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- Govind, Satish C, et al.
(författare)
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Role of N-terminal pro-brain natriuretic peptide in ST-segment elevation myocardial infarction : experience from a tertiary centre in India.
- 2011
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Ingår i: Critical Pathways in Cardiology. - 1535-282X .- 1535-2811. ; 10:4, s. 180-184
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Role of biomarkers in ST-segment elevation myocardial infarction (STEMI) is paramount, as they aid in diagnosis and gauge prognosis of the disease. In this project, we sought to study the short-term outcome and clinical associates of N-terminal pro-brain natriuretic peptide (NT-proBNP) in the setting of STEMI at a tertiary center in India. METHODS: In all, 173 STEMI patients (mean age: 57 ± 12 years, 38 women) had their NT-proBNP assayed in addition to troponins and high-sensitive C-reactive protein. Subjects were divided according to NT-proBNP levels into 2 groups: group 1 (NT-proBNP ≤100 pg/mL) and group 2 (NT-proBNP >100 pg/mL). RESULTS: NT-proBNP values (pg/mL) were elevated in group 2 (group 1: 61.7 ± 6.2; group 2: 1006.5 ± 990.6, P < 0.0001). Significantly greater number of females had elevated NT-proBNP (P < 0.05) that could be predicted by the duration of chest pain related to STEMI (area under the curve: 0.72), and age at presentation (area under the curve: 0.66). Multiple regression analysis showed a strong inverse association between NT-proBNP and left ventricular ejection fraction and a strong positive association between the peptide and high-sensitive C-reactive protein. A significant positive association was also noted between NT-proBNP and troponin I (all P < 0.05, Global R = 0.47). Diabetes mellitus and/or hypertension, and infarction localization showed no effect on NT-proBNP levels along with death, primary coronary intervention-related bleeding, and arrhythmias, (χ, P = ns). CONCLUSIONS: The data suggest that women are more likely to have increased NT-proBNP while presenting with STEMI. Duration of chest pain and age at presentation are the best predictors of elevated NT-proBNP, though without much bearing on short-term morbidity and mortality.
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| 3. |
- Kanti Saha, Samir, et al.
(författare)
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Relationship between 24- hour Holter variables, chest discomfort and syncope : Does age matter?
- 2013
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Ingår i: International Cardiovascular Forum Journal. - : Baracaray Publishing. - 2410-2636 .- 2409-3424. ; 1:2, s. 90-95
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Tidskriftsartikel (refereegranskat)abstract
- One hundred and forty four ambulatory, non-emergent human subjects from 20-88 years of age were investigated followingroutine 24 hour Holter monitoring referred by primary and tertiary care centers primarily for evaluation of palpitationsand syncope. The patients were grouped into 3 different age categories: a) 20-59 years of age (16%), B) 60-69 yearsof age (26.4%) and C) > 70 years of age (57.6%). Heart rate profile, RR intervals, symptoms, frequency of prematuresupra ventricular and ventricular complexes were registered. The data show that though the occurrence and frequencyof premature atrial and ventricular contractions over a period of 24 hours did not differ between the groups, the youngersubjects documented more subjective discomforts during the Holter monitoring. Extra-systoles in excess of 1000 beats / 24hour occured incessantly throughout the registration. patients with syncope and those without did not differ as regards theHolter variables. However, subjects with atrial fibrillation had acceptable rate control and had significantly lower incidenceof syncope than those with sinus rhythm. The findings suggest that in a county setting, Holter monitoring for evaluation ofsyncope may not be the first hand mode of investigation in a non emergent setting. on the contrary, the modality appearsto be valuable for monitoring patients with atrial fibrillation. Even mild symptoms in the elderly population may warrant closerclinical follow up to prevent cardiac events and/or syncope leading to serious physical injury.
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