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Cumulative lead exp...
Cumulative lead exposure : relationship to mortality and lung cancer morbidity in a cohort of smelter workers
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- Lundström, Nils-Göran (författare)
- Umeå universitet,Yrkes- och miljömedicin
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- Nordberg, Gunnar (författare)
- Umeå universitet,Yrkes- och miljömedicin
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Englyst, Vagn (författare)
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Gerhardsson, Lars (författare)
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Hagmar, Lars (författare)
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- Jin, Taiyi (författare)
- Umeå universitet,Yrkes- och miljömedicin
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Rylander, Lars (författare)
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- Wall, Stig (författare)
- Umeå universitet,Epidemiologi och global hälsa
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(creator_code:org_t)
- Scandinavian Journal of Work, Environment and Health, 1997
- 1997
- Engelska.
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Ingår i: Scandinavian Journal of Work, Environment and Health. - : Scandinavian Journal of Work, Environment and Health. - 0355-3140 .- 1795-990X. ; 23:1, s. 24-30
- Relaterad länk:
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https://www.sjweh.fi...
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https://urn.kb.se/re...
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https://doi.org/10.5...
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Abstract
Ämnesord
Stäng
- Objectives: The purpose of this study was to determine the mortality and cancer incidence of long-term lead smelter workers at a primary smelter.Methods: A cohort of 3979 workers employed for at least 1 year during 1928-1979 and a subcohort of 1992 workers employed in lead-exposed departments (lead only workers) was formed. The expected mortality in 1955-1987 and cancer incidence in 1958-1987 were calculated relative to the county rates, specified for cause, gender, 5-year age groups, and calendar year. A cumulative blood-lead index was used for the dose-response analyses.Results: The lung cancer incidence of the total cohort [standardized incidence ratio (SIR) 2.8, 95% confidence interval (95% CI) 2.1-3.8] and the group with the highest exposure (SIR 3.1, 95% CI 2.0-4.6) was high. Similar risk estimates were observed with a latency of 15 years. The workers hired before 1950 had higher lung cancer risk estimates (SIR 3.6, 95% CI 2.6-5.0) than the workers hired later (SIR 1.3, 95% CI 0.6-2.6, no latency period). The risk estimates for lung cancer were further elevated in the subcohort of lead-only workers (SIR 5.1, 95% CI 2.0-10.5 in the highest exposed subgroup; latency period of 15 years). No excesses of other malignancies were noted.Conclusions: The increased relative risks were probably mainly due to interactions between lead and other carcinogenic exposures, including arsenic. Further study is required concerning such possible interactions before a role in the induction of lung cancer can be ascribed to lead.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- copper-lead smelter
- cohort study
- lung cancer
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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