| 1. |
- Campbell, PJ, et al.
(författare)
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Pan-cancer analysis of whole genomes
- 2020
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 578:7793, s. 82-
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Tidskriftsartikel (refereegranskat)abstract
- Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1–3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10–18.
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| 2. |
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| 3. |
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| 4. |
- Jayaramulu, K., et al.
(författare)
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Covalent Graphene-MOF Hybrids for High-Performance Asymmetric Supercapacitors
- 2021
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Ingår i: Advanced Materials. - : Wiley-VCH Verlag. - 0935-9648 .- 1521-4095. ; 33:4
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Tidskriftsartikel (refereegranskat)abstract
- In this work, the covalent attachment of an amine functionalized metal-organic framework (UiO-66-NH2 = Zr6O4(OH)4(bdc-NH2)6; bdc-NH2 = 2-amino-1,4-benzenedicarboxylate) (UiO-Universitetet i Oslo) to the basal-plane of carboxylate functionalized graphene (graphene acid = GA) via amide bonds is reported. The resultant GA@UiO-66-NH2 hybrid displayed a large specific surface area, hierarchical pores and an interconnected conductive network. The electrochemical characterizations demonstrated that the hybrid GA@UiO-66-NH2 acts as an effective charge storing material with a capacitance of up to 651 F g−1, significantly higher than traditional graphene-based materials. The results suggest that the amide linkage plays a key role in the formation of a π-conjugated structure, which facilitates charge transfer and consequently offers good capacitance and cycling stability. Furthermore, to realize the practical feasibility, an asymmetric supercapacitor using a GA@UiO-66-NH2 positive electrode with Ti3C2TX MXene as the opposing electrode has been constructed. The cell is able to deliver a power density of up to 16 kW kg−1 and an energy density of up to 73 Wh kg−1, which are comparable to several commercial devices such as Pb-acid and Ni/MH batteries. Under an intermediate level of loading, the device retained 88% of its initial capacitance after 10 000 cycles. © 2020 The Authors. Advanced Materials published by Wiley-VCH GmbH
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| 5. |
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| 6. |
- Lovric, A, et al.
(författare)
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Single-cell sequencing deconvolutes cellular responses to exercise in human skeletal muscle
- 2022
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Ingår i: Communications biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 5:1, s. 1121-
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Tidskriftsartikel (refereegranskat)abstract
- Skeletal muscle adaptations to exercise have been associated with a range of health-related benefits, but cell type-specific adaptations within the muscle are incompletely understood. Here we use single-cell sequencing to determine the effects of exercise on cellular composition and cell type-specific processes in human skeletal muscle before and after intense exercise. Fifteen clusters originating from six different cell populations were identified. Most cell populations remained quantitatively stable after exercise, but a large transcriptional response was observed in mesenchymal, endothelial, and myogenic cells, suggesting that these cells are specifically involved in skeletal muscle remodeling. We found three subpopulations of myogenic cells characterized by different maturation stages based on the expression of markers such asPAX7,MYOD1,TNNI1, andTNNI2. Exercise accelerated the trajectory of myogenic progenitor cells towards maturation by increasing the transcriptional features of fast- and slow-twitch muscle fibers. The transcriptional regulation of these contractile elements upon differentiation was validated in vitro on primary myoblast cells. The cell type-specific adaptive mechanisms induced by exercise presented here contribute to the understanding of the skeletal muscle adaptations triggered by physical activity and may ultimately have implications for physiological and pathological processes affecting skeletal muscle, such as sarcopenia, cachexia, and glucose homeostasis.
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| 7. |
- Gustavsson, Emil K., et al.
(författare)
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The annotation of GBA1 has been concealed by its protein-coding pseudogene GBAP1
- 2024
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Ingår i: Science Advances. - 2375-2548. ; 10:26, s. 1-20
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Tidskriftsartikel (refereegranskat)abstract
- Mutations in GBA1 cause Gaucher disease and are the most important genetic risk factor for Parkinson’s disease. However, analysis of transcription at this locus is complicated by its highly homologous pseudogene, GBAP1. We show that >50% of short RNA-sequencing reads mapping to GBA1 also map to GBAP1. Thus, we used long-read RNA sequencing in the human brain, which allowed us to accurately quantify expression from both GBA1 and GBAP1. We discovered significant differences in expression compared to short-read data and identify currently unannotated transcripts of both GBA1 and GBAP1. These included protein-coding transcripts from both genes that were translated in human brain, but without the known lysosomal function—yet accounting for almost a third of transcription. Analyzing brain-specific cell types using long-read and single-nucleus RNA sequencing revealed region-specific variations in transcript expression. Overall, these findings suggest nonlysosomal roles for GBA1 and GBAP1 with implications for our understanding of the role of GBA1 in health and disease.
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| 8. |
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| 9. |
- Theis-Broehl, Katharina, et al.
(författare)
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Self-Assembly of Magnetic Nanoparticles in Ferrofluids on Different Templates Investigated by Neutron Reflectometry
- 2020
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Ingår i: Nanomaterials. - : MDPI AG. - 2079-4991. ; 10:6
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Forskningsöversikt (refereegranskat)abstract
- In this article we review the process by which magnetite nanoparticles self-assemble onto solid surfaces. The focus is on neutron reflectometry studies providing information on the density and magnetization depth profiles of buried interfaces. Specific attention is given to the near-interface "wetting" layer and to examples of magnetite nanoparticles on a hydrophilic silicon crystal, one coated with (3-Aminopropyl)triethoxysilane, and finally, one with a magnetic film with out-of-plane magnetization.
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| 10. |
- Beal, Jacob, et al.
(författare)
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Robust estimation of bacterial cell count from optical density
- 2020
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Ingår i: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 3:1
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Tidskriftsartikel (refereegranskat)abstract
- Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data.
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| 11. |
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| 12. |
- Gawdiya, Sandeep, et al.
(författare)
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Field Screening of Wheat Cultivars for Enhanced Growth, Yield, Yield Attributes, and Nitrogen Use Efficiencies
- 2023
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Ingår i: Agronomy. - : MDPI. - 2073-4395. ; 13:8
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Tidskriftsartikel (refereegranskat)abstract
- Optimizing nitrogen (N) inputs is crucial for maximizing wheat yield and ensuring environmental sustainability. Wheat’s economic significance in India calls for a comprehensive evaluation of its ecological implications to develop a resilient production system. This study aimed to identify and evaluate ten wheat cultivars for their yield and N-use efficiency under varying nitrogen inputs (control (N0), half of the recommended nitrogen (N75), and the recommended nitrogen (N150)) using the surface application of neem-oil-coated urea. All N inputs were applied in three splits, basal, crown root initiation, and tillering stages, and an experiment was conducted in a split-plot design. The application of N150 gave the highest dry matter accumulation (DMA) at harvesting stage (AHS) (871 g m−2), seed/spike (60), grain yield (GY = 7.4 t ha−1), straw yield (SY = 8.9 t ha−1), harvest index (HI = 45.2%), protein (12.5%), and total uptake of N (TUN) (223 kg ha−1) by the cultivar ‘HD 3249’, being closely followed by the cultivar ‘HD3117’. Six cultivars (‘HD 3298’, ‘HD 3117’, ‘HD 3249’, ‘PBW 550’, ‘HD 3086’, ‘HD 2967’) out of the ten cultivars evaluated responded well to different input treatments with respect to the grain yield efficiency index (GYEI ≥ 1). Regarding N input, N75 and N150 recorded the highest increases in plant height, AHS (16.5%; 21.2%), dry matter accumulation (DMA) at 30 days after sowing (DAS) (37.5%; 64%), DMA-60 DAS (42%; 53%), DMA-90 DAS (39.5%; 52.5%), TILL-30 DAS (19.8%; 26.4%), TILL-60 DAS (33.3%; 44%), TILL-90 DAS (37.2%; 47.2%), seed/spike (8%; 10%), 1000-grain weight (7.8%; 12.2%), and protein content (23.3%; and 33%) when compared with N0. Furthermore, the application of N75 and N150 improved GY (72.1%; 142.6%), SY (61.1%; 110.6%), BY (65.5%; 123%), and HI by 4.4% and 9%, respectively, over N0. Nitrogen addition (N75 and N150) also significantly increased total nitrogen uptake (104.7%; 205.6%), respectively, compared to N0. The correlation analysis revealed a positive association among most of the crop parameters. Overall, our research results suggest that the cultivars ‘HD 3249’ and ‘HD 3117’ have the potential to be effective options for improving N utilization efficiency, grain yield, and GYEI in North-West India.
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| 13. |
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| 14. |
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| 15. |
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| 16. |
- Picca, Anna, et al.
(författare)
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Altered Expression of Mitoferrin and Frataxin, Larger Labile Iron Pool and Greater Mitochondrial DNA Damage in the Skeletal Muscle of Older Adults
- 2020
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Ingår i: Cells. - : MDPI AG. - 2073-4409. ; 9:12
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Tidskriftsartikel (refereegranskat)abstract
- Mitochondrial dysfunction and iron (Fe) dyshomeostasis are invoked among the mechanisms contributing to muscle aging, possibly via a detrimental mitochondrial-iron feed-forward loop. We quantified the labile Fe pool, Fe isotopes, and the expression of mitochondrial Fe handling proteins in muscle biopsies obtained from young and older adults. The expression of key proteins of mitochondrial quality control (MQC) and the abundance of the mitochondrial DNA common deletion (mtDNA(4977)) were also assessed. An inverse association was found between total Fe and the heavier Fe isotope (Fe-56), indicating an increase in labile Fe abundance in cells with greater Fe content. The highest levels of labile Fe were detected in old participants with a Short Physical Performance Battery (SPPB) score <= 7 (low-functioning, LF). Protein levels of mitoferrin and frataxin were, respectively, higher and lower in the LF group relative to young participants and older adults with SPPB scores >= 11 (high-functioning, HF). The mtDNA(4977) relative abundance was greater in old than in young participants, regardless of SPPB category. Higher protein levels of Pink1 were detected in LF participants compared with young and HF groups. Finally, the ratio between lipidated and non-lipidated microtubule-associated protein 1A/1B-light chain 3 (i.e., LC3B II/I), as well as p62 protein expression was lower in old participants regardless of SPPB scores. Our findings indicate that cellular and mitochondrial Fe homeostasis is perturbed in the aged muscle (especially in LF older adults), as reflected by altered levels of mitoferrin and frataxin, which, together with MQC derangements, might contribute to loss of mtDNA stability.
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| 17. |
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| 18. |
- Saini, Apurve, et al.
(författare)
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Magnetic particle self-assembly at functionalized interfaces
- 2021
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Ingår i: Langmuir. - : American Chemical Society (ACS). - 0743-7463 .- 1520-5827. ; 37:14, s. 4064-4071
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Tidskriftsartikel (refereegranskat)abstract
- We study the assembly of magnetite nanoparticles in water-based ferrofluids in wetting layers close to silicon substrates with different functionalization without and with an out-of-plane magnetic field. For particles of nominal sizes 5, 15, and 25 nm, we extract density profiles from neutron reflectivity measurements. We show that self-assembly is only promoted by a magnetic field if a seed layer is formed at the silicon substrate. Such a layer can be formed by chemisorption of activated N-hydroxysuccinimide ester-coated nanoparticles at a (3-aminopropyl)triethoxysilane functionalized surface. Less dense packing is reported for physisorption of the same particles at a piranha-treated (strongly hydrophilic) silicon wafer, and no wetting layer is found for a self-assembled monolayer of octadecyltrichlorosilane (strongly hydrophobic) at the interface. We show that once the seed layer is formed and under an out-of-plane magnetic field further wetting layers assemble. These layers become denser with time, larger magnetic fields, higher particle concentrations, and larger moment of the nanoparticles.
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| 19. |
- Saini, P., et al.
(författare)
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Cesaro fins parametric optimization for enhancement in the solidification performance of a latent heat storage system with combined fins, foam, and nanoparticle
- 2023
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Ingår i: Energy Reports. - 2352-4847. ; 9, s. 5670-5687
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Tidskriftsartikel (refereegranskat)abstract
- The use of Phase Change Materials (PCMs) for latent thermal energy storage enhances the availability of solar energy. PCMs can store a large amount of energy in a small volume using almost entirely isothermal processes. Despite this, the poor thermal conductivity of PCMs is a significant disadvantage of current PCMs, severely limiting their energy storage capabilities. As a result, the solidification/melting rates are reduced to an unacceptable level, and the system reaction time is increased unreasonably. By combining the novel fin arrangement, nanoparticles, and metal foam, the current study improved the solidification rate of the PCM in the Latent Heat Thermal Energy Storage System (LHTESS). LHTESS was numerically evaluated in ANSYS Fluent 18.1 using a solidification and melting model. The addition of cesaro fins, nanoparticles, and metal foam significantly improved PCM solidification in the LHTESS. PCM solidification time was reduced by 42.42% and 39.39% in Type-3 and Type-5 fin configurations, respectively, when compared to Type-4 fin configuration. Furthermore, a temperature difference of 27 K between the Heat Thermal Fluid (HTF) and the PCM ensures the best solidification performance. By incorporating nanoparticles into PCM and metal foam, the solidification time is reduced by 73.68%. Depending on the foam structure and volume fraction of the nanoparticles, dispersing nanoparticles in PCM with metal foam saves up to 75% of the time. © 2023 The Author(s)
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| 20. |
- Saini, P., et al.
(författare)
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Experimental and numerical investigation of a hybrid solar thermal-electric powered cooking oven
- 2023
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Ingår i: Energy. - : Elsevier Ltd. - 0360-5442 .- 1873-6785. ; 280
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Tidskriftsartikel (refereegranskat)abstract
- The rapid development in technology and changing food habits have drastically altered the cooking method in recent years. Electric ovens are dominating the cooking sector in bakeries, restaurants, and domestic cooking. India holds the second position in terms of revenue generated by the sales of cookers and ovens. The electrical energy requirements are also adding up with electricity-based cooking. In addition, solar energy-dependent solar cooking appliances are available in the market, but they come with their own set of merits and demerits. This paper discusses the new concept and development of an Electric-Solar hybrid cooking appliance. The implemented control mechanism in the fully-featured hybrid OTG (Oven, Toaster, & Griller) oven shows the simplicity and ease of using solar energy in conjunction with electrical energy. The experimental and numerical results show that the temperature distribution inside an electric-solar hybrid oven saves energy up to 51% and takes much less cooking time than electric ovens and solar cooking appliances when operating in hybrid mode. The STEPCO (Solar Thermal-Electric Powered Cooking Oven) oven has demonstrated potential for a relatively quick return on investment, with a payback period of around 2.3 years in hybrid mode and 3.7 years in solar mode. Experimental testing has shown that the hybrid mode of the STEPCO oven achieves an impressive efficiency of 63%, which is significantly higher than that of the electric and solar modes, which are only 35% and 4.0%, respectively. Additionally, the STEPCO oven has the environmental benefit of emitting very little CO2 during the cooking process when used in hybrid mode and zero CO2 emissions when used in solar mode. © 2023
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| 21. |
- Saini, P. K., et al.
(författare)
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The PSI+ prion modulates cytochrome c oxidase deficiency caused by deletion of COX12
- 2022
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Ingår i: Molecular Biology of the Cell. - 1059-1524 .- 1939-4586. ; 33:14
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Tidskriftsartikel (refereegranskat)abstract
- Cytochrome c oxidase (CcO) is a pivotal enzyme of the mitochondrial respiratory chain, which sustains bioenergetics of eukaryotic cells. Cox12, a peripheral subunit of CcO oxidase, is required for full activity of the enzyme, but its exact function is unknown. Here experimental evolution of a Saccharomyces cerevisiae.cox12 strain for similar to 300 generations allowed to restore the activity of CcO oxidase. In one population, the enhanced bioenergetics was caused by a A375V mutation in the cytosolic AAA+ disaggregase Hsp104. Deletion or overexpression of HSP104 also increased respiration of the Delta cox12 ancestor strain. This beneficial effect of Hsp104 was related to the loss of the [PSI+] prion, which forms cytosolic amyloid aggregates of the Sup35 protein. Overall, our data demonstrate that cytosolic aggregation of a prion impairs the mitochondrial metabolism of cells defective for Cox12. These findings identify a new functional connection between cytosolic proteostasis and biogenesis of the mitochondrial respiratory chain.
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| 22. |
- Saini, P., et al.
(författare)
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Performance enhancement of fin and tube heat exchanger employing curved delta winglet vortex generator with circular punched holes
- 2023
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Ingår i: International Journal of Thermofluids. - : Elsevier B.V.. - 2666-2027. ; 20
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Tidskriftsartikel (refereegranskat)abstract
- The generation of vortices has recently gained attention as a potential passive technique for improving air-side heat transfer in a fin and tube heat exchanger. This study proposes novel configurations of a curved delta winglet vortex generator (CDWVG) with and without circular holes to improve heat transfer in FTHEs. The present study utilizes a three-dimensional numerical analysis to investigate the thermal-hydraulic performance analysis of fin and tube heat exchanger (FTHE) with curved delta winglet vortex generators (CDWVG) with or without circular holes, operating across a wide Reynolds number range (i.e., from 400 to 2000). In addition to being arranged in vertical and horizontal configurations, the CDWVGs are oriented in the same way as the flow direction. Therefore, the pressure distribution, temperature distribution, and flow structure distribution of an FTHE with a four-in-line circular tube configuration are analyzed and compared between FTHE without vortex generator (VG) and five different configurations of CDWVG (i.e., CDWVG without hole, CDWVG with 1 hole, CDWVG with 2 holes, CDWVG with 3 holes and CDWVG with 6 holes). The pressure drop (ΔP), London area goodness factor (LAGF) (j/f), Nusselt number (Nu), and Colburn factor (j) are also used to evaluate the thermo-hydraulic performance of FTHE. The FHTE performance with CDWVGs can be affected by the number of punched holes, which is evaluated using a dimensionless number including Performance Evaluation Criteria (PEC), Colburn factor, etc. The thermo-hydraulic efficiency of the FTHE is improved significantly by using CDWVGs with circular punched holes. Nusselt number decreases across all the VG configurations (i.e., CDWVG without hole, CDWVG with 1 hole, CDWVG with 2 holes, CDWVG with 3 holes, and CDWVG with 6 holes) due to the lower flow resistance. Compared to other CDWVG configurations, the 6-hole configuration of CDWVG is the most effective. The Nusselt number of CDWVG with 6 holes increases by 77.25% and 42.51% at Reynolds numbers of 400 and 2000, with respect to fin and tube heat exchangers without vortex generator, respectively. On the other hand, friction is decreased by 5.11%. Therefore, when considering the London area goodness factor, CDWVG with six holes is found to be superior to other CDWVG configurations. © 2023 The Authors
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| 23. |
- Saini, P., et al.
(författare)
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Performance enhancement of fin and tube heat exchanger employing curved trapezoidal winglet vortex generator with circular punched holes
- 2023
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Ingår i: International Journal of Heat and Mass Transfer. - : Elsevier BV. - 0017-9310 .- 1879-2189. ; 209
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Tidskriftsartikel (refereegranskat)abstract
- Vortex generation is a potential passive technology for increasing the heat transfer rate in the air side of fin and tube heat exchangers (FTHEs). This study proposes novel configurations of a curved trapezoidal winglet vortex generator (CTWVG) with and without circular holes to improve heat transfer in FTHEs. As per the literature, the streamlined form of the trapezoidal winglet demonstrates high heat transfer enhancement with low flow loss and pressure drop. But still, different design configurations are possible to augment the heat transfer characteristics of CTWVG further. The current study investigates the novel configurations of CTWVG (i.e., CTWVG without hole, CTWVG with 1 hole, CTWVG with 2 holes, CTWVG with 3 holes and CTWVG with 6 holes). A three-dimensional computational model is utilized to evaluate the thermal-hydraulic efficiency of FTHEs fitted with CTWVGs with or without circular holes for Reynolds numbers ranging from 400 to 2000. A common flow-down configuration of the CTWVG with circular tubes array is used to reduce the wake region. The thermo-hydraulic performance and flow structure of FTHE with four inline circular tube configurations are compared without VG and CTWVG with or without holes. Pressure drop (ΔP), Nusselt number (Nu), friction factor (f), Colburn factor (j), and London area goodness factor (j/f) are used for the thermal-hydraulic performance comparison. Results show that the number of punched holes has an impact on the FTHE performance, which is measured using a dimensionless number as performance evaluation criteria (i.e., (j/jo)/(f/fo)). CTWVGs with circular punched holes significantly increase the FTHE's thermo-hydraulic performance. The results indicate that the flow resistance is reduced in all cases (i.e., VG with no holes, VG with 6 holes, VG with 3 holes, VG with 2 holes, and VG with 1 hole) with a minor decrease in the Nusselt number. The CTWVG with six holes performs better than other CTWVG configurations. At Reynolds numbers 400 and 2000, the Nusselt number for CTWVG with six holes enhanced by 75.25% and 40.10%; pressure drop increased by 107.88% and 125.51%, respectively. On the other hand, friction is reduced by a factor of 8.1% in CTWVG with 6 holes compared to CTWVG without holes. The CTWVG with six holes performs better than other CTWVG configurations reported in the literature [48,54]. HTPF has increased by 30.96% (compared to rectangular winglet [48]) and 27.69% (compared to curved rectangular winglet [54]) with respect to values reported in the literature. The London area goodness factor (LAGF) has been increased by 275% compared to Modi et al. [48]. © 2023
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| 24. |
- Saini, P., et al.
(författare)
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Performance evaluation of a parabolic trough collector with a uniform helical wire coil flow insert
- 2024
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Ingår i: Results in Engineering (RINENG). - : Elsevier. - 2590-1230. ; 21
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Tidskriftsartikel (refereegranskat)abstract
- Solar energy is an extremely useful and dependable renewable energy source for meeting our society's diverse energy demands. Solar concentrator-based energy systems are currently the most efficient methods of using solar energy. Among these technologies, the parabolic trough collector is a mature and effective concentrating solar power technology with a wide range of real-world applications using solar alone or in combination with other energy sources. Flow insert is a potential approach for improving parabolic trough solar collector performance through enhanced heat transfer and heat absorption. The purpose of this study is to determine the feasibility of using a uniform helical wire coil flow insert in the LS-2 parabolic trough solar collector module. A computational fluid dynamic model developed in Ansys 18.1 is used in the current investigation. A uniform helical wire coil flow insert is modeled and compared with the plain tube without any insert inside it. Flow analysis, overall efficiency, exergy efficiency, and thermal efficiency are compared in the evaluation process. The overall efficiency and exergy efficiency of the parabolic trough collector are the most critical criteria in determining its performance. The parabolic trough collector is examined using a range of inlet fluid temperatures ranging from 303 K to 603 K and a volumetric flow rate of 50 L per minute to 250 L per minute. The pumping work is found to be the lowest, indicating that the increase in pressure drop has a negligible effect on the overall system performance. For the flow rate of 50 L per minute and inlet heat transfer fluid temperature of 303 K, the overall, exergy and thermal efficiency using a uniform helical wire coil flow insert are found to be 2.07 %, 2.1 %, and 2.2 %, respectively. © 2024 The Authors
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| 25. |
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