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- Kaasinen, E, et al.
(author)
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Impact of constitutional TET2 haploinsufficiency on molecular and clinical phenotype in humans
- 2019
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 1252-
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Journal article (peer-reviewed)abstract
- Clonal hematopoiesis driven by somatic heterozygous TET2 loss is linked to malignant degeneration via consequent aberrant DNA methylation, and possibly to cardiovascular disease via increased cytokine and chemokine expression as reported in mice. Here, we discover a germline TET2 mutation in a lymphoma family. We observe neither unusual predisposition to atherosclerosis nor abnormal pro-inflammatory cytokine or chemokine expression. The latter finding is confirmed in cells from three additional unrelated TET2 germline mutation carriers. The TET2 defect elevates blood DNA methylation levels, especially at active enhancers and cell-type specific regulatory regions with binding sequences of master transcription factors involved in hematopoiesis. The regions display reduced methylation relative to all open chromatin regions in four DNMT3A germline mutation carriers, potentially due to TET2-mediated oxidation. Our findings provide insight into the interplay between epigenetic modulators and transcription factor activity in hematological neoplasia, but do not confirm the putative role of TET2 in atherosclerosis.
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- Ben Henda, N., et al.
(author)
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OpenSAW : Open security analysis workbench
- 2017
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In: 20th International Conference on Fundamental Approaches to Software Engineering, FASE 2017 Held as Part of the European Joint Conferences on Theory and Practice of Software, ETAPS 2017. - Berlin, Heidelberg : Springer Berlin/Heidelberg. - 9783662544938 ; , s. 321-337
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Conference paper (peer-reviewed)abstract
- Software is today often composed of many sourced componets, which potentially contain security vulnerabilities, and therefore require testing before being integrated. Tools for automated test case generation, for example, based on white-box fuzzing, are beneficial for this testing task. Such tools generally explore limitations of the specific underlying techniques for solving problems related to, for example, constraint solving, symbolic execution, search heuristics and execution trace extraction. In this article we describe the design of OpenSAW, a more flexible general-purpose white-box fuzzing framework intended to encourage research on new techniques identifying security problems. In addition, we have formalized two unaddressed technical aspects and devised new algorithms for these. The first relates to generalizing and combining different program exploration strategies, and the second relates to prioritizing execution traces. We have evaluated OpenSAW using both in-house and external programs and identified several bugs.
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- Hall, C. Michael, et al.
(author)
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Denying bogus skepticism in climate change and tourism research.
- 2015
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In: Tourism Management. - : Elsevier BV. - 0261-5177 .- 1879-3193. ; 47, s. 352-356
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Journal article (peer-reviewed)abstract
- This final response to the two climate change denial papers by Shani and Arad further highlights the inaccuracies, misinformation and errors in their commentaries. The obfuscation of scientific research and the consensus on anthropogenic climate change may have significant long-term negative consequences for better understanding the implications of climate change and climate policy for tourism and create confusion and delay in developing and implementing tourism sector responses.
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- Hall, C. Michael, et al.
(author)
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No time for smokescreen skepticism : A rejoinder to Shani and Arad
- 2015
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In: Tourism Management. - : Elsevier BV. - 0261-5177 .- 1879-3193. ; 47, s. 341-347
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Journal article (peer-reviewed)abstract
- Shani and Arad (2014) claimed that tourism scholars tend to endorse the most pessimistic assessments regarding climate change, and that anthropogenic climate change was a "fashionable" and "highly controversial scientific topic". This brief rejoinder provides the balance that is missing from such climate change denial and skepticism studies on climate change and tourism. Recent research provides substantial evidence that reports on anthropogenic climate change are accurate, and that human-induced greenhouse gas emissions, including from the tourism industry, play a significant role in climate change. Some positive net effects may be experienced by some destinations in the short-term, but in the long-term all elements of the tourism system will be impacted. The expansion of tourism emissions at a rate greater than efficiency gains means that it is increasingly urgent that the tourism sector acknowledge, accept and respond to climate change. Debate on tourism-related adaptation and mitigation measures is to be encouraged and welcomed. Climate change denial is not.
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- Åstrand, Mikael, et al.
(author)
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Surrogate models for design and study of underground mine ventilation
- 2017
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Conference paper (peer-reviewed)abstract
- Ventilation is vital for the production in an underground mine. Therefore, it is important to have efficient and accurate design tools in order to ensure and optimize the airflows in the mine. There are several commercial software for airflow simulation based on first principles. However, the computational cost of simulation together with integrational obstacles when connecting simulation to control strategies limits the benefit of these tools. In this paper an approach utilizing surrogate models as a complementary design tool is presented. It is shown that using surrogate models one can with rather low computational expense evaluate and benchmark different control strategies. It is also shown that the models can be used for identifying possible bottlenecks in the system in advance. Moreover, the use of surrogate models transfer the simulation into a development-friendly environment (such as Matlab). A test case is used based on a real underground mine ventilation design. Two types of surrogate models are fitted to process data; multiple least squares regression and a Gaussian process model. Sensitivity analysis on the surrogate shows the potential of using surrogate models for identifying bottlenecks. Furthermore, the surrogate is used to benchmark two different control strategies for mine ventilation.
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