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- Parmhed, Sara, et al.
(författare)
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Transformative agreements and their practical impact : a librarian perspective
- 2023
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Ingår i: Insights the UKSG journal. - : Ubiquity Press. - 2048-7754. ; 36
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Tidskriftsartikel (refereegranskat)abstract
- This case study aims at describing how transformative agreements (TAs) have affected our profession with new tasks and workflows at two university libraries in Sweden, namely Karolinska Institutet University Library and Södertörn University Library. TAs are one of the mechanisms by which scientific publications are made open access; they involve moving libraries’ contracts with publishers from payment to read toward payment to publish. We will summarize the status and progress of open access in Sweden, in particular the significant growth of TAs over a short time span. We will then focus on describing how TAs have affected our everyday work and what new tasks they have imposed. We will share our experiences and point out things we find challenging, for example, we will explore questions about eligibility, the verification process, publication types and title changes during the contract period. We will also give some recommendations on how we would prefer the workflows surrounding the TAs to be. Finally, we will share our conclusions and comments about the impact of TAs on the publishing landscape and speculate about what will happen next.
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| 2. |
- Säll, Johanna, et al.
(författare)
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Salt-inducible kinases are required for glucose uptake and insulin signaling in human adipocytes
- 2023
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Ingår i: Obesity. - 1930-739X. ; 31:10, s. 2515-2529
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: Salt-inducible kinase 2 (SIK2) is abundantly expressed in adipocytes and downregulated in adipose tissue from individuals with obesity or insulin resistance. The main aims of this work were to investigate the involvement of SIKs in the regulation of glucose uptake in primary mature human adipocytes and to identify mechanisms underlying this regulation.METHODS: Primary mature adipocytes were isolated from human, rat, or mouse adipose tissue and treated with pan-SIK inhibitors. Adipocytes isolated from wild type, ob/ob, and SIK2 knockout mice were also used. Glucose uptake was examined by glucose tracer assay. The insulin signaling pathway was monitored by Western blotting, co-immunoprecipitation, and total internal reflection fluorescence microscopy.RESULTS: This study demonstrates that SIK2 is downregulated in obese ob/ob mice and that SIK activity is required for intact glucose uptake in primary human and mouse adipocytes. The underlying mechanism involves direct effects on the insulin signaling pathway, likely at the level of phosphatidylinositol (3,4,5)-trisphosphate (PIP3) generation or breakdown. Moreover, lack of SIK2 alone is sufficient to attenuate glucose uptake in mouse adipocytes.CONCLUSIONS: SIK2 is required for insulin action in human adipocytes, and the mechanism includes direct effects on the insulin signaling pathway.
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