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Nanoparticle-mediated metronomic chemotherapy in cancer : A paradigm of precision and persistence
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- Kirti, Apoorv (author)
- KIIT Univ, KIIT Sch Biotechnol, Bhubaneswar 751024, India.
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- Simnani, Faizan Zarreen (author)
- KIIT Univ, KIIT Sch Biotechnol, Bhubaneswar 751024, India.
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- Jena, Snehasmita (author)
- KIIT Univ, KIIT Sch Biotechnol, Bhubaneswar 751024, India.
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- Lenka, Sudakshya S. (author)
- KIIT Univ, KIIT Sch Biotechnol, Bhubaneswar 751024, India.
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- Kalalpitiya, Chethana (author)
- KIIT Univ, KIIT Sch Biotechnol, Bhubaneswar 751024, India.
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- Naser, Shaikh Sheeran (author)
- KIIT Univ, KIIT Sch Biotechnol, Bhubaneswar 751024, India.
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- Singh, Dibyangshee (author)
- KIIT Univ, KIIT Sch Biotechnol, Bhubaneswar 751024, India.
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- Choudhury, Anmol (author)
- KIIT Univ, KIIT Sch Biotechnol, Bhubaneswar 751024, India.
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- Sahu, Rudra Narayan (author)
- KIIT Univ, KIIT Sch Biotechnol, Bhubaneswar 751024, India.
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- Yadav, Anu (author)
- KIIT Univ, KIIT Sch Biotechnol, Bhubaneswar 751024, India.
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- Sinha, Adrija (author)
- KIIT Univ, KIIT Sch Biotechnol, Bhubaneswar 751024, India.
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- Nandi, Aditya (author)
- KIIT Univ, KIIT Sch Biotechnol, Bhubaneswar 751024, India.;UNAM, Inst Invest Mat, Coyoacan 04510, Cdmx, Mexico.
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- Panda, Pritam Kumar, PhD Student, 1991- (author)
- Uppsala universitet,Materialteori
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- Kaushik, Nagendra Kumar (author)
- Kwangwoon Univ, Plasma Biosci Res Ctr, Dept Elect & Biol Phys, Seoul 01897, South Korea.
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- Suar, Mrutyunjay (author)
- KIIT Univ, KIIT Sch Biotechnol, Bhubaneswar 751024, India.
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- Verma, Suresh K. (author)
- KIIT Univ, KIIT Sch Biotechnol, Bhubaneswar 751024, India.
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KIIT Univ, KIIT Sch Biotechnol, Bhubaneswar 751024, India KIIT Univ, KIIT Sch Biotechnol, Bhubaneswar 751024, India.;UNAM, Inst Invest Mat, Coyoacan 04510, Cdmx, Mexico. (creator_code:org_t)
- Elsevier, 2024
- 2024
- English.
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In: Cancer Letters. - : Elsevier. - 0304-3835 .- 1872-7980. ; 594
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Current methods of cancer therapy have demonstrated enormous potential in tumor inhibition. However, a high dosage regimen of chemotherapy results in various complications which affect the normal body cells. Tumor cells also develop resistance against the prescribed drugs in the whole treatment regimen increasing the risk of cancer relapse. Metronomic chemotherapy is a modern treatment method that involves administering drugs at low doses continuously, allowing the drug sufficient time to take its effect. This method ensures that the toxicity of the drugs is to a minimum in comparison to conventional chemotherapy. Nanoparticles have shown efficacy in delivering drugs to the tumor cells in various cancer therapies. Combining nanoparticles with metronomic chemotherapy can yield better treatment results. This combination stimulates the immune system, improving cancer cells recognition by immune cells. Evidence from clinical and pre-clinical trials supports the use of metronomic delivery for drug-loaded nanoparticles. This review focuses on the functionalization of nanoparticles for improved drug delivery and inhibition of tumor growth. It emphasizes the mechanisms of metronomic chemotherapy and its conjunction with nanotechnology. Additionally, it explores tumor progression and the current methods of chemotherapy. The challenges associated with nano-based metronomic chemotherapy are outlined, paving the way for prospects in this dynamic field.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Cancer
- Metronomic
- Chemotherapy
- Nanoparticle
- Therapy
- Liposome
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kirti, Apoorv
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Simnani, Faizan ...
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Jena, Snehasmita
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Lenka, Sudakshya ...
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Kalalpitiya, Che ...
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Naser, Shaikh Sh ...
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Singh, Dibyangsh ...
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Choudhury, Anmol
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Sahu, Rudra Nara ...
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Yadav, Anu
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Sinha, Adrija
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Nandi, Aditya
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Panda, Pritam Ku ...
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Kaushik, Nagendr ...
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Suar, Mrutyunjay
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Verma, Suresh K.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Letters
- By the university
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Uppsala University