vaccine efficacy for the prevention of the primary composite end point was 98% (95.89% confidence interval [CI], 86 to 100) in the per-protocol susceptible population and 44% (95% CI, 26 to 58) in an intention-to-treat population of all women who had undergone randomization (those with or without previous infection). The estimated vaccine efficacy against all high-grade cervical lesions, regardless of causal HPV type, in this intention-to-treat population was 17% (95% CI, 1 to 31). CONCLUSIONS: In young women who had not been previously infected with HPV-16 or HPV-18, those in the vaccine group had a significantly lower occurrence of high-grade cervical intraepithelial neoplasia related to HPV-16 or HPV-18 than did those in the placebo group.
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26. |
- Clark, Andrew G., et al.
(författare)
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Evolution of genes and genomes on the Drosophila phylogeny
- 2007
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 450:7167, s. 203-218
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Tidskriftsartikel (refereegranskat)abstract
- Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.
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27. |
- Coustenis, A., et al.
(författare)
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TandEM : Titan and Enceladus mission
- 2009
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Ingår i: Experimental astronomy. - : Springer Science and Business Media LLC. - 0922-6435 .- 1572-9508. ; 23:3, s. 893-946
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Tidskriftsartikel (refereegranskat)abstract
- TandEM was proposed as an L-class (large) mission in response to ESA's Cosmic Vision 2015-2025 Call, and accepted for further studies, with the goal of exploring Titan and Enceladus. The mission concept is to perform in situ investigations of two worlds tied together by location and properties, whose remarkable natures have been partly revealed by the ongoing Cassini-Huygens mission. These bodies still hold mysteries requiring a complete exploration using a variety of vehicles and instruments. TandEM is an ambitious mission because its targets are two of the most exciting and challenging bodies in the Solar System. It is designed to build on but exceed the scientific and technological accomplishments of the Cassini-Huygens mission, exploring Titan and Enceladus in ways that are not currently possible (full close-up and in situ coverage over long periods of time). In the current mission architecture, TandEM proposes to deliver two medium-sized spacecraft to the Saturnian system. One spacecraft would be an orbiter with a large host of instruments which would perform several Enceladus flybys and deliver penetrators to its surface before going into a dedicated orbit around Titan alone, while the other spacecraft would carry the Titan in situ investigation components, i.e. a hot-air balloon (MontgolfiSre) and possibly several landing probes to be delivered through the atmosphere.
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28. |
- Mazzali, P. A., et al.
(författare)
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High-Velocity Features : A Ubiquitous Property of Type Ia Supernovae
- 2005
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Ingår i: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 623, s. L37-L40
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Tidskriftsartikel (refereegranskat)abstract
- Evidence of high-velocity features (HVFs) such as those seen in the near-maximum spectra of some Type Ia supernovae (SNe Ia; e.g., SN 2000cx) has been searched for in the available SN Ia spectra observed earlier than 1 week before B maximum. Recent observational efforts have doubled the number of SNe Ia with very early spectra. Remarkably, all SNe Ia with early data (seven in our Research Training Network sample and 10 from other programs) show signs of such features, to a greater or lesser degree, in Ca II IR and some also in the Si II λ6355 line. HVFs may be interpreted as abundance or density enhancements. Abundance enhancements would imply an outer region dominated by Si and Ca. Density enhancements may result from the sweeping up of circumstellar material (CSM) by the highest velocity SN ejecta. In this scenario, the high incidence of HVFs suggests that a thick disk and/or a high-density companion wind surrounds the exploding white dwarf, as may be the case in single degenerate systems. Large-scale angular fluctuations in the radial density and abundance distribution may also be responsible: this could originate in the explosion and would suggest a deflagration as the more likely explosion mechanism. CSM interaction and surface fluctuations may coexist, possibly leaving different signatures on the spectrum. In some SNe, the HVFs are narrowly confined in velocity, suggesting the ejection of blobs of burned material.
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29. |
- Altavilla, G., et al.
(författare)
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The early spectral evolution of SN2004dt
- 2007
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 475:2, s. 585-595
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Tidskriftsartikel (refereegranskat)abstract
- Aims. We study the optical spectroscopic properties of Type Ia Supernova (SNIa) 2004dt, focusing our attention on the early epochs. Methods. Observation triggered soon after the SN 2004dt discovery allowed us to obtain a spectrophotometric coverage from day -10 to almost one year (similar to 353 days) after the B band maximum. Observations carried out on an almost daily basis allowed us a good sampling of the fast spectroscopic evolution of SN 2004dt in the early stages. To obtain this result, low-resolution, long-slit spectroscopy was obtained using a number of facilities. Results. This supernova, which in some absorption lines of its early spectra showed the highest degree of polarization ever measured in any SN Ia, has a complex velocity structure in the outer layers of its ejecta. Unburnt oxygen is present, moving at velocities as high as similar to 16 700 km s(-1), with some intermediate-mass elements (Mg, Si, Ca) moving equally fast. Modeling of the spectra based on standard density profiles of the ejecta fails to reproduce the observed features, whereas enhancing the density of outer layers significantly improves the fit. Our analysis indicates the presence of clumps of high-velocity, intermediate-mass elements in the outermost layers, which is also suggested by the spectropolarimetric data.
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30. |
- Richards, Stephen, et al.
(författare)
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The genome of the model beetle and pest Tribolium castaneum.
- 2008
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Ingår i: Nature. - 1476-4687. ; 452:7190, s. 949-55
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Tidskriftsartikel (refereegranskat)abstract
- Tribolium castaneum is a representative of earth’s most numerous eukaryotic order, a powerful model organism for the study of generalized insect development, and also an important pest of stored agricultural products. We describe its genome sequence here. This omnivorous beetle has evolved an ability to interact with a diverse chemical environment as evidenced by large expansions in odorant and gustatory receptors, as well as p450 and other detoxification enzymes. Developmental patterns in Tribolium are more representative of other arthropods than those found in Drosophila, a fact represented in gene content and function. For one, Tribolium has retained more ancestral genes involved in cell-cell communication than Drosophila, and some are expressed in the growth zone crucial for axial elongation in short germ development. Systemic RNAi in T. castaneum appears to use mechanisms distinct from those found in C. elegans, but nevertheless offers similar power for the elucidation of gene function and identification of targets for selective insect control.
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31. |
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32. |
- Altavilla, G., et al.
(författare)
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Type Ia SNe Along Redshift : The \mathcal {R}(Si II) Ratio and the Expansion Velocities in Intermediate-z Supernovae
- 2009
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Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 695, s. 135-148
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Tidskriftsartikel (refereegranskat)abstract
- We present a study of intermediate-z Type Ia supernovae (SNe Ia) using empirical physical diagrams which permit the investigation of those SNe explosions. This information can be very useful to reduce systematic uncertainties of the Hubble diagram of SNe Ia up to high z. The study of the expansion velocities and the measurement of the ratio \mathcal {R}(Si II) allow subtyping of SNe Ia as done in nearby samples. The evolution of this ratio as seen in the diagram \mathcal {R}(Si II)-(t) together with \mathcal {R}(Si II)max versus (B - V)0 indicates consistency of the properties at intermediate-z compared with the nearby SNe Ia. At intermediate-z, expansion velocities of Ca II and Si II are found similar to those of the nearby sample. This is found in a sample of six SNe Ia in the range 0.033 <=z<= 0.329 discovered within the International Time Programme of SNe Ia for Cosmology and Physics in the spring run of 2002.7The program run under Omega and Lambda from Supernovae and the Physics of Supernova Explosions within the International Time Programme at the telescopes of the European Northern Observatory (ENO) at La Palma (Canary Islands, Spain). Two SNe Ia at intermediate-z were of the cool FAINT type, one being an SN1986G-like object highly reddened. The \mathcal {R}(Si II) ratio as well as subclassification of the SNe Ia beyond templates help to place SNe Ia in their sequence of brightness and to distinguish between reddened and intrinsically red supernovae. This test can be done with very high z SNe Ia and it will help to reduce systematic uncertainties due to extinction by dust. It should allow to map the high-z sample into the nearby one.
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37. |
- Rubin, D., et al.
(författare)
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Looking Beyond Lambda with the Union Supernova Compilation
- 2009
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Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 695, s. 391-403
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Tidskriftsartikel (refereegranskat)abstract
- The recent robust and homogeneous analysis of the world's supernova distance-redshift data, together with cosmic microwave background and baryon acoustic oscillation data—provides a powerful tool for constraining cosmological models. Here we examine particular classes of scalar field, modified gravity, and phenomenological models to assess whether they are consistent with observations even when their behavior deviates from the cosmological constant Λ. Some models have tension with the data, while others survive only by approaching the cosmological constant, and a couple are statistically favored over Λ cold dark matter. Dark energy described by two equation-of-state parameters has considerable phase space to avoid Λ and next-generation data will be required to constrain such physics, with the level of complementarity between probes varying with cosmology.
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38. |
- Stanishev, Vallery, et al.
(författare)
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SN 2003du: 480 days in the life of a normal type Ia supernova
- 2007
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 469:2, s. 645-661
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Tidskriftsartikel (refereegranskat)abstract
- Aims.We present a study of the optical and near-infrared (NIR) properties of the Type Ia Supernova (SN Ia) 2003du.Methods: An extensive set of optical and NIR photometry and low-resolution long-slit spectra was obtained using a number of facilities. The observations started 13 days before B-band maximum light and continued for 480 days with exceptionally good time sampling. The optical photometry was calibrated through the S-correction technique.Results: The {UBVRIJHK} light curves and the color indices of SN 2003du closely resemble those of normal SNe Ia. SN 2003du reached a B-band maximum of 13.49 ± 0.02 mag on JD2 452 766.38 ± 0.5. We derive a B-band stretch parameter of 0.988 ±0.003, which corresponds to Δ m15=1.02 ±0.05, indicative of a SN Ia of standard luminosity. The reddening in the host galaxy was estimated by three methods, and was consistently found to be negligible. Using an updated calibration of the V and {JHK} absolute magnitudes of SNe Ia, we find a distance modulus μ=32.79±0.15 mag to the host galaxy, UGC 9391. We measure a peak {uvoir} bolometric luminosity of 1.35(±0.20)×1043 erg s-1 and Arnett's rule implies that M56Ni≃0.68 ±0.14 Mȯ of 56Ni was synthesized during the explosion. Modeling of the {uvoir} bolometric light curve also indicates M56Ni in the range 0.6-0.8 Mȯ. The spectral evolution of SN 2003du at both optical and NIR wavelengths also closely resembles normal SNe Ia. In particular, the Si II ratio at maximum R(Si II) = 0.22 ±0.02 and the time evolution of the blueshift velocities of the absorption line minima are typical. The pre-maximum spectra of SN 2003du showed conspicuous high-velocity features in the Ca II H&K doublet and infrared triplet, and possibly in Si II λ6355, lines. We compare the time evolution of the profiles of these lines with other well-observed SNe Ia and we suggest that the peculiar pre-maximum evolution of Si II λ6355 line in many SNe Ia is due to the presence of two blended absorption components.
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41. |
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42. |
- Camacho-Zuniga, C., et al.
(författare)
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Aromatic polysulfone copolymers for gas separation membrane applications
- 2009
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Ingår i: Journal of Membrane Science. - : Elsevier BV. - 0376-7388. ; 340:1-2, s. 221-226
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Tidskriftsartikel (refereegranskat)abstract
- New polysulfone (PSF) copolymers from bis(4-fluorophenyl)sulfone and based on equimolar mixtures of the rigid/compact naphthalene moiety with bulky connectors from bisphenols: tetramethyl, hexafluoro, and tetramethyl hexafluoro, respectively, were synthesized to measure significant physical properties related to the gas separation field. The flexible and transparent polymer dense films TM-NPSF, HF-NPSF and TMHF-NPSF show high glass transition temperatures Tg congruent to 230 degrees C and high decomposition temperatures To congruent to 400 degrees C (10wt.% loss, in air). Free volume cavity sizes, as determined by PALS, are in the range of 94-139 angstrom(3). Their gas permeability and selectivity combinations of properties, measured at 35 degrees C and 2 atm, are very attractive since their selectivity for the pair of gases H-2/CH4,O-2/N-2, and CO2/CH4 are higher than those for commercial PSF membranes, having similar or superior permeability coefficients for the most permeable gases H-2, O-2, and CO2. Especially important is the tetramethyl naphthalene polysulfone TM-NPSF membrane which reports selectivities for H-2/CH4, O-2/N-2 and CO2/CH4 of 122, 7.6 and 38 with corresponding permeability coefficients (in Barters) of 17 for H-2, 1.2 for O-2, and 5.2 for CO2. These results are interpreted in terms of free volume size and glass transition temperature together with the respective contribution of gas solubility and diffusivity to the overall selectivity coefficients. (C) 2009 Elsevier B.V. All rights reserved.
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43. |
- Coreno, M., et al.
(författare)
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Vis-UV fluorescence studies of fragments resulting from the relaxation of molecular core hole states
- 2007
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Ingår i: Physica Scripta. - 0031-8949 .- 1402-4896. ; 76:3, s. C90-C95
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Tidskriftsartikel (refereegranskat)abstract
- The absorption of soft x-ray radiation induces neutral and ionic core hole states in molecules. The relaxation of such states typically leads to a multi-step process, at the end of which photons in the visible and UV range can also be emitted from fragments. In this paper, we present results on Balmer and Lyman emission that originates from excited H atoms produced at the K-edge of the water, ammonia and methane molecules. Dissociation pathways leading to fluorescence emission are discussed.
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44. |
- Decleva, P, et al.
(författare)
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Shake-up transitions in S 2p, S 2s and F 1s photoionization of the SF6 molecule
- 2009
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Ingår i: Journal of Physics B. - : IOP Publishing. - 0953-4075 .- 1361-6455. ; 42:5, s. 055102-
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Tidskriftsartikel (refereegranskat)abstract
- Shake-up transitions occurring upon core photoionization in the SF6 molecule have been studied experimentally and theoretically. The S 2p, S 2s and F 1s shake-up satellite photoelectron spectra were measured using A1 Ka radiation at 1487 eV photon energy. They have been interpreted with the aid of ab initio configuration interaction calculations in the sudden-limit approximation. For the S 2p spectrum, conjugate shake-up transitions were also calculated. Clear evidence of conjugate processes is observed in the S 2p shake-up spectrum measured at 230 eV photon energy. The experimental and theoretical S 2p and S 2s shake-up spectra show very similar structures mainly due to orbital relaxation involving S 3s and 3p participation. For the calculation of the F 1s shake-up spectrum, the symmetry lowering of the molecule in the final states was considered, resulting in a good agreement with the experiment.
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45. |
- Demetris, Anthony J, et al.
(författare)
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Liver biopsy interpretation for causes of late liver allograft dysfunction.
- 2006
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Ingår i: Hepatology (Baltimore, Md.). - : Ovid Technologies (Wolters Kluwer Health). - 0270-9139 .- 1527-3350. ; 44:2, s. 489-501
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Tidskriftsartikel (refereegranskat)abstract
- Evaluation of needle biopsies and extensive clinicopathological correlation play an important role in the determination of liver allograft dysfunction occurring more than 1 year after transplantation. Interpretation of these biopsies can be quite difficult because of the high incidence of recurrent diseases that show histopathological, clinical, and serological features that overlap with each other and with rejection. Also, more than one insult can contribute to allograft injury. In an attempt to enable centers to compare and pool results, improve therapy, and better understand pathophysiological disease mechanisms, the Banff Working Group on Liver Allograft Pathology herein proposes a set of consensus criteria for the most common and problematic causes of late liver allograft dysfunction, including late-onset acute and chronic rejection, recurrent and new-onset viral and autoimmune hepatitis, biliary strictures, and recurrent primary biliary cirrhosis and primary sclerosing cholangitis. A discussion of differential diagnosis is also presented.
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